Hypoxia inducible factor-1 alpha plays a pivotal role in hepatic metastasis of pancreatic cancer: an immunohistochemical study.

abstract：BACKGROUND:Recently, a new digital cholangiopancreatoscopy (DCPS) has been developed. The aim of this study is to retrospectively evaluate the utility of new DCPS in patients with pancreaticobiliary diseases. METHODS:Digital cholangiopancreatoscopy was used in 26 patients (16 men) with pancreaticobiliary diseases that...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Tanaka R,Itoi T,Honjo M,Tsuchiya T,Kurihara T,Tsuji S,Tonozuka R,Kamada K,Sofuni A,Mukai S

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:For the establishment of personalized therapy, we investigated biomarkers that can contribute to the selection of adjuvant therapy for pancreatic ductal adenocarcinoma (PDAC). METHODS:Between 2005 and 2014, of 141 consecutive patients with PDAC who underwent R0 or R1 resection, 61 patients given gemcitabine...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Oba A,Ban D,Kirimura S,Akahoshi K,Mitsunori Y,Matsumura S,Ochiai T,Kudo A,Tanaka S,Minoru T

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:The effects of ablation with various settings of powers and times using a newly developed radiofrequency (RF) ablation device, the Habib™ EndoHPB catheter, are not well known. In the present study, we examined the effects of a novel RF ablation catheter using resected fresh pig livers and evaluated the macro...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Itoi T,Isayama H,Sofuni A,Itokawa F,Tamura M,Watanabe Y,Moriyasu F,Kahaleh M,Habib N,Nagao T,Yokoyama T,Kasuya K,Kawakami H

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:The National Clinical Database (NCD) in Japan is a nationwide registry that collects the data of more than 1,200,000 surgical cases annually from over 3,500 hospitals. Based on the NCD data, this study compared the perioperative outcomes of major laparoscopic liver resection (LLR) with those of major open li...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Takahara T,Wakabayashi G,Konno H,Gotoh M,Yamaue H,Yanaga K,Fujimoto J,Kaneko H,Unno M,Endo I,Seto Y,Miyata H,Miyazaki M,Yamamoto M

更新日期：2016-11-01 00:00:00

abstract：:Since the publication of the Tokyo Guidelines in 2007 and their revision in 2013, appropriate management for acute cholecystitis has been more clearly established. Since the last revision, several manuscripts, especially for alternative endoscopic techniques, have been reported; therefore, additional evaluation and re...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Mori Y,Itoi T,Baron TH,Takada T,Strasberg SM,Pitt HA,Ukai T,Shikata S,Noguchi Y,Teoh AYB,Kim MH,Asbun HJ,Endo I,Yokoe M,Miura F,Okamoto K,Suzuki K,Umezawa A,Iwashita Y,Hibi T,Wakabayashi G,Han HS,Yoon YS,Cho

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:The aim was to examine the diagnostic ability of an endocytoscope system (ECS) for detecting the longitudinal extent of bile duct cancer. METHODS:We observed the surfaces of the bile duct of 28 consecutive patients undergoing biliary surgery both directly and under methylene blue staining by using an ECS. B...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Yoshikawa T,Hakamada K,Ogasawara H,Kimura N,Kudo D,Sakamoto Y,Ishido K,Toyoki Y,Morohashi S,Kijima H

更新日期：2015-01-01 00:00:00

abstract：:Surgical resection, considered the optimal treatment of biliary papillomatosis, often remains incomplete due to high risk of recurrence in view of positive margins or recurrence on the remnant bile duct because of its multifocality. Resection of the whole biliary tree by liver transplantation and duodenopancreatectomy...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Vibert E,Dokmak S,Belghiti J

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:The Blumgart system has been used for local tumor assessment in perihilar cholangiocarcinoma to predict resectability and survival, and T3 tumors are considered unresectable disease. The aim was to validate the predictive performance of this system using a Japanese cohort. METHODS:Medical records of consecu...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Ebata T,Mizuno T,Yokoyama Y,Igami T,Yamaguchi J,Onoe S,Watanabe N,Nagino M

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:The aim of this study was to compare the long-term outcomes and perioperative outcomes of laparoscopic liver resection (LLR) with those of open liver resection (OLR) for hepatocellular carcinoma (HCC) between well-matched patient groups. METHODS:Hepatocellular carcinoma patients underwent primary liver rese...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Takahara T,Wakabayashi G,Beppu T,Aihara A,Hasegawa K,Gotohda N,Hatano E,Tanahashi Y,Mizuguchi T,Kamiyama T,Ikeda T,Tanaka S,Taniai N,Baba H,Tanabe M,Kokudo N,Konishi M,Uemoto S,Sugioka A,Hirata K,Taketomi A,Maeh

