Abstract:
:Recent epidemiological and experimental work confirms that inorganic lead compounds are associated with increased risks of tumorigenesis. In animals, these risks can be induced at doses that are not associated with organ toxicity and in mice that do not produce alpha-2 urinary globulin in the kidney. Thus the mechanisms of lead carcinogenicity are unlikely to be fully explained as toxicity-related sequelae of high dose exposure or as a rat-specific response involving overexpression of a renal protein. Plausible mechanisms of lead carcinogenicity include direct DNA damage, clastogenicity, or inhibition of DNA synthesis or repair. Lead may also generate reactive oxygen species and cause oxidative damage to DNA. Recent data indicate that lead can substitute for zinc in several proteins that function as transcriptional regulators, including protamines. Lead further reduces the binding of these proteins to recognition elements in genomic DNA, which suggests an epigenetic involvement of lead in altered gene expression. These events may be of particular relevance in transplacental exposures and later cancer.
journal_name
Am J Ind Medjournal_title
American journal of industrial medicineauthors
Silbergeld EK,Waalkes M,Rice JMdoi
10.1002/1097-0274(200009)38:3<316::aid-ajim11>3.0.subject
Has Abstractpub_date
2000-09-01 00:00:00pages
316-23issue
3eissn
0271-3586issn
1097-0274pii
10.1002/1097-0274(200009)38:3<316::AID-AJIM11>3.0.journal_volume
38pub_type
杂志文章,评审abstract:BACKGROUND:Per a Congressional directive and funding, this study describes worker and workplace characteristics of emergency department (ED) patients who reported their injury/illness to their employer. The study also responds to Congress's request to enumerate injured/ill self-employed workers and workers with chronic...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22607
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:This study compared floor laying using new working methods involving standing up, to the traditional methods involving working on one's knees. METHODS:The study group, 216 subjects, completed a training class in the use of the new floor-laying methods, and received free tools and advice in their use. The co...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20808
更新日期:2010-06-01 00:00:00
abstract::This Working Group was assembled to review and evaluate methods currently used to estimate work site exposures to biological agents and to present recommendations on suitable measurement strategies. The current state of exposure assessment was evaluated for environments with organic dust including agriculture, compost...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20066
更新日期:2004-10-01 00:00:00
abstract:BACKGROUND:Work-related musculoskeletal disorders (WMSD) among construction workers remain high. Participatory ergonomics (PE) interventions that engage workers and employers in reducing work injury risks have shown mixed results. METHODS:Eight-six workers from seven contractors participated in a PE program. A logic m...
journal_title:American journal of industrial medicine
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doi:10.1002/ajim.22586
更新日期:2016-06-01 00:00:00
abstract::Assessing the health risks of complex mixtures of polynuclear aromatic hydrocarbons such as diesel fumes and asphalt or bitumen continues to be a major challenge for occupational and environmental health scientists. The special Asphalt issue of the American Journal of Industrial Medicine (Cancer Mortality Among Europe...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.10215
更新日期:2003-03-01 00:00:00
abstract:BACKGROUND:A medical screening program began in 1986 for sheet metal workers exposed to asbestos, primarily while working alongside insulators applying spray-on asbestos materials, a practice banned in 1973. Exposure continues during maintenance, renovation, and repair. METHODS:Radiographic abnormalities among 26 397 ...
