Mammary analogue secretory carcinoma of salivary glands: a clinicopathologic study of 11 cases.

Abstract:

:Mammary analogue secretory carcinoma (MASC) is a recently described tumor sharing the histologic, immunohistochemical, and molecular profile of secretory carcinoma of breast. We aimed to evaluate the morphologic and histochemical features needed/required for the diagnosis of MASC without adjunct of molecular analysis. Six retrospective cases suspicious for MASC and 5 prospective cases reported as MASC were included in the study. Molecular analysis of ETV6 by fluorescence in situ hybridization was performed at the University of Pittsburg, USA. The ages of the patients ranged from 9 to 60 years (mean, 27.5 years). Histologically, all tumors showed mixed growth patterns including microcystic, macrocystic, papillary, tubular, and solid, papillary the being most common pattern. The tumor cells showed round to oval vesicular nuclei with small nucleoli, and eosinophilic to vacuolated cytoplasm. All cases demonstrated luminal and cytoplasmic mucin on periodic acid-Schiff with and without diastase digestion and alcian blue stain. ETV6 fusion gene rearrangement by fluorescence in situ hybridization was detected in 10 of 11 tumors. Recurrences occurred in 3 patients, and 1 patient died of disease 5 years after surgery. In conclusion, MASC is a relatively rare salivary gland malignancy exhibiting distinct histologic and histochemical features which can help to differentiate it from other mimics. Histologically, papillary-cystic and microcystic patterns are the main clues to diagnosis. The follicular pattern of acinic cell carcinoma might represent MASC, as 4 cases in our series had this pattern. Two patients in our series were 9 and 9½ years old respectively, which are the youngest ages ever recorded for MASC.

journal_name

Ann Diagn Pathol

authors

Din NU,Fatima S,Kayani N

doi

10.1016/j.anndiagpath.2016.04.003

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

49-53

eissn

1092-9134

issn

1532-8198

pii

S1092-9134(16)30025-9

journal_volume

22

pub_type

杂志文章
  • The role of routine immunohistochemistry for Helicobacter pylori in gastric biopsy.

    abstract::Helicobacter pylori infection is associated with gastritis, gastric ulcer, gastric adenocarcinoma, and mucosal associated lymphoid tissue lymphoma. Documenting the presence of H pylori in a gastric biopsy is essential for appropriate patient care. Several special stains and immunohistochemistry (IHC) stain for H pylor...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2010.05.002

    authors: Wang XI,Zhang S,Abreo F,Thomas J

    更新日期:2010-08-01 00:00:00

  • Significance of disease extent in high-grade cervical intraepithelial neoplasia excised with negative margins by loop electrosurgical excision procedure.

    abstract::Approximately 15% of patients with high-grade cervical intraepithelial neoplasia (CIN 2-3), treated by the loop electrosurgical excision procedure (LEEP) will experience a persistence or recurrence of their disease. The full spectrum of pathologic factors that may be predictive of an increased probability of this even...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2007.01.012

    authors: Fadare O,Cardoza-Favarato G

    更新日期:2008-02-01 00:00:00

  • Eosinophilic pancreatitis: a rare entity that can mimic a pancreatic neoplasm.

    abstract::Eosinophilic pancreatitis is a rare disorder that is frequently diagnosed only after pancreatic resection for suspected pancreatic tumor. It typically occurs in the setting of either eosinophilic gastroenteritis or the hypereosinophilic syndrome. Isolated eosinophilic infiltration of the pancreas is less common. We de...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章,评审

    doi:10.1053/adpa.2000.19371

    authors: Euscher E,Vaswani K,Frankel W

    更新日期:2000-12-01 00:00:00

  • Breast metastasis by medullary thyroid carcinoma detected by FDG positron emission tomography.

    abstract::Medullary thyroid carcinoma (MTC) is an uncommon thyroid cancer comprising 5% to 8% of thyroid neoplasms. In contrast to common thyroid tumors, this tumor originates from the calcitonin-producing C cells. Regional metastases to cervical lymph nodes occur early in the disease, whereas distant metastasis occurs late. Co...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2006.08.004

    authors: Nofech-Mozes S,Mackenzie R,Kahn HJ,Ehrlich L,Raphael SJ

    更新日期:2008-02-01 00:00:00

  • Cutaneous angiosarcoma. Analysis of 434 cases from the Surveillance, Epidemiology, and End Results Program, 1973-2007.

    abstract::Cutaneous angiosarcoma is an aggressive malignant mesenchymal vasoformative neoplasm that accounts for 1% of all soft tissue sarcomas. Using data from the National Cancer Institute's Surveillance, Epidemiology, and End Results program, we analyzed the demographics and survival of cutaneous angiosarcoma. The Surveillan...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2010.07.012

    authors: Albores-Saavedra J,Schwartz AM,Henson DE,Kostun L,Hart A,Angeles-Albores D,Chablé-Montero F

