Advances in the field of proprotein convertase subtilisin kexin type 9 inhibitors.


PURPOSE OF REVIEW:Proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitors are promising therapies that inhibit the degradation of low-density lipoprotein (LDL) receptors in the hepatocyte and thus increase LDL cholesterol (LDL-C) uptake from the blood. This review summarizes main findings in the field of PCSK9 inhibitors, from basic mechanism to clinical studies, and aims to provide a contemporary and practical overview of the clinical implication and future directions with PCSK9 inhibitors. RECENT FINDINGS:Monoclonal antibodies that inhibit PCSK9 reduce LDL-C levels by 40-70% across a wide range of patients with various LDL-C levels, and with different lipid-lowering regimens. These agents significantly reduce apolipoprotein B and lipoprotein (a), may have a potential role in plaque stabilization in acute coronary syndromes, and are safe and tolerable, even among statin-intolerant patients. Preliminary data with evolocumab and alirocumab demonstrate the potential reduction of cardiovascular (CV) events. These PCSK9 inhibitors were recently approved for clinical use, and recommended in the 2016 American College of Cardiology expert consensus document for nonstatin therapy for LDL-C lowering. SUMMARY:PCSK9 inhibitors are novel promising therapies to reduce LDL-C. Ongoing phase 3 clinical trials with more than 70 000 high-risk patients will examine their safety and efficacy in reducing cardiovascular disease.


Curr Opin Cardiol


Eisen A,Giugliano RP




Has Abstract


2016-11-01 00:00:00












  • Assessment of myocardial viability by PET.

    abstract:PURPOSE OF REVIEW:Viability assessment has a key role in the management of patients with ischemic heart disease. Positron emission tomography (PET) is a unique modality that evaluates myocardial viability via assessing the tissues metabolic and perfusion properties. The mainstay of metabolic imaging relies on glucose m...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Khalaf S,Chamsi-Pasha M,Al-Mallah MH

    更新日期:2019-09-01 00:00:00

  • Bridge or continue Coumadin for device surgery: a randomized controlled trial rationale and design.

    abstract:PURPOSE OF REVIEW:Many patients requiring cardiac arrhythmia device surgery are on chronic oral anticoagulation therapy. The periprocedural management of their anticoagulation presents a dilemma to physicians, particularly in the subset of patients with moderate-to-high risk of arterial thromboembolic events. Physician...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Birnie D,Healey JS,Krahn A,Essebag V,Sivakumaran S,Tang A,Simpson C

    更新日期:2009-01-01 00:00:00

  • Statins for primary prevention of cardiovascular disease: the benefits outweigh the risks.

    abstract:PURPOSE OF REVIEW:Statins significantly reduce cardiovascular morbidity and mortality in patients with and without coronary heart disease. Recently, much debate has focused on use of statins for primary prevention following a class-wide safety label change by the US Food and Drug Administration amidst concerns of worse...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Minder CM,Blumenthal RS,Blaha MJ

    更新日期:2013-09-01 00:00:00

  • Medical and surgical therapy for cardiac remodeling.

    abstract::Ventricular remodeling refers to changes in ventricular geometry, volume, mass, and myocellular structure in response to myocardial injury or alteration in loading conditions. Although initially adaptive as a consequence of the initial damage to the myocardium, progressive ventricular remodeling is ultimately a malada...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Bozkurt B

    更新日期:1999-05-01 00:00:00

  • Lessons from platelet inhibition and patient outcomes.

    abstract:PURPOSE OF REVIEW:Ticagrelor is a new, direct acting, reversibly binding P2Y12 receptor antagonist with more potent inhibition of platelets than clopidogrel and which does not require metabolic activation. It was compared with clopidogrel, on a background of the standard of care in a randomized trial in the Platelet In...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,随机对照试验


    authors: Held C

    更新日期:2012-07-01 00:00:00

  • Management of heart failure in the elderly.

    abstract:PURPOSE OF REVIEW:Heart failure is a major chronic illness with no definitive cure. With improving healthcare and with an aging population in many countries, heart failure has become a common disease of the elderly. Pharmacological management of heart failure in the elderly remains a challenge. The syndrome of heart fa...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Alghamdi F,Chan M

    更新日期:2017-03-01 00:00:00

  • Preventive cardiology.

    abstract::Over the past year, significant new advances have been made in preventive cardiology. New trials of lipid lowering, estrogen therapy, and hypertension control have added to our understanding of the pathophysiology and prevention of coronary atherosclerosis. This review highlights these new trials and provides insight ...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Foody JA

    更新日期:1999-09-01 00:00:00

  • Institutional and national trends in isolated mitral valve surgery over the past decade.

    abstract:PURPOSE OF REVIEW:To review trends in practice for mitral valve surgery in the US over the past decade. RECENT FINDINGS:Advances in the understanding of mitral valve pathophysiology and the technology involved with mitral valve surgery have led to significant changes of the current practice for mitral valve surgery, w...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Ad N,Barnett SD,Speir AM,Massimiano PS

