Reduction of 18F-FDG Dose in Clinical PET/MR Imaging by Using Silicon Photomultiplier Detectors.

Abstract:

:Purpose To determine the level of clinically acceptable reduction in injected fluorine 18 (18F) fluorodeoxyglucose (FDG) dose in time-of-flight (TOF)-positron emission tomography(PET)/magnetic resonance (MR) imaging by using silicon photomultiplier (SiPM) detectors compared with TOF-PET/computed tomography (CT) using Lu1.8Y0.2SiO5(Ce), or LYSO, detectors in patients with different body mass indexes (BMIs). Materials and Methods Patients were enrolled in this study as part of a larger prospective study with a different purpose than evaluated in this study (NCT02316431). All patients gave written informed consent prior to inclusion into the study. In this study, 74 patients with different malignant diseases underwent sequential whole-body TOF-PET/CT and TOF-PET/MR imaging. PET images with simulated reduction of injected 18F-FDG doses were generated by unlisting the list-mode data from PET/MR imaging. Two readers rated the image quality of whole-body data sets, as well as the image quality in each body compartment, and evaluated the conspicuity of malignant lesions. Results The image quality with 70% or 60% of the injected dose of 18F-FDG at PET/MR imaging was comparable to that at PET/CT. With 50% of the injected dose, comparable image quality was maintained among patients with a BMI of less than 25 kg/m2. PET images without TOF reconstruction showed higher artifact scores and deteriorated sharpness than those with TOF reconstruction. Conclusion Sixty percent of the usually injected 18F-FDG dose (reduction of up to 40%) in patients with a BMI of more than 25 kg/m2 results in clinically adequate PET image quality in TOF-PET/MR imaging performed by using SiPM detectors. Additionally, in patients with a BMI of less than 25 kg/m2, 50% of the injected dose may safely be used. © RSNA, 2017 Online supplemental material is available for this article.

journal_name

Radiology

journal_title

Radiology

authors

Sekine T,Delso G,Zeimpekis KG,de Galiza Barbosa F,Ter Voert EEGW,Huellner M,Veit-Haibach P

doi

10.1148/radiol.2017162305

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

249-259

issue

1

eissn

0033-8419

issn

1527-1315

journal_volume

286

pub_type

杂志文章
  • Ultrasound evaluation of cystic intracranial lesions in the neonate.

    abstract::Ultrasound detected cystic intracranial lesions in 18 infants. Lesions included porencephaly (6 infants), hydranencephaly (1 infant), a quadrigeminal cyst (1 infant), Dandy-Walker syndrome (1 infant), and cavum septi pellucidi and Vergae (9 infants). Cystic lesions of the infant brain can be delineated accurately with...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.137.2.6968920

    authors: Mack LA,Rumack CM,Johnson ML

    更新日期:1980-11-01 00:00:00

  • Computer-aided diagnosis applied to US of solid breast nodules by using neural networks.

    abstract:PURPOSE:To increase the capabilities of ultrasonographic (US) technology for the differential diagnosis of solid breast tumors by using a neural network. MATERIALS AND METHODS:One hundred forty US images of solid breast nodules were evaluated. When a sonogram was obtained, an analog video signal from the VCR output of...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.213.2.r99nv13407

    authors: Chen DR,Chang RF,Huang YL

    更新日期:1999-11-01 00:00:00

  • Tissue relaxation time: in vivo field dependence.

    abstract::Relaxation times (T1 and T2) were measured in vivo in mongrel dogs at fields of 0.3, 0.5, 1.0, 1.35, and 1.5 tesla (T). T1 was measured using nine values of inversion time ranging from 10 to 1,280 msec. T2 was measured with a four-point multiple spin-echo sequence. Relaxation times were calculated for muscle, kidney c...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.156.3.2991980

    authors: Johnson GA,Herfkens RJ,Brown MA

    更新日期:1985-09-01 00:00:00

  • Primary human breast adenocarcinoma: imaging and histologic correlates of intrinsic susceptibility-weighted MR imaging before and during chemotherapy.

    abstract:PURPOSE:To investigate the histopathologic and dynamic magnetic resonance (MR) imaging correlates of intrinsic susceptibility-weighted (ISW) MR imaging in patients with primary human breast adenocarcinoma and to assess the relationship between baseline transverse relaxation rate (R2*) and T2* relaxivity change (ΔR2*) a...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.10100421

    authors: Li SP,Taylor NJ,Makris A,Ah-See ML,Beresford MJ,Stirling JJ,d'Arcy JA,Collins DJ,Padhani AR

    更新日期:2010-12-01 00:00:00

  • Radiofrequency ablation as a substitute for surgery in elderly patients with nonresected breast cancer: pilot study with long-term outcomes.