    更新日期:2011-04-01 00:00:00

  • PD-L1 immuno-expression assay in thymomas: Study of 84 cases and review of literature.

    abstract:BACKGROUND AND AIMS:Programmed death ligand 1 (PD-L1), an immune check point inhibitor, is known to be expressed in several malignancies and is being considered as a prognostic factor and a potential immunotherapeutic target. The aim of this study was to characterize PD-L1 expression in thymomas and to determine correl...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2018.03.012

    authors: Guleria P,Husain N,Shukla S,Kumar S,Parshad R,Jain D

    更新日期:2018-06-01 00:00:00

  • Cystic pancreatic schwannoma in a 46-year-old man.

    abstract::Pancreatic schwannomas are a rare benign mesenchymal neoplasm of the pancreas. They are thought to arise from the epineurium of either autonomic sympathetic or parasympathetic fibers, which course through the pancreas with the vagus nerve. Large pancreatic schwannomas often undergo cystic change, which causes them to ...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2006.12.017

    authors: Tafe LJ,Suriawinata AA

    更新日期:2008-08-01 00:00:00

  • Trophogram, an immunohistochemistry-based algorithmic approach, in the differential diagnosis of trophoblastic tumors and tumorlike lesions.

    abstract::Recent histopathologic and molecular studies of trophoblastic cells in the normal placenta and in a variety of trophoblastic diseases have revealed that the latter recapitulate the differentiation of normal trophoblast in the early developing placenta. This new knowledge, especially the identification and characteriza...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章,评审

    doi:10.1016/j.anndiagpath.2007.04.001

    authors: Shih IeM

    更新日期:2007-06-01 00:00:00

  • Utility of thin-layer preparations in the endometrial cytology: evaluation of benign endometrial lesions.

    abstract::The purpose of the current study was to examine the use of thin-layer cytologic (TLC) preparation compared to conventional cytologic preparation (CCP) in the normal endometrium (proliferative, secretory, atrophic) and endometrial glandular and stromal breakdown (EGBD). During a 6-month period, we compiled 158 cases by...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2007.05.005

    authors: Norimatsu Y,Kouda H,Kobayashi TK,Moriya T,Yanoh K,Tsukayama C,Miyake Y,Ohno E

    更新日期:2008-04-01 00:00:00

  • Fibro-osseous pseudotumor of digits - Expanding the spectrum of clonal transient neoplasms harboring USP6 rearrangement.

    abstract::Fibro-osseous pseudotumors of the digits (FOPD) is a rare self-limiting lesion composed of bland looking hypercellular fibrous tissue and bone. USP6 rearrangement is a consistent genetic finding in aneurysmal bone cyst, nodular fasciitis, myositis ossificans and giant cell lesions of small bones. We report herein the ...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2018.05.003

    authors: Flucke U,Shepard SJ,Bekers EM,Tirabosco R,van Diest PJ,Creytens D,van Gorp JM

    更新日期:2018-08-01 00:00:00

  • Differentiated squamous intraepithelial lesion (dSIL)-like changes in the epidermis overlying anogenital melanocytic nevi: A diagnostic pitfall.

    abstract:BACKGROUND:Differentiated squamous intraepithelial lesion (dSIL) is morphologically and immunohistochemically analogous in the whole anogenital region. dSIL is a premalignant lesion frequently misinterpreted histopathologically as a benign dermatosis. The authors describe a peculiar change in the basal cell layer of th...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2016.11.002

    authors: Michalova K,Kazakov DV,Michal M,Hadravsky L,Kacerovska D,Rychly B,Miesbauerova M,Michal M

    更新日期:2017-02-01 00:00:00

  • Correlation of folate receptor alpha expression with clinicopathological parameters and outcome in triple negative breast cancer.

    abstract::Folate receptor alpha (FRα) is a membrane-bound protein with a high affinity for folate, which is necessary for the biosynthesis of amino acids and nucleotide bases. It has been shown to be a potential prognostic and therapeutic target, primarily in lung and ovarian cancer, as well as in breast cancer. The aim of this...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2020.151596

    authors: Zagorac I,Lončar B,Dmitrović B,Kralik K,Kovačević A

    更新日期:2020-10-01 00:00:00

  • The clinical use of a P63/cytokeratin7/18/cytokeratin5/14 antibody cocktail in diagnostic breast pathology.

    abstract::An antibody cocktail directed against p63, cytokeratin (CK)5/14, and CK7/18 is reported to be useful in distinguishing noninvasive from invasive breast lesions and for the characterization of intraductal epithelial proliferations. However, limited studies evaluate its use in clinical practice. A retrospective review o...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2014.08.007

    authors: Reisenbichler ES,Ross JR,Hameed O

    更新日期:2014-12-01 00:00:00

  • Upregulation of inhibitory signaling receptor programmed death marker-1 (PD-1) in disease evolution from cutaneous lymphoid dyscrasias to mycosis fungoides and Sezary's syndrome.

