Abstract：
BACKGROUND:Subgaleal hemorrhage (SGH) is reported to be associated with severe hemodynamic instability, coagulopathy, and even mortality. The importance of the presence or absence of neonatal encephalopathy in predicting SGH outcomes has not been explored. The aim of this study was to determine the relationship of clinical encephalopathy to short-term outcomes in neonates with SGH. METHODS:Neonates ≥35 weeks gestation, diagnosed radiologically with SGH between 2010 and 2017, were included. Cases were divided into encephalopathic and non-encephalopathic. Demographic, clinical, and outcome data were compared between groups. RESULTS:Of 54,048 live births, 56 had SGH, of them 13 (23%) had encephalopathy. When compared to the non-encephalopathic neonates, encephalopathic neonates had lower Apgar scores, lower hemoglobin, lower platelet count, longer neonatal intensive care unit stay, two (15%) deaths, and four (31%) required blood transfusion. No non-encephalopathic infant with SGH died or required blood transfusion. Notably, on magnetic resonance imaging (MRI), a majority of subgaleal collections had either no or minimal blood products. CONCLUSIONS:In the absence of encephalopathy, SGH is not associated with adverse short-term outcome. Neurological assessment is likely to identify infants at higher risk for adverse outcome. The absence of MRI signal consistent with blood in subgaleal collection warrants further research.
journal_name
Pediatr Resjournal_title
Pediatric researchauthors
El-Dib M,Parziale MP,Johnson L,Benson CB,Grant PE,Robinson J,Volpe JJ,Inder Tdoi
10.1038/s41390-019-0400-1subject
Has Abstractpub_date
2019-08-01 00:00:00pages
234-241issue
2eissn
0031-3998issn
1530-0447pii
10.1038/s41390-019-0400-1journal_volume
86pub_type
杂志文章abstract：:Galactose metabolism was studied in human ovarian tissue obtained from 14 women controls between 21 and 72 y of age, and one 21-y-old galactosemic patient with hypergonadotrophic hypogonadism. Tissue slices were incubated with 1-14C-galactose, and labeled intermediates were analyzed by anion-exchange column chromatogr...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198902000-00015
更新日期：1989-02-01 00:00:00
abstract：:The activity of UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase (EC 2.4.2.26), the enzyme that catalyzes the initiation of the polysaccharide chain linkage to the core protein of proteoglycans, was measured in costal cartilage from 20 fetal sheep of 65-138 days gestation. Activity of the enzyme was es...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198512000-00003
更新日期：1985-12-01 00:00:00
abstract：:Alpha-mannosidosis is a lysosomal storage disorder resulting from deficient activity of lysosomal alpha-mannosidase. It has been described previously in humans, cattle, and cats, and is characterized in all of these species principally by neuronal storage leading to progressive mental deterioration. Two guinea pigs wi...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199911000-00003
更新日期：1999-11-01 00:00:00
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journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/pr.2017.65
更新日期：2017-08-01 00:00:00
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journal_title：Pediatric research
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doi：10.1203/PDR.0b013e318176182b
更新日期：2008-08-01 00:00:00
abstract：:L-selectin, a surface adhesion glycoprotein expressed on leukocytes, has a well-established role in mediating inflammation and lymphocyte recirculation. Recent evidence suggests that L-selectin may also influence hematopoiesis. We observed that a greater proportion of CD34+ cells express L-selectin in cord blood compa...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199906000-00015
更新日期：1999-06-01 00:00:00
abstract：:Biotin responsive multiple carboxylase deficiency was suspected in a third trimester conceptus on the basis of enzymatic confirmation in fibroblasts cultured from an earlier sibling who suffered a demise in the immediate neonatal period. Maternal urinary organic acid profile was normal throughout the final 4 wk of pre...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198202000-00010
更新日期：1982-02-01 00:00:00
abstract：:Growth hormone (GH) regulates growth and development in the postnatal period but lacks somatotropic activity in the fetus. In contrast, the placental hormone placental lactogen (PL) stimulates amino acid transport, DNA synthesis, and somatomedin production in isolated fetal tissues, suggesting that PL may function as ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199208000-00015
更新日期：1992-08-01 00:00:00
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journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198101000-00014
更新日期：1981-01-01 00:00:00
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journal_title：Pediatric research
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更新日期：1989-08-01 00:00:00
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journal_title：Pediatric research
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doi：10.1203/PDR.0b013e31819dbe1e
更新日期：2009-05-01 00:00:00
abstract：:Lung deposition of inhaled drugs in ventilated neonates has been studied in models of questionable relevance. With conventional nebulizers, pulmonary deposition has been limited to 1% of the total dose. The objective of this study was to assess lung delivery of aerosols in a model of neonatal ventilation using a conve...