    更新日期:2008-03-01 00:00:00

  • Coarctation of the aorta: evaluation and management.

    abstract:PURPOSE OF REVIEW:Coarctation of the aorta is the discrete narrowing of the proximal descending aorta and is the sixth most common lesion in congenital heart disease. Repair of the coarctation can relieve the obstruction, but recurrent coarctation and future aneurysm formation can occur, and a heightened risk of vascul...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Tanous D,Benson LN,Horlick EM

    更新日期:2009-11-01 00:00:00

  • High-density lipoprotein cholesterol raising: does it matter?

    abstract:PURPOSE OF REVIEW:Cardiovascular disease (CVD) is the leading cause of morbidity and premature mortality in Europe and the United States, and is increasingly common in developing countries. High-density lipoprotein cholesterol (HDL-C) is an independent risk factor for CVD and is superior to low-density lipoprotein chol...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Schofield JD,France M,Ammori B,Liu Y,Soran H

    更新日期:2013-07-01 00:00:00

  • The pathogenesis of cardiac allograft vasculopathy.

    abstract::There has been an intensive effort in the past year to identify immunologic and nonimmunologic factors in the pathogenesis of cardiac allograft vasculopathy. Significant progress has been made regarding cell proliferation and cell death, with particular focus on cell growth factors, cell death factors, and their recep...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Dong C,Redenbach D,Wood S,Battistini B,Wilson JE,McManus BM

    更新日期:1996-03-01 00:00:00

  • Systematic review and meta-analysis in cardiac surgery: a primer.

    abstract:PURPOSE OF REVIEW:The purpose of this article is to review the strengths and weaknesses of systematic reviews and meta-analyses to inform our current understanding of cardiac surgery. RECENT FINDINGS:A systematic review and meta-analysis of a focused topic can provide a quantitative estimate for the effect of a treatm...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,meta分析


    authors: Yanagawa B,Tam DY,Mazine A,Tricco AC

    更新日期:2018-03-01 00:00:00

  • Anomalous origins of the coronary arteries: current knowledge and future perspectives.

    abstract:PURPOSE OF REVIEW:The purpose of this review is to survey the contemporary literature surrounding congenital anomalies of origin of the coronary arteries and to identify remaining gaps in knowledge. RECENT FINDINGS:In recent years, lineage tracing analyses and mechanistic studies in model organisms have enhanced our u...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Mazine A,Fernandes IM,Haller C,Hickey EJ

    更新日期:2019-09-01 00:00:00

  • Myocardial contrast echocardiography in acute coronary syndromes.

    abstract::Myocardial contrast echocardiography (MCE) is an emerging technique in which microbubble contrast agents are visualized in the coronary microvasculature. MCE is an ideal modality for the noninvasive evaluation of acute coronary syndromes because it provides portable, simultaneous assessment of regional wall motion and...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Ward RP,Lang RM

    更新日期:2002-09-01 00:00:00

  • Apoptosis as a therapeutic target in acutely ischemic myocardium.

    abstract::In addition to necrosis, apoptosis makes a significant contribution to cell death following acute myocardial ischemia; apoptosis is particularly enhanced during reperfusion. Several studies are beginning to indicate that the cell death by apoptosis may be preventable. A boost in the research in this direction has been...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Garg S,Hofstra L,Reutelingsperger C,Narula J

    更新日期:2003-09-01 00:00:00

  • The clinical implication of tissue renin angiotensin systems.

    abstract::The presence, and in many cases the regulated synthesis, of components of the renin-angiotensin system have been demonstrated in multiple tissues, indicating the existence of tissue angiotensin-generating systems. These vary with respect to which renin-angiotensin system components are synthesized locally and which ar...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Re RN

    更新日期:2001-11-01 00:00:00

  • Aortic valve disease.

    abstract::Management of aortic valve disease follows traditional algorithms: initial gross diagnosis, noninvasive imaging and quantitation, possible catheterization or angiography, and medical treatment until symptoms of prognosis prediction indicates surgery. Most advances in this subject reflect improved technology and additi...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Baxley WA

    更新日期:1994-03-01 00:00:00

  • Comparative imaging techniques and models.

    abstract::The explosion of high-resolution imaging technology in recent years has led to the increasing problem of choosing imaging modalities appropriate to specific clinical questions. In terms of structural information, for example, the relative benefits of ultrasound versus magnetic resonance imaging versus computed tomogr...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Simpson IA,Sahn DJ

    更新日期:1992-12-01 00:00:00

  • New advances in antirejection therapy.

    abstract:PURPOSE OF REVIEW:The prevention and treatment of rejection have been the major focus of clinical and research studies since the inception of heart transplantation. Recent improvement in survival after transplant has been in large part due to continued advancement in antirejection therapies. RECENT FINDINGS:The combin...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Chan M,Pearson GJ

    更新日期:2007-03-01 00:00:00

  • Management of patients with end-stage renal disease: coronary artery bypass graft surgery versus percutaneous coronary intervention.

