Metagenomics analysis of red blood cell and fresh-frozen plasma units.

Abstract:

BACKGROUND:Although the risk of transmitting infectious agents by blood transfusion is dramatically reduced after donor selection, leukoreduction, and laboratory testing, some could still be present in donor's blood. A description of metagenomes in blood products eligible for transfusion represents relevant information to evaluate the risk of pathogen transmission by transfusion. STUDY DESIGN AND METHODS:Detection of viruses, bacteria, and fungi genomes was made by high-throughput sequencing (HTS) of 600 manufactured blood products eligible for transfusion: 300 red blood cell (RBC) and 300 fresh-frozen plasma (FFP) units. RESULTS:Anelloviruses and human pegivirus, frequent in the blood of healthy individuals, were found. Human papillomavirus type 27 and Merkel cell polyomavirus, present on the skin, were also detected. Unexpectedly, astrovirus MLB2 was identified and characterized in a FFP unit. The presence of astrovirus MLB2 was confirmed in donor's blood and corresponded to an asymptomatic acute viremia. Sequences of bacteria and fungi were also detected; they are likely the result of environmental contamination. CONCLUSION:This study demonstrates that HTS is a promising tool for detecting common and less frequent infectious pathogens in blood products.

journal_name

Transfusion

journal_title

Transfusion

authors

Lau P,Cordey S,Brito F,Tirefort D,Petty TJ,Turin L,Guichebaron A,Docquier M,Zdobnov EM,Waldvogel-Abramowski S,Lecompte T,Kaiser L,Preynat-Seauve O

doi

10.1111/trf.14148

subject

Has Abstract

pub_date

2017-07-01 00:00:00

pages

1787-1800

issue

7

eissn

0041-1132

issn

1537-2995

journal_volume

57

pub_type

杂志文章
  • Evaluation of a new citrate-acetate-NaCl platelet additive solution for the storage of white cell-reduced platelet concentrates obtained from half-strength CPD pooled buffy coats.

    abstract:BACKGROUND:A new citrate-acetate-NaCl platelet additive solution, identified as PAS 2, was developed to prepare platelet concentrates (PCs) from pooled 0.5 CPD buffy coats (BCs). STUDY DESIGN AND METHODS:A study was undertaken to evaluate PAS 2 in vitro (n = 8) and in vivo (n = 9) against a commercially available solu...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1995.35195090662.x

    authors: van Rhenen DJ,Vermeij H,Kappers-Klunne M,Payrat JM

    更新日期:1995-01-01 00:00:00

  • Investigation of red blood cells from alpha1,3-galactosyltransferase-knockout pigs for human blood transfusion.

    abstract:BACKGROUND:Pigs are a potential source of red blood cells (RBCs) for transfusion into humans, but the presence of galactose-alpha1,3-galactose (Gal) epitopes on their surface, against which humans have anti-Gal, has been perceived as a major barrier. alpha1,3-Galactosyltransferase gene-knockout pigs, which do not expre...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2004.04002.x

    authors: Rouhani FJ,Dor FJ,Cooper DK

    更新日期:2004-07-01 00:00:00

  • Granulocyte transfusion kinetics measured by chemiluminescence, nitroblue tetrazolium reduction, and recovery of indium-111-labeled granulocytes.

    abstract::A 20-year-old man with chronic granulomatous disease (CGD) and who was receiving granulocyte transfusions for a refractory liver abscess was studied to compare the kinetics of 111In-labeled granulocytes with those of two functional granulocyte assays, nitroblue tetrazolium reduction and chemiluminescence. Transfused g...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1987.27187121467.x

    authors: Elliott GR,Clay ME,Mills EL,Abramson JS,McCullough J,Quie PG

    更新日期:1987-01-01 00:00:00

  • Simplification of the methods for adding and removing glycerol during freeze-preservation of human red blood cells with the high or low glycerol methods: biochemical modification prior to freezing.

