Abstract:
:Diclofenac is the most widely prescribed non-steroidal anti-inflammatory drug worldwide. Data collected during the last 10 years reported a dose-duration dependent increasing of cardiovascular risk associated with the use of diclofenac, supporting the evidence of a close association with the degree of COX-2 inhibition achieved in vivo. Nevertheless, the amplitude of cardiovascular risk associated with the administration of diclofenac at low doses and for the short-term duration is still poorly defined. Indeed, data did not show a clear and strong increasing of the risk for daily doses of 75 and of 50 mg. Concerning duration, while the identification of a safe temporal window is less defined, some studies reported an absence or a very low risk when the exposure is shorter than 30 days. Today, new low-dosage diclofenac formulations are available, allowing to reduce the systemic exposure, the degree of COX-2 inhibition and possibly the risk of occurrence of cardiovascular events. This is the reason why those new formulations may represent the ideal drug for the management of pain in the emergency setting.
journal_name
Eur Rev Med Pharmacol Scijournal_title
European review for medical and pharmacological sciencesauthors
Franceschi F,Saviano L,Petruzziello C,Gabrielli M,Santarelli L,Capaldi L,Di Leo M,Migneco A,Gilardi E,Merra G,Ojetti Vsubject
Has Abstractpub_date
2016-10-01 00:00:00pages
4401-4408issue
20eissn
1128-3602issn
2284-0729journal_volume
20pub_type
杂志文章abstract:BACKGROUND:Osteosarcoma is an aggressive cancerous neoplasm arising from primitive transformed cells of mesenchymal origin that exhibit osteoblastic differentiation and produce malignant osteoid. With the rapid development of tumor molecular biology, gene and viral therapy, a highly promising strategy for the treatment...
journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:
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abstract:OBJECTIVE:Pulmonary surfactant-associated protein B (SP-B), which is synthesized and secreted by alveolar epithelial type II cells, is crucial for normal functioning of pulmonary surfactant. Degeneration of pulmonary surfactant is the essential cause of acute lung injury (ALI). ALI is often studied in animal models usi...
journal_title:European review for medical and pharmacological sciences
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abstract:OBJECTIVE:To compare the placental exosome levels of normal pregnant women and pregnant women with gestational diabetes mellitus (GDM) in different gestational stages, and further investigate the effects of exosomes on the release of cytokines from human umbilical vein endothelial cells. PATIENTS AND METHODS:20 pregna...
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journal_title:European review for medical and pharmacological sciences
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journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章,评审
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journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章,评审
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journal_title:European review for medical and pharmacological sciences
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更新日期:2018-05-01 00:00:00
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journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章,评审
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journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章,评审
doi:
更新日期:2005-09-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:
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更新日期:2017-03-01 00:00:00
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journal_title:European review for medical and pharmacological sciences
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更新日期:2016-01-01 00:00:00
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journal_title:European review for medical and pharmacological sciences
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