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND/PURPOSE:To prevent or reduce hepatic complications after hepatectomy, it is important to employ preoperative predictive parameters and to determine the indications for hepatectomy. In the present study, we evaluated risk parameters in patients who underwent hepatectomy between 1994 and 2003, and selected thr...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Nanashima A,Tobinaga S,Abo T,Nonaka T,Takeshita H,Hidaka S,Sawai T,Nagayasu T

更新日期：2010-11-01 00:00:00

abstract：:Segmentectomy is anatomical resection of segments based on the classification of Couinaud. This procedure is performed mainly for hepatocellular carcinoma. Invasion of portal vein and intrahepatic metastases often occur with hepatocellular carcinoma. Thus, it is desirable to perform anatomical resection of the cancer-...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Yoshida H,Katayose Y,Rikiyama T,Motoi F,Onogawa T,Egawa S,Unno M

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Aspirin is widely used for the secondary prevention of ischemic stroke and cardiovascular disease. Perioperative aspirin may decrease thrombotic morbidity, but may also increase hemorrhagic morbidity. In particular, liver resection carries risks of bleeding, leading to higher risks of hemorrhagic morbidity. ...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Monden K,Sadamori H,Hioki M,Ohno S,Saneto H,Ueki T,Yabushita K,Ono K,Sakaguchi K,Takakura N

更新日期：2017-07-01 00:00:00

abstract：:Mucobilia is a rare pathologic condition characterized by the abnormal secretion and accumulation of abundant mucus within the biliary tree. It is usually seen in association with mucin-producing hepatobiliary and pancreatic tumors. Neoplastic transformation of these tumors can range from low-grade dysplasia to invasi...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Brown MA,Sakpal SV,Chamberlain RS

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:We report two cases in which portal blood flow via the peribiliary vascular plexus (PBP) was clearly demonstrated using contrast-enhanced intra-operative ultrasonography (CE-IOUS). METHODS:Two patients who underwent hemihepatectomies were investigated using CE-IOUS. Before injection of the contrast medium, bot...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Uchikawa Y,Kitamura H,Miyagawa S

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:There have been no reports showing the incidence of anastomotic stenosis of continuous hepaticojejunostomy (HJ) and identifying its risk factors for patients who underwent pancreaticoduodenectomy (PD). METHOD:We retrospectively investigated 200 patients whose HJ was established by unified method, single lay...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Asano T,Natsume S,Senda Y,Sano T,Matsuo K,Kodera Y,Hara K,Ito S,Yamao K,Shimizu Y

更新日期：2016-10-01 00:00:00

abstract：INTRODUCTION:Laparoscopic cholecystectomy (LC) is considered difficult in patients with an impacted gallstone (IG). We examined the efficacy of releasing an IG after percutaneous transhepatic gallbladder drainage (PTGBD) for acute cholecystitis (AC) and the usefulness of the Difficulty Score (DS) proposed in the Tokyo ...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Fujinaga A,Iwashita Y,Tada K,Watanabe K,Kawasaki T,Masuda T,Hirashita T,Endo Y,Ohta M,Inomata M

更新日期：2020-10-31 00:00:00

abstract：BACKGROUND:Pancreaticobiliary malignant diseases are primarily treated by surgical resection. However, the surgical indications for elderly patients, especially for pancreaticoduodenectomy (PD), must be carefully considered due to patient compliance. Whether PD can contribute to better prognoses in elderly patients rem...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Yamashita M,Adachi T,Ono S,Matsumura N,Adachi T,Natsuda K,Hidaka M,Eguchi S

更新日期：2020-10-15 00:00:00

abstract：:Liver function reserve estimation is important for selecting the appropriate patients for hepatectomy or ablation of tumors. Many liver function tests have been devised, but the indocyanine green (ICG) clearance test remains the most popular for its simplicity and perhaps accuracy. Compared with the Child-Pugh classif...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Fan ST

更新日期：2010-07-01 00:00:00

abstract：:The Milan criteria (MC) have been widely accepted as an effective way of selecting patients with early-stage hepatocellular carcinoma (HCC) for curative liver transplantation (LT). However, since a substantial subset of HCC patients exists that is beyond the MC but with the potential for good outcomes after LT, severa...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Takada Y,Tohyama T,Watanabe J

更新日期：2015-04-01 00:00:00

abstract：AIM:The aim of this study was to evaluate the outcomes following upfront pancreaticoduodenectomy (PD) in severely jaundiced (serum bilirubin level ≥15 mg/dl) patients with malignant distal common bile duct (CBD) obstruction. BACKGROUND:Recent studies have failed to show the benefits of preoperative biliary drainage (P...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Pamecha V,Sadashiv Patil N,Kumar S,Rajendran V,Gupta S,Vasantrao Sasturkar S,Kumar Sinha P,Arora A,Agarwal N,Baghmar S

