Lead as a carcinogen: experimental evidence and mechanisms of action.


:Recent epidemiological and experimental work confirms that inorganic lead compounds are associated with increased risks of tumorigenesis. In animals, these risks can be induced at doses that are not associated with organ toxicity and in mice that do not produce alpha-2 urinary globulin in the kidney. Thus the mechanisms of lead carcinogenicity are unlikely to be fully explained as toxicity-related sequelae of high dose exposure or as a rat-specific response involving overexpression of a renal protein. Plausible mechanisms of lead carcinogenicity include direct DNA damage, clastogenicity, or inhibition of DNA synthesis or repair. Lead may also generate reactive oxygen species and cause oxidative damage to DNA. Recent data indicate that lead can substitute for zinc in several proteins that function as transcriptional regulators, including protamines. Lead further reduces the binding of these proteins to recognition elements in genomic DNA, which suggests an epigenetic involvement of lead in altered gene expression. These events may be of particular relevance in transplacental exposures and later cancer.


Am J Ind Med


Silbergeld EK,Waalkes M,Rice JM




Has Abstract


2000-09-01 00:00:00














  • Nested case-control study of esophageal cancer in relation to occupational exposure to silica and other dusts.

    abstract:BACKGROUND:Standardized proportionate mortality ratio (SPMR) was found to be 2.2 (95% CI = 1.3-3.5) for esophageal cancer (EC) among workers exposed to refractory brick dust in a large iron-steel complex in China. METHODS:A nested case-control design within a cohort of industrial workers. One hundred and twenty-five E...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章


    authors: Pan G,Takahashi K,Feng Y,Liu L,Liu T,Zhang S,Liu N,Okubo T,Goldsmith DF

    更新日期:1999-03-01 00:00:00

  • Inhibition of RNA synthesis by benzene metabolites and their covalent binding to DNA in rabbit bone marrow mitochondria in vitro.

    abstract::Mitoplasts from rabbit bone marrow cells in vitro incubated with benzene metabolites showed a concentration-dependent inhibition of mitochondrial RNA synthesis. The 50% molar inhibitory concentration for each metabolite was determined to be p-benzoquinone, 2 X 10(-6); phenol, 2.5 X 10(-5); hydroquinone, 5 X 10(-5); ca...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章


    authors: Kalf GF,Snyder R,Rushmore TH

    更新日期:1985-01-01 00:00:00

  • MPH program at Manipal University, India-experiences, challenges, and lessons learned.

    abstract:BACKGROUND:The UAB-ITREOH program has initiated a skill-based MPH program at Manipal University (MU), India, in 2009, to address the critical need for trained public health professionals and build institutional public health training capacity in the country. METHODS:Funds from Fogarty have supported the curriculum dev...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章


    authors: Bhat HV,Kamath R,Arunkumar G,Delzell E,Tipre M,Upadhyay DK,Sathiakumar N

    更新日期:2013-01-01 00:00:00

  • Medical clearance for respirator use: sensitivity and specificity of a questionnaire.

    abstract:BACKGROUND:OSHA regulations require that workers receive medical clearance prior to respirator use, and recently, a detailed questionnaire has been provided to assist with this purpose. However, there are limited published data on the sensitivity and specificity of self-administered questionnaires for identifying indiv...

    journal_title:American journal of industrial medicine

    pub_type: 临床试验,杂志文章


    authors: Pappas GP,Takaro TK,Stover B,Beaudet N,Salazar M,Calcagni J,Shoop D,Barnhart S

    更新日期:1999-04-01 00:00:00

  • Predictors of delayed return to work after back injury: A case-control analysis of union carpenters in Washington State.

    abstract:METHODS:Union administrative records identified 20,642 union carpenters who worked in Washington State from 1989 to 2003. The Department of Labor and Industries provided records of workers' compensation claims and associated medical care. Work-related back claims (n = 4,241) were identified by ANSI codes (back, trunk, ...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章


    authors: Kucera KL,Lipscomb HJ,Silverstein B,Cameron W

    更新日期:2009-11-01 00:00:00

  • Variation across the agricultural season in organophosphorus pesticide urinary metabolite levels for Latino farmworkers in eastern North Carolina: project design and descriptive results.

