Abstract:
:Nostosins A and B were isolated from a hydrophilic extract of Nostoc sp. strain from Iran, which exhibits excellent tryps inhibitory activity. Nostosin A was the most potent natural tripeptide aldehyde as trypsin inhibitor up to now. Both R- and S-2-hydroxy-4-(4-hydroxy-phenyl) butanoic acid (Hhpba) were prepared and incorporated into the total synthesis of nostosin B, respectively. Careful comparison of the NMR spectra and optical rotation data of synthetic nostosin B (1a and 1b) with the natural product led to the unambiguous identification of the R-configuration of the Hhpba fragment, which was further confirmed by co-injection with the authentic sample on HPLC using both reversed phase column and the chiral AD-RH column.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Wang X,Feng J,Xu Z,Ye T,Meng Y,Zhang Zdoi
10.3390/md15030058subject
Has Abstractpub_date
2017-02-27 00:00:00issue
3issn
1660-3397pii
md15030058journal_volume
15pub_type
杂志文章相关文献
Marine Drugs文献大全abstract::Four 4-hydroxy-α-pyrones including three new ones named nipyrones A-C (1-3) together with one known analogue germicidin C (4) were discovered from a marine sponge-derived fungus Aspergillus niger cultivated in a solid rice culture. Their structures and absolute configurations were elucidated through a combination of s...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17060344
更新日期:2019-06-10 00:00:00
abstract::Despite the increasing availability of new classes of cancer treatment, such as immune- and targeted therapies, there remains a need for the development of new antiproliferative/cytotoxic drugs with improved pharmacological profiles that can also overcome drug resistant forms of cancer. In this study, we have identifi...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16020063
更新日期:2018-02-15 00:00:00
abstract::A series of novel marinopyrroles with sulfide and sulphone spacers were designed and synthesized. Their activity to disrupt the binding of the pro-apoptotic protein, Bim, to the pro-survival proteins, Mcl-1 and Bcl-xL, was evaluated using ELISA assays. Fluorescence-quenching (FQ) assays confirmed the direct binding of...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12084311
更新日期:2014-07-29 00:00:00
abstract::This work describes the synthesis and biological evaluation of a new heterocyclic hybrid derived from the ellipticine and the marine alkaloid makaluvamine A. Pyridoquinoxalinedione 12 was obtained in seven steps with 6.5% overall yield. 12 and its intermediates 1-11 were evaluated for their in vitro cytotoxic activity...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13010655
更新日期:2015-01-19 00:00:00
abstract::Two strains of Azadinium poporum, one from the Korean West coast and the other from the North Sea, were mass cultured for isolation of new azaspiracids. Approximately 0.9 mg of pure AZA-36 (1) and 1.3 mg of pure AZA-37 (2) were isolated from the Korean (870 L) and North Sea (120 L) strains, respectively. The structure...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13116687
更新日期:2015-10-30 00:00:00
abstract::The potential of marine natural products to become new drugs is vast; however, research is still in its infancy. The chemical and biological diversity of marine toxins is immeasurable and as such an extraordinary resource for the discovery of new drugs. With the rapid development of next-generation sequencing (NGS) an...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md15040103
更新日期:2017-03-30 00:00:00
abstract::Water extracts and polysaccharides from Anabaena sp., Ecklonia sp., and Jania sp. were tested for their activity against the fungal plant pathogen Botrytis cinerea. Water extracts at 2.5, 5.0, and 10.0 mg/mL inhibited B. cinerea growth in vitro. Antifungal activity of polysaccharides obtained by N-cetylpyridinium brom...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17050299
更新日期:2019-05-20 00:00:00
abstract::Cyanobacteria are photosynthetic microorganisms that colonize diverse environments worldwide, ranging from ocean to freshwaters, soils, and extreme environments. Their adaptation capacities and the diversity of natural products that they synthesize, support cyanobacterial success in colonization of their respective ec...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md17060320
更新日期:2019-05-30 00:00:00
