Abstract:
OBJECTIVE:To develop and validate a volume-based, quantitative imaging marker by integrating multi-parametric MR images for predicting glioblastoma survival, and to investigate its relationship and synergy with molecular characteristics. METHODS:We retrospectively analysed 108 patients with primary glioblastoma. The discovery cohort consisted of 62 patients from the cancer genome atlas (TCGA). Another 46 patients comprising 30 from TCGA and 16 internally were used for independent validation. Based on integrated analyses of T1-weighted contrast-enhanced (T1-c) and diffusion-weighted MR images, we identified an intratumoral subregion with both high T1-c and low ADC, and accordingly defined a high-risk volume (HRV). We evaluated its prognostic value and biological significance with genomic data. RESULTS:On both discovery and validation cohorts, HRV predicted overall survival (OS) (concordance index: 0.642 and 0.653, P < 0.001 and P = 0.038, respectively). HRV stratified patients within the proneural molecular subtype (log-rank P = 0.040, hazard ratio = 2.787). We observed different OS among patients depending on their MGMT methylation status and HRV (log-rank P = 0.011). Patients with unmethylated MGMT and high HRV had significantly shorter survival (median survival: 9.3 vs. 18.4 months, log-rank P = 0.002). CONCLUSION:Volume of the high-risk intratumoral subregion identified on multi-parametric MRI predicts glioblastoma survival, and may provide complementary value to genomic information. KEY POINTS:• High-risk volume (HRV) defined on multi-parametric MRI predicted GBM survival. • The proneural molecular subtype tended to harbour smaller HRV than other subtypes. • Patients with unmethylated MGMT and high HRV had significantly shorter survival. • HRV complements genomic information in predicting GBM survival.
journal_name
Eur Radioljournal_title
European radiologyauthors
Cui Y,Ren S,Tha KK,Wu J,Shirato H,Li Rdoi
10.1007/s00330-017-4751-xsubject
Has Abstractpub_date
2017-09-01 00:00:00pages
3583-3592issue
9eissn
0938-7994issn
1432-1084pii
10.1007/s00330-017-4751-xjournal_volume
27pub_type
杂志文章abstract::The 2017 Core of the computed tomography (CT)/magnetic resonance imaging (MRI) Liver Imaging Reporting and Data System (LI-RADS) provides clear definitions and concise explanations of the CT/MRI diagnostic algorithm. Nevertheless, there remain some practical and controversial issues that radiologists should be aware o...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-018-5641-6
更新日期:2019-03-01 00:00:00
abstract::The rectum has become the most successful area of the gastrointestinal tract to be studied with MRI. Its anatomical location, fixed in the pelvic fat, and its lack of peristalsis, make it an ideal organ to be scanned with MRI. In addition, MRI allows a direct sagittal and coronal display, of key importance to colorect...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s003300050328
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVES:To evaluate a whole body (WB) continuous-table-movement (CTM) MR protocol for the assessment of multiple myeloma (MM) in comparison to a step-by-step WB protocol. METHODS:Eighteen patients with MM were examined at 1.5T using a WB CTM protocol (axial T2-w fs BLADE, T1-w GRE sequence) and a step-by-step WB pr...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-010-1865-9
更新日期:2010-12-01 00:00:00
abstract:UNLABELLED:This paper summarizes information about breast MRI to be provided to women and referring physicians. After listing contraindications, procedure details are described, stressing the need for correct scheduling and not moving during the examination. The structured report including BI-RADS® categories and furth...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-015-3807-z
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:This retrospective study aims to assess the accuracy of two-phase computed tomography (CT) and transoesophageal echocardiography (TEE) for the detection of left atrial (LA) thrombus in patients with mitral stenosis (MS) and atrial fibrillation (AF), by using intraoperative findings as the reference standard. ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-013-2944-5
更新日期:2013-11-01 00:00:00
abstract::Meningeal hemangiopericytoma (MHP) is extremely rare in childhood. Mean age at diagnosis is between 38 and 43 years. We present an 8-year-old boy with MHP of the middle cranial fossa. Imaging findings were indistinguishable from an aggressive bone tumor such as Ewing's sarcoma. Imaging findings are presented and discu...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003309900222
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVES:To compare image quality and radiation dose between dual-energy subtraction (DES)-based bone suppression images (D-BSIs) and software-based bone suppression images (S-BSIs). METHODS:Chest radiographs (CXRs) of forty adult patients were obtained with the two X-ray devices, one with DES and one with bone supp...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-07596-w
更新日期:2021-01-13 00:00:00
abstract::Here we report our experience of a neuroprotective adaptation of the technique of CT-guided radiofrequency (RF) ablation of spinal osteoid osteomas. Over 9 years seven patients underwent eight CT-guided RF treatments for osteoid osteoma. CT-guided RF ablation was performed with general anaesthesia. The lesion was heat...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-009-1404-8
更新日期:2009-09-01 00:00:00
abstract::The aim of this study was to assess the capability of a 3D isotropic MRI T2-weighted sequence (3D T2 ISO) in the depiction of changes of neurovascular bundles (NVBs) after bilateral nerve-sparing radical retropubic prostatectomy (RRP). Furthermore, our aim was also to introduce a new MRI classification score of the NV...
