Basics and applications of stem cells in the pancreas.

Abstract:

:Enormous efforts have been made to establish pancreatic stem/progenitor cells as a source for regenerative medicine for the treatment of diabetes mellitus. In recent years, it has been recognized that the self-renewal of beta cells is the dominant process involved in postnatal beta-cell regeneration and expansion. Nevertheless, several in-vitro studies have suggested that ductal or as yet unidentified cells are candidates for pancreatic stem/progenitor cells that can differentiate into multilineage cells, including insulin(+) cells. The question remains as to whether beta cells are generated postnatally from stem/progenitor cells other than pre-existing beta cells. Furthermore, mutated pancreatic stem cells are considered to be prospective candidates for cancer stem cells or tumor-initiating cells. This review highlights recent progress in pancreatic stem/progenitor cell research.

authors

Sekine K,Taniguchi H

doi

10.1007/s00534-012-0545-3

subject

Has Abstract

pub_date

2012-11-01 00:00:00

pages

594-9

issue

6

eissn

1868-6974

issn

1868-6982

journal_volume

19

pub_type

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