Abstract:
BACKGROUND:While low dose computed tomography (LDCT) screening for lung cancer is recommended for high-risk smokers, ages 55-74 years, information about asbestos exposure may not be routinely elicited. Asbestos exposure is associated with declining respiratory function over time; however, the effect of a history of asbestos exposure in LDCT screening cohorts is limited. We report the relationship between asbestos exposure and pulmonary function in a cohort of heavy smokers with a history of occupational asbestos exposure, hypothesizing that these subjects will have additional decreased pulmonary function. We also examined relationships between spirometric measurements and the presence of isolated pleural plaques. METHODS:A cross-sectional study was performed using data from the NYU Lung Cancer Biomarker Center cohort to compare study subjects with a history asbestos exposure primarily in the period since 1970 when tighter federal standards were in place (n = 359) to those without asbestos exposure (n = 1038) with respect to pulmonary function, LDCT lung imaging findings, and clinical symptoms. We further classified individuals with asbestos exposure by length of exposure time to examine the effect of duration of exposure on pulmonary function. Lastly, for asbestos-exposed participants, we examined the association of spirometric measurements with the presence of absence of isolated pleural plaques. RESULTS:Individuals with asbestos exposure had decreased FVC % predicted compared to those with no asbestos exposure (76% vs. 85% predicted, P < 0.01) and FEV1 % predicted (64% vs. 67% predicted, P < 0.01). Since there was no change in FEV1 /FVC ratio, the findings are consistent with restrictive impairment. Those with ≥20 years of exposure had a lower mean FVC % predicted compared to those with less than 20 years of exposure (74% vs. 78% predicted, P = 0.017). Individuals with asbestos exposure were more likely to have pleural plaques (P < 0.001) on CT. Those with isolated pleural plaques had lower mean % predicted FEV1 (P = 0.005) and FVC (P = 0.001) compared to those without pleural plaques. CONCLUSIONS:Occupational asbestos exposure in a cohort of heavy smokers was associated with a significant restrictive decline in pulmonary function, with longer duration of exposure associated with greater decline. The presence of isolated pleural plaques was also associated with reduced lung function.
journal_name
Am J Ind Medjournal_title
American journal of industrial medicineauthors
Lopatin S,Tsay JC,Addrizzo-Harris D,Munger JS,Pass H,Rom WNdoi
10.1002/ajim.22571subject
Has Abstractpub_date
2016-03-01 00:00:00pages
178-85issue
3eissn
0271-3586issn
1097-0274journal_volume
59pub_type
杂志文章abstract:BACKGROUND:Between 1987 and 1992, the Finnish Institute of Occupational Health (FIOH) initiated and implemented the Asbestos Program that aimed at reducing asbestos-related risks. It was a cooperative effort between government authorities, labor market organizations, and health care and labor protection personnel. MET...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20282
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND:A 5-year longitudinal study examined nonmalignant respiratory effects of wood processing dust exposure. METHODS:Ten study plants, investigator selected from 447 candidate plants, included 1 sawmill-planing-plywood, 1 plywood, 1 milling, 3 cabinet and 4 furniture facilities. Personal dust samples (2363) were...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20594
更新日期:2008-08-01 00:00:00
abstract::The occupational injury experience of the U.S. and Australian construction industries for 1988-1991 was compared to identify similarities and differences in risk and to share information vital for planning strategies for prevention. There were 4,158 deaths in the U.S. and 264 in the Australian construction industries....
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0274(199608)30:2<202::AID-AJIM1
更新日期:1996-08-01 00:00:00
abstract::This commentary challenges a recently published perception that Dr. Le Roy Upson Gardner had not actually discovered in 1942 that inhaled chrysotile fibers could induce malignant neoplasia in mice. The handwritten laboratory notes and some of Dr. Gardner's slides have recently been found. They verify that the tumors h...