journal_title:European radiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00330-008-1102-y
更新日期:2009-01-01 00:00:00
abstract::Our objective was to evaluate, in a routine clinical setting, the role of spiral CT as a second procedure in patients with clinically suspected pulmonary embolism (PE) and abnormal perfusion scan. We prospectively studied the role of spiral CT in 279 patients suspected of PE. All patients started their diagnostic algo...
journal_title:European radiology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00330-002-1709-3
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVE:To prospectively compare reduced-dose (RD) CT colonography (CTC) with standard-dose (SD) imaging using several reconstruction algorithms. METHODS:Following SD supine CTC, 40 patients (mean age, 57.3 years; 17 M/23 F; mean BMI, 27.2) underwent an additional RD supine examination (targeted dose reduction, 70-9...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-015-3603-9
更新日期:2015-07-01 00:00:00
abstract::The purpose of the present study was to evaluate the usefulness of a new gray-scale test pattern (NGTP) that was developed to easily adjust the gradients of thoracic CT imaging and enable visual consistency. The Society of Motion Picture and Television Engineers (SMPTE) pattern and the NGTP were used for comparison. T...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-004-2315-3
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVES:To investigate the feasibility of low-concentration contrast media (LC-CM) in cerebral and cervical dual-energy CT angiography (DE-CTA) using an advanced monoenergetic (Mono+) reconstruction technique. METHODS:Sixty-five consecutive patients prospectively selected to undergo cerebral and cervical DE-CTA wer...
journal_title:European radiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00330-018-5407-1
更新日期:2018-10-01 00:00:00
abstract::The purpose of this study was to explain radiographic features of giant cell tumors of the tendon sheath (GCTTS), in particular, osseous extension, by correlating imaging findings with histology in order to increase the accuracy of radiological diagnosis. In a series of 200 consecutive osseous (pseudo) tumors of the h...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-006-0320-4
更新日期:2007-02-01 00:00:00
abstract::The purpose was to evaluate low-dose CT colonography without cathartic cleansing in terms of image quality, polyp visualization and patient acceptance. Sixty-one patients scheduled for colonoscopy started a low-fiber diet, lactulose and amidotrizoic-acid for fecal tagging 2 days prior to the CT scan (standard dose, 5....
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-007-0668-0
更新日期:2007-12-01 00:00:00
abstract::The potential relative beneficial aspects of upright, weight-bearing (pMRI), dynamic-kinetic (kMRI) spinal imaging over that of recumbent MRI (rMRI) include the revelation of occult spinal disease dependent on true axial loading, the unmasking of kinetic-dependent spinal disease and the ability to scan the patient in ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-005-2666-4
更新日期:2005-09-01 00:00:00
abstract::The aim of this study was to evaluate feasibility, safety, and effectiveness of radio-frequency (RF) thermal ablation, performed by using a cooled-tip electrode needle, in the treatment of liver metastases. Twenty-nine patients (20 males and 9 females; age range 43-77 years) with one to four hepatic metastases 1.1-4.8...
