Abstract：
:Nostosins A and B were isolated from a hydrophilic extract of Nostoc sp. strain from Iran, which exhibits excellent tryps inhibitory activity. Nostosin A was the most potent natural tripeptide aldehyde as trypsin inhibitor up to now. Both R- and S-2-hydroxy-4-(4-hydroxy-phenyl) butanoic acid (Hhpba) were prepared and incorporated into the total synthesis of nostosin B, respectively. Careful comparison of the NMR spectra and optical rotation data of synthetic nostosin B (1a and 1b) with the natural product led to the unambiguous identification of the R-configuration of the Hhpba fragment, which was further confirmed by co-injection with the authentic sample on HPLC using both reversed phase column and the chiral AD-RH column.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Wang X,Feng J,Xu Z,Ye T,Meng Y,Zhang Zdoi
10.3390/md15030058subject
Has Abstractpub_date
2017-02-27 00:00:00issue
3issn
1660-3397pii
md15030058journal_volume
15pub_type
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