Abstract：
:Children with chromosome 22q11.2 deletion syndrome (22q11DS) are significantly impaired in their academic performance and functionality due to cognitive deficits, especially in attention, memory, and other facets of executive function. Compounding these cognitive deficits is the remarkably high risk of major psychoses, occurring in 25% of adolescents and adults with the disorder. There are currently no evidence-based interventions designed to improve the cognitive deficits in these individuals. We implemented a neuroplasticity-based computerized cognitive remediation program for 12 weeks in 13 adolescents with 22q11DS, assessed feasibility, and measured changes in cognition before and after the intervention compared to a control group of 10 age- and gender-matched children with 22q11DS. Our results indicated that despite their cognitive impairments, this intervention is feasible in children with 22q11DS, with high rates of adherence and satisfaction. Our preliminary analyses indicate that gains in cognition occur with the intervention. Further study in a larger randomized controlled trial would enable assessment of efficacy of this novel intervention.
journal_name
Res Dev Disabiljournal_title
Research in developmental disabilitiesauthors
Harrell W,Eack S,Hooper SR,Keshavan MS,Bonner MS,Schoch K,Shashi Vdoi
10.1016/j.ridd.2013.05.009subject
Has Abstractpub_date
2013-09-01 00:00:00pages
2606-13issue
9eissn
0891-4222issn
1873-3379pii
S0891-4222(13)00193-5journal_volume
34pub_type
杂志文章abstract：:The purpose of the present study was to develop a new assessment procedure of social information processing (SIP) for adolescents, to explore its validity and to examine whether it differentiated between IQ groups. Ninety-four adolescents within secure residential care were administered the SIP instrument, the Youth S...
journal_title：Research in developmental disabilities
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更新日期：2014-06-01 00:00:00
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journal_title：Research in developmental disabilities
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journal_title：Research in developmental disabilities
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journal_title：Research in developmental disabilities
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journal_title：Research in developmental disabilities
pub_type： 杂志文章
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更新日期：2011-07-01 00:00:00
abstract：:The present study sought to examine the longitudinal psychoeducational, neurocognitive, and psychiatric outcomes of children and adolescents with chromosome 22q11.2 deletion syndrome (22q11DS), a population with a high incidence of major psychiatric illnesses appearing in late adolescence/early adulthood. Little is kn...
journal_title：Research in developmental disabilities
pub_type： 杂志文章
doi：10.1016/j.ridd.2012.12.003
更新日期：2013-05-01 00:00:00
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更新日期：2020-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-02-01 00:00:00
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journal_title：Research in developmental disabilities
pub_type： 杂志文章
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journal_title：Research in developmental disabilities
pub_type： 杂志文章
doi：10.1016/j.ridd.2011.05.020
更新日期：2011-11-01 00:00:00
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journal_title：Research in developmental disabilities
pub_type： 杂志文章
doi：10.1016/j.ridd.2012.07.030
更新日期：2013-01-01 00:00:00
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更新日期：2011-05-01 00:00:00
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pub_type： 杂志文章
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更新日期：2015-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2014-03-01 00:00:00
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journal_title：Research in developmental disabilities
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更新日期：2009-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2017-01-01 00:00:00
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pub_type： 杂志文章
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journal_title：Research in developmental disabilities
pub_type： 杂志文章,评审
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更新日期：2018-08-01 00:00:00
abstract：:Three residential staff aged 22-38 years participated in this study which measured the accuracy of their data collection, following instruction, in-service, and in-service plus feedback. The experimenter trained them to collect data on targeted maladaptive behavior of one consumer at one time of the day. Following the...
journal_title：Research in developmental disabilities
pub_type： 杂志文章
doi：10.1016/j.ridd.2013.11.009
更新日期：2014-02-01 00:00:00
