Mitochondrial Iron Accumulation in Parietal and Chief Cells in Iron Pill Gastritis Following Billroth II Gastrectomy: Case Report Including Electron Microscopic Examination.

Abstract:

:Iron pill gastritis has been shown to be associated with superficial gastric erosion and deposition of iron in lamina propria and gastric antral glands. However, iron absorption in gastric parietal and chief cells is rare. We present a case of a 62-year-old man with iron deficiency anemia. His past medical history is significant for Billroth II surgery. His medications include ferrous sulphate 325mg. Esophagogastroduodenoscopy showed diffuse circumferential abnormal mucosa at the gastro-jejunal anastomosis. The mucosa was erythematous and violaceous. Biopsy showed reactive gastropathy with iron deposits predominantly in macrophages, parietal cells, and chief cells. These findings were confirmed by iron stain and later by electron micrography of the gastric mucosa that showed iron deposits in mitochondria and cytoplasm of the parietal and chief cells.

journal_name

Ann Clin Lab Sci

authors

Shafique K,Araujo JL,Veluvolu R,Cassai N,Desoto-Lapaix F,Pincus MR,Wieczorek RL

subject

Has Abstract

pub_date

2017-05-01 00:00:00

pages

354-356

issue

3

eissn

0091-7370

issn

1550-8080

pii

47/3/354

journal_volume

47

pub_type

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