Abstract:
:The first β-lactone synthetase enzyme is reported, creating an unexpected link between the biosynthesis of olefinic hydrocarbons and highly functionalized natural products. The enzyme OleC, involved in the microbial biosynthesis of long-chain olefinic hydrocarbons, reacts with syn- and anti-β-hydroxy acid substrates to yield cis- and trans-β-lactones, respectively. Protein sequence comparisons reveal that enzymes homologous to OleC are encoded in natural product gene clusters that generate β-lactone rings, suggesting a common mechanism of biosynthesis.
journal_name
Biochemistryjournal_title
Biochemistryauthors
Christenson JK,Richman JE,Jensen MR,Neufeld JY,Wilmot CM,Wackett LPdoi
10.1021/acs.biochem.6b01199subject
Has Abstractpub_date
2017-01-17 00:00:00pages
348-351issue
2eissn
0006-2960issn
1520-4995journal_volume
56pub_type
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