更新日期：2019-11-01 00:00:00

abstract：:Enormous efforts have been made to establish pancreatic stem/progenitor cells as a source for regenerative medicine for the treatment of diabetes mellitus. In recent years, it has been recognized that the self-renewal of beta cells is the dominant process involved in postnatal beta-cell regeneration and expansion. Nev...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Sekine K,Taniguchi H

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Indocyanine green (ICG) is a synthetic dye that is widely used to evaluate liver function in critically ill patients, before liver resection or after liver transplantation. Controversy still exists about the impact exerted on the ICG ratio after 15 min (ICG R15) by differences in liver perfusion rates, hyper...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Janssen MW,Druckrey-Fiskaaen KT,Omidi L,Sliwinski G,Thiele C,Donaubauer B,Polze N,Kaisers UX,Thiery J,Wittekind C,Hauss JP,Schön MR

更新日期：2010-03-01 00:00:00

abstract：:Lactate measurements have proven utility as a triage tool, therapeutic guide, and prognostic indicator, with broad use in Acute Care and transplantation. Its value in guiding therapy and predicting outcomes following liver resection is less well-defined. This systematic review in accordance with Preferred Reporting It...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Connolly C,Stättner S,Niederwieser T,Primavesi F

更新日期：2020-07-01 00:00:00

abstract：:Surgical intervention and, more recently, endoscopic intervention have been performed for the treatment of malignant gastric outlet obstruction. Recently, endoscopic ultrasonography (EUS)-guided gastrojejunostomy using special devices has been established. In line with this, we have developed a novel EUS-guided double...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Itoi T,Ishii K,Tanaka R,Umeda J,Tonozuka R

更新日期：2015-01-01 00:00:00

abstract：:Heterogeneity is one of the essential hallmarks of malignancies. Within bulk cancer cells, a striking variability differs in biological characteristics including the proliferation rate, cell-cell interaction, metastatic tendency and even sensitivity to anticancer therapies. Such diversity makes the investigation and t...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Tanaka S

更新日期：2015-07-01 00:00:00

abstract：:Left hepatectomy is one of the most common types of hepatectomy. In order to perform the procedure, surgeons need to possess all the basic skills for accomplishing any liver resection. The most important points to bear in mind in relation to left hepatectomy are: (1) a precise recognition of the surgical anatomy of th...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Kobayashi A,Miyagawa S

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND AND STUDY AIMS:Expression of the forkhead/winged helix family of transcription factor P3+ regulatory T cells (FOXP3(+) Treg), a master gene of regulatory T cells (Treg) is observed in patients with autoimmune pancreatitis (AIP). We investigated the usefulness of detection of FOXP3(+) Treg in the main duodena...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Kubota K,Kato S,Watanabe S,Fujita K,Yoneda M,Takahashi H,Inamori M,Shimamura T,Kirikoshi H,Kobayashi N,Saito S,Hisatomi K,Matsuhashi N,Nakajima A

更新日期：2011-05-01 00:00:00

abstract：:Revealing the mechanism of adult organ maintenance and regeneration after injury is fundamental to our understanding of the pathogenesis of diseases. Considering the results of pulse and chase experiments using inducible insulin-Cre or Elastase-Cre, and more recently HNF1b-Cre, adult pancreatic cells (beta, acinar, an...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Kawaguchi Y,Takaori K,Uemoto S

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:We aimed to clarify the clinical usefulness of one-step self-expandable metal stent (SEMS) placement for distal malignant biliary obstruction by comparing with two-step SEMS placement. METHODS:We retrospectively compared early complications, bilirubin level decreasing rate, and period of hospitalization bet...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Shimizu S,Naitoh I,Nakazawa T,Hayashi K,Miyabe K,Kondo H,Yoshida M,Yamashita H,Ohara H,Joh T

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND/PURPOSE:Ampulla of Vater (AoV) carcinoma is a rare tumor that accounts for approximately 0.2% of gastrointestinal malignancies. There are no clinical guidelines concerning the treatment of AoV carcinoma. This study aimed to investigate the effectiveness of adjuvant treatment in AoV carcinoma following curati...

journal_title：Journal of hepato-biliary-pancreatic sciences

authors： Kim HS,Jang JY,Yoon YS,Park SJ,Kwon W,Kim SW,Han HS,Han SS,Park JS,Yoon DS

更新日期：2020-10-01 00:00:00