    abstract:PURPOSE OF REVIEW:Coronary artery disease is common in patients with end-stage renal disease (ESRD) on hemodialysis. ESRD patients are prone to atherosclerosis and are likely to present with advanced CAD requiring coronary artery bypass graft surgery (CABG) or percutaneous coronary intervention (PCI). RECENT FINDINGS:...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Karkhanis R,Tam DY,Fremes SE

    更新日期:2018-09-01 00:00:00

  • Evidence supporting secondary prevention strategies.

    abstract::Currently 14 million individuals in the United States have coronary disease. Within the next 2 decades, this number is expected to increase to 21 million persons. To minimize the excessive risk of recurrent cardiac events in these people, evidence-based, cost-effective prevention strategies must be developed. This rev...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Blazing MA,O'Connor CM

    更新日期:1999-07-01 00:00:00

  • Sex differences in hypertrophic cardiomyopathy: new insights.

    abstract:PURPOSE OF REVIEW:Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiomyopathy, diagnosed by left ventricular hypertrophy of at least 15 mm maximal wall thickness (MWT). Recent studies reported a sex difference in clinical presentation, progression and outcome of HCM. This review provides an overview of ...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: van Driel B,Nijenkamp L,Huurman R,Michels M,van der Velden J

    更新日期:2019-05-01 00:00:00

  • Dronedarone: a novel antiarrhythmic agent for the treatment of atrial fibrillation.

    abstract:PURPOSE OF REVIEW:To describe the electrophysiological profile and the clinical portfolio of dronedarone, a new multichannel-blocking antiarrhythmic drug developed for the treatment of atrial fibrillation. RECENT FINDINGS:Dronedarone is a derivative of amiodarone that is free of iodine and less lipophilic. The drug ha...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Duray GZ,Ehrlich JR,Hohnloser SH

    更新日期:2010-01-01 00:00:00

  • Innovations in cardiac transplantation.

    abstract:PURPOSE OF REVIEW:As the number of people living with heart failure continues to grow, future treatments will focus on efficient donor organ donation and ensuring safe and durable outcomes. This review will focus on organ procurement, graft surveillance and emerging therapies. RECENT FINDINGS:Preliminary studies into ...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章


    authors: Hasan R,Ela AAE,Goldstein D

    更新日期:2017-05-01 00:00:00

  • Cardiovascular implications and complications of the coronavirus disease-2019 pandemic: a world upside down.

    abstract:PURPOSE OF REVIEW:The new pandemic of coronavirus disease-2019 (COVID-19) has produced a global tumult and has overburdened national health systems. We herein discuss the cardiovascular implications and complications of this pandemic analyzing the most recent data clustered over the last several months. RECENT FINDING...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章


    authors: Manolis AS,Manolis TA,Manolis AA,Melita H

    更新日期:2020-12-30 00:00:00

  • cGMP manipulation in cardiometabolic disease: chances and challenges.

    abstract:PURPOSE OF REVIEW:Cardiovascular and metabolic diseases are closely linked and commonly occur in the same patients. This review focuses on the cyclic guanosine monophosphate (cGMP) system and its crosstalk between metabolism and the cardiovascular system. RECENT FINDINGS:Recent studies suggest that cGMP, which serves ...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Jordan J,Hildebrand S,Pfeifer A

    更新日期:2019-07-01 00:00:00

  • Prevention and control of hypertension: developing a global agenda.

    abstract:PURPOSE OF REVIEW:This review demonstrates the need for enhancing strategic approaches to the prevention and control of hypertension, a global health issue. RECENT FINDINGS:An epidemic of chronic noncommunicable diseases is threatening national healthcare systems' sustainability and the economy of many countries. Incr...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Campbell NR,Niebylski ML,World Hypertension League Executive.

    更新日期:2014-07-01 00:00:00

  • Transcatheter device closure of atrial septal defects: more to think about than just closing the hole.

    abstract:PURPOSE OF REVIEW:To review current controversies in the transcatheter device closure of ostium secundum atrial septal defects (ASD). RECENT FINDINGS:Transcatheter device closure of ASD (TC-ASD) has well established efficacy and safety. For most individual patients with suitable anatomy, TC-ASD is the preferred method...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: O'Byrne ML,Glatz AC,Gillespie MJ

    更新日期:2018-01-01 00:00:00

  • Percutaneous valve replacement: a paradigm shift.

    abstract:PURPOSE OF REVIEW:Valvular heart disease is often associated with significant morbidity and mortality. Surgical treatment of stenotic or regurgitant valvular lesions can alter the natural history of the disease process, yielding excellent short and long-term results, meaning that this has been accepted as the gold stan...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章


    authors: Sinha AK,Kini AS,Sharma SK

    更新日期:2007-09-01 00:00:00

  • Minimally invasive CABG.

    abstract::For more than three decades, conventional coronary artery bypass grafting (full sternotomy, cardiopulmonary bypass, and cardioplegic arrest) has been the treatment of choice for patients with multi-vessel coronary artery disease. However, neurologic injury secondary to ascending aortic manipulation and systemic inflam...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审


    authors: Filsoufi F,Aklog L,Adams DH

    更新日期:2001-09-01 00:00:00