Abstract:
PURPOSE:To compare a glycosaminoglycan chemical exchange saturation transfer (gagCEST) imaging method, which enables sampling of the water signal as a function of the presaturation offset (z-spectrum) at 13 points in clinically feasible imaging times, with sodium 23 ((23)Na) magnetic resonance (MR) imaging in patients after cartilage repair surgery (matrix-associated autologous chondrocyte transplantation and microfracture therapy). MATERIALS AND METHODS:One female patient (67.3 years), and 11 male patients (median age, 28.8 years; interquartile range [IQR], 24.6-32.3 years) were examined with a 7-T whole-body system, with approval of the local ethics committee after written informed consent was obtained. A modified three-dimensional gradient-echo sequence and a 28-channel knee coil were used for gagCEST imaging. (23)Na imaging was performed with a circularly polarized knee coil by using a modified gradient-echo sequence. Statistical analysis of differences and Spearman correlation were applied. RESULTS:The median of asymmetries in gagCEST z-spectra summed over all offsets from 0 to 1.3 ppm was 7.99% (IQR, 6.33%-8.79%) in native cartilage and 5.13% (IQR, 2.64%-6.34%) in repair tissue. A strong correlation (r = 0.701; 95% confidence interval: 0.21, 0.91) was found between ratios of signal intensity from native cartilage to signal intensity from repair tissue obtained with gagCEST or (23)Na imaging. The median of dimensionless ratios between native cartilage and repair tissue was 1.28 (IQR, 1.20-1.58) for gagCEST and 1.26 (IQR, 1.21-1.48) for (23)Na MR imaging. CONCLUSION:The high correlation between the introduced gagCEST method and (23)Na imaging implies that gagCEST is a potentially useful biomarker for glycosaminoglycans.
journal_name
Radiologyjournal_title
Radiologyauthors
Schmitt B,Zbýn S,Stelzeneder D,Jellus V,Paul D,Lauer L,Bachert P,Trattnig Sdoi
10.1148/radiol.11101841subject
Has Abstractpub_date
2011-07-01 00:00:00pages
257-64issue
1eissn
0033-8419issn
1527-1315pii
radiol.11101841journal_volume
260pub_type
杂志文章相关文献
RADIOLOGY文献大全abstract::Methyl glucamine sodium diatrizoate (Renografin 76) was directly infused into the isolated arteries to the sino-atrial and atrioventricular nodes of anesthetized dogs, causing a dose-related inhibition of sino-atrial nodal automaticity and atrioventricular nodal conductivity; these effects were not attenuated by auton...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/121.1.205
更新日期:1976-10-01 00:00:00
abstract:PURPOSE:To compare the accuracy of magnetic resonance (MR) imaging with that of the current clinical standard of endoscopy and endoscopic biopsy, to determine whether MR imaging depicts subclinical cancers missed at endoscopy and endoscopic biopsy, and to determine whether MR imaging can identify patients without nasop...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.10101241
更新日期:2011-02-01 00:00:00
abstract::Evaluation of graft patency following reconstructive venous surgery may be difficult, especially in patients in whom a distal arteriovenous fistula has been constructed. We describe a method of visualizing these venous bypass grafts using digital subtraction angiography that is easy and provides satisfactory results. ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.160.1.3520650
更新日期:1986-07-01 00:00:00
abstract::Presacral abscesses developed in two men (aged 59 and 76 years) after abdominoperineal resection. Computed tomography was performed to demonstrate the distance from the abscess to the perineum and the distance of the abscess anterior to the sacrum. Then, lateral and anteroposterior fluoroscopy was performed to guide t...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.190.2.8284420
更新日期:1994-02-01 00:00:00
abstract:PURPOSE:To describe the magnetic resonance (MR) imaging findings of subcutaneous granuloma annulare (SGA), a rare mass of early childhood. MATERIALS AND METHODS:MR imaging studies and clinical records in six children aged 2 1/2-4 years in whom SGA was diagnosed between 1993 and 1997 were retrospectively reviewed. All ...
journal_title:Radiology
pub_type: 杂志文章,评审
doi:10.1148/radiology.210.3.r99mr11845
更新日期:1999-03-01 00:00:00
abstract::The intracarotid amobarbital sodium, or Wada, test has been used to localize speech and memory function prior to surgical treatment of temporal lobe seizures. The authors mixed technetium-99m hexamethyl-propyleneamine oxime (HMPAO) with amobarbital sodium and injected the mixture in 25 patients with epilepsy. Single p...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.178.3.1994430
更新日期:1991-03-01 00:00:00
abstract::Extracranial applications of diffusion-weighted (DW) magnetic resonance (MR) imaging are gaining increasing importance, including in head and neck radiology. The main indications for performing DW imaging in this relatively small but challenging region of the body are tissue characterization, nodal staging, therapy mo...
