Abstract:
PURPOSE:To investigate the histopathologic and dynamic magnetic resonance (MR) imaging correlates of intrinsic susceptibility-weighted (ISW) MR imaging in patients with primary human breast adenocarcinoma and to assess the relationship between baseline transverse relaxation rate (R2*) and T2* relaxivity change (ΔR2*) and the response to neoadjuvant chemotherapy (NAC). MATERIALS AND METHODS:Institutional ethics approval and informed consent were obtained. Between September 2001 and January 2008, 83 women (median age, 46 years; age range, 26-72 years) with breast cancer were recruited to undergo dynamic contrast medium-enhanced (DCE), dynamic susceptibility contrast-enhanced (DSC), and ISW MR imaging before and after two cycles of NAC. After excluding necrotic, infiltrating, and invasive lobular carcinomas, 31 patients were available for baseline assessment and 27 were available for response assessment. Transfer constant, leakage space, rate constant, initial area under the gadolinium concentration-time curve at 60 seconds, relative blood volume (rBV), relative blood flow (rBF), and R2* were calculated. Relationships between baseline R2* and histopathologic variables (tumor grade, estrogen receptor status, progesterone receptor status, human epidermal growth factor 2 status), tumor size, and dynamic MR imaging parameters were sought. Baseline adenocarcinoma R2* (n = 31) and ΔR2* (n = 27) were correlated with final pathologic response. RESULTS:Inverse correlations between baseline R2* and rBV (ρ = -0.48, P = .013) and rBF (ρ = -0.44, P = .024) were found, but not after NAC. No relationships were observed between baseline R2* and other kinetic imaging parameters, histopathologic characteristics, or tumor size (P > .05). Baseline R2* values were lower in tumors than in normal breast tissue (31.8 sec(-1) vs 36.2 sec(-1), P = .017) but not after NAC. Increases in R2* were observed after treatment (31.1 sec(-1) vs 34.8 sec(-1), P = .006), with larger increases correlating with pathologic response. ΔR2* was not as effective as DCE or DSC MR imaging parameters in the prediction of response. CONCLUSION:R2* is influenced by blood volume in untreated breast adenocarcinomas. Increases in R2* after two cycles of NAC correlate with pathologic response. Therapy-induced uncoupling of the relationship between R2* and rBV and rBF is consistent with responding tumors becoming hypoxic early during treatment. SUPPLEMENTAL MATERIAL:http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.10100421/-/DC1.
journal_name
Radiologyjournal_title
Radiologyauthors
Li SP,Taylor NJ,Makris A,Ah-See ML,Beresford MJ,Stirling JJ,d'Arcy JA,Collins DJ,Padhani ARdoi
10.1148/radiol.10100421subject
Has Abstractpub_date
2010-12-01 00:00:00pages
643-52issue
3eissn
0033-8419issn
1527-1315pii
radiol.10100421journal_volume
257pub_type
杂志文章相关文献
RADIOLOGY文献大全abstract::Skull scintigraphy was performed in 68 children with suspected craniosynostosis after injection of technetium-99m methylene diphosphonate. The scans demonstrated four patterns of sutural activity: normal, absent, increased, and wide. When correlated with surgical findings, "absent" indicated fused sutures, "increased"...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/133.3.615
更新日期:1979-12-01 00:00:00
abstract:PURPOSE:To describe the placement of a nasolacrimal polyurethane stent with a new introducer set and hook. MATERIALS AND METHODS:The authors designed a soft polyurethane stent, an introducer that does not require balloon dilation, and a hook that can remove a ball-tipped guide wire from the inferior nasal meatus under...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.194.1.7997560
更新日期:1995-01-01 00:00:00
abstract::Seventy "low-suspicion," nonpalpable solid breast nodules were evaluated with stereotaxic fine-needle aspiration with cytologic analysis as an alternative to follow-up mammography. Sonography was performed in all cases to determine the solid nature of the nodules. Eight cysts were incorrectly classified with sonograph...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.183.3.1584910
更新日期:1992-06-01 00:00:00
abstract::The pathological changes in the female urethra, para-urethral glands, and bladder neck, which manifest clinically as urethral syndrome, produce radiological signs which are recognizable but for which the authors have not found previous reports. The radiographic manifestations of this disease are clearly demonstrated b...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/119.2.287
更新日期:1976-05-01 00:00:00