journal_title：Pediatric research
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doi：10.1203/01.PDR.0000156244.84422.55
更新日期：2005-07-01 00:00:00
abstract：:Fetal lung cyclic AMP phosphodiesterase, cyclic AMP, phosphatidyl choline, and incorporation of precursors into phosphatidyl choline were measured in rabbits after maternal administration of hydrocortisone phosphate and aminophylline. Both agents inhibited lung phosphodiesterase activity and augmented cyclic AMP conce...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-197606000-00011
更新日期：1976-06-01 00:00:00
abstract：:To determine the importance of peroxisomes and mitochondria in hydroxyeicosatetraenoic acid (HETE) oxidation in vivo, urinary excretion of 12- and 15-HETE was measured in eight patients with a peroxisome deficiency disorder (Zellweger syndrome) showing normal mitochondrial beta-oxidation capacity, in three patients wi...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199601000-00022
更新日期：1996-01-01 00:00:00
abstract：:Iron is essential for fetal organ development, but the effect of isolated iron deficiency on nephrogenesis is unknown. Human premature infants are at risk for disrupted nephrogenesis because glomerular development is incomplete until 36-wk gestation. We modeled the effects of iron on postnatal glomerulogenesis in four...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/PDR.0b013e3181be79c2
更新日期：2009-12-01 00:00:00
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journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199511000-00015
更新日期：1995-11-01 00:00:00
abstract：:Our aim was to compare white matter (WM) microstructure in preterm infants with and without punctate WM lesions on MRI using tract-based spatial statistics (TBSS) and probabilistic tractography. We studied 23 preterm infants with punctate lesions, median GA at birth 30 (25-35) wk, and 23 GA- and sex-matched preterm co...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/PDR.0b013e3182182836
更新日期：2011-06-01 00:00:00
abstract：:Beta cells are partially replaced in neonatal rodents after deletion with streptozotocin (STZ). Exposure of pregnant rats to a low protein (LP) diet impairs endocrine pancreas development in the offspring, leading to glucose intolerance in adulthood. Our objective was to determine whether protein restriction has a sim...
journal_title：Pediatric research
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doi：10.1203/PDR.0b013e3181e17c90
更新日期：2010-07-01 00:00:00
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更新日期：2006-06-01 00:00:00
abstract：:The objective was to determine in infants with perinatal depression whether the relative concentrations of N-acetylaspartate and lactate in the neonatal period are associated with (1) neurodevelopmental outcome at 30 mo of age or (2) deterioration in outcome from age 12 to 30 mo; and to determine whether socioeconomic...
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doi：10.1203/00006450-200207000-00014
更新日期：2002-07-01 00:00:00
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doi：10.1203/01.PDR.0000098500.94041.9B
更新日期：2004-01-01 00:00:00
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更新日期：2004-10-01 00:00:00
abstract：:Mutations of genes involved in the innate immune system have been reported to be associated with an increased sepsis rate in adults. We determined the -159T mutation of the CD14 gene, the 896G mutation of the toll-like receptor 4 gene, the 3020insC mutation of the NOD2 gene (NOD2-3020insC), the IL-6 174G/C promoter po...
journal_title：Pediatric research
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doi：10.1203/01.PDR.0000112100.61253.85
更新日期：2004-04-01 00:00:00
abstract：:Newborn Sprague-Dawley rat pups were found to have reduced net tubular reclamation of the beta-amino acid taurine in vivo. The reabsorption of this compound increased between the 2nd and 4th week of life and the excreted taurine fell despite a rise in glomerular filtration rate indicative of increased transport with m...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-197907000-00012
更新日期：1979-07-01 00:00:00
abstract：:Plasma antioxidant status and total radical-trapping antioxidant potential (TRAP) of children (n = 24) with cystic fibrosis (CF) were compared with those of children (n = 21) without the disease. Children with CF were found to have elevated plasma concentrations of ascorbic acid (94.6 +/- 58.2 mumol/L), with respect t...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199303000-00008
更新日期：1993-03-01 00:00:00
abstract：:Recent data suggest that umbilical venous perfusion of the fetal liver has an important influence on fetal growth and postnatal liver function, and that maternal factors in late pregnancy modify this circulation. In a longitudinal study of 160 low-risk pregnancies, we determined how umbilical and portal venous blood f...
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doi：10.1203/pdr.0b013e318163a1de
更新日期：2008-03-01 00:00:00
abstract：:We measured body composition, basal metabolic rate (BMR), and total energy expenditure in 28 nonobese and 35 obese adolescents aged 12-18 y using indirect calorimetry and the doubly labeled water method. BMR was highly correlated with fat-free mass in both the nonobese and obese groups (r = 0.77 and 0.84, respectively...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199002000-00022
更新日期：1990-02-01 00:00:00
abstract：:Sparse-fur mice, 28 d of age with the x-chromosomal inherited defect of ornithine carbamoyltransferase, were used to investigate if tryptophan and the serotonin pathway in the brain are affected in this animal model which closely resembles the human inborn error of metabolism. Increased concentrations of tryptophan an...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198404000-00014
更新日期：1984-04-01 00:00:00
abstract：:Catecholamines (CA) are released from and resynthesized in the adrenal medulla in response to stress. In the mature animal, stimulus-secretion-synthesis coupling occurs through transsynaptic (neuronal) activity. In contrast, in the immature animal, before functional adrenal innervation, certain stressors (hypoglycemia...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199412000-00006
更新日期：1994-12-01 00:00:00
abstract：:Our objective was to determine the quantitative changes of individual triacylglycerol (TG) species in liver and carcass during early postnatal growth. Pregnant rats were killed at d 21 of pregnancy, and neonatal rats were killed at d 3 or 9 after birth. Quantitative changes in fatty acids and TG species of fetal/neona...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199201000-00009
更新日期：1992-01-01 00:00:00