abstract::Sulphated polysaccharides with anti-thrombotic and anti-coagulant activities have been found in various marine biota. In this study, a previously characterised anti-thrombotic and anti-coagulant extract from blacklip abalone was fractionated by anion exchange chromatography (AEC), pooled (on a sulphated polysaccharide...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15080240
更新日期:2017-08-04 00:00:00
abstract::Three new polyoxygenated steroids, michosterols A-C (1-3), and four known compounds (4-7) were isolated from the ethyl acetate (EtOAc) extract of the soft coral Lobophytum michaelae, collected off the coast of Taitung. The structures of the new compounds were elucidated on the basis of spectroscopic analyses and compa...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16030093
更新日期:2018-03-13 00:00:00
abstract::Sargassum horneri (S. horneri), an edible brown alga, has been proposed as a functional food with an improvement effect on abnormal skin immune responses. The present study investigates the anti-allergic effect of an ethanol extract from S. horneri (SHE) on immunoglobulin E (IgE)/bovine serum albumin (BSA)-mediated ac...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18120594
更新日期:2020-11-26 00:00:00
abstract::Chitosan is sensitive to environmental pH values due to its electric property. This study investigates whether the pH-responsive chitosan assay can provide a simple method to evaluate the aggressive behavior of cancer cells with cell detachment ratio. The epithelial-mesenchymal transition (EMT) is induced with transfo...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17120659
更新日期:2019-11-23 00:00:00
abstract::In the last decades, research has focused on the capabilities of microbes to secrete exopolysaccharides (EPS), because these polymers differ from the commercial ones derived essentially from plants or algae in their numerous valuable qualities. These biopolymers have emerged as new polymeric materials with novel and u...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md12053005
更新日期:2014-05-22 00:00:00
abstract::The vast oceans of the world, which comprise a huge variety of unique ecosystems, are emerging as a rich and relatively untapped source of novel bioactive compounds with invaluable biotechnological and pharmaceutical potential. Evidence accumulated over the last decade has revealed that the diversity of marine microor...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md13052924
更新日期:2015-05-13 00:00:00
abstract::D. salina is one of the recognized natural sources to produce beta-carotene, and an useful model for studying the role of inhibitors and enhancers of carotenogenesis. However there is little information in D. salina regarding whether the isoprenoid substrate can be influenced by stress factors (carotenogenic) or selec...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md7010045
更新日期:2009-01-01 00:00:00
abstract::An anti-fibrotic compound produced by Streptomycesn xiamenensis, found in mangrove sediments, was investigated for possible therapeutic effects against fibrosis. The compound, N-[[3,4-dihydro-3S-hydroxy-2S-methyl-2-(4'R-methyl-3'S-pentenyl)-2H-1-benzopyran-6-yl]carbonyl]-threonine (1), was isolated from crude extracts...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md10030639
更新日期:2012-03-01 00:00:00
abstract::Sea cucumbers produce numerous compounds with a wide range of chemical structural diversity. Among these, saponins are the most diverse and include sulfated, non-sulfated, acetylated and methylated congeners with different aglycone and sugar moieties. In this study, MALDI and ESI tandem mass spectrometry, in the posit...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13010597
更新日期:2015-01-16 00:00:00
abstract::The deterioration of bone formation is a leading cause of age-related bone disorders. Lack of bone formation is induced by decreased osteoblastogenesis. In this study, osteoblastogenesis promoting effects of algal phlorotannin, phlorofucofuroeckol A (PFF-A), were evaluated. PFF-A was isolated from brown alga Eckloniac...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17100543
更新日期:2019-09-21 00:00:00
abstract::Haloferax mediterranei produces C50 carotenoids that have strong antioxidant properties. The response surface methodology (RSM) tool helps to accurately analyze the most suitable conditions to maximize C50 carotenoids production by haloarchaea. The effects of temperature (15⁻50 °C), pH (4-10), and salinity (5⁻28% NaCl...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16100372
更新日期:2018-10-09 00:00:00
