Association of genetic polymorphisms around the LIN28B gene and idiopathic central precocious puberty risks among Chinese girls.

abstract：:The effect of intrauterine growth retardation (IUGR) on cerebral and adrenal monoamine metabolism was studied in the fetuses of eight nulliparous rat dams after unilateral uterine artery ligation on d 18 of gestation. On d 22 (term = 23 d), four dams were subjected to normoxia and four to hypoxia (10% O2) for 58 min w...

journal_title：Pediatric research

authors： Thordstein M,Hedner T

更新日期：1992-02-01 00:00:00

abstract：:Infantile Refsum's disease is characterized by high levels of phytanic acid and the absence of normal hepatic peroxisomes. We investigated the in vivo influence of phytol, a precursor of phytanic acid, on peroxisomes by both biochemical and morphological methods. Enhanced supply of phytol in the diet of adult mice cau...

journal_title：Pediatric research

authors： Van den Branden C,Vamecq J,Wybo I,Roels F

更新日期：1986-05-01 00:00:00

abstract：:The precise mechanism by which the most common cause of bacterial enterocolitis in humans, Campylobacter jejuni, perturbs the intestinal mucosa remains elusive. To define effects of C. jejuni infection on mucosal permeability, Madin-Darby canine kidney (MDCK)-I and T84 cell monolayers were infected with C. jejuni for ...

journal_title：Pediatric research

authors： Wine E,Chan VL,Sherman PM

更新日期：2008-12-01 00:00:00

abstract：:Groups of newborn rats were transthoracically inoculated with 1 X 10(6) type III group B streptococci/g body wt, either alone or in combination with 1.5 microgram/g body wt of type-specific antibody derived from hybridoma cell lines. Ninety-four percent of the animals who received bacteria alone died. In contrast, non...

journal_title：Pediatric research

authors： Christensen RD,Rothstein G,Hill HR,Pincus SH

更新日期：1983-10-01 00:00:00

abstract：BACKGROUND:The pathogenesis of neonatal group B Streptococcus (GBS) lung infection may be associated with surfactant dysfunction or deficiency. This study aimed to investigate the efficacy of surfactants on early postnatal GBS infection in ventilated newborn rabbit lungs. METHODS:A near-term newborn rabbit model was e...

journal_title：Pediatric research

authors： Xu Y,Dong Y,Guo X,Sun B

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:A growing body of evidence defines inflammation as a hallmark feature of disease pathogenesis of Duchenne muscular dystrophy. To tailor potential immune modulatory interventions, a better understanding of immune dysregulation in Duchenne muscular dystrophy is needed. We now asked whether dystrophin deficienc...

journal_title：Pediatric research

authors： Kranig SA,Tschada R,Braun M,Patry C,Pöschl J,Frommhold D,Hudalla H

更新日期：2019-08-01 00:00:00

abstract：:The microbiome, of which the bacterial component alone (microbiota), is estimated to include 10 times more cells than human cells of the body, blooms immediately after birth and evolves in composition and complexity throughout childhood. The gut microbiome has a profound impact on gastrointestinal tract development, m...

journal_title：Pediatric research

authors： Unger S,Stintzi A,Shah P,Mack D,O'Connor DL

更新日期：2015-01-01 00:00:00

abstract：:Epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-alpha) are mitogenic to the intestinal epithelium. To further clarify their role in the developing human fetal gut, their expression was studied in fetuses at 15 to 20 wk of gestation. TGF-alpha mRNA was present throughout the gastrointestinal tra...

journal_title：Pediatric research

authors： Miettinen PJ

更新日期：1993-05-01 00:00:00

abstract：:In view of their known high incidence of noninsulin dependent diabetes (NIDDM), we sought to determine whether Native American (Plains Indian) children and adolescents show evidence of risk factors for both NIDDM and cardiovascular disease. Children and adolescents between the ages of 4 and 19 y were recruited, and fi...

journal_title：Pediatric research

authors： Blackett PR,Taylor T,Russell D,Lu M,Fesmire J,Lee ET

更新日期：1996-07-01 00:00:00

abstract：:Adenylate cyclase activity was measured in membrane preparations of cultured fibroblasts from controls and patients with cystic fibrosis. Enzyme activity increased as the transition from exponential growth to confluence occurred; sodium fluoride-stimulated activity more markedly displayed this relationship than basal ...

journal_title：Pediatric research

authors： Wright RK,Buehler BA,Schott SN,Rennert OM

更新日期：1978-08-01 00:00:00

abstract：BACKGROUND:Physical activity (PA) is essential for children throughout their growth and maturation. It improves physiological and psychological health and limits the risk of developing metabolic disorders. However, some chronic physiological and metabolic diseases may lead to decreased PA. The diversity of outcomes in ...