journal_title:Radiology
pub_type: 杂志文章,评审
doi:10.1148/radiol.11101821
更新日期:2012-04-01 00:00:00
abstract:PURPOSE:To determine the transvaginal hysterosonographic appearances of benign and malignant endometrial disease. MATERIALS AND METHODS:From April 11, 1994, through August 1, 1996, a total of 88 women (age range, 25-81 years) underwent transvaginal hysterosonography and histopathologic evaluation of the endometrium af...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.210.2.r99fe37393
更新日期:1999-02-01 00:00:00
abstract::In magnetic resonance (MR) imaging the distinction between vascular signal from flowing blood and thrombus of any nature is often difficult. Even though there are qualitative criteria to identify intravascular signal as coming from flowing blood, these can fail, and no definitive statement can be made on the nature of...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.164.2.3602400
更新日期:1987-08-01 00:00:00
abstract:PURPOSE:To retrospectively assess the apparent diffusion coefficient (ADC) for prediction of malignancy and prognosis of malignant astrocytic tumors. MATERIALS AND METHODS:The institutional review board approved this study and did not require patient informed consent. Findings from 37 consecutive patients (21 men, 16 ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2413051276
更新日期:2006-12-01 00:00:00
abstract::Blunt trauma to the abdomen is the main cause of pancreatic injury in childhood. One of the most common causes of injury is child abuse. Pancreatitis, pancreatic pseudocyst, and loculated peripancreatic effusion are sequellae of this trauma. The diagnosis of these lesions is aided by ultrasound. Pancreatic injury in c...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.135.1.6153810
更新日期:1980-04-01 00:00:00
abstract:PURPOSE:To investigate the effects of increasing doses of angiotensin II on hepatic hemodynamics in the normal rabbit liver and in hepatic VX2 tumors by using dynamic contrast material-enhanced perfusion computed tomography (CT). MATERIALS AND METHODS:This study was approved by the institutional animal care and use co...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.11101868
更新日期:2011-09-01 00:00:00
abstract::History A 57-year-old woman presented with right breast swelling and enlargement and a palpable mass in the right lower inner breast. There was no history of fever, trauma, skin redness, or nipple discharge. The patient had a history of breast augmentation, with retropectoral silicone implants placed 2.5 years ago. Sc...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2018160440
更新日期:2018-08-01 00:00:00
abstract::The radiopharmaceutical iodine 131 metaiodobenzylguanidine (I-131 MIBG) has been shown to locate pheochromocytomas scintigraphically with a false-negative rate of approximately 13%. To improve image quality and reduce the false-negative rate, I-123 was examined as a radioactive label for MIBG, as it has many advantage...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.155.3.4001380
更新日期:1985-06-01 00:00:00
abstract::Gadolinium-labeled diethylenetriaminepentaacetic acid was used as a contrast agent for stereotactic magnetic resonance (MR) imaging in six selected patients with brain tumors who underwent stereotactic biopsy. Regions of contrast enhancement demonstrated by computed tomography (CT) and MR imaging in four of the six pa...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.166.3.2829270
更新日期:1988-03-01 00:00:00
abstract:PURPOSE:To characterize early changes in cardiac anatomy and function for lamin A/C gene (LMNA) mutation carriers by using magnetic resonance (MR) imaging and to develop tools to analyze and visualize the findings. MATERIALS AND METHODS:The ethical review board of the institution approved the study, and informed writt...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2491071584
更新日期:2008-10-01 00:00:00
abstract:PURPOSE:To compare the performance of magnetic resonance (MR) imaging after the administration of superparamagnetic iron oxide (SPIO) and dual-phase computed tomography (CT) in the depiction of liver metastases. MATERIALS AND METHODS:Fifty-one hepatic resection candidates with known colorectal metastases were examined...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.210.2.r99fe05459
更新日期:1999-02-01 00:00:00
abstract::Five infants with intrathoracic transdiaphragmatic duplication cysts are presented. Diagnosis was possible from the combination of several features on plain chest radiographs: (a) right-sided cystic areas lying posteriorly in the chest, (b) lower cervical or upper dorsal spinal dysraphism, and (c) unusual gas collecti...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/131.3.663
更新日期:1979-06-01 00:00:00
abstract::In a study of 726 patients, xeroradiography of the thyroid using a modified oblique projection was found to be superior to conventional soft-tissue radiography in detecting calcification in thyroid tumors because of edge enhancement. This facilitated a diagnosis of carcinoma in 75% of 68 primary tumors and 55% of 33 r...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.141.2.7291570
更新日期:1981-11-01 00:00:00
abstract:PURPOSE:To characterize the effect of low-frequency contrast material-enhanced ultrasound on the vascular endothelium and to determine the parameters and techniques required to deliver a therapeutic agent by using the chorioallantoic membrane (CAM) model. MATERIALS AND METHODS:All in vivo animal procedures were conduc...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2431060167
更新日期:2007-04-01 00:00:00
abstract::The Investigational Review Board approved the protocol, and all patients provided signed informed consent. The protocol was compliant with HIPAA. The purpose of the study was to prospectively test the hypothesis that addition of low-dose dobutamine and quantification of inotropic reserve in segments with 1%-50% infarc...