journal_title:American journal of industrial medicine
pub_type: 传,历史文章,杂志文章
doi:10.1002/ajim.4700270413
更新日期:1995-04-01 00:00:00
abstract::Fertility among men working in semiconductor manufacturing during 1984-89 was assessed in a 1990-91 cross-sectional study of eight companies. Men working in wafer fabrication rooms (fabs) (n = 241, 165 births) were compared to men in nonfabrication (nonfab) jobs (n = 447, 300 births). Results showed that 17% of fab me...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700280618
更新日期:1995-12-01 00:00:00
abstract:BACKGROUND:Self-reported exposure to secondhand smoke (SHS) has been associated with elevated inflammatory markers in adults. The association between SHS indicated by serum cotinine and markers of inflammation has not been investigated in adult workers. METHODS:Using the subpopulation of employed participants (20 year...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20591
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:No previous studies investigated the interaction of effort-reward imbalance (ERI) and overcommitment on blood pressure. Our aim was to investigate associations of ERI and overcommitment (and their interaction) with blood pressure and hypertension within a Chinese population. METHODS:Seven hundred thirty-fou...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22254
更新日期:2013-12-01 00:00:00
abstract::A Health Hazard Evaluation was conducted by the National Institute for Occupational Safety and Health in an area of a large chemical plant that manufactured the stilbene derivative 4,4'-diaminostilbene-2,2'-disulfonic acid, an intermediate used for the production of optical brightening agents. Men employed in the area...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700180107
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Occupational health problems among home-helpers have been reported in a series of studies, and the need for intervention has been pointed out. To facilitate decisions regarding interventions and to establish baseline values for future evaluation of preventive efforts, the present study aimed to elucidate the...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.10028
更新日期:2002-01-01 00:00:00
abstract::In August, 1990, a regional transit authority began removing paint on two overhead bridges on a commuter railroad line running through a residential neighborhood of Lynn, Massachusetts, an industrial city north of Boston. The contracted work involved the sandblasting of existing bridge paint to prepare the surface for...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700230126
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Autopsied lungs from 29 hard rock miners were investigated to determine the relationship of the dust content to pathology, radiology, and occupational exposure. METHODS:Each lung was divided horizontally into three sections. Pathological and radiological studies and chemical analyses were carried out on sam...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20589
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND:Job-exposure matrices (JEM) are used for exposure assessment in occupational studies, but they can involve errors. We assessed agreement between the Nordic Occupational Cancer Studies JEM (NOCCA-JEM) and aggregate and individual dose estimates for cosmic radiation exposure among Finnish airline personnel. M...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22705
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:We sought to gain insight into workers' knowledge, beliefs, and attitudes on the subject of testing for genetic susceptibility to beryllium. METHODS:Five focus groups were held with 30 current and former beryllium workers and nine family members. Audio recordings were transcribed and assessed by hierarchica...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20962
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:Demographic, labor market and economic forces are combining to produce increases in the number and percentage of U.S. workers 55 and older. In some ways these workers will be our most skilled and productive employees but in others the most vulnerable. METHODS:The literature on aging and work was reviewed, i...
journal_title:American journal of industrial medicine
pub_type: 杂志文章,评审
doi:10.1002/ajim.20569
更新日期:2008-04-01 00:00:00
abstract::The etiology of retroperitoneal fibrosis is unknown in 70% of the cases. The aim of our study was to examine the possible association between occupational asbestos exposure and retroperitoneal fibrosis; only two cases have been reported in the literature. We gathered all the cases of retroperitoneal fibrosis diagnosed...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(199804)33:4<418::aid-ajim1
更新日期:1998-04-01 00:00:00
abstract:BACKGROUND:We evaluated particulate matter in combined induced sputum (IS) and oxidation in exhaled breath condensate (EBC) to test whether underlying inflammatory changes are present in asymptomatic welders. METHODS:Thirty welders from the Israel Defense Forces exposed to aluminum/iron (Group 1) or to cadmium/chromiu...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20586
更新日期:2008-07-01 00:00:00
abstract::The occupational histories of fathers were collected prospectively as part of the Avon Longitudinal Study of Pregnancy and Childhood (ALSPAC), and were used to investigate the association of paternal job title with a baby's birth weight and gestational age. The analysis cohort consisted of 4,795 singleton live-born ba...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(199706)31:6<738::aid-ajim1
