Abstract:
OBJECTIVE:The aims of this prospective study were to investigate temporal changes in mood status and distress level, as well as the development of depression, during pegylated interferon (PEG-IFN)-based treatment of patients with chronic hepatitis C (CHC). We also explored whether baseline demographic, psychiatric, and personality traits predicted the evolution of depression. METHODS:CHC patients without depression were screened with laboratory tests; psychiatric interviews; and evaluations of mood symptoms, level of distress, and personality traits. A total of 67 treatment-naïve patients with CHC were consecutively treated with PEG-IFN-α-2a plus ribavirin for 48 (genotype 1, n=29) or 24 (genotype 2, n=38) weeks. Patients were followed prospectively every 4 weeks during the treatment period. RESULTS:Seven patients (10.4%) were diagnosed with major depressive disorder (MDD), and eight (11.9%) developed subsyndromal depression. Times to onset of MDD and subsyndromal depression were 6.67±5.01 and 11.11±5.58 weeks, respectively, after initiation of treatment. Patients who developed MDD had significantly increased fatigue and anxiety and poor psychological well-being during the course of treatment. Pretreatment subthreshold mood symptoms were a significant predictor of depression. CONCLUSION:An early psychiatric assessment may be helpful in improving psychological well-being in those with CHC, leading to adherence to PEG-IFN-based treatment.
journal_name
Psychiatry Investigjournal_title
Psychiatry investigationauthors
Choi JS,Kim W,Sohn BK,Lee JY,Jung HY,Oh S,Joo SK,Kim HY,Jung YJdoi
10.4306/pi.2017.14.3.314subject
Has Abstractpub_date
2017-05-01 00:00:00pages
314-324issue
3eissn
1738-3684issn
1976-3026journal_volume
14pub_type
杂志文章abstract::Despite the fact that the lifetime and yearly prevalence rates of mental illness continue rising, such diseases have only been acknowledged as involved in workplace health issue since the 2000s. Additionally, while the number of recognized cases of mental illnesses is rather low compared to their prevalence, they have...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2016.10.24
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVE:Autistic spectrum traits are postulated to lie on a continuum that extends between individuals with autism and individuals with typical development. The present study was carried out to investigate functional and network abnormalities associated with autistic spectrum trait in healthy male subjects. METHODS:...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2018.07.27
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:For the proper treatment of first-episode psychosis, assessment of treatment response, remission, relapse, and recovery is important. Therefore, the present study aimed to develop operational definitions of clinical outcomes in first-episode psychosis. METHODS:A questionnaire was developed by a panel of expe...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2019.0240
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVE:This study aimed to identify the core symptoms of delirium, particularly in elderly people associated with major risk factors, using the Korean version of the Delirium Rating Scale-Revised-98. METHODS:The study sample consisted of 200 patients (mean age: 72.7±3.9 years, male: 68.5%) who had been diagnosed wi...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2017.10.06
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:The present study aimed to report the initial seizure threshold (IST) of a brief-pulse bilateral electroconvulsive therapy (BP-BL ECT) in Korean patients with schizophrenia/schizoaffective disorder and to identify IST predictors. METHODS:Among 67 patients who received ECT and diagnosed with schizophrenia/sch...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2019.06.20.2
更新日期:2019-09-01 00:00:00
abstract::Differentiating early Alzheimer's disease (AD) from depression with cognitive impairment is challenging in the elderly. To develop a model for differentiating these two conditions using electroencephalography (EEG), we enrolled 11 patients with early probable AD and 11 age- and cognitive function-matched patients with...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2017.14.5.708
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:This study investigated the treatment response and cognitive enhancement effects of buspirone augmentation of escitalopram in patients with major depressive disorder (MDD), according to atypical feature subtypes of MDD. METHODS:An 8 week, randomized, parallel-controlled, open-label study was conducted. The C...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2020.0017
更新日期:2020-08-01 00:00:00
abstract::Dementia with Lewy bodies (DLB) is the second most common cause of degenerative dementia after Alzheimer's disease (AD), and is clinically characterized by the progressive cognitive decline with fluctuations in cognition and alertness, recurrent visual hallucinations and Parkinsonism. Once these characteristic symptom...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2009.6.4.233
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVE:This study was conducted at Hanawon-a government sponsored educational facility for the settlement of North Korean refugees during their initial phase in South Korea-in 2004 to explore their mental health status and traumatic experiences in North Korea and during their escape period. METHODS:A survey was con...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2008.5.4.213
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:This study was conducted to confirm the results of the authors' previous research on schizophrenia manifesting high serum homocysteine and low folate levels. This study is anchored on a theory that a high serum homocysteine concentration affects schizophrenia by virtue of a neurotoxic mechanism, and on a repo...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2011.8.2.134
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:The purpose of the present study was to clarify the relationship between white matter tracts and cognitive symptoms in children with high-functioning autism spectrum disorder (ASD). METHODS:We examined the cognitive functions of 17 children with high-functioning ASD and 18 typically developing (TD) controls ...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2019.01.16
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:To examine the reliability and validity of the self-report Korean version of Strengths and Difficulties Questionnaire (SDQ-Kr) in the community sample. METHODS:The SDQ-Kr was administered to a large sample of school children and adolescents (n=2814) and youth attendees of a psychiatric clinic (n=385) aged 11...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2015.12.4.491
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:This study aimed to investigate the adolescent brain activation patterns in response to performance feedback (PF), social reward (SR) and monetary reward (MR) and their association with psychological factors. METHODS:Functional magnetic resonance imaging (fMRI) was performed while middle school boys (n=15) p...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2013.10.1.47
