Abstract:
:The Quantitative Imaging Biomarkers Alliance (QIBA) Profile for fluorodeoxyglucose (FDG) PET/CT imaging was created by QIBA to both characterize and reduce the variability of standardized uptake values (SUVs). The Profile provides two complementary claims on the precision of SUV measurements. First, tumor glycolytic activity as reflected by the maximum SUV (SUVmax) is measurable from FDG PET/CT with a within-subject coefficient of variation of 10%-12%. Second, a measured increase in SUVmax of 39% or more, or a decrease of 28% or more, indicates that a true change has occurred with 95% confidence. Two applicable use cases are clinical trials and following individual patients in clinical practice. Other components of the Profile address the protocols and conformance standards considered necessary to achieve the performance claim. The Profile is intended for use by a broad audience; applications can range from discovery science through clinical trials to clinical practice. The goal of this report is to provide a rationale and overview of the FDG PET/CT Profile claims as well as its context, and to outline future needs and potential developments.
journal_name
Radiologyjournal_title
Radiologyauthors
Kinahan PE,Perlman ES,Sunderland JJ,Subramaniam R,Wollenweber SD,Turkington TG,Lodge MA,Boellaard R,Obuchowski NA,Wahl RLdoi
10.1148/radiol.2019191882subject
Has Abstractpub_date
2020-03-01 00:00:00pages
647-657issue
3eissn
0033-8419issn
1527-1315journal_volume
294pub_type
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