    abstract:BACKGROUND:Community Participatory Approach to Measuring Farmworker Pesticide Exposure, PACE3, used a longitudinal design to document pesticide biomarkers among farmworkers. This article presents an overview of PACE3 and provides a descriptive analysis of participant characteristics and one set of pesticide biomarkers,...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章


    authors: Arcury TA,Grzywacz JG,Chen H,Vallejos QM,Galván L,Whalley LE,Isom S,Barr DB,Quandt SA

    更新日期:2009-07-01 00:00:00

  • A strategy to reduce healthy worker effect in a cross-sectional study of asthma and metalworking fluids.

    abstract::This report describes the reanalysis of a cross-sectional study of asthma in a large cohort of autoworkers with exposure to metalworking fluids (MWF). There is strong evidence from case reports, clinical studies, and medical surveillance data that exposure to MWF can cause asthma, yet no association was found in the o...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章


    authors: Eisen EA,Holcroft CA,Greaves IA,Wegman DH,Woskie SR,Monson RR

    更新日期:1997-06-01 00:00:00

  • Cancer incidence in a chlorochemical plant in Isère, France: an occupational cohort study, 1979-2002.

    abstract:BACKGROUND:A major French chlorine chemical plant (chlor-alkali process with diaphragm cell and manufacturing of organochlorine chemicals) has used or produced known or suspected carcinogenic compounds. METHODS:A cohort study, based on the plant occupational health service and the regional cancer registry, analyzed th...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章


    authors: Bonneterre V,Mathern G,Pelen O,Balthazard AL,Delafosse P,Mitton N,Colonna M

    更新日期:2012-09-01 00:00:00

  • Racial differences in prevalence of a supratypic HLA-genetic marker immaterial to pre-employment testing for susceptibility to chronic beryllium disease.

    abstract:BACKGROUND:A beryllium materials manufacturer is conducting a limited pilot program that offers testing for HLA-DP beta 1E69 with genetic counseling through a third party to applicants for employment. An important consideration in this regard is the prevalence of this marker in the general population, and its consequen...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章


    authors: Weston A,Ensey J,Kreiss K,Keshava C,McCanlies E

    更新日期:2002-06-01 00:00:00

  • Lung cancer risk among workers exposed to man-made mineral fibers (MMMF) in the Swedish prefabricated house industry.

    abstract::Mortality and cancer incidence was investigated among 2,807 workers, employed for at least one year before 1972, at 11 Swedish companies manufacturing prefabricated wooden houses. A total of 1,068 workers had been exposed to man-made mineral fibers (MMMF) used for insulation. Mortality was followed from 1969 to 1988 a...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章


    authors: Gustavsson P,Plato N,Axelson O,Brage HN,Hogstedt C,Ringbäck G,Tornling G,Wingren G

    更新日期:1992-01-01 00:00:00

  • Occupational implications of the chlorofluorocarbon ban in Sweden.

    abstract::Limitations on the use of full halogenated chlorofluorocarbons (CFCs) may create occupational environmental problems. These are currently largely unknown, because the toxicology of most CFC substitutes is unknown. Therefore, toxicity testing of CFC substitutes is necessary, and this can best be done before their use c...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章,评审


    authors: Olander L,Colmsjö A,Holmberg B,Krantz S,Landström U

    更新日期:1991-01-01 00:00:00

  • Diesel exhaust and lung cancer in the trucking industry: exposure-response analyses and risk assessment.

    abstract:BACKGROUND:Diesel exhaust is considered a probable human carcinogen by the International Agency for Research on Cancer (IARC). The epidemiologic evidence rests on studies of lung cancer among truck drivers, bus drivers, shipyard workers, and railroad workers. The general public is exposed to diesel exhaust in ambient a...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章


    authors: Steenland K,Deddens J,Stayner L

    更新日期:1998-09-01 00:00:00

  • Comparison of a self-administered questionnaire and a telephone interview of 146 Danish waste collectors.

    abstract::Methods to collect epidemiologic data include, among other means, self-administered questionnaires and personal and telephone interviews. In some studies, these data collection methods are used simultaneously. However, little is known about the comparability of the data obtained, thus, the validity of pooling data. A ...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章


    authors: van Ooijen M,Ivens UI,Johansen C,Skov T

    更新日期:1997-05-01 00:00:00

  • Pulmonary function abnormality and respiratory tract irritation symptoms in epichlorohydrin-exposed workers in Taiwan.

