Abstract:
:Oxygenation instability is a very common problem in the premature infant that manifests as intermittent hypoxemia episodes (HEs). These are particularly frequent in premature infants who are on mechanical ventilation beyond the first weeks after birth. However, they can also occur in spontaneously breathing infants. Some of these episodes are due to central apnea, but in ventilated infants, they are frequently due to contractions of the abdominal musculature that can splint the respiratory pump, resulting in periods of decreased lung volume and hypoventilation. HEs are often followed by periods of hyperoxemia that results from excessive oxygen supplementation given to correct the hypoxemia. These episodes increase in frequency with postnatal age and are more common in infants with chronic lung disease. Although the evidence is not conclusive, their detrimental effects on the infant's neurologic, ocular, and respiratory system may be significant. There is no specific treatment for HEs, but several interventions are available to ameliorate the severity and duration of the episodes. Further research is needed to define the impact of HEs on the preterm infant's developing central nervous system and other organ systems and to develop effective strategies to prevent these episodes.
journal_name
Am J Perinatoljournal_title
American journal of perinatologyauthors
Bancalari E,Claure Ndoi
10.1055/s-0038-1637760subject
Has Abstractpub_date
2018-05-01 00:00:00pages
534-536issue
6eissn
0735-1631issn
1098-8785journal_volume
35pub_type
杂志文章,评审abstract:OBJECTIVE:The aim of this study is to examine the hypothesis that prolonged rupture of membranes (PROM) is associated with increased cord blood erythropoietin (EPO) concentrations, proportional to the duration of ruptured membranes. STUDY DESIGN:This study is a prospective, cross-sectional, observational (nonintervent...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0034-1384643
更新日期:2015-03-01 00:00:00
abstract::We report a case with spontaneous rupture of the renal pelvis during pregnancy. A 34-year-old Japanese woman was referred at 20 weeks' gestation because of sudden severe right flank pain. She had severe colic pain radiating to the right lower abdomen with percussion tenderness at the right costovertebral angle and was...
journal_title:American journal of perinatology
pub_type: 杂志文章,评审
doi:10.1055/s-2002-28489
更新日期:2002-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Congenital pulmonary airway malformation (CPAM) is a group of rare congenital malformations of the lung and airways. Lung ultrasound (LU) is increasingly used to diagnose neonatal respiratory diseases since it is quick, easy to learn, and radiation-free, but no formal data exist for congenital ...
journal_title:American journal of perinatology
pub_type: 杂志文章,多中心研究
doi:10.1055/s-0038-1645861
更新日期:2018-10-01 00:00:00
abstract::Carbamoyl phosphate synthetase deficiency is a type of an inborn error of metabolism with a poor prognosis. Carbamoyl phosphate synthetase is a liver-specific enzyme, and its deficiency can only be diagnosed by enzyme assay using liver biopsy specimens. A pregnant woman at risk for carbamoyl phosphate synthetase defic...
journal_title:American journal of perinatology
pub_type: 杂志文章,评审
doi:10.1055/s-2007-994579
更新日期:1994-03-01 00:00:00
abstract::We evaluated if maternal demographic and ultrasound parameters predict perinatal mortality in preterm intrauterine growth restriction (IUGR). Retrospective cohort study of preterm IUGR (delivery gestational age <35 weeks and birth weight <10th percentile for gestation). We excluded twins and fetuses with aneuploidy, i...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0029-1223284
更新日期:2009-11-01 00:00:00
abstract::We studied the effect of antenatal corticosteroids on the incidence of respiratory disorders in singleton neonates born between 34 and 36 weeks of gestation. Retrospective analysis was conducted of the incidence of respiratory distress syndrome (RDS) and other respiratory disorders (need for mechanical ventilation, co...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-1022470
更新日期:2008-02-01 00:00:00
abstract::A case is presented of a primigravida with transient diabetes insipidus, gestational hypertension, and multiple seizures resistant to magnesium sulfate and diazepam. After addition of phenytoin, no further seizures occurred. Transient diabetes insipidus in pregnancy has been previously associated with hypertension, li...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999504
更新日期:1990-07-01 00:00:00
abstract:OBJECTIVE:To compare the obstetric recommendations in American Congress of Obstetricians and Gynecologists (ACOG) practice bulletins (PB) with similar topics in UpToDate (UTD). STUDY DESIGN:We accessed all obstetric PB and cross-searched UTD (May 1999-May 2013). We analyzed only the PB which had corresponding UTD chap...
