Abstract:
:Many membrane-bound molecules in cells form small clusters. It has been hypothesized that these clusters convert an analog extracellular signal into a digital intracellular signal and that this conversion increases signaling fidelity. However, the mechanism by which clusters digitize a signal and the subsequent effects on fidelity remain poorly understood. Here we demonstrate using a stochastic model of cooperative cluster formation that sufficient cooperation leads to digital signaling. We show that despite reducing the number of output states, which decreases fidelity, digitization also reduces noise in the system, which increases fidelity. The tradeoff between these effects leads to an optimal cluster size that agrees with experimental measurements.
journal_name
Biophys Jjournal_title
Biophysical journalauthors
Roob E 3rd,Trendel N,Rein Ten Wolde P,Mugler Adoi
10.1016/j.bpj.2016.02.031subject
Has Abstractpub_date
2016-04-12 00:00:00pages
1661-1669issue
7eissn
0006-3495issn
1542-0086pii
S0006-3495(16)00219-8journal_volume
110pub_type
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