journal_title:American journal of industrial medicine
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更新日期:2019-07-01 00:00:00
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journal_title:American journal of industrial medicine
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更新日期:1998-07-01 00:00:00
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journal_title:American journal of industrial medicine
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更新日期:2004-12-01 00:00:00
abstract:BACKGROUND:Engineering or administrative methods are often insufficient or impractical to control exposure to chemicals in anatomy laboratories. This study explored the feasibility of wearing one or a combination of respirators and goggles used as personal protective equipment (PPE) to control exposure in one such labo...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
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更新日期:2003-03-01 00:00:00
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journal_title:American journal of industrial medicine
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更新日期:1993-07-01 00:00:00
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journal_title:American journal of industrial medicine
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更新日期:2016-01-01 00:00:00
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journal_title:American journal of industrial medicine
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更新日期:2003-10-01 00:00:00
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journal_title:American journal of industrial medicine
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doi:10.1002/ajim.20425
更新日期:2007-02-01 00:00:00
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journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700230304
更新日期:1993-03-01 00:00:00
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journal_title:American journal of industrial medicine
pub_type: 杂志文章
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更新日期:2012-09-01 00:00:00
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journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20176
更新日期:2005-07-01 00:00:00
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journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0274(199609)30:3<317::AID-AJIM1
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND:Migrant and seasonal farmworkers are at risk for occupational illnesses from pesticide exposure, and the effectiveness of pesticide safety regulations has not been evaluated. It is important to learn from farmworker safety experiences to develop effective measures to improve agricultural workplace safety. M...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.1042
更新日期:2001-05-01 00:00:00
abstract::The present study examines the association between asbestos-related pleural plaques and lung function in a group of workers with occupational exposure to asbestos. Exposure, smoking, and respiratory histories, chest radiographs, flow-volume loops, and single breath DLCOs were obtained on 383 railroad workers. A score ...
journal_title:American journal of industrial medicine
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doi:10.1002/ajim.4700140604
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:The etiology of Parkinson's disease (PD) is considered to have a strong environmental component, but relatively few studies have investigated the potential association between occupation and the disease. METHODS:In a population-based case-control study, we collected comprehensive occupational histories from...
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更新日期:2001-06-01 00:00:00
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journal_title:American journal of industrial medicine
pub_type: 杂志文章,评审
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更新日期:2002-05-01 00:00:00
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journal_title:American journal of industrial medicine
pub_type: 杂志文章
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journal_title:American journal of industrial medicine
pub_type: 杂志文章
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更新日期:1997-05-01 00:00:00
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journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20158
更新日期:2005-05-01 00:00:00
abstract::The use and maintenance of firearms is a common and often preventable source of adult lead exposure that is often poorly understood by medical professionals. This case describes an elevated blood lead level (BLL) in an adult man due to the exposure sources of ammunition reloading and indoor target shooting in the base...
journal_title:American journal of industrial medicine
pub_type:
doi:10.1002/ajim.23119
更新日期:2020-08-01 00:00:00
abstract::To investigate the effects of styrene exposure on peripheral, central, and autonomic nervous system functions in man, we measured the distribution of nerve conduction velocities (DCV), short-latency somatosensory evoked potentials (SSEP), and variability in electrocardiographic R-R interval (CVRR) as well as conventio...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
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更新日期:1991-01-01 00:00:00
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journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22436
更新日期:2015-06-01 00:00:00
abstract::To better understand the methodological challenges faced by intervention research in health care, workshops reviewed two intervention studies to reduce back injuries among nursing home staff and two studies on the use of precautions to prevent occupational transmission of bloodborne pathogens. These studies adapted ri...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0274(199604)29:4<412::AID-AJIM2
更新日期:1996-04-01 00:00:00
abstract:BACKGROUND:Epichlorohydrin (ECH) is a strong irritant of the eyes, respiratory tract, and skin. The aims of this study were to examine the dose-response relationship between observed abnormal pulmonary function tests and respiratory tract irritation symptoms among epichlorohydrin-exposed workers in Taiwan. METHODS:A t...
journal_title:American journal of industrial medicine
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更新日期:2003-04-01 00:00:00
abstract::To determine the nature of respiratory functional impairment caused by asbestos-induced visceral pleural fibrosis (VPF) and to discover which pulmonary physiological variable best reveals it, we examined 59 asbestos-exposed construction workers having asbestos-related changes on chest radiographs. Computed tomography ...
journal_title:American journal of industrial medicine
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更新日期:1995-09-01 00:00:00