journal_title:American journal of perinatology
pub_type: 杂志文章,评审
doi:10.1055/s-0034-1396684
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:To determine the risk of gestational diabetes mellitus (GDM) and insulin resistance (IR) in obesity defined by body mass index (BMI), waist-to-hip ratio (WHR), or both combined. METHODS:Secondary analysis of a randomized multicenter trial of antioxidant supplementation versus placebo in nulliparous low-risk ...
journal_title:American journal of perinatology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1055/s-0035-1562928
更新日期:2016-01-01 00:00:00
abstract::Arteriovenous malformations of the Vein of Galen continue to present diagnostic and therapeutic challenges in the neonatal period. Approximately 40-50% of all malformations of the Vein of Galen present in the neonatal period, usually with congestive heart failure. These neonates represent the most severe cases and are...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2000-13456
更新日期:2000-01-01 00:00:00
abstract::Diagnosis of fetal pulmonary hypoplasia could be of great benefit to the obstetrician in the management of those pregnancies complicated by prolonged preterm ruptured membranes. Ultrasonography and magnetic resonance imaging were employed for fetal diagnosis of pulmonary hypoplasia and we were unable to predict accura...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994689
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVE:Neonatal biomarkers of inflammation were examined in relation to early neurodevelopment and gait in very-low-birth-weight (VLBW) preterm children. We hypothesized that preterm infants exposed to higher levels of neonatal inflammation would demonstrate lower scores on Bayley Scales of Infant Toddler Developmen...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0035-1557106
更新日期:2016-01-01 00:00:00
abstract::Disulfiram has been used effectively to deter alcohol consumption in patients with a history of alcohol abuse. Its use in reproductive age women has become increasingly common in recent years, intensifying the risk of fetal exposure. Nonspecific but significant abnormalities have been described in the infants of women...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994688
更新日期:1993-01-01 00:00:00
abstract::A markedly elevated peripheral nucleated erythrocyte count is reported in a term nonmacrosomic infant with congenital hyperinsulinism born to a nondiabetic mother. With control of hypoglycemia and hyperinsulinism, the count declined to normal. A relationship of hyperinsulinism and erythropoiesis, not related to fetal ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994568
更新日期:1994-03-01 00:00:00
abstract::In 18 women with gestational diabetes the variables of an oral glucose tolerance test (fasting and 2-hour blood glucose values and area under the blood glucose curve) performed in the last trimester of pregnancy correlated significantly with the urinary C-peptide excretion during the first 12 hours of the life (r = 0....
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999674
更新日期:1988-04-01 00:00:00
abstract::Seventy premature infants (birthweight 1.75 kg or less, gestational age 33 weeks or less) with hemoglobin less than 10 g/dL and hematocrit less than 30% were studied and randomly divided into three groups. All of them received oral elemental iron 3 mg/kg/day and vitamin E 5 mg/kg/day during the study period. Recombina...
journal_title:American journal of perinatology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1055/s-2007-994483
更新日期:1995-09-01 00:00:00
abstract::To study a possible relation between the use of postnatal glucocorticoids and the incidence and severity of retinopathy of prematurity (ROP), we conducted a retrospective study over a 4-year period that compared data of 161 preterm infants treated with hydrocortisone for bronchopulmonary dysplasia (BPD) with the data ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2000-13437
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:Normal initial blood glucose values in healthy newborns are not well defined and are subject to controversy. Despite substantive research, there is no single initial value of glucose that can be used with certainty of safety in newborns, and thus various protocols and cutoffs have been proposed. STUDY DESIGN...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0038-1667293
更新日期:2019-01-01 00:00:00
abstract::Ehlers-Danlos syndrome type IV (EDS IV) is a rare but serious disorder of connective tissue that is characterized by the abnormal production or secretion of type III collagen. Experience with pregnant patients exhibiting this syndrome is limited. This report describes the successful management of a pregnancy in a woma...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999756
更新日期:1987-04-01 00:00:00
abstract::To determine the accuracy of antenatal renal pelvis measurement as a screening tool for renal anomalies we reviewed the antenatal ultrasounds performed at our institution over 1 year. Renal pelvis dilation was found in 3.8% of pregnancies followed by our obstetrics department. In nine (17.6%) infants renal anomalies w...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-993918
更新日期:1998-03-01 00:00:00
abstract::Trichosporon beigelii is an uncommon cause of sepsis in low-birth-weight infants. We present two cases of neonatal trichosporonosis and two cases of neonatal trichosporon colonization to familiarize neonatologists with this entity and to discuss management considerations. A 23-week-gestation male developed clinical ev...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994109
更新日期:1997-02-01 00:00:00
abstract::Background Association studies of various gene variants in neonatal sepsis show conflicting results. Objective We performed a systematic review of candidate gene association studies in neonatal sepsis to provide pooled estimates of risk for selected gene variants. Methods We performed a search using MeSH terms "infect...