更新日期:1997-06-01 00:00:00
abstract::Occupational health studies of agricultural workers have generally excluded migrant and seasonal farmworkers, and this population experiences a high degree of health risk from agricultural exposures. A survey of dermatologic disorders among migrant and seasonal farmworkers will be used to illustrate this point. Data f...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700180317
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVE:Longitudinal assessment of lower respiratory symptoms (LRS) in community members with World Trade Center (WTC) exposures. METHODS:Adult members of a treatment program with complete standardized visits were evaluated (n = 798). Association of demographic characteristics, mental health symptoms and lung functi...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22642
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Although there are many studies on working adolescents, information on youth who simultaneously hold jobs on both a farm and in other sectors of the economy is lacking. METHODS:Six high schools in rural Minnesota were evaluated for adolescent work practices and injury incidence. A 20-page self-administered ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.10095
更新日期:2002-08-01 00:00:00
abstract::In a survey of chronic respiratory symptoms and airflow obstruction of a rural population aged 20-65 years, the effects of both farming and, in particular, the exposure to grain dust on the respiratory health of the people was examined. Of the 1,892 subjects (82% of the eligible population) studied, 924 were males and...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700150103
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Occupational exposures may be related to the development of brain cancer. The objective was to estimate occupational-specific risk of gliomas and meningiomas among Swedish men and women gainfully employed in 1970 over the period 1971-1989, and the influence of occupational exposure to chemical substances. M...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.10107
更新日期:2002-09-01 00:00:00
abstract:BACKGROUND:A medical screening program began in 1986 for sheet metal workers exposed to asbestos, primarily while working alongside insulators applying spray-on asbestos materials, a practice banned in 1973. Exposure continues during maintenance, renovation, and repair. METHODS:Radiographic abnormalities among 26 397 ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22998
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Self-reported work histories can be critical for both epidemiologic and clinical purposes. However, the complexity of some work histories, such as those of migrant farm workers, can hamper recall, resulting in inaccurate reporting. Memory aids may reduce such error. This study assesses the reliability of wor...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.1119
更新日期:2001-11-01 00:00:00
abstract::Using injury information from the 1986 Mine Safety and Health Administration database, and demographic information from a 1986 sample survey of the miner population, acute traumatic injury rates for male workers in underground bituminous coal mines were computed by age, current job experience, and total mine work expe...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700230304
更新日期:1993-03-01 00:00:00
abstract::Recent epidemiological and experimental work confirms that inorganic lead compounds are associated with increased risks of tumorigenesis. In animals, these risks can be induced at doses that are not associated with organ toxicity and in mice that do not produce alpha-2 urinary globulin in the kidney. Thus the mechanis...
journal_title:American journal of industrial medicine
pub_type: 杂志文章,评审
doi:10.1002/1097-0274(200009)38:3<316::aid-ajim11>3.0.
更新日期:2000-09-01 00:00:00
abstract:BACKGROUND:The purpose of the study was to evaluate trends in occupational lead exposures throughout U.S. industry after the establishment of the general industry lead standard in 1978 and the construction industry standard in 1993. METHODS:Lead exposure measurements collected by the Occupational Safety and Health Adm...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20008
更新日期:2004-06-01 00:00:00
abstract::Two workers (23 and 28 years old) developed rhinitis and bronchial asthma after occupational contact with the isocyanate MDI. Positive skin prick test results for MDI-HSA and IgE antibodies to all isocyanate-HSA conjugates were obtained in both cases, and the inhalation challenge test with MDI produced immediate and l...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0274(199605)29:5<467::AID-AJIM5
更新日期:1996-05-01 00:00:00
abstract:BACKGROUND:Workers in foundry and pottery are exposed to a mixture of chemicals and silica, which is suspected to cause genetic alterations. METHODS:To investigate the potential hazard associated with the occupational exposure to silica, DNA damage in the peripheral lymphocytes of 30 foundry and 22 pottery workers wer...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.10222
更新日期:2003-06-01 00:00:00
abstract:BACKGROUND:A major French chlorine chemical plant (chlor-alkali process with diaphragm cell and manufacturing of organochlorine chemicals) has used or produced known or suspected carcinogenic compounds. METHODS:A cohort study, based on the plant occupational health service and the regional cancer registry, analyzed th...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22069
更新日期:2012-09-01 00:00:00