Abstract：
:Cerebral autoregulation (CA) is the mechanism that aims to maintain adequate cerebral perfusion during changes in blood pressure (BP). Transfer function analysis (TFA), the most reported method in literature to quantify CA, shows large between-study variability in outcomes. The aim of this study is to investigate the role of measurement artifacts in this variation. Specifically, the role of distortion in the BP and/or CBFV measurementon TFA outcomes was investigated. The influence of three types of artifacts on TFA outcomes was studied: loss of signal, motion artifacts, and baseline drifts. TFA metrics of signals without the simulated artifacts were compared with those of signals with artifacts. TFA outcomes scattered highly when more than 10% of BP signal or over 8% of the CBFV signal was lost, or when measurements contained one or more artifacts resulting from head movement. Furthermore, baseline drift affected interpretation of TFA outcomes when the power in the BP signal was 5 times the power in the LF band. In conclusion, loss of signal in BP and loss in CBFV, affects interpretation of TFA outcomes. Therefore, it is vital to validate signal quality to the defined standards before interpreting TFA outcomes.
journal_name
Med Eng Physjournal_title
Medical engineering & physicsauthors
Meel-van den Abeelen AS,de Jong DL,Lagro J,Panerai RB,Claassen JAdoi
10.1016/j.medengphy.2016.02.001subject
Has Abstractpub_date
2016-05-01 00:00:00pages
490-7issue
5eissn
1350-4533issn
1873-4030pii
S1350-4533(16)00035-7journal_volume
38pub_type
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