Abstract:
:Background Existing guidelines are inconsistent regarding the indications for staging brain MRI in patients with newly diagnosed, early-stage non-small cell lung cancer (NSCLC). Purpose To evaluate the diagnostic yield of staging brain MRI in the initial evaluation of lung cancer. Materials and Methods This retrospective, observational, single-institution study included patients with newly diagnosed NSCLC who underwent staging chest CT and staging brain MRI from November 2017 to October 2018. Diagnostic yield was defined as the proportion of patients with brain metastases among all patients. Yield was stratified into clinical stage groups per the eighth edition of the American Joint Committee on Cancer staging guidelines, based on staging chest CT and in adenocarcinoma with epidermal growth factor receptor (EGFR) gene mutation and anaplastic lymphoma kinase (ALK) gene rearrangement. Subgroup analyses were performed on the basis of cell types and molecular markers. The χ2 test was performed to compare the diagnostic yields, and Bonferroni correction was used to account for multiple testing between stage groups. Results A total of 1712 patients (mean age, 64 years ± 10 [standard deviation]; 1035 men) were included. The diagnostic yield of staging brain MRI in newly diagnosed NSCLC was 11.9% (203 of 1712; 95% confidence interval [CI]: 10.4%, 13.5%). In clinical stage IA, IB, and II disease, the diagnostic yields were 0.3% (two of 615; 95% CI: 0.0%, 1.2%), 3.8% (seven of 186; 95% CI: 1.5%, 7.6%), and 4.7% (eight of 171; 95% CI: 2.0%, 9.0%), respectively. The diagnostic yield was higher in patients with adenocarcinoma (13.6%; 176 of 1297; 95% CI: 11.8%, 15.6%) than squamous cell carcinoma (5.9%; 21 of 354; 95% CI: 3.7%, 8.9%) and in patients with EGFR mutation-positive adenocarcinoma (17.5%; 85 of 487; 95% CI: 14.2%, 21.1%) than with EGFR mutation-negative adenocarcinoma (10.6%; 68 of 639; 95% CI: 8.4%, 13.3%) (P < .001 for both). Conclusion The diagnostic yield of staging brain MRI in clinical stage IA non-small cell lung cancer was low, but staging brain MRI had a higher diagnostic yield in clinical stage IB and epidermal growth factor receptor mutation-positive adenocarcinoma. © RSNA, 2020 Online supplemental material is available for this article.
journal_name
Radiologyjournal_title
Radiologyauthors
Kim M,Suh CH,Lee SM,Kim HC,Aizer AA,Yanagihara TK,Bai HX,Guenette JP,Huang RY,Kim HSdoi
10.1148/radiol.2020201194subject
Has Abstractpub_date
2020-11-01 00:00:00pages
419-427issue
2eissn
0033-8419issn
1527-1315journal_volume
297pub_type
杂志文章相关文献
RADIOLOGY文献大全abstract:PURPOSE:To quantitatively determine the delivery of systemic liposomal doxorubicin to tumors treated with pulsed high-intensity focused ultrasound and to study the mechanism underlying this delivery in a murine model. MATERIALS AND METHODS:All animal work was performed in compliance with guidelines and approval of ins...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2342030889
更新日期:2005-02-01 00:00:00
abstract:PURPOSE:To determine the feasibility and accuracy of a protocol for calculating whole-organ renal perfusion (renal blood flow [RBF]) and regional perfusion on the basis of biphasic computed tomography (CT), with concurrent dynamic contrast material-enhanced (DCE) CT perfusion serving as the reference standard. MATERIA...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2015142757
更新日期:2016-04-01 00:00:00
abstract:PURPOSE:To retrospectively compare the pain control requirements of patients undergoing computed tomography (CT)-guided percutaneous radiofrequency (RF) ablation with those of patients undergoing CT-guided percutaneous cryoablation of small (< or = 4-cm) renal tumors. MATERIALS AND METHODS:The study was HIPAA complian...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2371040829
更新日期:2005-10-01 00:00:00
abstract:PURPOSE:To determine the computed tomographic (CT) findings in patients with allergic fungal sinusitis. MATERIALS AND METHODS:The authors retrospectively reviewed CT scans and surgical and histopathologic reports in 45 patients (27 male, 18 female; age range, 8-68 years) with allergic fungal sinusitis from multiple in...