abstract::A new eunicellin diterpenoid, cladieunicellin I (1), and a new natural eunicellin, litophynin I diacetate (2), were isolated from a Formosan soft coral identified as Cladiella sp. The structures of eunicellins 1 and 2 were elucidated by spectroscopic methods and by comparison of the spectral data with those of related...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11114585
更新日期:2013-11-14 00:00:00
abstract::The dinoflagellate Prorocentrum belizeanum is responsible for the production of several toxins involved in the red tide phenomenon known as Diarrhetic Shellfish Poisoning (DSP). In this paper we report on the biosynthetic origin of an okadaic acid water-soluble ester derivative, DTX5c, on the basis of the spectroscopi...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md10102234
更新日期:2012-10-01 00:00:00
abstract::Four new sesquiterpene lactones (3, 4, 6 and 7) and three known compounds, purpuride (1), berkedrimane B (2) and purpuride B (5), were isolated from the marine fungus, Talaromyces minioluteus (Penicillium minioluteum). New compounds were drimane sesquiterpenes conjugated with N-acetyl-l-valine, and their structures we...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13063567
更新日期:2015-06-05 00:00:00
abstract::Prostate cancer (PCa), the most common malignancy in men, is a major cause of cancer deaths. A better understanding of the mechanisms that drive tumor initiation and progression may identify actionable targets to improve treatment of this patient group. As a dietary carotenoid, astaxanthin has been demonstrated to exe...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15030066
更新日期:2017-03-08 00:00:00
abstract::Domoic acid epileptic disease is characterized by spontaneous recurrent seizures weeks to months after domoic acid exposure. The potential for this disease was first recognized in a human case study of temporal lobe epilepsy after the 1987 amnesic shellfish-poisoning event in Quebec, and was characterized as a chronic...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md12031185
更新日期:2014-03-06 00:00:00
abstract::The dinoflagellate Dinophysis spp. is responsible for diarrhetic shellfish poisoning (DSP). In the bivalves exposed to the toxic bloom of the dinoflagellate, dinophysistoxin 3 (DTX3), the 7-OH acylated form of either okadaic acid (OA) or DTX1, is produced. We demonstrated in vitro acylation of OA with palmitoyl CoA in...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11020300
更新日期:2013-01-29 00:00:00
abstract::Collagen is the major fibrillar protein in most living organisms. Among the different types of collagen, type I collagen is the most abundant one in tissues of marine invertebrates. Due to the health-related risk factors and religious constraints, use of mammalian derived collagen has been limited. This triggers the s...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md18090471
更新日期:2020-09-18 00:00:00
abstract::Species in the genus Gambierdiscus produce ciguatoxins (CTXs) and/or maitotoxins (MTXs), which may cause ciguatera fish poisoning (CFP) in humans if contaminated fish are consumed. Species of Gambierdiscus have previously been isolated from macroalgae at Rangitahua (Raoul Island and North Meyer Islands, northern Kerma...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15070219
更新日期:2017-07-11 00:00:00
abstract::During an investigation of the chemistry of the Red Sea Verongiid sponge Pseudoceratina arabica, we discovered a small molecule, pseudoceratonic acid (1), along with the new moloka'iamine derivatives, ceratinines N (2), O (3), and the previously reported compounds moloka'iamine (4), hydroxymoloka'iamine (5) and cerati...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18110525
更新日期:2020-10-23 00:00:00
abstract::Thirteen nitrogen-containing molecules (1a/1b and 2-12) were isolated from the Indonesian sponge Acanthostrongylophora ingens, highlighting the richness of this organism as a source of alkaloids. Their structures were elucidated using one- and two-dimensional NMR spectroscopy and HR-ESI-MS, while the stereochemistry o...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17080472
更新日期:2019-08-15 00:00:00
abstract::AIDS is a pandemic responsible for more than 35 million deaths. The emergence of resistant mutations due to drug use is the biggest cause of treatment failure. Marine organisms are sources of different molecules, some of which offer promising HIV-1 reverse transcriptase (RT) inhibitory activity, such as the diterpenes...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11114127
更新日期:2013-10-29 00:00:00