    abstract:BACKGROUND:Negative immunoregulatory checkpoints impede effective immune responses to tumor and reduce the action of anticancer agents. One such example is programmed death marker-1 (PD-1), an inhibitory signaling receptor expressed on activated and regulatory T-cells. PD-1 expression was reported in a few reports, but...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2017.02.003

    authors: Nguyen GH,Olson LC,Magro CM

    更新日期:2017-06-01 00:00:00

  • Histopathological review of 667 cases of oral mucoceles with emphasis on uncommon histopathological variations.

    abstract::Mucoceles can occur in the oral cavity, appendix, bladder, paranasal sinuses, and lacrimal sac. In the oral cavity, mucoceles arise from pathological alterations in the minor salivary gland ducts. In this study, we aimed to histologically reevaluate cases of oral mucoceles to identify possible variants. A total of 667...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2016.02.001

    authors: de Brito Monteiro BV,Bezerra TM,da Silveira ÉJ,Nonaka CF,da Costa Miguel MC

    更新日期:2016-04-01 00:00:00

  • Five rare cases of Ewing sarcoma, including with epithelial differentiation, involving the female genital tract, displaying EWSR1 rearrangement: Diagnostic challenge and treatment implications.

    abstract::We present clinicopathological and molecular cytogenetic features of five rare cases of Ewing sarcomas, occurring in the female genital tract. A 40 year-old lady presented with a 5.4 cm-sized vaginal mass of 3 months duration, which was histopathologically diagnosed as ES. She defaulted chemotherapy and 8 months later...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2019.05.003

    authors: Rekhi B,Agrawal R,Shetty O,Deodhar KK,Menon S,Ghosh J,Kerkar R,Maheshwari A

    更新日期:2019-08-01 00:00:00

  • Serrated lesions of the colon A window on a more clear classification.

    abstract::Serrated polyps evaluation represents a challenge for pathologists for lacking of univocal criteria that leads to different inter -individual interpretation. The aim of our review is to offer an alternative simpler histologic and endoscopic approach to these lesions for a more correct relationship between endoscopists...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章,评审

    doi:10.1016/j.anndiagpath.2019.05.006

    authors: Villanacci V,Baronchelli C,Manenti S,Bassotti G,Salviato T

    更新日期:2019-08-01 00:00:00

  • Distinctive immunohistochemical staining in littoral cell angioma using ERG and WT-1.

    abstract::Littoral cell angioma (LCA) is a rare vascular tumor of the spleen. It has an immunohistochemical staining pattern that is somewhat distinctive but can still be occasionally confused with other vascular and stromal proliferations in the spleen. In this study, LCA was evaluated using Ets-related gene (ERG) and Wilms tu...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2015.02.007

    authors: O'Malley DP,Kim YS,Weiss LM

    更新日期:2015-06-01 00:00:00

  • Primary chondrosarcoma of ethmoid bone in a 6-year-old child.

    abstract::Chondrosarcoma (CS) is a distinctly uncommon tumor in young patients and tends to be located in the extremities. Cartilaginous tumors in young patients are benign tumors. We report a case of a childhood CS in a 6-year-old boy who presented with right-sided proptosis. Radiological examination revealed a large destructi...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2005.09.004

    authors: Mahesha V,Goyal R,Vaiphei K,Nada R,Gupta AK

    更新日期:2006-06-01 00:00:00

  • Are epidermal growth factor and transforming growth factor responsible for pseudoepitheliomatous hyperplasia associated with granular cell tumors?

    abstract::Granular cell tumors (GCT) are uncommon benign neoplasms that have a predilection for the head and neck region. These tumors can frequently be associated with pseudoepitheliomatous hyperplasia (PEH), which in turn may be mistaken for squamous cell carcinoma. Although epidermal growth factors are overexpressed in squam...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1053/adpa.2003.50011

    authors: Barkan GA,Paulino AF

    更新日期:2003-04-01 00:00:00

  • Prognostic factors in malignant mixed tumors of the salivary gland: correlation of immunohistochemical markers with histologic classification.

    abstract::Malignant mixed tumor of salivary glands is a rare tumor whose variable behavior and prognosis are related for the most part to the clinical stage and histologic grade of the carcinomatous component. The purpose of this study is to predict prognosis by comparing the histologic grading and subclassification of the carc...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1053/adpa.2002.34728

    authors: Xin W,Paulino AF

    更新日期:2002-08-01 00:00:00

  • Pleomorphic myofibrosarcoma of the tibia with aneuploid DNA content.

