Abstract：
BACKGROUND:Leishmaniasis is a parasitic disease that appears with a range of symptoms including cutaneous, mucocutaneous, and visceral leishmaniasis. The present study sought to determine the antileishmanial effect of the extract of Artemisia dracunculus (Tarragon) compared to control treatment with pentavalent antimony (meglumine). METHODS:This experimental study was performed in 2014-2015. A. dracunculus were collected from West Azerbaijan Province, Iran and dried; then the ethanolic extract of the plant was prepared. The effect of different concentrations of Artemisia's extract was compared with Glucantime ® in the stationary phase by MTT colorimetric assay and Trypan blue staining. Human peripheral blood mononuclear cells (HPBMCs) treated with L. major and production of IFN-γ and IL-4 cytokines measured at concentrations of 25, 20, 10 and 5μg/ml A. dracunculus. RESULTS:Treatment with the extract did not affect the survival of the parasites during the first 48 h; however, on the third day (72 h), all concentrations significantly reduced the number of parasites with an efficacy of more than 50% at 10 μg/ml (P<0.01), 20μg/ml (P<0.001), and 25 μg/ml (P<0.0001). Moreover, IFN-γ and IL-4 secretion from the HPBMCs was significantly affected in a dose-dependent manner, compared to the control (no extract). The IFN-γ/IL-4 ratio further confirmed this notion. CONCLUSION:A. dracunculus extract cannot only exert potent antileishmanial activity but may also enhance cellular immunity to this parasite. Further studies are required to determine the main compound(s) responsible for these effects of the plant.
journal_name
Iran J Parasitoljournal_title
Iranian journal of parasitologyauthors
Rezaei R,Hazrati Tappeh K,Seyyedi S,Mikaili Psubject
Has Abstractpub_date
2017-07-01 00:00:00pages
398-407issue
3eissn
1735-7020issn
2008-238Xjournal_volume
12pub_type
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journal_title：Iranian journal of parasitology
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journal_title：Iranian journal of parasitology
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journal_title：Iranian journal of parasitology
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journal_title：Iranian journal of parasitology
pub_type： 杂志文章
doi：
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journal_title：Iranian journal of parasitology
pub_type： 杂志文章
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更新日期：2013-01-01 00:00:00
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journal_title：Iranian journal of parasitology
pub_type： 杂志文章,评审
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更新日期：2017-07-01 00:00:00
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journal_title：Iranian journal of parasitology
pub_type： 杂志文章
doi：
更新日期：2010-03-01 00:00:00
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更新日期：2017-10-01 00:00:00
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