journal_title：Pediatric research

authors： Bourdier P,Saidi O,Rochette E,Ratel S,Merlin E,Pereira B,Duché P

更新日期：2019-08-01 00:00:00

abstract：:The fibroblast of the fetal and neonatal lung is intimately involved with lung development and function. Additionally, the perinatal rat lung fibroblast is a significant source of prostaglandins (PG) I2 and E2, which in turn affect lung development and function. Their effects may be mediated by cAMP. We, therefore, te...

journal_title：Pediatric research

authors： Teixeira FJ,Bevan ML,Olson DM

更新日期：1992-04-01 00:00:00

abstract：:Docosahexaenoic acid (DHA), a 22-carbon, highly unsaturated, n-3 fatty acid, is important for optimal nervous system function. In this study, designed to quantify how preformed dietary DHA regulates metabolic pathways in vivo, 8-d-old rat pups were divided into four groups and fed artificial rat milk diets. One group ...

journal_title：Pediatric research

authors： Lefkowitz W,Lim SY,Lin Y,Salem N Jr

更新日期：2005-01-01 00:00:00

abstract：:Cerebral malaria is the most severe neurological complication of infection with Plasmodium falciparum. With >575,000 cases annually, children in sub-Saharan Africa are the most affected. Surviving patients have an increased risk of neurological and cognitive deficits, behavioral difficulties, and epilepsy making cereb...

journal_title：Pediatric research

authors： Idro R,Marsh K,John CC,Newton CR

更新日期：2010-10-01 00:00:00

abstract：:The response to the capsular polysaccharide of Haemophilus influenzae type b (Hib PS) has been used to determine the molecular basis of antibody gene diversity in humans. In contrast to the relatively restricted nature of anti-Hib PS heavy-chain variable region gene expression, a variety of light-chain variable region...

journal_title：Pediatric research

authors： Adderson EE,Shackelford PG,Quinn A,Wilson PM,Carroll WL

更新日期：1993-03-01 00:00:00

abstract：:Essential fatty acid deficiency (EFAD) occurs in infants fed fat-free mixtures of glucose and amino acids. Although infusion of lipid emulsion rapidly reverses clinical symptoms, little is known about effects on tissue fatty acids. To study this question, five groups (n = 4/group) of neonatal pigs were studied. Three ...

journal_title：Pediatric research

authors： Andersen DW,Filer LJ Jr,Stegink LD

更新日期：1984-12-01 00:00:00

abstract：BACKGROUND:There is an emerging evidence that pulmonary hypertension is associated with amino acid, carnitine, and thyroid hormone aberrations. We aimed to characterize metabolic profiles measured by the newborn screen (NBS) in infants with persistent pulmonary hypertension of the newborn (PPHN) METHODS: Nested case-co...

journal_title：Pediatric research

authors： Steurer MA,Oltman S,Baer RJ,Feuer S,Liang L,Paynter RA,Rand L,Ryckman KK,Keller RL,Jelliffe-Pawlowski LL

更新日期：2018-08-01 00:00:00

abstract：:Prothrombin of newborns was investigated by means of the quantitative immunoelectrophoresis and the two-dimensional immunoelectrophoresis. The plasma of 10 of 24 healthy term newborns and of 5 preterm infants taken immediately after birth showed one prothrombin precipitate in the alpha-2-beta-globulin position when a ...

journal_title：Pediatric research

authors： Muntean W,Petek W,Rosanelli K,Mutz ID

更新日期：1979-11-01 00:00:00

abstract：:Carbonic anhydrase II (CA II) is the only soluble isozyme of CA which is known to be expressed in kidney. We recently identified a deficiency of this enzyme as the basis for the autosomal recessive syndrome of osteopetrosis with renal tubular acidosis and cerebral calcification. In order to explore the physiological i...

journal_title：Pediatric research

authors： Sly WS,Whyte MP,Krupin T,Sundaram V

更新日期：1985-10-01 00:00:00

abstract：:Factors, such as insulin, found in human and pig colostrum and mature milk likely influence small intestinal growth and development. Although pharmacologic doses of insulin injected parenterally may accelerate small intestinal development in altricial animals such as the rodent, the effects of oral insulin on intestin...