journal_title:European radiology
pub_type: 临床试验,杂志文章
doi:10.1007/s003300050536
更新日期:1998-01-01 00:00:00
abstract::Skeletal muscle is one of the most unusual sites of metastasis from any malignancy. We report a patient with rapidly progressive contractures due to metastatic infiltration of a carcinoma of unknown origin into the skeletal muscle. This 61-year-old man presented with a 1-month history of rapidly evolving, painful rest...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050657
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVES:To evaluate the quantitative parameters obtained from dynamic MR T2*-weighted images as predictors of survival taking into consideration the biasing effects of other survival-related covariates. METHODS:Thirty-nine patients (60 ± 14 years; survival 267 ± 191 days) with high-grade gliomas (8 grade III, 31 gr...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-013-2967-y
更新日期:2013-12-01 00:00:00
abstract::Recently, a new oral liver-specific manganese-based MR agent (CMC-001) has been introduced. This contrast medium is delivered to the liver in high concentrations in the portal vein and very low doses in the hepatic artery, as only small amounts of manganese enter the general circulation. It is taken up by the hepatocy...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-006-0336-9
更新日期:2007-01-01 00:00:00
abstract::Bilateral tuberculous mastoiditis (TOM) in an immunocompetent child is a very uncommon form of tuberculous infection presentation. This report shows the CT and MR imaging of bilateral tuberculous otomastoiditis consisting of aggressive signs of middle ear and mastoid involvement with bony destruction and periauricular...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-008-1130-7
更新日期:2009-06-01 00:00:00
abstract::The purpose of this study was to evaluate the technical feasibility of MR-guided percutaneous breast biopsy (LCNB) and breast hook wire marking in a low-field (0.23 T) MRI system with optical instrument tracking. MR-guided core biopsy and/or hook wire marking was performed on 13 lesions observable at MR imaging only. ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-006-0377-0
更新日期:2007-03-01 00:00:00
abstract:OBJECTIVE:Osteoporosis is a prevalent and treatable condition, but it remains underdiagnosed. In this study, a deep learning-based system was developed to automatically measure bone mineral density (BMD) for opportunistic osteoporosis screening using low-dose chest computed tomography (LDCT) scans obtained for lung can...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-06679-y
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVES:To analyse the implementation, applicability and accuracy of the pretest probability calculation provided by NICE clinical guideline 95 for decision making about imaging in patients with chest pain of recent onset. METHODS:The definitions for pretest probability calculation in the original Duke clinical sco...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-018-5322-5
更新日期:2018-09-01 00:00:00
abstract::In a controlled patient study we investigated the potential of attenuation-based on-line modulation of the tube current to reduce milliampere values (mAs) in CT examinations of children without loss of image quality. mAs can be reduced for non-circular patient cross sections without an increase in noise if tube curren...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-001-1255-4
更新日期:2002-06-01 00:00:00
abstract:OBJECTIVES:In chemotherapy monitoring, an estimation of the change in tumour size is an important criterion for the assessment of treatment success. This requires a comparison between corresponding lesions in the baseline and follow-up computed tomography (CT) examinations. We evaluate the clinical benefits of an autom...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-012-2545-8
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the feasibility of using magnetisation transfer (MT) MRI of the kidney at 3.0 T to assess renal function. METHODS:Forty-four patients who underwent abdominal MRI on a 3.0-T system including gradient-echo (GRE) sequences with and without MT pulse were included. In each patient, MT ratio (MTR) of t...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-013-2841-y
更新日期:2013-08-01 00:00:00
abstract::The aim of our study was to evaluate a mammography unit capable of magnification of up to fourfold at an equivalent or lower dose than with current systems. A prototype mammography tube with an electron-beam-focusing technology resulting in a focal spot size of 40-120 micro m was combined with a highly intensifying sc...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050399
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:Sufficiently sized studies to determine the value of the iliolumbar ligament (ILL) as an identifier of the L5 vertebra in cases of a lumbosacral transitional vertebra (LSTV) are lacking. METHODS:Seventy-one of 770 patients with LSTV (case group) and 62 of 611 subjects without LSTV with confirmed L5 level wer...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-014-3277-8
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVES:To compare image quality and radiation dose of abdominal split-filter dual-energy CT (SF-DECT) combined with monoenergetic imaging to single-energy CT (SECT) with automatic tube voltage selection (ATVS). METHODS:Two-hundred single-source abdominal CT scans were performed as SECT with ATVS (n = 100) and SF-D...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-018-5338-x
更新日期:2018-08-01 00:00:00