Myeloid neoplasms with eosinophilia.

abstract：:Ristocetin and vancomycin are structurally similar glycopeptide antibiotics. Both vancomycin and ristocetin in high concentrations (3.0 mg/ml) cause the precipitation of fibrinogen, plasminogen, and IgG from platelet-poor plasma (PPP). In contrast to ristocetin, vanomycin (0.5-1.5 mg/ml) does not agglutinate platelets...

journal_title：Blood

authors： Moake JL,Cimo PL,Peterson DM,Roper P,Natelson EA

更新日期：1977-09-01 00:00:00

abstract：:Chronic graft-versus-host disease (GVHD) requires long-term immunosuppressive therapy after hematopoietic cell transplantation. We retrospectively analyzed a cohort of 751 patients with chronic GVHD to identify characteristics associated with the duration of immunosuppressive treatment. Among the 274 patients who disc...

journal_title：Blood

authors： Stewart BL,Storer B,Storek J,Deeg HJ,Storb R,Hansen JA,Appelbaum FR,Carpenter PA,Sanders JE,Kiem HP,Nash RA,Petersdorf EW,Moravec C,Morton AJ,Anasetti C,Flowers ME,Martin PJ

更新日期：2004-12-01 00:00:00

abstract：:In this issue of Blood, Rollin et al demonstrate that heparin-induced thrombocytopenia and thrombosis (HIT) patients homozygous for arginine (R) at position 131 in the immunoglobulin (Ig)G receptor FcγRIIA have a significantly higher incidence of thrombosis, and show that plasma IgG may play a key role in modulating t...

journal_title：Blood

authors： Padmanabhan A

更新日期：2015-04-09 00:00:00

abstract：:Preterm birth affects 1 out of 9 infants in the United States and is the leading cause of long-term neurologic handicap and infant mortality, accounting for 35% of all infant deaths in 2008. Although cytokines including interferon-γ (IFN-γ), interleukin-10 (IL-10), IL-6, and IL-1 are produced in response to in utero i...

journal_title：Blood

authors： Krow-Lucal ER,Kim CC,Burt TD,McCune JM

更新日期：2014-03-20 00:00:00

abstract：:A large English pedigree in which heterocellular hereditary persistence of fetal hemoglobin (HPFH) segregates is described. beta-globin cluster deletions and gamma gene promoter mutations associated with HPFH have been excluded. Of particular importance in this pedigree is the absence of any cosegregating hemoglobinop...

journal_title：Blood

authors： Craig JE,Rochette J,Sampietro M,Wilkie AO,Barnetson R,Hatton CS,Demenais F,Thein SL

更新日期：1997-07-01 00:00:00

abstract：:The murine Ly6-E gene is transcriptionally induced by interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma in a variety of distinct cell types. The mechanism of IFN inducibility in B-cell lines was investigated by deletion analysis of the promoter and by identifying DNA binding proteins in mobility shift assays. A reg...

journal_title：Blood

authors： Khodadoust MM,Khan KD,Park EH,Bothwell AL

更新日期：1998-10-01 00:00:00

abstract：:Patients with disseminated follicular non-Hodgkin's lymphoma (NHL) are only occasionally cured with standard chemotherapy regimens. Although most of these tumors are initially responsive to chemotherapy, in 40% to 70% of patients the lymphoma will eventually transform to an NHL of higher grade malignancy and a poorer ...

journal_title：Blood

authors： Schouten HC,Bierman PJ,Vaughan WP,Kessinger A,Vose JM,Weisenburger DD,Armitage JO

更新日期：1989-11-15 00:00:00

abstract：:The formation and functioning of the factor X activating complex on the surface of cultured human venous endothelial cells (HVEC) were investigated. To the HVEC monolayer human factors IXa, VIII, X, CaCl2, and S-2222 were added, and a gradually increasing activation of factor X was observed. The maximum activity of 88...

journal_title：Blood

authors： Váradi K,Elödi S

更新日期：1987-02-01 00:00:00

abstract：:To define conditions for improved efficiency of retroviral-mediated gene transfer and expression in primate progenitor cells, four rhesus monkeys were treated with a 200 mg/kg intravenous bolus of 5-fluorouracil (5-FU). The kinetics of hematopoietic suppression and recovery were assessed in peripheral blood, bone marr...

journal_title：Blood

authors： Wieder R,Cornetta K,Kessler SW,Anderson WF

更新日期：1991-02-01 00:00:00

abstract：:We have investigated whether recombinant erythropoietin (r-Epo) elicits a change in intracellular free calcium (IFC) in purified Epo-responsive cells in spleens of mice treated with phenylhydrazine. Colony-forming units (CFU-E) were prepared by negative selection through immunologic panning. Anti-Forssman, Mac-1, Ia, ...

journal_title：Blood

authors： Imagawa S,Smith BR,Palmer-Crocker R,Bunn HF

更新日期：1989-05-01 00:00:00

abstract：:Dendritic cells (DCs) represent a family of ontogenically distinct leukocytes involved in immune response regulation. The ability of DCs to stimulate T-cell immunity has led to their use as vectors for immunotherapy vaccines. However, it is unclear whether and to what degree in vitro-generated DCs are representative o...

