Severity of Hypertension Correlates with Risk of Thromboembolic Stroke.

Abstract:

:Hypertension plays a significant role in the development of atrial fibrillation (AF) and its complications. The coexistence of the two diseases increases the risk of thromboembolism events. Although CHADS2 and CHA2DS2-VASc scores have been used in the evaluation of the thromboembolism events in AF patients, the different levels of the blood pressure are not appropriately recognized. In this study, the 970 AF patients were divided into three groups according to the severity of hypertension. The CHADS2 and CHA2DS2-VASc scores in the patients of grade 3 hypertension were significantly higher than those of the patients with grade 1 and 2 hypertension, respectively (P < 0.05). Both the CHADS2 and CHA2DS2-VASc scores were positively related to the severity of hypertension (P < 0.001). Our data demonstrated that three grades for hypertensive subjects with AF significantly improved antithrombotic risk stratification in addition to current clinical risk stratification models, such as CHADS2 and CHA2DS2-VASc scores.

authors

Pang H,Han B,Fu Q,Cao Q

doi

10.1007/s12265-017-9754-0

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

368-373

issue

4

eissn

1937-5387

issn

1937-5395

pii

10.1007/s12265-017-9754-0

journal_volume

10

pub_type

杂志文章
  • Electrophysiology Translational Considerations in Cardio-Oncology: QT and Beyond.

    abstract::With improved screening and the advent of many novel therapeutics, patients with cancer are living longer and often surviving their disease. Cardiovascular complications have significant impact on both short- and long-term morbidity and mortality in these patients. While a great deal of attention has been paid to card...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-019-09924-y

    authors: Alomar M,Fradley MG

    更新日期:2020-06-01 00:00:00

  • Genomic DNA pooling strategy for next-generation sequencing-based rare variant discovery in abdominal aortic aneurysm regions of interest-challenges and limitations.

    abstract::The costs and efforts for sample preparation of hundreds of individuals, their genomic enrichment for regions of interest, and sufficient deep sequencing bring a significant burden to next-generation sequencing-based experiments. We investigated whether pooling of samples at the level of genomic DNA would be a more ve...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s12265-011-9263-5

    authors: Harakalova M,Nijman IJ,Medic J,Mokry M,Renkens I,Blankensteijn JD,Kloosterman W,Baas AF,Cuppen E

    更新日期:2011-06-01 00:00:00

  • Direct reprogramming of mouse fibroblasts into cardiac myocytes.

    abstract::The potency of specific transcription factors as cell fate determinants was first demonstrated by the discovery of MyoD, a master gene for skeletal muscle transdifferentiation. More recently, the induction of pluripotency in somatic cells using a combination of stem cell-specific transcription factors has been reporte...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-012-9412-5

    authors: Inagawa K,Ieda M

    更新日期:2013-02-01 00:00:00

  • Oxidized HDL, as a Novel Biomarker for Calcific Aortic Valve Disease, Promotes the Calcification of Aortic Valve Interstitial Cells.

    abstract::Calcific aortic valve disease (CAVD) is characterized by progressive mineralization of the aortic valve. Lipid infiltration and oxidative stress are the driving forces for the initiation and development of this disease. However, it remains unknown whether oxidized high-density lipoprotein (ox-HDL) plays a role in the ...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章

    doi:10.1007/s12265-019-09903-3

    authors: Sun JT,Chen YY,Mao JY,Wang YP,Chen YF,Hu X,Yang K,Liu Y

    更新日期:2019-12-01 00:00:00

  • Novel antiplatelet agents: ALX-0081, a Nanobody directed towards von Willebrand factor.

    abstract::This manuscript reviews the studies performed with ALX-0081 (INN: caplacizumab), a Nanobody targeting von Willebrand factor, in the context of current antithrombotic therapy in coronary artery disease. ALX-0081 specifically inhibits platelet adhesion to the vessel wall, and may control platelet aggregation and subsequ...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-012-9435-y

    authors: Bartunek J,Barbato E,Heyndrickx G,Vanderheyden M,Wijns W,Holz JB

    更新日期:2013-06-01 00:00:00

  • Translational Challenges in Cardiovascular Tissue Engineering.

    abstract::Valvular heart disease and congenital heart defects represent a major cause of death around the globe. Although current therapy strategies have rapidly evolved over the decades and are nowadays safe, effective, and applicable to many affected patients, the currently used artificial prostheses are still suboptimal. The...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-017-9728-2

    authors: Emmert MY,Fioretta ES,Hoerstrup SP

    更新日期:2017-04-01 00:00:00

  • An early study on the mechanisms that allow tissue-engineered vascular grafts to resist intimal hyperplasia.

