Abstract：
:Heart failure (HF) has high morbidity and mortality in children. This study aimed to investigate the value of cardiac myosin binding protein-C (cMyBP-C) as a diagnostic and prognostic biomarker in children with heart failure. This study was a prospective case-control study that involved 50 children with acute HF and 25 healthy children of matched age and sex as a control group. cMyBP-C plasma levels were measured in patients with HF at the time of admission and 1 month after treatment. Echocardiographic assessment was done for all children. All patients were followed up for a period of 3 months. There was a significant increase in plasma levels of cMyBP-C (ng/ml) in patients with HF at admission (122.44 ± 41.01) as compared to patients after treatment (71.38 ± 49.68) and to control group (24.40 ± 9.83). This increase was associated with increased severity of HF according to pediatric Ross classification of HF. Significant increase in plasma levels of cMyBP-C at admission and its persistent increase after treatment were associated with adverse outcome of mortality and readmission. Plasma levels of cMyBP-C were significantly correlated with echocardiographic and clinical assessment of heart failure. Plasma levels of cMyBP-C were a good biomarker for diagnosis of HF with sensitivity 100% and specificity 96% at cutoff point of 45 ng/ml. Its value in predicting adverse outcome in HF patients was obtained by ROC curve with sensitivity of 90% and specificity 93% at a cutoff point of 152 ng/ml cMyBP-C at admission. cMyBP-C may be a novel useful diagnostic and prognostic biomarker in children with heart failure and determination of severity of HF in these patients.
journal_name
Pediatr Cardioljournal_title
Pediatric cardiologyauthors
El Amrousy D,Hodeib H,Suliman G,Hablas N,Salama ER,Esam Adoi
10.1007/s00246-016-1532-2subject
Has Abstractpub_date
2017-02-01 00:00:00pages
418-424issue
2eissn
0172-0643issn
1432-1971pii
10.1007/s00246-016-1532-2journal_volume
38pub_type
杂志文章abstract：BACKGROUND:The optimal surgical strategy for pulmonary atresia with ventricular septal defect (PA/VSD) in neonates and young infants is controversial. Staged repair may be associated with a higher risk of inter-stage mortality, while primary repair may lead to frequent post-repair re-interventions. METHODS:From 2004 t...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-020-02352-9
更新日期：2020-06-01 00:00:00
abstract：:Hammock mitral valve (MV), also known as anomalous mitral arcade, is a rare congenital anomaly. We report a case of a 10-month-old child who presented with congestive heart failure and was found to have severe mitral stenosis (MS) secondary to a hammock MV anomaly. Detailed advanced imaging with cardiac MRI and three-...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-017-1797-0
更新日期：2018-03-01 00:00:00
abstract：:The treatment of recurrent supraventricular tachycardia in a 3-week-old infant is described. Multiple doses of adenosine were used successfully to convert the dysrhythmia, without adverse effects or apparent tachyphylaxis. ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s002469900222
更新日期：1997-11-01 00:00:00
abstract：:Cardiac surgery for congenital heart disease often necessitates a period of myocardial ischemia during cardiopulmonary bypass and cardioplegic arrest, followed by reperfusion after aortic cross-clamp removal. In experimental models, myocardial ischemia-reperfusion is associated with significant oxidative stress and ve...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-016-1345-3
更新日期：2016-04-01 00:00:00
abstract：:The reported prenatal detection rates (PDRs) for significant congenital heart disease (sCHD) have been suboptimal, even in the current era. Changes in prenatal ultrasound policy and training may lead to improved prenatal detection of sCHD. This study analyzed the results of a policy to assess fetal cardiac outflow tra...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-012-0526-y
更新日期：2013-03-01 00:00:00
abstract：:Exercise testing can highlight repolarisation abnormalities in adults with coronary artery disease. Late after Kawasaki disease (KD), increased QT dispersion (QTd) has been reported on resting ECG in children, but there are no reported studies of QTd during exercise. Our objective was to determine the pattern of QTd r...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-012-0201-3
更新日期：2012-06-01 00:00:00
abstract：:The COVID-19 pandemic has had devastating direct consequences on the health of affected patients. It has also had a significant impact on the ability of unaffected children to be physically active. We evaluated the effect of deconditioning from social distancing and school shutdowns implemented during the COVID-19 pan...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-020-02513-w
更新日期：2021-01-04 00:00:00
abstract：:Quantification of left ventricular (LV) mass by echocardiography has not been validated against the gold standard of cardiac magnetic resonance imaging (CMR) in the pediatric population. The purpose of this study was to compare LV mass by two-dimensional and conventional M-mode echocardiography versus CMR in children....