    abstract::Simple methods have been developed for adding and removing glycerol during freeze-preservation with 20 per cent W/V glycerol at minus 150 C, or with 40 per cent W/V glycerol at minus 80 C. A one-step method with a 35 per cent W/V glycerol solution is used to prepare 20 per cent W/V glycerolized red blood cells, and a ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1975.15375160354.x

    authors: Valeri CR

    更新日期:1975-05-01 00:00:00

  • Importance of ionized magnesium measurement for monitoring of citrate-anticoagulated plateletpheresis.

    abstract:BACKGROUND:The infusion of citrate during apheresis may affect the levels of ionized magnesium in the blood. Hypomagnesemia and concomitant hypocalcemia could influence the parathormone response and could be responsible for some of the symptoms observed during apheresis. STUDY DESIGN AND METHODS:The study reports meas...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1997.37497265343.x

    authors: Mercan D,Bastin G,Lambermont M,Dupont E

    更新日期:1997-04-01 00:00:00

  • Evaluation of two viral inactivation methods for the preparation of safer factor VIII and factor IX concentrates.

    abstract::We report here the results of our evaluation of two procedures to eliminate viruses in factor VIII and factor IX coagulation factor concentrates. Both procedures were equally effective in the in vitro destruction of marker viruses. However, in a controlled infectivity test in chimpanzees, treatment at 60 degrees C for...

    journal_title:Transfusion

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1537-2995.1985.25686071421.x

    authors: Heldebrant CM,Gomperts ED,Kasper CK,McDougal JS,Friedman AE,Hwang DS,Muchmore E,Jordan S,Miller R,Sergis-Davenport E

    更新日期:1985-11-01 00:00:00

  • Iron deficiency anemia at admission for labor and delivery is associated with an increased risk for Cesarean section and adverse maternal and neonatal outcomes.

    abstract:BACKGROUND:Maternal iron deficiency anemia (IDA) impacts placenta and fetus. We evaluated effects of IDA at admission for delivery on cesarean rates, and adverse maternal and neonatal outcomes. STUDY DESIGN AND METHODS:Medical records from Jerusalem (2005-2012) identified women with a live-birth singleton fetus in cep...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13252

    authors: Drukker L,Hants Y,Farkash R,Ruchlemer R,Samueloff A,Grisaru-Granovsky S

    更新日期:2015-12-01 00:00:00

  • A comprehensive program to minimize platelet outdating.

    abstract:BACKGROUND:Platelet (PLT) transfusions are essential for patients who are bleeding or have an increased risk of bleeding due to a decreased number or abnormal function of circulating PLTs. A shelf life of 5 days for PLT products presents an inventory management challenge. In 2006, greater than 10% of apheresis PLTs mad...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2010.03039.x

    authors: Fuller AK,Uglik KM,Braine HG,King KE

    更新日期:2011-07-01 00:00:00

  • Red cell transfusions in coronary artery bypass surgery (DRGs 106 and 107)

    abstract::To study red cell transfusion practice in 3216 coronary artery bypass graft (CABG) cases in 11 hospitals in 1988, abstracted patient records were stratified by diagnosis related group (DRG) (that is, DRG 106, coronary artery bypass without catheterization, or DRG 107, coronary artery bypass with catheterization) and I...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1992.32592327721.x

    authors: Surgenor DM,Wallace EL,Churchill WH,Hao SH,Chapman RH,Collins JJ Jr

    更新日期:1992-06-01 00:00:00

  • Assessment of cell viability, early apoptosis, and hematopoietic potential in umbilical cord blood units after storage.

    abstract:BACKGROUND:Successful hematopoietic stem cell transplantation using stored umbilical cord blood (CB) largely depends on cell dose and quality of CB units. The aim of this study was to assess the degree of early apoptosis, in addition to cell viability and hematopoietic potential, in umbilical CB units after storage. S...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13120

    authors: Kim KM,Huh JY,Hong SS,Kang MS

    更新日期:2015-08-01 00:00:00

  • Preparation of white cell-depleted red cells for 42-day storage using an integral in-line filter.

