Tropically adapted cattle of Africa: perspectives on potential role of copy number variations.

Abstract:

:Africa is host to diverse and locally adapted cattle breeds that are expected to survive the harsh and extreme tropical environments associated with diseases and parasite infections, heat stress and episodes of feed and water scarcity. Genomic copy number variations (CNVs) are considered to be primary role players in cattle breed formation and adaptation where isolation and genetic drift together with subsequent mutations have created an enormous diversity of local populations. CNVs are modifications in DNA structure comprising deletions, duplications and insertions that are >1 kb in size. Despite attracting much attention, the frequency and pattern of bovine CNV events, especially in African cattle breeds, are for the most part largely unknown. Characterization of genetic variation in the indigenous cattle of Africa will be a vital step toward dissecting the molecular mechanisms underlying phenotypic variation and local adaptation. This review therefore aims to describe the current knowledge regarding bovine CNVs and the implications and potentials they encompass for dissecting genetic adaptation and the genotypic skeleton of tropical African cattle populations.

journal_name

Anim Genet

journal_title

Animal genetics

authors

Wang MD,Dzama K,Rees DJ,Muchadeyi FC

doi

10.1111/age.12391

subject

Has Abstract

pub_date

2016-04-01 00:00:00

pages

154-64

issue

2

eissn

0268-9146

issn

1365-2052

journal_volume

47

pub_type

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