Synchronization of pancreatic islet oscillations by intrapancreatic ganglia: a modeling study.

Abstract:

:Plasma insulin measurements from mice, rats, dogs, and humans indicate that insulin levels are oscillatory, reflecting pulsatile insulin secretion from individual islets. An unanswered question, however, is how the activity of a population of islets is coordinated to yield coherent oscillations in plasma insulin. Here, using mathematical modeling, we investigate the feasibility of a potential islet synchronization mechanism, cholinergic signaling. This hypothesis is based on well-established experimental evidence demonstrating intrapancreatic parasympathetic (cholinergic) ganglia and recent in vitro evidence that a brief application of a muscarinic agonist can transiently synchronize islets. We demonstrate using mathematical modeling that periodic pulses of acetylcholine released from cholinergic neurons is indeed able to coordinate the activity of a population of simulated islets, even if only a fraction of these are innervated. The role of islet-to-islet heterogeneity is also considered. The results suggest that the existence of cholinergic input to the pancreas may serve as a regulator of endogenous insulin pulsatility in vivo.

journal_name

Biophys J

journal_title

Biophysical journal

authors

Fendler B,Zhang M,Satin L,Bertram R

doi

10.1016/j.bpj.2009.05.016

subject

Has Abstract

pub_date

2009-08-05 00:00:00

pages

722-9

issue

3

eissn

0006-3495

issn

1542-0086

pii

S0006-3495(09)01019-4

journal_volume

97

pub_type

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