A polypeptide based podophyllotoxin conjugate for the treatment of multi drug resistant breast cancer with enhanced efficiency and minimal toxicity.

abstract：:Recently, the progress in biomaterials for biomedical applications brings the focus of the research community toward nanomaterials. The nanofibrous matrices offer certain advantages (structural similarity to extracellular matrix, high surface area-to-volume ratio, increased elasticity, biostability, and strength) comp...

journal_title：Acta biomaterialia

authors： Sapru S,Das S,Mandal M,Ghosh AK,Kundu SC

更新日期：2018-09-15 00:00:00

abstract：:This work reports and discusses the influence of four phosphonium-based ionic liquids (PhILs), namely trihexyl(tetradecyl) phosphonium dicyanamide, [P(6,6,6,14)][dca]; trihexyl(tetradecyl) phosphonium bis(trifluoromethylsulfonyl)imide, [P(6,6,6,14)][Tf(2)N]; tetrabutyl phosphonium bromide, [P(4,4,4,4)][Br]; and tetrab...

journal_title：Acta biomaterialia

authors： Dias AM,Marceneiro S,Braga ME,Coelho JF,Ferreira AG,Simões PN,Veiga HI,Tomé LC,Marrucho IM,Esperança JM,Matias AA,Duarte CM,Rebelo LP,de Sousa HC

更新日期：2012-03-01 00:00:00

abstract：:In total hip arthroplasty, osteolysis of the acetabulum often occurs at the backside of cups in the area of screw holes, indicating a clinically relevant amount of polyethylene (PE) wear particles in this area. In order to avoid a possible migration of wear particles to the acetabulum-bone, screw hole plugs are provid...

journal_title：Acta biomaterialia

authors： Braun S,Vardag S,Mueller U,Schroeder S,Sonntag R,Bormann T,Gotterbarm T,Kretzer JP

更新日期：2019-10-01 00:00:00

abstract：:Owing to its bio- and osteoconductivity, hydroxyapatite (HA) is a widely used implant material, but its osteogenic properties are only partly evaluated in vitro and in vivo. The present study focused on bone healing adjacent to HA-coated titanium (Ti) implants, with or without incorporated lithium ions (Li(+)). Specia...

journal_title：Acta biomaterialia

authors： Thorfve A,Lindahl C,Xia W,Igawa K,Lindahl A,Thomsen P,Palmquist A,Tengvall P

更新日期：2014-03-01 00:00:00

abstract：:Prosthetic joint infection (PJI) is a well-known and persisting problem. Active release coatings have promise to provide early protection to an implant by eradicating small colony biofilm contaminants or planktonic bacteria that can form biofilm. Traditional antibiotics can be limited as active release agents in that ...

journal_title：Acta biomaterialia

authors： Williams DL,Epperson RT,Ashton NN,Taylor NB,Kawaguchi B,Olsen RE,Haussener TJ,Sebahar PR,Allyn G,Looper RE

更新日期：2019-07-15 00:00:00

abstract：:Postoperative adhesion is a serious complication that can further lead to morbidity and/or mortality. Polymer anti-adhesion barrier material provides an effective precaution to reduce the probability of postoperative adhesion. Clinical application requires these materials to be easily handled, biocompatible, biodegrad...

journal_title：Acta biomaterialia

authors： Yang Y,Liu X,Li Y,Wang Y,Bao C,Chen Y,Lin Q,Zhu L

更新日期：2017-10-15 00:00:00

abstract：:The aim of the present study was to evaluate the biocompatibility and bone mineralization potential of 45S5 Bioglass-derived glass-ceramic scaffolds using a chick embryo shell-less (ex ovo) culture system. Chick embryos were divided into two groups: control (C) and experimental (E). Scaffolds were placed on the chorio...

journal_title：Acta biomaterialia

authors： Vargas GE,Mesones RV,Bretcanu O,López JM,Boccaccini AR,Gorustovich A

更新日期：2009-01-01 00:00:00

abstract：UNLABELLED:ECM-based materials are appealing for tissue engineering strategies because they may promote stem cell recruitment, cell infiltration, and cell differentiation without the need to supplement with additional biological factors. Cartilage ECM has recently shown potential to be chondroinductive, particularly in...

journal_title：Acta biomaterialia

authors： Beck EC,Barragan M,Tadros MH,Gehrke SH,Detamore MS

更新日期：2016-07-01 00:00:00

abstract：UNLABELLED:Many chorioretinal diseases are chronic and need sustained drug delivery systems to keep therapeutic drug level at the disease site. Many intravitreal drug delivery systems under developing do not have mechanism incorporated for a non-invasive monitoring of drug release. The current study prepared rugate por...

journal_title：Acta biomaterialia

authors： Hou H,Nieto A,Belghith A,Nan K,Li Y,Freeman WR,Sailor MJ,Cheng L

更新日期：2015-09-01 00:00:00

abstract：:Magnesium (Mg) is a promising biomaterial for degradable implant applications that has been extensively studied in vitro and in vivo in recent years. In this study, we developed a procedure that allows an optimized and uniform in vitro assessment of the cytocompatibility of Mg-based materials while respecting the stan...