journal_title:Radiology
pub_type: 临床试验,杂志文章
doi:10.1148/radiol.2403051150
更新日期:2006-09-01 00:00:00
abstract::Purpose To reduce radiotracer requirements for amyloid PET/MRI without sacrificing diagnostic quality by using deep learning methods. Materials and Methods Forty data sets from 39 patients (mean age ± standard deviation [SD], 67 years ± 8), including 16 male patients and 23 female patients (mean age, 66 years ± 6 and ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2018180940
更新日期:2019-03-01 00:00:00
abstract:PURPOSE:To compare quantified measurements with color Doppler ultrasonography (US) with those obtained with conventional duplex US in the differential diagnosis of suspect lesions in the breast. MATERIALS AND METHODS:A computer-assisted protocol was used to calculate the color pixel density (CPD) and the mean color va...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.192.3.8058950
更新日期:1994-09-01 00:00:00
abstract::Doppler sonography and magnetic resonance (MR) angiography were prospectively used in combination as a substitute for conventional angiography in 24 consecutive patients likely to undergo carotid endarterectomy. Of 19 patients (20 lesions) who underwent carotid endarterectomy, 18 had not undergone preoperative angiogr...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.186.2.8421730
更新日期:1993-02-01 00:00:00
abstract::An investigation of the relationship between breast parenchymal patterns and breast cancer prevalence in a large referral population is presented. Mammograms were assigned to one of four categories according to our interpretation of Wolfe's classification. Cancer prevalence for the four patterns was similar when uncor...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/125.2.387
更新日期:1977-11-01 00:00:00
abstract::One hundred forty patients with testicular seminoma were treated at the State University of New York Health Science Center at Syracuse between 1966 and 1985. Disease was classified as stage II in 32 patients (23%): stage IIA in 21 patients and stage IIB in 11 patients. All patients underwent irradiation below the diap...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.172.2.2748840
更新日期:1989-08-01 00:00:00
abstract::Sustentacular-talar tarsal coalitions can be difficult to detect radiographically. The sustentacular-talar articulation is a part of the talocalcaneonavicular joint. Thus, arthrography of this joint, combined with tangential views of the sustentaculotalar articulation (Harris views), provides a new and simple method t...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/15.3.730
更新日期:1975-06-01 00:00:00
abstract:PURPOSE:To evaluate the clinical, pathologic, and magnetic resonance (MR) imaging findings in adenoma malignum, a rare variant of uterine cervical adenocarcinoma. MATERIALS AND METHODS:Medical records of all patients (n = 7) with adenoma malignum of the uterine cervix diagnosed pathologically between 1988 and 1996 wer...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.204.1.9205220
更新日期:1997-07-01 00:00:00
abstract::Areas of sclerosis in the phalanges, particularly the terminal phalanges, are common in sarcoidosis despite the rarity of osteosclerotic changes in other bones. Of 37 patients with sarcoidosis with osseous changes of the hands or feet, 20 (54%) has sclerosis either alone or in combination with bone destruction. Of 48 ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/115.2.279
更新日期:1975-05-01 00:00:00
abstract::Computed tomography (CT) is widely used to assess patients with nonspecific abdominal pain or who are suspected of having colitis. The authors recommend multidetector CT with oral, rectal, and intravenous contrast material and thin sections, which can accurately demonstrate inflammatory changes in the colonic wall and...
journal_title:Radiology
pub_type: 杂志文章,评审
doi:10.1148/radiol.2403050818
更新日期:2006-09-01 00:00:00