journal_title:Radiology
pub_type: 杂志文章,多中心研究
doi:10.1148/radiology.207.2.9577490
更新日期:1998-05-01 00:00:00
abstract::All screening radiographs of the chest and other medical records of 107 patients with histologically proved lung cancer in a fixed population were reviewed to assess the efficacy of biennial chest radiography in detecting lung cancer. Radiographic abnormalities caused by tumors were initially detected in 58 patients (...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.148.2.6306720
更新日期:1983-08-01 00:00:00
abstract:PURPOSE:To compare various subjective, empiric, and pharmacokinetic methods for interpreting findings at dynamic magnetic resonance (MR) imaging of the breast. MATERIALS AND METHODS:Dynamic spiral breast MR imaging was performed in 52 women suspected of having or with known breast disease. Gadolinium-enhanced images w...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.209.2.9807580
更新日期:1998-11-01 00:00:00
abstract::The value of computed tomography (CT) in determining the cause of obstructive jaundice in 67 proved cases is described. The presence of stones, the level of obstruction, the relative size of the ringlike structures produced by the dilated bile duct, and the shape of the distal visualized ring have proved to be the mos...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.139.3.7232730
更新日期:1981-06-01 00:00:00
abstract:PURPOSE:To use videomicroscopy of tumor-bearing livers of live mice to depict tumors directly to determine the exact nature of rims seen on corresponding ultrasonographic (US) scans. MATERIALS AND METHODS:Seventy-six hepatic colorectal cancer metastases were studied in exteriorized livers of 18 mice by using intravita...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.215.3.r00jn16852
更新日期:2000-06-01 00:00:00
abstract::In order to test a hypothesis that the routine use of one midsagittal and four preselected coronal reconstruction images would disclose lesions unsuspected on standard cranial computed tomography (CT) scans, 204 patient examinations were subjected to such multiplanar reconstruction manipulation; the original CT diagno...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.140.1.7244210
更新日期:1981-07-01 00:00:00
abstract::Portable sustained graded traction for control of the displaced cervical spine particularly for patients undergoing tomography or gas myelography, is described. ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/125.3.826
更新日期:1977-12-01 00:00:00
abstract::Six cases of bronchogenic carcinoma metastatic to bone are reported in which the radiographic pattern of the skeletal metastases was remarkably similar. In each case, the osseous involvement was predominantly cortical, producing a focal area of geographic bone destruction. Predominant roentgen involvement of the corte...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.137.1.7422860
更新日期:1980-10-01 00:00:00
abstract::A transhepatic computed-tomographic-guided biopsy of a right adrenal mass is described. This method is simpler to perform than the usual posterior biopsy carried out with the patient prone and is less likely to cause a complicating pneumothorax. In seven of eight patients with right adrenal masses, adrenal tissue was ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.148.2.6867360
更新日期:1983-08-01 00:00:00
abstract:PURPOSE:To compare a glycosaminoglycan chemical exchange saturation transfer (gagCEST) imaging method, which enables sampling of the water signal as a function of the presaturation offset (z-spectrum) at 13 points in clinically feasible imaging times, with sodium 23 ((23)Na) magnetic resonance (MR) imaging in patients ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.11101841
更新日期:2011-07-01 00:00:00
abstract::Radiographs of 45 patients with evidence of acute unilateral ureteral obstruction at intravenous urography, obtained at least 24 hours after injection of contrast material, were retrospectively studied. Vicarious contrast material excretion (VCME) as evidence by gallbladder opacification on delayed radiographs was see...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.177.3.2243980
更新日期:1990-12-01 00:00:00
abstract::Background Cardiac MRI late gadolinium enhancement (LGE) scar volume is an important marker for outcome prediction in patients with hypertrophic cardiomyopathy (HCM); however, its clinical application is hindered by a lack of measurement standardization. Purpose To develop and evaluate a three-dimensional (3D) convolu...