    abstract::Intimal hyperplasia is one of the prominent failure mechanisms for arteriovenous fistulas and arteriovenous access grafts. Human tissue-engineered vascular grafts (TEVGs) were implanted as arteriovenous grafts in a novel baboon model. Ultrasound was used to monitor flow rates and vascular diameters throughout the stud...

    journal_title:Journal of cardiovascular translational research

    pub_type: 评论,杂志文章

    doi:10.1007/s12265-011-9306-y

    authors: Prichard HL,Manson RJ,DiBernardo L,Niklason LE,Lawson JH,Dahl SL

    更新日期:2011-10-01 00:00:00

  • Speckle-Tracking Echocardiographic Strain Analysis Reliably Estimates Degree of Acute LV Unloading During Mechanical LV Support by Impella.

    abstract::Non-invasive means of evaluating appropriate cardiac unloading remain to be established. We hypothesized that myocardial deformation assessed by echocardiographic speckle-tracking strain analysis can reliably estimate the degree of left ventricular (LV) unloading under mechanical circulatory support. A total of 24 Yor...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章

    doi:10.1007/s12265-018-9812-2

    authors: Hammoudi N,Watanabe S,Bikou O,Ceccaldi A,Fish K,Yamada KP,Miyashita S,Lebreton G,Hajjar RJ,Ishikawa K

    更新日期:2019-04-01 00:00:00

  • The Dynamics of Cardiovascular Biomarkers in non-Elite Marathon Runners.

    abstract::The number of recreational/non-elite athletes participating in marathons is increasing, but data regarding impact of endurance exercise on cardiovascular health are conflicting. This study evaluated 79 recreational athletes of the 2016 Barcelona Marathon (72% men; mean age 39 ± 6 years; 71% ≥35 years). Blood samples w...

    journal_title:Journal of cardiovascular translational research

    pub_type: 信件

    doi:10.1007/s12265-017-9744-2

    authors: Roca E,Nescolarde L,Lupón J,Barallat J,Januzzi JL,Liu P,Cruz Pastor M,Bayes-Genis A

    更新日期:2017-04-01 00:00:00

  • Haptoglobin genotype and its role in diabetic cardiovascular disease.

    abstract::Over the past decade, several longitudinal epidemiological studies have brought attention to the haptoglobin genotype and its importance in determining diabetic vascular disease risk. This manuscript presents an overview of the biology of the haptoglobin genotype and reviews the literature concerning its role in the d...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-012-9361-z

    authors: Costacou T,Levy AP

    更新日期:2012-08-01 00:00:00

  • A Novel Wireless Left Atrial Pressure Monitoring System for Patients with Heart Failure, First Ex-Vivo and Animal Experience.

    abstract::The V-LAP™ measures left atrial pressure (LAP) and enables bi-directional communications with an external unit, designed to monitor heart failure patients. We hereby describe the pre-clinical experience. Following an ex vivo phase, the system was implanted at the interatrial septum of 10 ovine subjects. LAP readouts w...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章

    doi:10.1007/s12265-018-9856-3

    authors: Perl L,Soifer E,Bartunek J,Erdheim D,Köhler F,Abraham WT,Meerkin D

    更新日期:2019-08-01 00:00:00

  • Biomarkers of diastolic dysfunction and myocardial fibrosis: application to heart failure with a preserved ejection fraction.

    abstract::Comprehensive diagnostic criteria, accurate prognostic indicators, and effective treatment for patients with heart failure and a preserved ejection fraction (HFpEF) represent a critically important unmet need in cardiovascular medicine. Novel approaches to fill this unmet need are likely to be facilitated by targeting...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-013-9472-1

    authors: Zile MR,Baicu CF

    更新日期:2013-08-01 00:00:00

  • Mechanical circulatory support-results, developments and trends.

    abstract::The implantation of ventricular assist devices (VADs) is a valuable option in patients with end-stage heart failure. The number of VAD implantations is growing worldwide. Between July 1987 and July 2010, we implanted 1,598 VADs in 1,455 patients. The majority were male (81.0%), and their mean age was 49.4 years (range...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章

    doi:10.1007/s12265-011-9268-0

    authors: Krabatsch T,Schweiger M,Stepanenko A,Kukucka M,Vierecke J,Lehmkuhl HB,Huebler M,Hennig E,Potapov E,Hetzer R

    更新日期:2011-06-01 00:00:00

  • The "missing" link between acute hemodynamic effect and clinical response.

    abstract::The hemodynamic, mechanical and electrical effects of cardiac resynchronization therapy (CRT) occur immediate and are lasting as long as CRT is delivered. Therefore, it is reasonable to assume that acute hemodynamic effects should predict long-term outcome. However, in the literature there is more evidence against tha...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-011-9331-x

    authors: Prinzen FW,Auricchio A

    更新日期:2012-04-01 00:00:00

  • Implantation of a Poly-L-Lactide GCSF-Functionalized Scaffold in a Model of Chronic Myocardial Infarction.