    abstract:PURPOSE:To determine the efficacy and tolerance of ultrasonography (US)-guided percutaneous radiofrequency (RF) ablation with endocrine therapy in elderly patients with breast cancer who decline or are not candidates for surgery. MATERIALS AND METHODS:Internal ethics committee approval was obtained, and patients gave ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.12111303

    authors: Palussière J,Henriques C,Mauriac L,Asad-Syed M,Valentin F,Brouste V,Mathoulin-Pélissier S,Tunon de Lara C,Debled M

    更新日期:2012-08-01 00:00:00

  • Selective injection of contrast media: inflammatory effects on rabbit fallopian tubes.

    abstract::The inflammatory effects of fallopian tube catheterization and selective injection of seven contrast agents (ethiodized oil, diatrizoate meglumine 52%, diatrizoate meglumine 66%, iothalamate meglumine 60%, iopamidol, ioxitol, and ioxaglate) were evaluated in 88 rabbits. The contrast agent used was randomly selected an...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.180.1.1647040

    authors: Thurmond AS,Hedgpeth PL,Scanlan RM

    更新日期:1991-07-01 00:00:00

  • Sonography of portosystemic venous collaterals in portal hypertension.

    abstract::Portosystemic venous collaterals were studied with sonography in 40 patients with known portal hypertension. Eight patients had technically inadequate scans, while 32 had optimal scans. Sixty groups of venous collaterals were identified. At least one collateral pathway was seen in 28 patients, for a sensitivity of 88%...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.146.1.6849040

    authors: Subramanyam BR,Balthazar EJ,Madamba MR,Raghavendra BN,Horii SC,Lefleur RS

    更新日期:1983-01-01 00:00:00

  • Sleep apnea syndrome: comparison of MR imaging of the oropharynx with physiologic indexes.

    abstract:PURPOSE:To compare magnetic resonance (MR) imaging of the oropharynx in patients with sleep apnea syndrome with fiberoptic nasopharyngoscopy, and oropharyngeal pressure and apnea index values. MATERIALS AND METHODS:After sleep induction, 24 patients with sleep apnea syndrome and nine patients with non-sleep-apnea snor...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.201.2.8888230

    authors: Suto Y,Matsuda E,Inoue Y,Suzuki T,Ohta Y

    更新日期:1996-11-01 00:00:00

  • MR imaging and scintigraphy of gene expression through melanin induction.

    abstract:PURPOSE:To determine whether an expression vector that encodes for human tyrosinase, the key enzyme in the melanin production pathway, can be used to image gene expression with magnetic resonance (MR) imaging and scintigraphy. MATERIALS AND METHODS:Mouse fibroblasts and human embryonal kidney cells were transfected wi...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.204.2.9240530

    authors: Weissleder R,Simonova M,Bogdanova A,Bredow S,Enochs WS,Bogdanov A Jr

    更新日期:1997-08-01 00:00:00

  • Ultrasound mammography for the augmented breast.

    abstract::Ultrasound examinations were performed on 25 women with augmented breasts using whole-breast water-path scanning. In these patients, ultrasound imaged carcinoma, benign lesions, and fibrous capsule formation; these were confirmed by surgery. In addition, it was noted that certain prostheses appeared to be displaced po...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.146.3.6828690

    authors: Cole-Beuglet C,Schwartz G,Kurtz AB,Patchefsky AS,Goldberg BB

    更新日期:1983-03-01 00:00:00

  • Endometrial blood flow analysis in postmenopausal women: can it help differentiate benign from malignant causes of endometrial thickening?

    abstract:PURPOSE:To determine if prominent vascularity and low pulsatility index (PI) and resistive index (RI) in endometrial arteries help differentiate carcinoma from benign lesions. MATERIALS AND METHODS:Forty-five postmenopausal women with at least 8-mm-thick endometrium at endovaginal ultrasound (US) underwent color duple...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.195.3.7753990

    authors: Sheth S,Hamper UM,McCollum ME,Caskey CI,Rosenshein NB,Kurman RJ

    更新日期:1995-06-01 00:00:00

  • A pattern recognition method for the removal of streaking artifact in computed tomography.

    abstract::A new method is presented for the removal of streaking artifact in computed tomography. The method uses a nearest-neighbor pattern recognition technique to redetermine ray sums that intersect the foreign object responsible for the streaking. When the method is applied to the removal of streaking artifact caused by lea...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.141.1.7291530

    authors: Morin RL,Raeside DE

    更新日期:1981-10-01 00:00:00

  • Cervical carcinoma: MR imaging with an endorectal surface coil.

    abstract::Ten consecutive patients with biopsy-proved invasive cervical carcinoma underwent magnetic resonance (MR) imaging with both a standard body coil and with an endorectal surface coil. The endorectal coil provided a markedly improved signal-to-noise ratio, enabling the use of small fields of view; thus, the images had si...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.180.1.2052730

    authors: Milestone BN,Schnall MD,Lenkinski RE,Kressel HY

    更新日期:1991-07-01 00:00:00

  • Hybrid PET/MR imaging of the heart: feasibility and initial results.