journal_title：Blood

authors： Maraskovsky E,Daro E,Roux E,Teepe M,Maliszewski CR,Hoek J,Caron D,Lebsack ME,McKenna HJ

更新日期：2000-08-01 00:00:00

abstract：:Bone marrow CD34(+) cell apoptosis (annexin V), proliferation (Ki-67), and Bcl-2-related protein expression was evaluated by flow cytometry in 102 patients with myelodysplastic syndrome (MDS) and acute myeloid leukemia secondary to MDS (MDS-AML) and in 30 normal donors (NBM). Apoptosis was significantly increased in r...

journal_title：Blood

authors： Parker JE,Mufti GJ,Rasool F,Mijovic A,Devereux S,Pagliuca A

更新日期：2000-12-01 00:00:00

abstract：:Seventy-five patients with resistant acute leukemia or lymphoma received high-dose cyclophosphamide and etoposide to explore the activity of this combination in resistant hematologic malignancies, and to determine the maximum doses of these drugs that can be combined without bone marrow transplantation. Etoposide was ...

journal_title：Blood

authors： Brown RA,Herzig RH,Wolff SN,Frei-Lahr D,Pineiro L,Bolwell BJ,Lowder JN,Harden EA,Hande KR,Herzig GP

更新日期：1990-08-01 00:00:00

abstract：:Individuals with impaired perforin-dependent cytotoxic function (Ctx(-)) develop a fatal inflammatory disorder called hemophagocytic lymphohistiocytosis (HLH). It has been hypothesized that immune hyperactivation during HLH is caused by heightened infection, defective apoptosis/responsiveness of Ctx(-) lymphocytes, or...

journal_title：Blood

authors： Lykens JE,Terrell CE,Zoller EE,Risma K,Jordan MB

更新日期：2011-07-21 00:00:00

abstract：:Terminal erythroid differentiation starts from morphologically recognizable proerythroblasts that proliferate and differentiate to generate red cells. Although this process has been extensively studied in mice, its characterization in humans is limited. By examining the dynamic changes of expression of membrane protei...

journal_title：Blood

authors： Hu J,Liu J,Xue F,Halverson G,Reid M,Guo A,Chen L,Raza A,Galili N,Jaffray J,Lane J,Chasis JA,Taylor N,Mohandas N,An X

更新日期：2013-04-18 00:00:00

abstract：:A new human leukemia cell line, KT-1, was established from a patient in the blastic crisis phase of chronic myelogenous leukemia (CML). This cell line had a positive reaction for intracytoplasmic myeloperoxidase and two Philadelphia chromosomes (Ph1) [t(9;22)(q34;q11)] and lacked normal copies of chromosomes 9 and 22....

journal_title：Blood

authors： Yanagisawa K,Yamauchi H,Kaneko M,Kohno H,Hasegawa H,Fujita S

更新日期：1998-01-15 00:00:00

abstract：:The expression of early and mature B cell markers, surface beta 2-microglobulin (B2M) and cytoplasmic immunoglobulin (clg) by aneuploid tumor cells in bone marrow aspirates from 44 patients with multiple myeloma was evaluated by correlated DNA immunofluorescence flow cytometry. Myeloma tumor cells of almost 90% of the...

journal_title：Blood

authors： Epstein J,Barlogie B,Katzmann J,Alexanian R

更新日期：1988-04-01 00:00:00

abstract：:Skewed X-chromosome inactivation in peripheral blood granulocytes becomes more frequent with increasing age, affecting up to half of those over 75 years old. To investigate the mechanisms underlying this phenomenon, X-inactivation profiles in 33 monozygotic and 22 dizygotic elderly twin pairs were studied. Differentia...

journal_title：Blood

authors： Vickers MA,McLeod E,Spector TD,Wilson IJ

更新日期：2001-03-01 00:00:00

abstract：:Haploinsufficiency of ribosomal proteins (RPs) has been proposed to be the common basis for the anemia observed in Diamond-Blackfan anemia (DBA) and myelodysplastic syndrome with loss of chromosome 5q [del(5q) MDS]. We have modeled DBA and del(5q) MDS in zebrafish using antisense morpholinos to rps19 and rps14, respec...

journal_title：Blood

authors： Payne EM,Virgilio M,Narla A,Sun H,Levine M,Paw BH,Berliner N,Look AT,Ebert BL,Khanna-Gupta A

更新日期：2012-09-13 00:00:00

abstract：:Gene therapy for inherited disorders of blood cells will require both efficient methods for stable gene transfer and nonablative bone marrow conditioning regimens to allow engraftment of modified hematopoietic progenitor cells (HPCs). We have used a sensitive murine system for detecting HPC engraftment using congenic ...