    abstract:BACKGROUND:Epichlorohydrin (ECH) is a strong irritant of the eyes, respiratory tract, and skin. The aims of this study were to examine the dose-response relationship between observed abnormal pulmonary function tests and respiratory tract irritation symptoms among epichlorohydrin-exposed workers in Taiwan. METHODS:A t...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章


    authors: Luo JC,Kuo HW,Cheng TJ,Chang MJ

    更新日期:2003-04-01 00:00:00

  • Neutrophil chemotaxis to extracts of grain plant components.

    abstract::Exposure to grain dust has been associated with a neutrophilic bronchitis. In vitro studies suggest several possible mechanisms for recruitment of neutrophils, including direct chemotaxis to aqueous grain dust extracts and release of chemotactic activity by bronchial epithelial cells in response to challenge with grai...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章


    authors: Von Essen SG,O'Neill DP,Robbins RA,Rennard SI

    更新日期:1994-01-01 00:00:00

  • Assessment and management of occupational risks in the Nordic (Scandinavian) countries.

    abstract::Occupational health standards in the Scandinavian countries are of national concern and may thus vary from country to country. There is an internordic collaboration in the scientific criteria work, but there are also national formal procedures for standard setting. There is a greater tendency to accept eye, nose, or t...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章


    authors: Holmberg B,Lundberg P

    更新日期:1989-01-01 00:00:00

  • Retired and former asbestos workers in Hawaii.

    abstract::In 1979, a pilot survey defined respiratory status and unmet health care needs of retired and former male asbestos workers in Hawaii. Of 1,401 identified subjects, 741 were contacted and 411 were interviewed. Forty-five subjects were between 39 and 54 years of age; 208, between 55 and 64; and 158, age 65 or more. They...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章


    authors: Fournier-Massey G,Wong G,Hall TC

    更新日期:1984-01-01 00:00:00

  • The effect of long working hours on cerebrovascular and cardiovascular disease; A case-crossover study.

    abstract:BACKGROUND:This study investigated the relationship between weekly working hours and the occurrence of cerebro-cardiovascular diseases using a case-crossover study design. METHODS:We investigated average working hours during the 7 days before the onset of illness (hazard period) and average weekly working hours betwee...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章


    authors: Shin KS,Chung YK,Kwon YJ,Son JS,Lee SH

    更新日期:2017-09-01 00:00:00

  • Hospitalizations among female home-helpers in Denmark, 1981-1997.

    abstract:BACKGROUND:Occupational health problems among home-helpers have been reported in a series of studies, and the need for intervention has been pointed out. To facilitate decisions regarding interventions and to establish baseline values for future evaluation of preventive efforts, the present study aimed to elucidate the...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章


    authors: Hannerz H,Tüchsen F

    更新日期:2002-01-01 00:00:00

  • Death certificate-based occupational mortality surveillance in the United States.

    abstract::Surveillance of cause-specific mortality patterns by occupation and industry through the use of death certificate records is a simple and relatively inexpensive approach to the generation of leads as to potential occupational disease problems. Researchers from the National Institute for Occupational Safety and Health ...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章,评审


    authors: Dubrow R,Sestito JP,Lalich NR,Burnett CA,Salg JA

    更新日期:1987-01-01 00:00:00

  • Low back pain disability: relative costs by antecedent and industry group.

    abstract:BACKGROUND:Previous studies of workers' compensation claims for low back pain (LBP) have revealed that the preponderance of disability is borne by a fraction of cases. However, less is known regarding the influence of occupational factors on these extreme conditions. METHODS:Workers' compensation claims (n=107,867) fo...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章


    authors: Murphy PL,Courtney TK

    更新日期:2000-05-01 00:00:00

  • Carpal tunnel syndrome: validation of an interview questionnaire on occupational exposure.

    abstract::The objectives of this study were 1) to summarize in a clinically meaningful way information on occupational risk factors for carpal tunnel syndrome (CTS), and 2) to test a questionnaire on risk factors that could be used by physicians with their patients. For the two objectives, a systematic literature review was per...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章,评审


    authors: Rossignol M,Patry L,Sacks S

    更新日期:1998-03-01 00:00:00

  • Pulmonary adenocarcinoma with epidermal growth factor receptor-mutations in asbestos exposed non-smokers: A case series.

