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Evaluation of the efficacy of a posaconazole and anidulafungin combination in a murine model of pulmonary aspergillosis due to infection with Aspergillus fumigatus.

Abstract：

:Posaconazole (PSC) in combination with anidulafungin (AFG) was evaluated in a murine model of pulmonary aspergillosis. Immunosuppressed animals were infected via the nasal cavity with 2 different A. fumigatus strains. The animals received PSC (oral, 20mg/kg per day) and/or AFG (i.p., 10mg/kg per day) for 7days. On Day 8, the mice were euthanized and fungal burdens were determined from the lungs. Survival curves were constructed for mortality analysis. Compared to untreated groups, groups singly treated with PSC or AFG showed a reduced fungal burden in the lungs (P=0.0001-0.006) and prevention of mortality (66.66-83.33% of survival). Combination treatment with PSC and AFG significantly reduced the fungal burden (or sterilized the lungs) compared to the findings in the untreated and monotherapy groups and improved the survival rate to 100%. The PSC and AFG combination therapy was highly effective and should be evaluated in larger-scale experiments.

journal_name

Diagn Microbiol Infect Dis

journal_title

Diagnostic microbiology and infectious disease

authors

Bedin Denardi L,Pantella Kunz de Jesus F,Keller JT,Weiblen C,de Azevedo MI,Oliveira V,Morais Santurio J,Hartz Alves S

doi

10.1016/j.diagmicrobio.2017.10.004

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

40-43

issue

1

eissn

0732-8893

issn

1879-0070

pii

S0732-8893(17)30315-2

journal_volume

90

pub_type

杂志文章

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