    abstract:PURPOSE:To assess the feasibility of hybrid imaging of the heart with fluorine 18 fluorodeoxyglucose (FDG) on an integrated 3-T positron emission tomography (PET)/magnetic resonance (MR) imaging system. MATERIALS AND METHODS:The present study was approved by the local institutional review board. Written informed conse...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.13130231

    authors: Nensa F,Poeppel TD,Beiderwellen K,Schelhorn J,Mahabadi AA,Erbel R,Heusch P,Nassenstein K,Bockisch A,Forsting M,Schlosser T

    更新日期:2013-08-01 00:00:00

  • Postphlebographic thrombosis: a double-blind study with methylglucamine metrizoate and metrizamide.

    abstract::A double-blind, randomized study was conducted in 170 patients to compare the effects of two hypertonic contrast media in phlebography of the leg: one was ionic [methylglucamine metrizoate (Isopaque Cerebral, 280 mg I/mI)] and the other nonionic [metrizamide (Amipaque, 280 mg I/mI)]. Ninety patients who showed no veno...

    journal_title:Radiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1148/radiology.140.3.7025090

    authors: Laerum F,Holm HA

    更新日期:1981-09-01 00:00:00

  • Progression of renal artery fibromuscular dysplasia in 42 patients as seen on angiography.

    abstract::Forty-two hypertensive patients with fibromuscular dysplasia who had angiographic evidence of the development of new disease or of the progression of existing disease were studied. Renal arterial disease was classified as medial fibroplasia with aneurysms (12 patients), subadventitial fibroplasia (24 patients), or int...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.139.1.7208940

    authors: Goncharenko V,Gerlock AJ Jr,Shaff MI,Hollifield JW

    更新日期:1981-04-01 00:00:00

  • Color Doppler US in the evaluation of acute scrotal disease.

    abstract::Twenty-seven patients presented with painful acute scrotal swelling. After a clinical impression was established, all patients underwent diagnostic imaging with color Doppler ultrasound (US). Seven patients underwent surgical exploration for testicular torsion diagnosed with color Doppler US (100% operative confirmati...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.176.2.2195590

    authors: Lerner RM,Mevorach RA,Hulbert WC,Rabinowitz R

    更新日期:1990-08-01 00:00:00

  • Mesenteric circulation: three-dimensional MR angiography with a gadolinium-enhanced multiecho gradient-echo technique.

    abstract::To evaluate the mesenteric circulation with magnetic resonance (MR) angiography, the authors examined 16 individuals (12 patients, four volunteers) with a gadolinium-enhanced, breath-hold, fat-saturated, multiecho, three-dimensional, gradient-echo sequence. Twenty examinations were performed. Grades of 3 or 4 (on a fi...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.202.1.8988220

    authors: Shirkhoda A,Konez O,Shetty AN,Bis KG,Ellwood RA,Kirsch MJ

    更新日期:1997-01-01 00:00:00

  • Deep venous thrombosis: longitudinal study with duplex US.

    abstract::Forty-nine patients with deep venous thrombosis (DVT) of the lower limb were studied with repeated duplex ultrasound (US) for at least 1 year or until the vein became normal at US. Standard anticoagulant therapy was given for 3 months. In 36 patients, the veins became normal within 1 year. The likelihood of normalizat...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.179.1.2006290

    authors: Mantoni M

    更新日期:1991-04-01 00:00:00

  • Breast cancer screening: first round in the population-based program in Valencia, Spain. Collaborative Group of Readers of the Breast Cancer Screening Program of the Valencia Community.

    abstract:PURPOSE:To analyze the results of round 1 of the population-based Valencia Breast Cancer Screening Program. MATERIALS AND METHODS:In this program, 78,224 (72.98%) of the 107,178 women invited (aged 45-65 years) underwent screening. Complementary views were obtained in 5,771 women (7.38%). Among the total population st...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.206.1.9423680

    authors: Vizcaíno I,Salas D,Vilar JS,Ruiz-Perales F,Herranz C,Ibáñez J

    更新日期:1998-01-01 00:00:00

  • Relationship of Trochlear Morphology and Patellofemoral Joint Alignment to Superolateral Hoffa Fat Pad Edema on MR Images in Individuals with or at Risk for Osteoarthritis of the Knee: The MOST Study.

    abstract::Purpose To determine the relationship of patellofemoral joint alignment and trochlear morphology to superolateral Hoffa fat pad (SHFP) edema on magnetic resonance (MR) images in older adults with or at risk for osteoarthritis of the knee. Materials and Methods Institutional review board approval and written informed c...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2017162342

    authors: Widjajahakim R,Roux M,Jarraya M,Roemer FW,Neogi T,Lynch JA,Lewis CE,Torner JC,Felson DT,Guermazi A,Stefanik JJ