更新日期:2013-03-01 00:00:00
abstract:Objective:Research has shown that intranasal oxytocin affects social cognition and behavior; however, its effects vary based on social context, individual characteristics and dose. The present study aimed to determine effective dose of oxytocin spray on emotion recognition in healthy Korean males. Methods:The study fo...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2018.02.19
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to explore the prognostic values of biomarkers of neurodegeneration as measured by magnetic resonance imaging (MRI) and amyloid burden as measured by amyloid positron emission tomography (PET) in predicting conversion to Alzheimer's disease (AD) in patients with mild cognitive impair...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2017.14.2.205
更新日期:2017-03-01 00:00:00
abstract::Bile Salt Export Pump (BSEP) Deficiency disease, including Progressive Familial Intrahepatic Cholestasis type 2 (PFIC2), is a rare disease, usually leading within the first ten years to portal hypertension, liver failure, hepatocellular carcinoma. Often liver transplantation is needed. Sodium 4-phenylbutyrate (4-PB) s...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2016.13.5.580
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVE:To analyze the clinical, psychopathological, physical, and sleep-related evolution of adolescents with restricting-type of anorexia nervosa (AN-R) after 10 weeks of a daytime hospital program. METHODS:Body composition, physical activity and sleep were measured objectively before and after 10 weeks of treatme...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2020.0016
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:Although specific temperaments have been known to be related to autonomic nervous function in some psychiatric disorders, there are few studies that have examined the relationship between temperaments and autonomic nervous function in a normal population. In this study, we examined the effect of temperament o...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2012.9.3.293
更新日期:2012-09-01 00:00:00
abstract::Electroconvulsive therapy (ECT) is not currently used as a first-line treatment for obsessive-compulsive disorder (OCD). However, several related case reports have demonstrated that ECT seems to be effective for severe OCD, especially when first-line therapies have failed. In this study, we describe the courses, detai...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2014.11.2.210
更新日期:2014-04-01 00:00:00
abstract::I report here an elderly woman receiving perphenazine together with terbinafine. After 1 week of terbinafine treatment she experienced extrapyramidal symptoms and, in particular, akathisia. Her symptoms did not disappear for 6 weeks, and so at 2 weeks prior to this most recent admission she had stopped taking terbinaf...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2012.9.4.422
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:Seasonal affective disorder and seasonal changes in mood and behavior are associated with several genes that regulate circadian rhythms. In this study, we investigated the relationship between the C825T polymorphism of the G-protein β3 subunit and seasonal variations in mood and behavior in a young healthy Ko...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2017.09.21
更新日期:2018-02-01 00:00:00
abstract:Objective:The anti-epileptogenic drug levetiracetam has anticonvulsant and anti-epileptogenesis effects. Synergy between cell death and inflammation can lead to increased levels of apoptosis inhibitory factors and brain-derived neurotrophic factor, aberrant neurogenesis and extended axon sprouting. Once hyperexcitation...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2017.14.6.844
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to identify patterns of brain activation elicited by erotic visual stimuli in patients treated with either Selective Serotonin Reuptake Inhibitors (SSRIs) or mirtazipine. METHODS:Nine middle-aged men with major depressive disorder treated with an SSRI and ten middle-aged men w...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2009.6.2.85
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVE:Recently, an increasing number of Korean male conscripts have been retiring because of military maladjustment despite the presence of qualifying medical and psychological screening tests in the Korean army. These problems suggest the presence of a common personality problem. To further examine this possibilit...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2013.10.2.131
更新日期:2013-06-01 00:00:00
abstract::Although delusion of theft (DT) is the most frequent type of delusion in Alzheimer's disease (AD), its relationship to cognitive functions remains unclear. The aim of this study was to demonstrate the relationship between DT and cognitive functions in mild AD. Two hundred eighty-nine mild AD patients were enrolled in ...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2017.09.20
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:Continuous performance tests (CPTs) are frequently used in clinical practice to assess the attentiveness of ADHD children. Although most CPTs do not categorize T scores by intelligence, there is great diversity of opinion regarding the interrelation between intelligence and CPT performance. This study aimed t...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2011.8.3.227
更新日期:2011-09-01 00:00:00
abstract::Obesity has become a major public health problem over the past two decades. Non-surgical management of obesity does not often achieve its long term goals. Surgical treatment is roaring in popularity because of dramatic and durable results. However, outcomes from bariatric surgery have become a significant area of scru...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2015.12.1.152
更新日期:2015-01-01 00:00:00
abstract: Objective:We utilized a spectral and network analysis technique with an integrated support vector classification algorithm for the automated detection of cognitive capacity using resting state electroencephalogram (EEG) signals. Methods:An eyes-closed resting EEG was recorded in 158 older subjects, and spectral EEG p...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2018.04.03.1
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVE:The purpose of the study was to develop the Korean version of the Stage of Change Readiness and Treatment Eagerness Scale for Smoking Cessation (K-SOCRATES-S) based on the Korean version of the Stages of Readiness for Change and Eagerness for Treatment scale (K-SOCRATES). This paper also demonstrates its reli...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2012.9.3.223
更新日期:2012-09-01 00:00:00
abstract::Transcranial direct current stimulation (tDCS), a non-invasive neuromodulation technique, has been increasingly used to treat bipolar depression. Researchers recently noticed the risk of tDCS-emergent mania/hypomania in depressed patients and started to evaluate this risk by launching a meta-analysis. Here we present ...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2018.08.11.1
更新日期:2018-09-01 00:00:00