abstract::The purpose of this study was to prospectively use a whole-heart three-dimensional (3D) coronary magnetic resonance (MR) angiography technique specifically adapted for use at 3 T and a parallel imaging technique (sensitivity encoding) to evaluate coronary arterial anomalies and variants (CAAV). This HIPAA-compliant st...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2471070274
更新日期:2008-04-01 00:00:00
abstract::The purpose of this study was to assess the blooming artifacts in ex vivo coronary arteries at multidetector computed tomography (CT) and flat-panel-volume CT by comparing measured areas of calcified plaque with respect to the reference standard of histopathologic findings. Three ex vivo hearts were scanned with multi...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2483072003
更新日期:2008-10-01 00:00:00
abstract::Background Existing guidelines are inconsistent regarding the indications for staging brain MRI in patients with newly diagnosed, early-stage non-small cell lung cancer (NSCLC). Purpose To evaluate the diagnostic yield of staging brain MRI in the initial evaluation of lung cancer. Materials and Methods This retrospect...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2020201194
更新日期:2020-11-01 00:00:00
abstract::Percutaneous transperitoneal fine-needle lymph-node biopsy was performed in 52 patients to establish a diagnosis of metastatic disease in nodal defects detected during lymphography. The procedure was found to be highly accurate, with few false-negatives and no false-positives. ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/131.3.647
更新日期:1979-06-01 00:00:00
abstract:PURPOSE:To evaluate the accuracy of positron emission tomography (PET) with 2-deoxy-2-[fluorine-18] fluoro-D-glucose (FDG) in the detection of osseous and soft-tissue metastases of prostate cancer. MATERIALS AND METHODS:Thirty-four patients (mean age, 71 years) with biopsy-proved prostate cancer and known or suspected...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.199.3.8638000
更新日期:1996-06-01 00:00:00
abstract::Positive-mode xeroradiography is an excellent method of visualizing soft-tissue structures in mammography and other procedures; however, toner deletions over a large area may preclude adequate delineation of the soft tissues near high-density structures such as bone. Use of the negative mode in the development cycle p...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/124.3.689
更新日期:1977-09-01 00:00:00
abstract:PURPOSE:To evaluate oxygen-enhanced T1-mapping magnetic resonance (MR) imaging as a noninvasive method for visualization and quantification of regional inflammation after segmental allergen challenge in asthmatic patients compared with control subjects. MATERIALS AND METHODS:After institutional review board approval, ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.14132607
更新日期:2015-01-01 00:00:00
abstract::The authors adapted the transport system of a computed tomographic (CT) scanner with continuous rotation capability to examine complete lung subvolumes during a single breath hold. Twenty-four adult patients underwent scanning with up to 12 continuous 1-second rotations, and data acquisition was synchronized with long...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.176.3.2389050
更新日期:1990-09-01 00:00:00
abstract:PURPOSE:To assess the anatomic development of native arteriovenous fistula (AVF) during the first 6 weeks after creation by using ultrasonographic (US) measurements in a multicenter hemodialysis fistula maturation study. MATERIALS AND METHODS:Each institutional review board approved the prospective study protocol, and...
journal_title:Radiology
pub_type: 杂志文章,多中心研究
doi:10.1148/radiol.2015150385
更新日期:2016-05-01 00:00:00
abstract::Recent advances in ultrasound and computed tomography have permitted localization of orbital lesions, and sophisticated high-energy irradiation techniques facilitate improved dose distribution without significant damage to normal tissue. Three patients treated for orbital pseudotumor are discussed. ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/127.2.507
更新日期:1978-05-01 00:00:00
abstract::History A 52-year-old man with a history of urinary tract infections and a previous clinical diagnosis of left inguinal hernia presented to the nephrologist with recent onset of dysuria and increasing swelling in the left inguinoscrotal region in the absence of fever or scrotal trauma. There was no relevant surgical o...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.16141805
更新日期:2016-06-01 00:00:00
abstract::Background Early stage hepatocellular carcinoma (HCC) is the ideal candidate for resection in patients with preserved liver function; however, cancer will recur in half of these patients and no reliable prognostic tool has been established. Purpose To investigate the effectiveness of radiomic features in predicting tu...