    abstract:BACKGROUND:Cigarette smoke and asbestos are recognized causes of lung carcinoma and together promote carcinogenesis. Adenocarcinoma is currently the most common cause of lung cancer in the USA and it has been linked to both smoking and asbestos exposure. Mutations in the epidermal growth factor gene receptor (EGFR) occ...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章


    authors: Kradin RL,Iafrate J,Christiani DC

    更新日期:2017-03-01 00:00:00

  • Lung cancer risk among construction workers in California, 1988-2007.

    abstract:BACKGROUND:Although lung cancer risks can vary by race/ethnicity and by construction occupation, these risks have not been examined extensively. METHODS:This study analyzed 110,937 lung cancer cases identified from the California Cancer Registry between 1988 and 2007. Mean age at diagnosis, proportion diagnosed at an ...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章


    authors: Calvert GM,Luckhaupt S,Lee SJ,Cress R,Schumacher P,Shen R,Tak S,Deapen D

    更新日期:2012-05-01 00:00:00

  • Socioeconomic and health status of electronics workers employed in organized industry.

    abstract::To study their socioeconomic and health status, 1,770 workers in the organized electronics industry in India were surveyed. Mean age of the workers employed in this industry was 32.5 +/- 6.01 years. The average per capita income/month was Rupees 333, indicating a higher socioeconomic status, compared with the status o...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章


    authors: Mathur N,Gupta BN,Rastogi SK,Mahendra PN,Pangtey BS,Husain T,Bharti RS

    更新日期:1993-02-01 00:00:00

  • Change in prevalence of asbestos-related disease among sheet metal workers 1986 to 2016.

    abstract:BACKGROUND:A medical screening program began in 1986 for sheet metal workers exposed to asbestos, primarily while working alongside insulators applying spray-on asbestos materials, a practice banned in 1973. Exposure continues during maintenance, renovation, and repair. METHODS:Radiographic abnormalities among 26 397 ...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章


    authors: West GH,Sokas RK,Welch LS

    更新日期:2019-07-01 00:00:00

  • Estimation of the global burden of disease attributable to contaminated sharps injuries among health-care workers.

    abstract:BACKGROUND:The global burden of hepatitis B (HBV), hepatitis C (HCV), and human immunodeficiency virus (HIV) infection due to percutaneous injuries among health care workers (HCWs) is estimated. METHODS:The incidence of infections attributable to percutaneous injuries in 14 geographical regions on the basis of the pro...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章


    authors: Prüss-Ustün A,Rapiti E,Hutin Y

    更新日期:2005-12-01 00:00:00

  • Occupational injury and work organization among immigrant Latino residential construction workers.

    abstract:BACKGROUND:Rates of occupational injury among immigrant workers are widely believed to be underestimated. The goal of this study was to enhance understanding of the burden of occupational injury and the work organization factors underlying injury among immigrant Latino residential construction workers. METHODS:Prospec...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章


    authors: Grzywacz JG,Quandt SA,Marín A,Summers P,Lang W,Mills T,Evia C,Rushing J,Donadio K,Arcury TA

    更新日期:2012-08-01 00:00:00

  • Correlates of bone and blood lead levels in carpenters.

    abstract::In the course of a health screening for construction carpenters, 127 subjects underwent blood lead testing, administration of detailed questionnaires, and in vivo measurement of bone lead levels with a 109Cd K-X-ray fluorescence (K-XRF) instrument. The mean age of subjects was 48.5 (SD = 9.8) years. Blood lead levels ...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章


    authors: Watanabe H,Hu H,Rotnitzky A

    更新日期:1994-08-01 00:00:00

  • Reducing occupation-based disparities related to tobacco: roles for occupational health and organized labor.

    abstract:BACKGROUND:Persistent and growing occupation-based disparities related to tobacco pose a serious public health challenge. Tobacco exacts a disproportionate toll on individuals employed in working class occupations, due to higher prevalence of smoking and exposure to secondhand smoke among these workers compared to othe...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章


    authors: Barbeau EM,McLellan D,Levenstein C,DeLaurier GF,Kelder G,Sorensen G

    更新日期:2004-08-01 00:00:00