    abstract::A new blood pack system for the preparation of white cell-depleted red cells was studied. The system is a modified additive-solution quadruple-unit blood pack that incorporates a cellulose-acetate fiber depth filter in-line between the AS-3 additive bag and the CP2D collection bag. Mean +/- SD white cell removal from ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1989.29689318446.x

    authors: Davey RJ,Carmen RA,Simon TL,Nelson EJ,Leng BS,Chong C,Garcez RB,Sohmer PR

    更新日期:1989-07-01 00:00:00

  • The successful implementation of an automated institution-wide assessment of hemoglobin and ABO typing to dynamically estimate red blood cell inventory requirements.

    abstract:BACKGROUND:Blood bank inventories must balance adequate supply with minimal outdate rates. The day-to-day practice of ordering red blood cell (RBC) inventory usually involves manually comparing current inventory levels with predetermined thresholds calculated from historical usage and ordering the difference. To date, ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15272

    authors: Quinn J,Campbell C,Gomez A,Kumar-Misir A,Watson S,Liwski D,Covello T,Tennankore KK,Chisholm N,Sadek I,Cheng C

    更新日期:2019-07-01 00:00:00

  • Issues in the quality of umbilical cord blood stem cells for transplantation.

    abstract:BACKGROUND:Because the frequency of umbilical cord blood (UCB) stem cell transplantation has increased, the quality of UCB available in banks is an important part of the success of UCB stem cell transplants. STUDY DESIGN AND METHODS:A quality assurance monitoring system was used to evaluate 268 UCB units provided to u...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2005.04265.x

    authors: McCullough J,McKenna D,Kadidlo D,Schierman T,Wagner J

    更新日期:2005-06-01 00:00:00

  • Predicting improvement in detection of bacteria in apheresis platelets by maintaining constant component sampling proportion.

    abstract:BACKGROUND:In spite of interventions, approximately 1000 per 1,000,000 platelet (PLT) collections are contaminated with bacteria at collection. The current prestorage culture procedure at some blood centers is to inoculate a fixed volume from the collection bag (4-8 mL) regardless of collection volume. The sensitivity ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2012.03821.x

    authors: Tomasulo PA,Wagner SJ

    更新日期:2013-04-01 00:00:00

  • Impact of a policy to permit the return of donors repeat-reactive to the Abbott PRISM antibody to hepatitis B core antigen assay.

    abstract:BACKGROUND:The expected donor loss from recent implementation of antibody to hepatitis B core antigen (anti-HBc) testing in Canada was uncertain but potentially significant based on US experience. To reduce donor loss from false-reactive tests, repeat-reactive donors without other evidence of infection were eligible to...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2008.01973.x

    authors: O'Brien SF,Yi QL,Fan W,Fearon MA,Scalia V,Goldman M

    更新日期:2009-02-01 00:00:00

  • Additional molecular bases of the clinically important p blood group phenotype.

    abstract:BACKGROUND:The purpose of this study was to explore the molecular basis of the p phenotype by analysis of the recently cloned 4-alpha-galactosyltransferase gene responsible for synthesis of Pk (Gb3) antigen. STUDY DESIGN AND METHODS:Forty samples from individuals of eight different nationalities were investigated by s...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2003.00425.x

    authors: Hellberg A,Steffensen R,Yahalom V,Sojka BN,Heier HE,Levene C,Poole J,Olsson ML

    更新日期:2003-07-01 00:00:00

  • Etoricoxib-induced immune hemolytic anemia: first case presenting acute kidney failure.

    abstract:BACKGROUND:Etoricoxib is a selective inhibitor of cyclooxygenase 2 used mainly to treat osteoarticular pain. Here, we report the case of a patient who developed acute kidney failure and immune hemolytic anemia after the use of etoricoxib. STUDY DESIGN AND METHODS:An 83-year-old female patient developed immune hemolyti...

    journal_title:Transfusion

    pub_type:

    doi:10.1111/trf.15226

    authors: Burgos Pratx L,Santoro D,Coca Mogro B,Valiente VL,Camino P,Scordo W,Salamone H