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-018-1991-8
更新日期：2019-02-01 00:00:00
abstract：:We report on a 4-kg infant with Alagille syndrome and congenital heart disease consisting of atrial septal defect (ASD), patent ductus arteriosus (PDA), and severe peripheral pulmonic stenosis. He underwent successful orthotopic liver transplant along with catheter closure of the ASD and PDA using the Amplatzer device...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：
更新日期：2002-11-01 00:00:00
abstract：:Despite improved outcomes following modifications to the Fontan technique, significant morbidity and mortality persist. We sought to determine if abnormal pre-Fontan catheterization hemodynamic data will predict postoperative prolonged hospital stay (PHLOS) and adverse post-discharge outcomes. This is a retrospective ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-020-02430-y
更新日期：2020-12-01 00:00:00
abstract：:When the common pulmonary vein fails to develop, the embryonic connections of the pulmonary veins to one or more of the systemic veins almost always persist. Anomalous pulmonary venous connections to the inferior vena cava (IVC) are typically characterized by hypoplasia of the involved pulmonary veins and pulmonary ar...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-005-0920-9
更新日期：2005-11-01 00:00:00
abstract：:For some congenital heart lesions, higher institutional surgical volume has been associated with better survival than in lower volume centers. The relationship between institutional surgical volume and mortality in infants after total anomalous pulmonary vein return (TAPVR) repair has not been well explored. The Texas...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-019-02224-x
更新日期：2020-01-01 00:00:00
abstract：:Killian-Pallister syndrome is a rare dysmorphic condition characterized by specific clinical manifestations and tetrasomy 12p. Although the association of this condition with congenital heart disease has been previously documented, no cases have been reported in association with Fallot's tetralogy. We report one such ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s002469900420
更新日期：1999-03-01 00:00:00
abstract：:Three cases of criss-cross heart with severe and complex congenital defects are reported. Precise preoperative diagnosis of the morphologic abnormalities made it possible to choose an optimal method of surgical treatment: all patients successfully underwent a Fontan-type surgical procedure. ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02239574
更新日期：1990-04-01 00:00:00
abstract：:Little has been published about specific problems that may occur during long-distance transports of newborn cardiac patients. During a 4-year period after centralization of pediatric heart surgery in Sweden, 286 transports were prospectively investigated. A majority (77.3%) of the transports were carried out by nonspe...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s002460010254
更新日期：2001-09-01 00:00:00
abstract：:This prospective observational study conducted in a neonatal intensive care unit aimed to evaluate echocardiographic changes provoked by anemia and transfusion of packed red blood cells (pRBCs) in premature infants. In this study, 32 anemic premature infants had serial echocardiographic assessment of left ventricular ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-012-0154-6
更新日期：2012-04-01 00:00:00
abstract：:A case report of a neonate with cardiac tumors in association with tuberous sclerosis is presented. The rare complication of pulmonary embolism and its successful treatment by anticoagulation and thrombolytic therapy is described. The treatment of these cardiac tumors is conservative, because the tumors regress sponta...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s002460010247
更新日期：2001-07-01 00:00:00
abstract：:A 14-year-old boy after a Mustard procedure for transposition of the great arteries developed pulmonary hypertension secondary to baffle obstruction. This occurred over several years without apparent significant symptomatology. Systemic-level pressure prevailed in the left (pulmonary) ventricle and provided an opportu...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s002469900470
更新日期：1999-07-01 00:00:00
abstract：:Plastic bronchitis is a rare, potentially life-threatening condition in which protein casts form within and occlude the bronchus, resulting in pulmonary failure, and has been identified as a complication after the Fontan procedure. We present a case of a 5-year-old girl who had undergone an extracardiac fenestrated Fo...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-005-0913-8