    abstract::A previously developed poly-L-lactide scaffold releasing granulocyte colony-stimulating factor (PLLA/GCSF) was tested in a rabbit chronic model of myocardial infarction (MI) as a ventricular patch. Control groups were constituted by healthy, chronic MI and nonfunctionalized PLLA scaffold. PLLA-based electrospun scaffo...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章

    doi:10.1007/s12265-016-9718-9

    authors: Spadaccio C,Nappi F,De Marco F,Sedati P,Taffon C,Nenna A,Crescenzi A,Chello M,Trombetta M,Gambardella I,Rainer A

    更新日期:2017-02-01 00:00:00

  • Aerobic Exercise Prevents Insulin Resistance Through the Regulation of miR-492/Resistin Axis in Aortic Endothelium.

    abstract::Previously, we found that miR-492 delayed the progression of atherosclerosis (AS) by acting as an up-stream regulator of resistin. Therefore, we hypothesized that the anti-atherogenic effects of exercise are related to miR-492-mediated downregulation of resistin and repair of endothelial injury. In this study, we inve...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章

    doi:10.1007/s12265-018-9828-7

    authors: Cai Y,Xie KL,Zheng F,Liu SX

    更新日期:2018-12-01 00:00:00

  • The left ventricular outflow in hypertrophic cardiomyopathy: from structure to function.

    abstract::Left ventricular outflow tract obstruction (LVOTO) is one of the defining features of hypertrophic cardiomyopathy (HCM) and one of the main determinants of prognosis. Although the importance of obstruction was recognized since the original description by Teare and Brock, its exact cause and methods for its relief are ...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-009-9153-2

    authors: Yacoub MH,El-Hamamsy I,Said K,Magdi G,Abul Enein F,George R,Rossi A,Olivotto I,Cecchi F

    更新日期:2009-12-01 00:00:00

  • Nutrition as a vehicle for cardiovascular translational research.

    abstract::It is becoming increasingly evident that poor nutrition plays an important role in inducing cardiovascular disease. Just as importantly, data now support the contention that appropriate nutritional interventions may have just as important an effect in preventing or delaying the appearance of cardiovascular disease. If...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-009-9116-7

    authors: Rodriguez-Leyva D,McCullough RS,Pierce GN

    更新日期:2009-09-01 00:00:00

  • Comparison of High-Dose Rosuvastatin Versus Low-Dose Rosuvastatin Plus Ezetimibe on Carotid Atherosclerotic Plaque Inflammation in Patients with Acute Coronary Syndrome.

    abstract::We compared the effects of ezetimibe/rosuvastatin 10/5 mg versus rosuvastatin 20 mg on carotid atherosclerotic plaque inflammation measured by 18FDG PET/CT. Fifty patients with acute coronary syndrome (ACS) were randomly assigned to the ezetimibe/rosuvastatin 10/5 mg and rosuvastatin 20 mg groups. The primary outcome ...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1007/s12265-020-10009-4

    authors: Oh M,Kim H,Shin EW,Sung C,Kim DH,Moon DH,Kim N,Eo JS,Kim JW,Lee CW

    更新日期:2020-12-01 00:00:00

  • Rad-deletion Phenocopies Tonic Sympathetic Stimulation of the Heart.

    abstract::Sympathetic stimulation modulates L-type calcium channel (LTCC) gating to contribute to increased systolic heart function. Rad is a monomeric G-protein that interacts with LTCC. Genetic deletion of Rad (Rad-/-) renders LTCC in a sympathomimetic state. The study goal was to use a clinically inspired pharmacological str...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章

    doi:10.1007/s12265-016-9716-y

    authors: Levitan BM,Manning JR,Withers CN,Smith JD,Shaw RM,Andres DA,Sorrell VL,Satin J

    更新日期:2016-12-01 00:00:00

  • Sex-Specific Aspects in the Pathophysiology and Imaging of Coronary Macro- and Microvascular Disease.

    abstract::Sex differences in coronary artery disease (CAD) are well established, with women presenting with non-obstructive CAD more often than men do. However, recent evidence has identified coronary microvascular dysfunction as the underlying cause for cardiac complaints, yet sex-specific prevalence numbers are inconclusive. ...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-019-09906-0

    authors: Groepenhoff F,Bots SH,Kessler EL,Sickinghe AA,Eikendal ALM,Leiner T,den Ruijter HM

    更新日期:2020-02-01 00:00:00

  • Correction to: Sex and Gender Differences in Ischemic Heart Disease: Endocrine Vascular Disease Approach (EVA) Study Design.

    abstract::The authors of this study protocol would like to amend it and clarify that medication adherence was assessed using the 4-item validated Morisky, Green, Levine scale [Morisky DE, Green LW, Levine DM. Concurrent and predictive validity of a self-reported measure of medication adherence. Med Care. 1986 Jan;24(1):67-74] r...

    journal_title:Journal of cardiovascular translational research

    pub_type: 已发布勘误

    doi:10.1007/s12265-019-09870-9

    authors: Raparelli V,Proietti M,Lenzi A,Basili S,EVA Collaborators.