    更新日期:2019-05-01 00:00:00

  • A new radioimmunoassay for the detection of small amounts of white cells and platelets in red cell concentrates: implications for blood transfusion.

    abstract::In the procedure for quality control of red cell concentrates, made white cell (WBC)-poor by filtration, the particle-counting technique was found to be insufficiently sensitive in detecting the remaining WBCs and platelets. Therefore, direct radioimmunoassays were developed using murine monoclonal antibodies specific...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1990.30290162896.x

    authors: Webster MR,Prins HK,Huisman JG

    更新日期:1990-02-01 00:00:00

  • Blood use in liver transplantation.

    abstract::During the first 5 years (1981-1985) of the liver transplantation program in Pittsburgh, a total (preoperative, intraoperative, and postoperative) of 18,668 packed red cell units, 23,627 fresh-frozen plasma units, 20,590 platelet units, and 4241 cryoprecipitate units was transfused for the procedures. This represents ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1987.27387235624.x

    authors: Lewis JH,Bontempo FA,Cornell F,Kiss JE,Larson P,Ragni MV,Rice EO,Spero JA,Starzl TE

    更新日期:1987-05-01 00:00:00

  • Long-term return and donation pattern of those who begin donating at different ages: A retrospective cohort analysis of blood donors in Australia.

    abstract:BACKGROUND:This study compared the likelihood of return to donate and donation rate ratio by age of donors at their first donation when followed up to 12 years. STUDY DESIGN AND METHODS:Donation history of two cohorts of first-time donors (those donating in 2007 and 2013) was extracted until March 2019 from Australian...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.16187

    authors: Priyono A,Masser BM,Dyda A,Davison TE,Irving DO,Karki S

    更新日期:2020-11-12 00:00:00

  • Complement activation and adult respiratory distress syndrome during intermittent flow apheresis procedures.

    abstract::We observed complement (C) activation during intermittent flow apheresis procedures (Haemonetics model 30) in four subjects, two of whom developed adult respiratory distress syndrome (ARDS). Actual C3 conversion during apheresis was illustrated by the finding of significantly elevated C3d levels (p less than 0.05) and...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1986.26186124040.x

    authors: Boogaerts MA,Roelant C,Goossens W,Verwilghen RL

    更新日期:1986-01-01 00:00:00

  • HNA-3a-specific antibodies recognize choline transporter-like protein-2 peptides containing arginine, but not glutamine at Position 154.

    abstract:BACKGROUND:Antibodies specific for the neutrophil antigen HNA-3a cause severe, sometimes fatal transfusion-related acute lung disease (TRALI) when transfused, but it has not been possible to screen blood donors for anti-HNA-3a because using neutrophils as targets was impractical and molecular properties of the antigen ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2011.03145.x

    authors: Curtis BR,Sullivan MJ,Holyst MT,Szabo A,Bougie DW,Aster RH

    更新日期:2011-10-01 00:00:00

  • Peripartum hyperhemolysis prophylaxis and management in sickle cell disease: A case report and narrative review.

    abstract:BACKGROUND:Sickle cell disease (SCD) is associated with hematologic complications including delayed hemolytic transfusion reactions (DHTRs) and pregnancy-related morbidity and mortality. Hyperhemolysis syndrome (HS) is the most severe form of DHTR in patients with SCD, in which both transfused and native red blood cell...

    journal_title:Transfusion

    pub_type:

    doi:10.1111/trf.16003

    authors: Vasanthamohan L,Choo S,Marshall T,Symons YT,Matsui D,Eastabrook G,Solh Z

    更新日期:2020-08-26 00:00:00

  • Plateletpheresis does not cause long-standing platelet-derived growth factor release into the donor blood.

    abstract:BACKGROUND:Recently, long-standing elevations of soluble growth factors released from platelets (PLTs) after contact with artificial surfaces during dialysis were described. They could be jointly responsible for the high frequency of death from cardiovascular diseases in dialysis patients. There are no comparable data ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2005.04269.x

    authors: Zimmermann R,Loew D,Weisbach V,Strasser E,Ringwald J,Zingsem J,Eckstein R