更新日期：2005-09-01 00:00:00
abstract：:A retrospective study of children dying with active varicella revealed 11 of 17 cases who had unsuspected interstitial myocarditis at the time of their death. In addition, a prospective study of 6 children, consecutively admitted to the hospital with active varicella, were evaluated for evidence of cardiac dysfunction...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02082333
更新日期：1982-01-01 00:00:00
abstract：:Left atrial tumor, diagnosed as myxoma at first investigation, was later demonstrated to be a malignant fibrosarcoma with myxoid change. Myxoma should be diagnosed and managed carefully because of its wide range of histopathologic features. ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s002460010218
更新日期：2001-05-01 00:00:00
abstract：:A very rare combination including tetralogy of Fallot (TOF), absent pulmonary valve, and isolated left pulmonary artery is described. A 4-month-old girl presented with mild cyanosis and severe dyspnea. Echocardiography established the diagnosis of TOF and absent pulmonary valve with severe pulmonary regurgitation and ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-008-9282-4
更新日期：2008-11-01 00:00:00
abstract：:Children with acquired and congenital heart disease (CHD) are increasingly surviving to adulthood. Our aim was to determine the prevalence of coronary artery disease (CAD) risk factors in children at known risk for early CAD or with severe CHD. We recruited children (8-19 years) at risk for early CAD-Kawasaki disease ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-017-1750-2
更新日期：2018-02-01 00:00:00
abstract：:Quantification of pulmonary regurgitation (PR), pulmonary flow distribution, and ventricular function is important for clinical surveillance in repaired Tetralogy of Fallot (TOF). Cardiovascular magnetic resonance (CMR) is the established reference, but cost, test duration, and patient discomfort are potential limitat...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-018-2035-0
更新日期：2019-03-01 00:00:00
abstract：:Intrathoracic ventricular aneurysms and diverticula can be differentiated by several criteria. Contractility is the only reliable parameter: aneurysms expand, whereas diverticula contract during ventricular systole. ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s002460010264
更新日期：2001-09-01 00:00:00
abstract：:Long-term oral warfarin is recommended in pediatric Kawasaki disease patients with large coronary artery aneurysms; however, heterogeneity is considerable. This study aimed to determine variables affecting warfarin dosage in Kawasaki disease. The enrolled individuals (194 children) were divided into four groups: (1) C...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-018-1957-x
更新日期：2019-01-01 00:00:00
abstract：:The timing of pulmonary valve replacement (PVR) in asymptomatic patients with repaired tetralogy of Fallot (TOF) is typically based on cardiac magnetic resonance imaging-derived ventricular volume measurements. Current criteria do not account for sex-based differences in chamber size. The purpose of this study was to ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-019-02181-5
更新日期：2019-10-01 00:00:00
abstract：:Adrenomedullin (ADM) is a vasoactive peptide with potent dilatory effects. We studied whether perioperative myocardial injury could be altered by the presence of ADM. Blood samples from 19 children with congenital heart disease undergoing surgical repair were collected at six time points: preoperative, on cardiopulmon...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s002460010046
更新日期：2000-05-01 00:00:00
abstract：:Although transthoracic echocardiography (TTE) is the first-line examination for the study of coronary lesions in Kawasaki disease, CT coronary angiography (CTCA) is increasingly used and showed good results. Our aim is to evaluate the contribution of CTCA in the detection of coronary lesions and to compare its results...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-018-2044-z
更新日期：2019-02-01 00:00:00
abstract：:We report a 4-month-old infant with torsade de pointes secondary to procainamide treatment. The infant presented with atrial flutter and converted to normal sinus rhythm with intravenous procainamide. Oral procainamide therapy was initiated as the infusion was tapered, and the patient subsequently developed incessant ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF00796823
更新日期：1995-03-01 00:00:00