journal_title:Radiology
pub_type: 杂志文章,多中心研究
doi:10.1148/radiol.2020191470
更新日期:2020-03-01 00:00:00
abstract:PURPOSE:To quantify regional ejection fraction (EF) in patients with myocardial infarction (MI) by using merged late gadolinium enhancement (LGE) and cine magnetic resonance (MR) imaging, and compare this method with the standardized 17-segment American Heart Association approach. MATERIALS AND METHODS:After instituti...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2493080340
更新日期:2009-01-01 00:00:00
abstract::Cerebral amyloid angiopathy (CAA) is a cause of intracerebral hemorrhage in a significant proportion of normotensive patients. Two cases of pathologically proved multiple intracerebral hemorrhages due to CAA are reported. These hemorrhages are accurately demonstrated on computed tomography and are typically superficia...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.151.2.6709910
更新日期:1984-05-01 00:00:00
abstract:PURPOSE:To determine whether computed tomographic (CT) findings can help differentiate between benign and clinically worrisome causes of pneumatosis intestinalis (PI) in children. MATERIALS AND METHODS:This retrospective study was approved by the institutional review board, and requirement for informed consent was wai...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2532090168
更新日期:2009-11-01 00:00:00
abstract:PURPOSE:To evaluate the effect of in utero exposure to a single dose of water-soluble intravenous iodinated contrast medium on thyroid function at birth. MATERIALS AND METHODS:This study was approved by the institutional review board, with waiver of consent, and was HIPAA compliant. Maternal and newborn records were r...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.10100163
更新日期:2010-09-01 00:00:00
abstract:PURPOSE:To determine whether liver tumor detection is increased by acquiring multiple dynamic arterial phase and portal venous phase magnetic resonance (MR) images. MATERIALS AND METHODS:Dynamic MR imaging was performed in 205 patients at 1.5 T with use of a fast spoiled gradient-echo technique (repetition time, 9-12 ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.201.2.8888220
更新日期:1996-11-01 00:00:00
abstract::Computed tomographic metrizamide myelography (CTMM) was performed on 25 infants and children and 2 adults with normal spinal cords. Both the cord and the cauda equina were precisely outlined. The most detailed information was obtained with a small window setting, with the image subsequently magnified and color-reverse...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/130.3.691
更新日期:1979-03-01 00:00:00
abstract::Hyperpolarized metabolic magnetic resonance (MR) imaging offers greatly enhanced sensitivity to multinuclear MR spectroscopy, opening up a new tool with which to noninvasively assess metabolic changes in the diseased heart. In this issue of Radiology, O h-Ici et al ( 1 ) have demonstrated this ability by exploring the...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2016152489
更新日期:2016-03-01 00:00:00
abstract::A review of the sonographic findings in 17 children with non-inflammatory neck masses suggests that while ultrasound is nonspecific with regard to the differential diagnosis, it can show whether a mass is cystic, solid, or complex. Sonography is also useful in clarifying the anatomical extent of a lesion and involveme...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.147.3.6682560
更新日期:1983-06-01 00:00:00
abstract::Clinical, radiographic, and radionuclide angiographic findings of three cases of jugular glomic tumor associated with hearing loss are discussed. In one case computed tomographic findings are discussed. It is concluded that radioisotopic techniques may be useful in diagnosis and follow-up of this tumor. ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/121.3.673
更新日期:1976-12-01 00:00:00
abstract::Lung scintigrams and pulmonary angiograms of 111 patients with suspected pulmonary embolism who had matching perfusion defects and radiographic abnormalities (infiltrate, atelectasis, or effusion) were reviewed. In 14 patients perfusion defects were substantially smaller than the corresponding radiographic opacity; on...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/133.1.189
更新日期:1979-10-01 00:00:00
abstract::With the recent improvements in diagnosis and treatment of distal radius and carpal injuries, the hand surgeons' expectations of relevant radiologic interpretation of imaging studies are heightened. Conventional radiographic examinations, as well as more sophisticated and invasive studies, have important roles in the ...
journal_title:Radiology
pub_type: 杂志文章,评审
doi:10.1148/radiology.219.1.r01ap1311
更新日期:2001-04-01 00:00:00
abstract:PURPOSE:To determine the feasibility and safety of ultrasonographically (US) guided percutaneous radiofrequency (RF) ablation in the local treatment of invasive breast carcinomas 2 cm or less in greatest diameter. MATERIALS AND METHODS:RF ablation of 21 malignant lesions was performed in 20 patients immediately before...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2311030651
更新日期:2004-04-01 00:00:00
abstract::Magnetic resonance imaging of the pituitary gland in a patient with secondary hemochromatosis is described. On T1-weighted images, the anterior lobe had almost no signal intensity, and only the high-signal posterior lobe was seen. These findings are compatible with the distribution of iron deposition and clinical symp...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.168.1.3380960
更新日期:1988-07-01 00:00:00
abstract::The sequelae of disk degeneration are among the leading causes of functional incapacity in both sexes and are a common source of chronic disability in the working years. Disk degeneration involves structural disruption and cell-mediated changes in composition. Mechanical, traumatic, nutritional, and genetic factors al...
journal_title:Radiology
pub_type: 杂志文章,评审
doi:10.1148/radiol.2451051706
更新日期:2007-10-01 00:00:00