    更新日期:2020-02-01 00:00:00

  • Platelet function testing in patients with acute coronary syndrome.

    abstract::In patients with an acute coronary syndrome (ACS), inhibition of the platelet P2Y12 receptor is standard of care. The shortcomings of the most commonly used P2Y12 receptor inhibitor clopidogrel-that is its delayed onset of action, its interindividual response variability, and the phenomenon of high on-treatment platel...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-013-9450-7

    authors: Orban M,Sibbing D

    更新日期:2013-06-01 00:00:00

  • General overview of the Seventh International Symposium on Stem Cell Therapy and Cardiovascular Innovations.

    abstract::The Seventh International Symposium on Stem Cell Therapy and Cardiovascular Innovations was held in Madrid on the 6th and 7th of May 2010. Gathering for the seventh consecutive year the most relevant researchers and opinion leaders on cardiovascular cell therapy, it has become the most important worldwide event on thi...

    journal_title:Journal of cardiovascular translational research

    pub_type:

    doi:10.1007/s12265-010-9247-x

    authors: Gutiérrez E,Sanz-Ruiz R,Alvarez EV,Villa A,Fernández L,Vázquez S,Lorenzo J,Fernández-Santos E,Sánchez PL,Fernández-Avilés F

    更新日期:2011-04-01 00:00:00

  • CYP-mediated pharmacologic interference with optimal platelet inhibition.

    abstract::Variability of response to clopidogrel and prasugrel is a multifactorial process, with clinical consequences, and drug-drug interactions have been proposed as potential factors. Biological modulation of clopidogrel response has been demonstrated for atorvastatin and omeprazole. However, investigations assessing clinic...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-012-9442-z

    authors: Cuisset T,Quilici J

    更新日期:2013-06-01 00:00:00

  • MicroRNAs and diabetic complications.

    abstract::Both Type 1 and Type 2 diabetes can lead to debilitating microvascular complications such as retinopathy, nephropathy and neuropathy, as well as macrovascular complications such as cardiovascular diseases including atherosclerosis and hypertension. Diabetic complications have been attributed to several contributing fa...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-012-9368-5

    authors: Natarajan R,Putta S,Kato M

    更新日期:2012-08-01 00:00:00

  • Role of Heat Shock Protein 27 in Modulating Atherosclerotic Inflammation.

    abstract::Atherosclerosis is the primary cause of heart attacks, and while efforts to prevent its development or progression have historically focused largely on reducing cholesterol levels, there is now important proof-of-principle data that supports the role that inflammation plays in atherogenesis. Heat shock protein 27 (HSP...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-020-10000-z

    authors: Inia JA,O'Brien ER

    更新日期:2020-07-13 00:00:00

  • Identification of streptococcal m-protein cardiopathogenic epitopes in experimental autoimmune valvulitis.

    abstract::The M protein of rheumatogenic group A streptococci induces carditis and valvulitis in Lewis rats and may play a role in pathogenesis of rheumatic heart disease. To identify the epitopes of M5 protein that produce valvulitis, synthetic peptides spanning A, B, and C repeat regions contained within the extracellular dom...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章

    doi:10.1007/s12265-013-9526-4

    authors: Kirvan CA,Galvin JE,Hilt S,Kosanke S,Cunningham MW

    更新日期:2014-03-01 00:00:00

  • Regulation of mammalian microRNA expression.

    abstract::MicroRNAs are widely expressed, approximately 22-nucleotide-long non-protein-coding RNAs. They are first transcribed as much longer primary transcripts, which then undergo a series of processing steps to yield the single-stranded, mature microRNAs. Like other classes of RNAs in a cell, the biogenesis of microRNAs is u...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-010-9166-x

    authors: Zhang X,Zeng Y

    更新日期:2010-06-01 00:00:00

  • Endothelial cell death and intimal foam cell accumulation in the coronary artery of infected hypercholesterolemic minipigs.

    abstract::Apoptosis of endothelial cells (ECs) has been suggested to play a role in atherosclerosis. We studied the synergism of hypercholesterolemia with Chlamydia pneumoniae and influenza virus infections on EC morphology and intimal changes in a minipig model. The coronary artery was excised at euthanasia (19 weeks of age) a...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章

    doi:10.1007/s12265-013-9463-2

    authors: Birck MM,Saraste A,Hyttel P,Odermarsky M,Liuba P,Saukko P,Hansen AK,Pesonen E

    更新日期:2013-08-01 00:00:00