    更新日期:2017-09-01 00:00:00

  • Abdominal abscess drainage under radiologic guidance: causes of failure.

    abstract::The results of percutaneous drainage of abdominal abscesses in 136 patients are analyzed, revealing a failure rate of 23% (31 patients). The mortality rate was 1.4% (two patients); the rate of serious complications was 5% (seven patients). Failure rate was lowest in critically ill patients having palliative drainage o...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.159.2.2421370

    authors: Lang EK,Springer RM,Glorioso LW 3rd,Cammarata CA

    更新日期:1986-05-01 00:00:00

  • Shielding the hand during cross-compression angiography.

    abstract::A simple method of shielding the hand during cross-compression angiography is described. A standard lead glove with the fingertips cut out of the palmar aspect is used, allowing sensation and mobility while still protecting the hand. ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/128.2.509

    authors: Nusbacher N,Pollak L,Bryk D

    更新日期:1978-08-01 00:00:00

  • Clear cell chondrosarcoma.

    abstract::The clinical, radiologic, and histopathologic features of three cases of clear cell chondrosarcoma are described. On radiographs, this rather benign-appearing tumor resembles a chondroblastoma when it occurs at the end of a long bone, and may occasionally show a calcified matrix. However, it has distinctive tumor cell...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.154.1.3964950

    authors: Kumar R,David R,Cierney G 3rd

    更新日期:1985-01-01 00:00:00

  • Nuclear imaging, tomographic nuclear imaging, and gray scale ultrasound in the evaluation of the porta hepatis.

    abstract::Twenty-six patients with an eqivocal portal defect on conventional nuclear images were evaluated with a multiplane tomographic nuclear scanner and gray scale ultrasound. In most cases the correct determination (normal or abnormal) for an area of decreased uptake could be made from the multiplane tomographic scans. Whe...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/122.3.773

    authors: Sample WF,Gray RK,Poe ND,Graham LS,Bennett LR

    更新日期:1977-03-01 00:00:00

  • Periportal low attenuation at CT in childhood.

    abstract::Periportal low attenuation, defined as a low-attenuation rim around the portal vein and its branches that is seen on contrast material-enhanced computed tomographic (CT) scans, has been described in a variety of conditions in adults. The authors reviewed the appearance of periportal low attenuation on CT scans of 30 c...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.183.3.1584920

    authors: Siegel MJ,Herman TE

    更新日期:1992-06-01 00:00:00

  • The QIBA Profile for FDG PET/CT as an Imaging Biomarker Measuring Response to Cancer Therapy.

    abstract::The Quantitative Imaging Biomarkers Alliance (QIBA) Profile for fluorodeoxyglucose (FDG) PET/CT imaging was created by QIBA to both characterize and reduce the variability of standardized uptake values (SUVs). The Profile provides two complementary claims on the precision of SUV measurements. First, tumor glycolytic a...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2019191882

    authors: Kinahan PE,Perlman ES,Sunderland JJ,Subramaniam R,Wollenweber SD,Turkington TG,Lodge MA,Boellaard R,Obuchowski NA,Wahl RL

    更新日期:2020-03-01 00:00:00

  • Fluoroscopy and Cone-Beam CT-guided Fixation by Internal Cemented Screw for Pathologic Pelvic Fractures.

    abstract::Purpose To evaluate the safety and efficacy of palliative treatment of patients with pathologic pelvic by using fluoroscopy and cone-beam CT needle guidance software to perform percutaneous fixation by internal cemented screw (FICS). Materials and Methods This single-center study involved retrospective analysis of 100...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2018181105

    authors: Roux C,Tselikas L,Yevich S,Sandes Solha R,Hakime A,Teriitehau C,Gravel G,de Baere T,Deschamps F

    更新日期:2019-02-01 00:00:00

  • MR imaging response of brain metastases after gamma knife stereotactic radiosurgery.

    abstract:PURPOSE:To characterize the magnetic resonance (MR) imaging response of brain metastases after gamma knife stereotactic radiosurgery and determine whether imaging features and tumor response rates correlate with local tumor control and survival. MATERIALS AND METHODS:Serial MR examinations were performed in 48 patient...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.211.3.r99jn48807

    authors: Peterson AM,Meltzer CC,Evanson EJ,Flickinger JC,Kondziolka D

    更新日期:1999-06-01 00:00:00

  • A simple traction device for use in the radiology department.

    abstract::Portable sustained graded traction for control of the displaced cervical spine particularly for patients undergoing tomography or gas myelography, is described. ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/125.3.826

    authors: Deeb ZL,Drayer BP,Rosenbaum AE

    更新日期:1977-12-01 00:00:00