Hybrid PET/MR imaging of the heart: feasibility and initial results.

Abstract:

PURPOSE:To assess the feasibility of hybrid imaging of the heart with fluorine 18 fluorodeoxyglucose (FDG) on an integrated 3-T positron emission tomography (PET)/magnetic resonance (MR) imaging system. MATERIALS AND METHODS:The present study was approved by the local institutional review board. Written informed consent was obtained from all patients before imaging. Twenty consecutive patients with myocardial infarction (n = 20) underwent cardiac PET/MR imaging examination. Ten patients underwent additional cardiac PET/computed tomography (CT) before PET/MR. Two-dimensional half-Fourier acquisition single-shot turbo spin-echo sequences, balanced steady-state free precession cine sequences, two-dimensional turbo inversion-recovery magnitude T2-weighted sequences, and late gadolinium-enhanced (LGE) segmented two-dimensional inversion-recovery turbo fast low-angle shot sequences were performed. According to the 17-segment model, PET tracer uptake, wall motion, and late gadolinium enhancement were visually assessed for each segment on a binary scale, and categorical intermethod agreement was calculated by using the Cohen κ. The maximum standardized uptake value was measured in corresponding myocardial locations on PET/CT and PET/MR images. RESULTS:Agreement was substantial over all patients and segments between PET and LGE images (κ = 0.76) and between PET and cine images (κ = 0.78). In 306 segments, 97 (32%) were rated as infarcted on PET images, compared with 93 (30%) rated as infarcted on LGE images and with 90 (29%) rated as infarcted on cine images. In a subgroup of patients (n = 10) with an additional PET/CT scan, no significant difference in myocardial tracer uptake between PET/CT and PET/MR images was found (paired t test, P = .95). CONCLUSION:Cardiac PET/MR imaging with FDG is feasible and may add complementary information in patients with ischemic heart disease.

journal_name

Radiology

journal_title

Radiology

authors

Nensa F,Poeppel TD,Beiderwellen K,Schelhorn J,Mahabadi AA,Erbel R,Heusch P,Nassenstein K,Bockisch A,Forsting M,Schlosser T

doi

10.1148/radiol.13130231

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

366-73

issue

2

eissn

0033-8419

issn

1527-1315

pii

radiol.13130231

journal_volume

268

pub_type

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