journal_title:Radiology
pub_type: 杂志文章,多中心研究
doi:10.1148/radiol.2019190737
更新日期:2020-01-01 00:00:00
abstract::The diagnostic accuracy of both planar and single-photon emission computed tomography (SPECT) bone scintigraphy, radionuclide angiography, arthrography, and conventional radiography was evaluated in 36 patients with temporomandibular joint (TMJ) dysfunction undergoing preoperative testing. The sensitivity of SPECT bon...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.149.2.6226060
更新日期:1983-11-01 00:00:00
abstract::The sonograms of 34 patients with surgically proved pelvic hemoperitoneum were reviewed. In 15 of these patients clotted blood was found at surgery in the pelvis or cul-de-sac. In nine of these patients (60%), ultrasound demonstrated echogenic fluid collections or "masses" with an echogenicity equal to or greater than...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.145.1.7122870
更新日期:1982-10-01 00:00:00
abstract:PURPOSE:To measure scanner and patient variation in computed tomographic (CT) numbers for electron-beam CT and to determine the ability of calibration phantoms to reduce variability in calcium quantitation. MATERIALS AND METHODS:Two calibration phantoms were imaged to ensure longitudinal homogeneity and to determine t...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.196.1.7784560
更新日期:1995-07-01 00:00:00
abstract:PURPOSE:To describe and evaluate a method of tomosynthesis breast imaging with a full-field digital mammographic system. MATERIALS AND METHODS:In this tomosynthesis method, low-radiation-dose images were acquired as the x-ray source was moved in an arc above the stationary breast and digital detector. A step-and-expos...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.205.2.9356620
更新日期:1997-11-01 00:00:00
abstract:PURPOSE:To compare the diagnostic accuracy of two-dimensional (2D) full-field digital mammography with that of two-view (mediolateral and craniocaudal) and single-view (mediolateral oblique) tomosynthesis in an observer study involving two institutions. MATERIALS AND METHODS:Ethical committee approval was obtained. Al...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.11103514
更新日期:2012-03-01 00:00:00
abstract::A retrospective study involving 498 women with a total of 666 breast lesions was undertaken to determine the relative efficacy of one- and two-view mammography in the follow-up evaluation of "low-suspicion" abnormal mammographic findings. These abnormalities consisted of well-defined masses (47.1%), well-defined punct...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.180.2.2068300
更新日期:1991-08-01 00:00:00
abstract::This study evaluates the mammographic findings in 352 patients, aged 30-85 years, who underwent spot localization and biopsy for evaluation of nonpalpable breast abnormalities. Malignancy was found at biopsy in 114 cases. The mammographic appearance (specifically, whether grouped microcalcifications, mass, or both wer...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.169.2.2845470
更新日期:1988-11-01 00:00:00
abstract::Two cases of adenoid cystic carcinoma of the trachea, and a review of the literature, are presented. This unusual and often undiagnosed tumor closely mimics asthma and chronic bronchitis. Although many patients die within 2 to 3 years of the onset of symptoms without appropriate treatment, adequate therapy should lead...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/122.3.597
更新日期:1977-03-01 00:00:00
abstract:PURPOSE:To assess pregnancy outcome in patients with amniotic sheets and to determine whether outcome is affected by placental implantation on the amniotic sheet. MATERIALS AND METHODS:Sonograms obtained during the 2nd and 3rd trimesters were reviewed in 157 patients with amniotic sheets to confirm the presence of an ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.206.3.9494500
更新日期:1998-03-01 00:00:00
abstract::Although intravascular foreign bodies are routinely removed with percutaneous extraction, surgical retrieval is performed of most nonvascular foreign bodies. The authors describe six cases in which percutaneous extraction was performed for removal of nonvascular foreign bodies. These foreign bodies included an intraab...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.187.3.8497610
更新日期:1993-06-01 00:00:00
abstract::This report describes the radiologic appearance of the intravenous oxygenator (IVOX), an intracorporeal CO2-O2 exchanger for use in patients with severe respiratory deficiency, and the extensive radiographic and sonographic support required for its use. Six patients aged 19-39 years who had severe adult respiratory di...
journal_title:Radiology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1148/radiology.187.3.8497630
更新日期:1993-06-01 00:00:00
abstract::The number of folds in the proximal jejunum was measured retrospectively in 25 studies of patients with adult celiac disease and 75 control subjects. The average number of folds per inch of proximal jejunum in the group with celiac disease was 2.88 (none to five), as against 4.88 (three to seven) in the controls. The ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.158.3.3945730
更新日期:1986-03-01 00:00:00
abstract:PURPOSE:To determine if the addition of three-dimensional (3D) proton magnetic resonance (MR) spectroscopic imaging to endorectal MR imaging helps diagnose extracapsular extension (ECE) of prostate cancer. MATERIALS AND METHODS:Endorectal MR imaging and 3D MR spectroscopic imaging were performed in 53 patients with pr...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.213.2.r99nv26481
更新日期:1999-11-01 00:00:00
abstract:PURPOSE:To assess interobserver and intraobserver reliability of three quantitative measures of coronary artery calcium burden: calcium "score," number of calcified lesions, and calcified area. MATERIALS AND METHODS:Electron beam computed tomographic (CT) scanning was used in a series of 25 patients to detect coronary...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.190.2.8284380
更新日期:1994-02-01 00:00:00
abstract::The American College of Radiology's Commission on Nuclear Magnetic Resonance has recommended adoption of the term "Magnetic Resonance" as a replacement. The author offers background and rationale for this shift in terminology. ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.150.1.6689780
更新日期:1984-01-01 00:00:00