journal_title：Pediatric research

authors： Shulman RJ

更新日期：1990-08-01 00:00:00

abstract：BACKGROUND:Kawasaki disease was well known for coronary artery abnormalities with few reports of incidence of acute kidney injury (AKI). Our aim was to identify the rate of AKI in patients with Kawasaki disease and its associated factors. METHODS:All patients with Kawasaki disease admitted to a medical center from Feb...

journal_title：Pediatric research

authors： Chuang GT,Tsai IJ,Lin MT,Chang LY

更新日期：2016-08-01 00:00:00

abstract：:Tracheal epithelial cells obtained from adult and infant ferrets were grown in primary culture in vitro. Cells from adult animals grew readily, and many ciliated cells were observed in the cultures. Successful cultures were derived from infant animals, but cell number in infant and adult cultures began to decrease aft...

journal_title：Pediatric research

authors： Kercsmar CM,Chung Y,Davis PB

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND:Necrotising enterocolitis (NEC) and late-onset sepsis (LOS) are the leading causes of death among preterm infants in the developed world. This study aimed to explore the serum proteome and metabolome longitudinally in preterm infants with NEC or LOS, matched to controls. METHODS:Nineteen patients (10 cases,...

journal_title：Pediatric research

authors： Stewart CJ,Nelson A,Treumann A,Skeath T,Cummings SP,Embleton ND,Berrington JE

更新日期：2016-03-01 00:00:00

abstract：:We used in vivo microdialysis to determine the impact of a focal hypoxic-ischemic insult on hippocampal amino acid efflux in the immature brain. Microdialysis probes were inserted into the right hippocampus of postnatal d 7 rats. To induce hypoxic-ischemic injury, the right carotid artery was ligated and animals were ...

journal_title：Pediatric research

authors： Silverstein FS,Naik B,Simpson J

更新日期：1991-12-01 00:00:00

abstract：BACKGROUND:Subgaleal hemorrhage (SGH) is reported to be associated with severe hemodynamic instability, coagulopathy, and even mortality. The importance of the presence or absence of neonatal encephalopathy in predicting SGH outcomes has not been explored. The aim of this study was to determine the relationship of clin...

journal_title：Pediatric research

authors： El-Dib M,Parziale MP,Johnson L,Benson CB,Grant PE,Robinson J,Volpe JJ,Inder T

更新日期：2019-08-01 00:00:00

abstract：:Clinical studies have suggested that the early stages of bilirubin encephalopathy are reversible. These phenomena are investigated at the cellular level using the neuroblastoma cell line N-115 as a model system. To determine whether the cell line N-115 can recover from bilirubin toxicity, and whether the cellular func...

journal_title：Pediatric research

authors： Amit Y,Poznansky MJ,Schiff D

更新日期：1989-04-01 00:00:00

abstract：:Infants with sudden infant death syndrome have higher hypoxanthine (Hx) concentrations in their vitreous humor than infants with respiratory distress syndrome and other infant control populations. However, previous research on piglets and pigs applying continuous hypoxemia has not been able to reproduce the concentrat...

journal_title：Pediatric research

authors： Stoltenberg L,Rootwelt T,Oyasaeter S,Rognum TO,Saugstad OD

更新日期：1993-12-01 00:00:00

abstract：:In a patient with extrapyramidal movement disorder and extremely low creatinine concentrations in serum and urine, in vivo proton magnetic resonance spectroscopy disclosed a generalized depletion of creatinine in the brain. Oral substitution of arginine, a substrate for creatine synthesis, resulted in an increase of b...

journal_title：Pediatric research

authors： Stöckler S,Holzbach U,Hanefeld F,Marquardt I,Helms G,Requart M,Hänicke W,Frahm J

更新日期：1994-09-01 00:00:00

abstract：:Cerebellar injury has been increasingly recognized as a complication of preterm birth, with decreased cerebellar volumes seen on follow-up neuroimaging. A cohort of 38 preterm newborns, including 14 with two scans, was studied with MRI, including single-shot fast spin-echo diffusion tensor imaging (DTI) sequence speci...

journal_title：Pediatric research

authors： Tam EW,Ferriero DM,Xu D,Berman JI,Vigneron DB,Barkovich AJ,Miller SP

更新日期：2009-07-01 00:00:00

abstract：:In muscle, sepsis reduces protein synthesis (MPS) by restraining translation in neonates and adults. Even though protein accretion decreases with development as neonatal MPS rapidly declines by maturation, the changes imposed by development on the sepsis-associated decrease in MPS have not been described. Pigs at 7 an...

journal_title：Pediatric research

authors： Orellana RA,Wilson FA,Gazzaneo MC,Suryawan A,Davis TA,Nguyen HV

更新日期：2011-06-01 00:00:00