    abstract::Myofibrosarcomas of the tibia are exceedingly rare, with only one case reported in the literature. We describe DNA ploidy of high-grade myofibrosarcoma of the tibia in correlation with clinicomorphologic and ultrastructural features in a 16-year-old adolescent girl. Radiological studies revealed an expanding osteolyti...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2007.04.002

    authors: Gonzalez FA,Vazquez AC,Uscanga CC,Cortes IJ,Malagon D

    更新日期:2007-10-01 00:00:00

  • Postradiation-associated sclerosing mediastinitis diagnosed in fine needle aspiration specimen: A cytological-pathological correlation.

    abstract::Sclerosing mediastinitis (SM) is an aggressive fibroproliferative process in the mediastinum that may lead to encasement of mediastinal structures within a dense fibrotic mass. This disease may cause significant clinical complications, morbidity, and even mortality. The etiology and pathogenesis of SM is unclear and i...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2017.01.004

    authors: Giorgadze T,Koizumi JH,Ronen S,Chaump M,Magro CM

    更新日期:2017-04-01 00:00:00

  • Utility of a standardized protocol for submitting clinically suspected endometrial polyps to the pathology laboratory.

    abstract::The purpose of the study is to assess whether a protocol for submitting clinically suspected endometrial polyps will improve the detection rate of polyps and evaluation of the background endometrium. A retrospective review from 1999 to 2015 was performed. Cases were divided into (1) polyps and curettings placed in 2 c...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2016.05.002

    authors: Safdar NS,Giannico GA,Desouki MM

    更新日期:2016-08-01 00:00:00

  • TP53 mutations are common in mantle cell lymphoma, including the indolent leukemic non-nodal variant.

    abstract:INTRODUCTION:Mantle cell lymphoma (MCL) is an aggressive B-cell neoplasm, but clinically indolent subtypes are also recognized. Data on the utility of mutation profiling in the context of routine workup and its role in risk-stratification of MCL patients are limited. In this study, we describe the mutational landscape ...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2019.05.004

    authors: Sakhdari A,Ok CY,Patel KP,Kanagal-Shamanna R,Yin CC,Zuo Z,Hu S,Routbort MJ,Luthra R,Medeiros LJ,Khoury JD,Loghavi S

    更新日期:2019-08-01 00:00:00

  • Squamous cell carcinoma of the penis with rhabdoid features.

    abstract::A 76-year-old man presented with a tumoral lesion in his penis that had all the light microscopic and immunohistochemical features of a squamous cell carcinoma with rhabdoid phenotype. We believe that this is the fourth reported case of squamous cell carcinoma with rhabdoid features and the first one located in the pe...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1053/adpa.2002.36654

    authors: Urdiales-Viedma M,Fernandez-Rodriguez A,De Haro-Muñoz T,Pichardo-Pichardo S

    更新日期:2002-12-01 00:00:00

  • Reflections on the use of controls in immunohistochemistry and proposal for application of a multitissue spring-roll control block.

    abstract::The conventional positive control in immunohistochemistry consists of a separately immunostained slide containing tissue known to show positive reaction with the antibody. Although it can indicate that the reagents are sound, it cannot guarantee that the appropriate reagents have indeed been dispensed in the correct o...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章,评审

    doi:10.1053/adpa.2000.17892

    authors: Chan JK,Wong CS,Ku WT,Kwan MY

    更新日期:2000-10-01 00:00:00

  • Aggressive meningiomas involving the parotid gland.

    abstract::Parotid masses remain challenging secondary to the great diversity of primary tumors that may arise in the salivary glands and propensity for regional and even distant metastases to occur in this region. Meningioma must also be considered in the differential diagnosis of parotid masses, whether from direct extension, ...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2011.08.006

    authors: Joggerst KH,Langford LA,Williams MD

    更新日期:2012-04-01 00:00:00

  • Melanocytic "ball-in-mitts" and "microalveolar structures" and their role in the development of cellular blue nevi.

    abstract::To test the hypothesis of whether cellular blue nevi (CBN) may originate from "ordinary" compound and dermal nevi, a total of 275 melanocytic nevi including 59 CBN, 34 ordinary blue nevi, 87 combined nevi (including 43 so-called clonal nevi), 35 deep penetrating nevi, and 60 ordinary compound and dermal nevi (30 of ea...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2007.03.001

    authors: Kazakov DV,Michal M

    更新日期:2007-06-01 00:00:00

  • Expression of the p16(INK4a) gene product in premalignant and malignant epithelial lesions of the gallbladder.

    abstract::The sequence of molecular changes leading to neoplastic transformation in the gallbladder remains elusive. The aim of this study is to characterize the spectrum of nuclear p16 protein product immunohistochemical expression in tissue microarray cores taken from resected gallbladders, comprising histologically normal ga...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2007.06.003

    authors: Lynch BC,Lathrop SL,Ye D,Ma TY,Cerilli LA

    更新日期:2008-06-01 00:00:00