journal_title：Acta biomaterialia

authors： Jung O,Smeets R,Porchetta D,Kopp A,Ptock C,Müller U,Heiland M,Schwade M,Behr B,Kröger N,Kluwe L,Hanken H,Hartjen P

更新日期：2015-09-01 00:00:00

abstract：:Implant-associated infections is one of the most challenging post-operative complications in bone-related implantations. To tackle this clinical issue, we developed a low-cost and durable surface coating for medical grade titanium implants that uses positively charged silane molecules. The in vitro antimicrobial tests...

journal_title：Acta biomaterialia

authors： Shen J,Gao P,Han S,Kao RYT,Wu S,Liu X,Qian S,Chu PK,Cheung KMC,Yeung KWK

更新日期：2020-09-15 00:00:00

abstract：UNLABELLED:To use siRNA (small interfering RNA) for gene therapy, a gene delivery system is often necessary to overcome several challenging requirements including rapid excretion, low stability in blood serum, non-specific accumulation in tissues, poor cellular uptake and inefficient intracellular release. Active and/o...

journal_title：Acta biomaterialia

authors： Zhi D,Zhao Y,Cui S,Chen H,Zhang S

更新日期：2016-05-01 00:00:00

abstract：:Copper-containing bioactive glass nanoparticles (Cu-BG NPs) with designed compositions and sizes were synthesized and incorporated into chitosan (CH)/silk fibroin (SF)/glycerophosphate (GP) composites to prepare injectable hydrogels for cell-free bone repair. The resulting Cu-BG/CH/SF/GP gels were found to exhibit wel...

journal_title：Acta biomaterialia

authors： Wu J,Zheng K,Huang X,Liu J,Liu H,Boccaccini AR,Wan Y,Guo X,Shao Z

更新日期：2019-06-01 00:00:00

abstract：:Cell-instructive hydrogels are attractive for skin repair and regeneration, serving as interactive matrices to promote cell adhesion, cell-driven remodeling and de novo deposition of extracellular matrix components. This paper describes the synthesis and photocrosslinking of cell-instructive pectin hydrogels using cel...

journal_title：Acta biomaterialia

authors： Pereira RF,Barrias CC,Bártolo PJ,Granja PL

更新日期：2018-01-15 00:00:00

abstract：:Three-dimensional (3D) printing is a promising technology for tissue engineering. However, 3D-printing methods are limited in their ability to produce desired microscale features or electrochemical properties in support of robust cell adhesion, proliferation, and differentiation. This study addresses this deficiency b...

journal_title：Acta biomaterialia

authors： Liu X,George MN,Park S,Miller Ii AL,Gaihre B,Li L,Waletzki BE,Terzic A,Yaszemski MJ,Lu L

更新日期：2020-07-15 00:00:00

abstract：:The biodegradable metallic devices undergo stress/strain-induced corrosion when they are used for load-bearing applications. The stress/strain induced-corrosion behavior causes differences in corrosion rate, corrosion morphology, strain distribution and mechanical performance of the devices. One representative example...

journal_title：Acta biomaterialia

authors： Chen K,Lu Y,Tang H,Gao Y,Zhao F,Gu X,Fan Y

更新日期：2020-09-01 00:00:00

abstract：:Patterned surfaces direct cell spatial dynamics, yielding cells oriented along the surface geometry, in a process known as contact guidance. The Rho family of GTPases controls the assembly of focal adhesions and cytoskeleton dynamics, but its role in modulating bone-cell alignment on patterned surfaces remains unknown...

journal_title：Acta biomaterialia

authors： Calzado-Martín A,Méndez-Vilas A,Multigner M,Saldaña L,González-Carrasco JL,González-Martín ML,Vilaboa N

更新日期：2011-04-01 00:00:00

abstract：:The rationale for the use of polymer-ceramic composites for bone regeneration stems from the natural composition of bone, with collagen type I and biological apatite as the main organic and inorganic constituents, respectively. In the present study composite materials of PolyActive™ (PA), a poly(ethylene oxide terepht...

journal_title：Acta biomaterialia

authors： Nandakumar A,Cruz C,Mentink A,Tahmasebi Birgani Z,Moroni L,van Blitterswijk C,Habibovic P

更新日期：2013-03-01 00:00:00

abstract：:A challenge in using bioactive melt-derived glass in bone regeneration is to produce scaffolds with interconnected pores while maintaining the amorphous nature of the glass and its associated bioactivity. Here we introduce a method for creating porous melt-derived bioactive glass foam scaffolds with low silica content...

journal_title：Acta biomaterialia

authors： Nommeots-Nomm A,Labbaf S,Devlin A,Todd N,Geng H,Solanki AK,Tang HM,Perdika P,Pinna A,Ejeian F,Tsigkou O,Lee PD,Esfahani MHN,Mitchell CA,Jones JR

更新日期：2017-07-15 00:00:00

abstract：:We report on new types of chitosan-based nanogels via an ortho ester-based linkage, used as drug carriers for efficient chemotherapy. First, we synthesized a novel diacrylamide containing ortho ester (OEAM) as an acid-labile cross-linker. Subsequently, methacrylated succinyl-chitosan (MASCS) was prepared and polymeriz...