journal_title：Blood

authors： Mardiney M 3rd,Malech HL

更新日期：1996-05-15 00:00:00

abstract：:The SJL/J mouse strain has a high spontaneous incidence of a B-cell neoplasm, reticulum cell neoplasm type B (RCN B). In addition, following irradiation, 10% to 30% of these mice develop acute myelomonocytic leukemia (radiation-induced acute myeloid leukemia [RI-AML]), an incidence that can be increased to 50% by trea...

journal_title：Blood

authors： Haran-Ghera N,Krautghamer R,Lapidot T,Peled A,Dominguez MG,Stanley ER

更新日期：1997-04-01 00:00:00

abstract：:Fanconi anemia (FA) is a genetic disorder associated with bone marrow (BM) failure and leukemia. Recent studies demonstrate variable immune defects in FA. However, the cause for FA immunodeficiency is unknown. Here we report that deletion of Fanca or Fancd2 dysregulates the suppressive activity of regulatory T cells (...

journal_title：Blood

authors： Du W,Erden O,Wilson A,Sipple JM,Schick J,Mehta P,Myers KC,Steinbrecher KA,Davies SM,Pang Q

更新日期：2014-03-20 00:00:00

abstract：:The cells of hematopoietic and vascular endothelial cell lineages are believed to share a common precursor, termed hemangioblast. However, the existence of a growth factor acting relatively specifically on hemangioblasts remains unclear. Here we report the identification of hemangiopoietin (HAPO), a novel growth facto...

journal_title：Blood

authors： Liu YJ,Lu SH,Xu B,Yang RC,Ren Q,Liu B,Li B,Lu M,Yan FY,Han ZB,Han ZC

更新日期：2004-06-15 00:00:00

abstract：:Vascular cell adhesion molecule-1 (VCAM-1) and endothelial-leukocyte adhesion molecule-1 (ELAM-1) are adhesive proteins induced on endothelium by cytokines. We examined the contribution of these adhesive proteins to human peripheral blood monocyte adherence to endothelium using transfected Chinese hamster ovary (CHO) ...

journal_title：Blood

authors： Carlos T,Kovach N,Schwartz B,Rosa M,Newman B,Wayner E,Benjamin C,Osborn L,Lobb R,Harlan J

更新日期：1991-05-15 00:00:00

abstract：:Expression of the von Willebrand factor (vWF) gene is restricted to the endothelial and megakaryocyte lineages. Within the endothelium, expression of vWF varies between different vascular beds. We have previously shown that the human vWF promoter spanning a region between -2182 (relative to the start site of transcrip...

journal_title：Blood

authors： Guan J,Guillot PV,Aird WC

更新日期：1999-11-15 00:00:00

abstract：:Nitric oxide (NO) is a potent radical produced by nitric oxide synthase (NOS) and has pleiotrophic activities in health and disease. As mast cells (MCs) play a central role in both homeostasis and pathology, we investigated NOS expression and NO production in human MC populations. Endothelial NOS (eNOS) was ubiquitous...

journal_title：Blood

authors： Gilchrist M,McCauley SD,Befus AD

更新日期：2004-07-15 00:00:00

abstract：:Postthrombotic syndrome (PTS) is a chronic complication of deep venous thrombosis (DVT) that reduces quality of life and has important socioeconomic consequences. More than one-third of patients with DVT will develop PTS, and 5% to 10% of patients will develop severe PTS, which may manifest as venous ulceration. The p...

journal_title：Blood

authors： Kahn SR

更新日期：2009-11-19 00:00:00

abstract：:Human hematopoietic colony-forming cells (CFC) express the CD34 antigen (CD34+) as well as differentiation antigens such as CD33 and HLA-DR. CD34+ cells that do not express these latter differentiation antigens have been shown to contain few CFC in direct culture, but generate increasing numbers of CFC when cultured o...

journal_title：Blood

authors： Litzow MR,Brashem-Stein C,Andrews RG,Bernstein ID

更新日期：1991-06-01 00:00:00

abstract：:To evaluate internal tandem duplication (ITD) insertion sites and length as well as their clinical impact in younger adult patients with FLT3-ITD-positive acute myeloid leukemia (AML), sequencing after DNA-based amplification was performed in diagnostic samples from 241 FLT3-ITD-mutated patients. All patients were tre...

journal_title：Blood

authors： Kayser S,Schlenk RF,Londono MC,Breitenbuecher F,Wittke K,Du J,Groner S,Späth D,Krauter J,Ganser A,Döhner H,Fischer T,Döhner K,German-Austrian AML Study Group (AMLSG).

更新日期：2009-09-17 00:00:00

abstract：:Inhibitors of bromodomain and extraterminal motif proteins (BETs) are being evaluated for the treatment of cancer and other diseases, yet much remains to be learned about how BET proteins function during normal physiology. We used genomic and genetic approaches to examine BET function in a hematopoietic maturation sys...

journal_title：Blood

authors： Stonestrom AJ,Hsu SC,Jahn KS,Huang P,Keller CA,Giardine BM,Kadauke S,Campbell AE,Evans P,Hardison RC,Blobel GA

更新日期：2015-04-30 00:00:00