    更新日期:2005-03-01 00:00:00

  • Demonstration of gene dosage effects on antigens in the Duffy, Ss, and Rh systems using an enzyme-linked immunosorbent assay.

    abstract::Using a recently developed enzyme-linked immunosorbent assay, gene dosage effects were demonstrated for the Duffy, Ss, and Rh red blood cell antigen systems. We report a comparison by an antibody-binding assay of the relative amounts of Fya and Fyb antigens on FyaFya, FyaFyb, FybFyb, FyaFyx, and FyxFyx erthrocytes, an...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1982.22683068606.x

    authors: Caren LD,Bellavance R,Grumet FC

    更新日期:1982-11-01 00:00:00

  • Reduction in red blood cell transfusion associated with engagement of the ordering physician.

    abstract:BACKGROUND:Data on red blood cell (RBC) transfusion in the United States show variation in practice and overprescribing or overdosing is considered to be prevalent. Education or restrictive interventions could modify practice. STUDY DESIGN AND METHODS:RBC transfusion and mortality rates were recorded in a single insti...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12552

    authors: Tavares MM,Diquattro PJ,Sweeney JD

    更新日期:2014-10-01 00:00:00

  • Complete or partial seroreversion in immunocompetent individuals after self-limited HCV infection: consequences for transfusion.

    abstract:BACKGROUND:The disappearance of anti-HCV antibodies over time, after a self-limited infection, also referenced seroreversion, has been observed. The frequency of this phenomenon remains controversial, especially in immunocompetent subjects. However, it has important implications in the context of transfusion inquiries,...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2004.00656.x

    authors: Lefrère JJ,Girot R,Lefrère F,Guillaume N,Lerable J,Le Marrec N,Bouchardeau F,Laperche S

    更新日期:2004-03-01 00:00:00

  • Antibody response in an ABO-incompatible blood transfusion. Antigen specificity and immunoglobulin class.

    abstract::The anti-A response in a group B patient accidentally given 1 unit transfusion of A1 blood is described. The antibody response is characterized both with conventional agglutination techniques and with radioimmunoassay using pure group A antigens with different core saccharide structures (type 1, 2, and 4 chains) and c...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1988.28588337343.x

    authors: Rydberg L,Breimer ME,Samuelsson BE

    更新日期:1988-09-01 00:00:00

  • Hematopoietic cell infusion-related adverse events in pediatric/small recipients in a prospective/multicenter study.

    abstract:BACKGROUND:Hematopoietic cell infusion-related adverse events (HCI-AEs) in hematopoietic stem cell transplantations (HSCTs) have been largely attributed to toxicity of dimethyl sulfoxide (DMSO) for cryopreservation, but HSC products also contain various cells and plasma components. Our recent prospective study of 1125 ...

    journal_title:Transfusion

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1111/trf.15786

    authors: Ikeda K,Ohto H,Yamada-Fujiwara M,Okuyama Y,Fujiwara SI,Muroi K,Mori T,Kasama K,Kanamori H,Iseki T,Nagamura-Inoue T,Kameda K,Kanda J,Nagai K,Fujii N,Ashida T,Hirose A,Takahashi T,Minakawa K,Tanosaki R

    更新日期:2020-05-01 00:00:00

  • Sequence analysis of two variable cytomegalovirus genes for distinction between transfusion- and breast milk-transmitted infections in a very-low-birthweight infant.

    abstract:BACKGROUND:Cytomegalovirus (CMV) infections in very-low-birthweight infants can lead to serious clinical consequences. When CMV-related symptoms occur after transfusion, CMV transmission is often attributed to the transfusion products rather than to breast milk. However, it is sometimes difficult to distinguish between...

    journal_title:Transfusion

    pub_type:

    doi:10.1111/trf.13547

    authors: Yamagishi N,Furui Y,Koshinami S,Ichijo K,Shimizu Y,Hoshi Y,Gotanda Y,Miyakawa K,Uchida S,Tadokoro K,Nagai T,Satake M

    更新日期:2016-06-01 00:00:00