journal_title:American journal of perinatology
pub_type: 杂志文章,meta分析,评审
doi:10.1055/s-0036-1597132
更新日期:2017-06-01 00:00:00
abstract::Aim To determine the challenges, if any, in translating the benefits of surfactant replacement therapy (SRT) to a resource-limited setting. Method This was a retrospective descriptive study comparing the outcome of 75 cases who received surfactant and 69 controls who did not at the University Hospital of the West Indi...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0036-1598023
更新日期:2017-07-01 00:00:00
abstract::Chart review of 73 patients with 3.5 cm or more dilation, intact membranes, and regular contractions at less than 36 weeks. Forty-four (group A) received tocolysis with magnesium sulfate, and 13 of the 44 also received indomethacin. Twenty-nine (group B) received no tocolysis. Obstetric and neonatal outcomes were comp...
journal_title:American journal of perinatology
pub_type: 临床试验,杂志文章
doi:10.1055/s-2007-994478
更新日期:1995-07-01 00:00:00
abstract::Previous work has shown that fetal hydrographic magnetic resonance imaging (MRI) provided additional information complementary to T2-weighted single-shot fast spin echo (ssFSE) images. The objective of this study was to determine if hydrographic MRI provides better conspicuity of fetal eye structures compared with ssF...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0031-1295636
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:This study was aimed to evaluate the prevalence of sonographic markers for placenta accreta spectrum (PAS) in pregnancies at low-risk for PAS. STUDY DESIGN:Pregnant women at low-risk for PAS presenting for routine second trimester ultrasound who enrolled in the study were evaluated prospectively for sonograp...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0038-1676488
更新日期:2019-07-01 00:00:00
abstract::The Diabetes in Pregnancy Study Group of North America (DPSG-NA) was founded in 1997 in San Antonio, Texas, out of the recognition that the field of maternal-fetal medicine should support and conduct research to address the specialized needs of pregnant women with type 1, type 2, or gestational diabetes mellitus. Sinc...
journal_title:American journal of perinatology
pub_type: 历史文章,杂志文章
doi:10.1055/s-0036-1585082
更新日期:2016-11-01 00:00:00
abstract::With the increasing survival of extremely premature infants there is a large number of them who are developing chronic lung disease (CLD), but the severity of the lung damage is considerably less than that observed in the classic form of bronchopulmonary dysplasia (BPD). Because many of these infants have only a mild ...
journal_title:American journal of perinatology
pub_type: 杂志文章,评审
doi:10.1055/s-2001-12940
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:To review developmental outcomes of neonates with mild hypoxic-ischemic encephalopathy (HIE) treated with therapeutic hypothermia (TH). STUDY DESIGN:Neonates ≥35 weeks' gestation with mild HIE/TH (TH group, n = 30) were matched with healthy term-born infants (control group, n = 30) and reviewed for the prese...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0038-1676973
更新日期:2019-11-01 00:00:00
abstract::The significance and management of prepartum bradycardia is not well established in prepartum fetal assessment. The incidence of prolonged bradycardia was 3.5% (45 per 1284), defined as a decrease of greater than or equal to 40 beats per minute of the fetal heart rate (FHR) below the baseline for at least 2 minutes. T...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999972
更新日期:1985-10-01 00:00:00