journal_title：Acta biomaterialia

authors： Yang G,Wang X,Fu S,Tang R,Wang J

更新日期：2017-09-15 00:00:00

abstract：:This study assessed the role of immobilized cell adhesion moieties on controlling the cellular attachment, adhesion and phenotype of cardiac muscle cells towards developing scaffolds for cardiac muscle tissue engineering. Collagen I, laminin and the cell-adhesive oligopeptide, arginine-glycine-aspartic acid (RGD) at c...

journal_title：Acta biomaterialia

authors： LaNasa SM,Bryant SJ

更新日期：2009-10-01 00:00:00

abstract：:Periodontal diseases like periodontitis and peri-implantitis have been linked with Gram-negative anaerobes. The incorporation of various chemotherapeutic agents, including metal ions, into several materials and devices has been extensively studied against periodontal bacteria, and materials doped with metal ions have ...

journal_title：Acta biomaterialia

authors： Goudouri OM,Kontonasaki E,Lohbauer U,Boccaccini AR

更新日期：2014-08-01 00:00:00

abstract：:Scaffolds for tissue engineering and regenerative medicine are usually subjected to different mechanical loads during in vitro and in vivo degradation. In this study, the in vitro degradation process of electrospun poly(L-lactide-co-glycolide) (PLGA) scaffolds was examined under continuous tensile load and compared wi...

journal_title：Acta biomaterialia

authors： Li P,Feng X,Jia X,Fan Y

更新日期：2010-08-01 00:00:00

abstract：:Macrophages represent a large component of the tumour microenvironment and are described to establish interactions with cancer cells, playing crucial roles in several stages of cancer progression. The functional plasticity of macrophages upon stimulation from the environment makes them susceptible to the influence of ...

journal_title：Acta biomaterialia

authors： Cardoso AP,Gonçalves RM,Antunes JC,Pinto ML,Pinto AT,Castro F,Monteiro C,Barbosa MA,Oliveira MJ

更新日期：2015-09-01 00:00:00

abstract：:After skin tissue injury or pathological removal, vascularization timing is paramount in graft survival. As full thickness skin grafts often fail to become perfused over larger surfaces, split-thickness grafts are preferred and can be used together with biomaterials, which themselves are non-angiogenic. One way of pro...

journal_title：Acta biomaterialia

authors： McLuckie M,Robotti F,Sanchez-Macedo N,Enderlin D,Frese L,Cheng PF,Levesque MP,Egaña JT,Poulikakos D,Ferrari A,Lindenblatt N

更新日期：2020-04-01 00:00:00

abstract：:Nitric oxide (NO) is an endogenous molecule with many critical biological functions that depend on its concentration. At high levels, NO provides broad-spectrum antibacterial effects through both its pathogen inhibition and killing abilities. However, its short half-life has been a great challenge to its clinical appl...

journal_title：Acta biomaterialia

authors： Hoang Thi TT,Lee Y,Le Thi P,Park KD

更新日期：2018-02-01 00:00:00

abstract：:A chitosan oligosaccharide (CSO)-indomethacin (IDM) conjugate (CI) was synthesized to fabricate chemosensitizing nanoparticles (NPs) for tumor-targeted drug delivery. IDM was conjugated to a CSO backbone via amide bond formation, of which successful synthesis was confirmed by proton-nuclear magnetic resonance analyses...

journal_title：Acta biomaterialia

authors： Lee JY,Termsarasab U,Lee MY,Kim DH,Lee SY,Kim JS,Cho HJ,Kim DD

更新日期：2017-07-15 00:00:00

abstract：:This study aimed to investigate the fluoride release properties and the effect on bond strength of two experimental adhesive cements. Synthesized particles of nano-fluorapatite (nano-FA) or nano-fluorohydroxyapatite (nano-FHA) were incorporated into a resin-modified glass ionomer cement (Fuji Ortho LC) and characteriz...

journal_title：Acta biomaterialia

authors： Lin J,Zhu J,Gu X,Wen W,Li Q,Fischer-Brandies H,Wang H,Mehl C

更新日期：2011-03-01 00:00:00

abstract：:Human embryonic stem cells (hESCs) are an exciting cell source as they offer an unlimited supply of cells that can differentiate into all cell types for regenerative medicine applications. To date, there has been no report on hESCs with calcium phosphate cement (CPC) scaffolds for bone regeneration in vivo. The object...

journal_title：Acta biomaterialia

authors： Liu X,Wang P,Chen W,Weir MD,Bao C,Xu HH

更新日期：2014-10-01 00:00:00

abstract：:We have developed a class of peptide amphiphile (PA) molecules that self-assemble into three-dimensional nanofiber networks under physiological conditions in the presence of polyvalent metal ions. The assembly can be triggered by adding PA solutions to cell culture media or other synthetic physiological fluids contain...

journal_title：Acta biomaterialia

authors： Beniash E,Hartgerink JD,Storrie H,Stendahl JC,Stupp SI

更新日期：2005-07-01 00:00:00