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Single blind randomised controlled trial of GAME (Goals - Activity - Motor Enrichment) in infants at high risk of cerebral palsy.

Abstract：

BACKGROUND:Cerebral palsy (CP) is caused by a lesion in the developing infant brain. Recent neuroplasticity literature suggests that intensive, task-specific intervention ought to commence early, during the critical period of neural development. AIMS:To determine whether "GAME" (Goals - Activity - Motor Enrichment), a motor learning, environmental enrichment intervention, is effective for improving motor skills in infants at high risk of CP. METHODS AND PROCEDURES:Single blind randomised controlled trial of GAME versus standard care. Primary outcome was motor skills on the Peabody Developmental Motor Scales-2 (PDMS-2). Secondary outcomes included Canadian Occupational Performance Measure (COPM), Bayley Scales of Infant and Toddler Development (BSID-III) and Gross Motor Function Measure-66 (GMFM-66). Outcome assessors were masked to group allocation and data analyzed with multiple regression. OUTCOMES AND RESULTS:All n=30 infants enrolled received the assigned intervention until 16 weeks post enrolment. At 12 months of age, n=26 completed assessments. Significant between group differences were found in raw scores on the PDMS-2 in favour of GAME (B=20.71, 95%CI 1.66-39.76, p=0. 03) and at 12 months on the total motor quotient (B=8.29, 95%CI 0.13-16.45,p =0.05). Significant between group differences favored GAME participants at 12 months on the cognitive scale of the BSID-III and satisfaction scores on the COPM. CONCLUSION:GAME intervention resulted in advanced motor and cognitive outcomes when compared with standard care.

journal_name

Res Dev Disabil

journal_title

Research in developmental disabilities

authors

Morgan C,Novak I,Dale RC,Guzzetta A,Badawi N

doi

10.1016/j.ridd.2016.04.005

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

256-67

eissn

0891-4222

issn

1873-3379

pii

S0891-4222(16)30075-0

journal_volume

55

pub_type

杂志文章,随机对照试验

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