Abstract:
OBJECTIVE:Neonatal biomarkers of inflammation were examined in relation to early neurodevelopment and gait in very-low-birth-weight (VLBW) preterm children. We hypothesized that preterm infants exposed to higher levels of neonatal inflammation would demonstrate lower scores on Bayley Scales of Infant Toddler Development, 3rd ed. (BSID-III) and slower gait velocity at 18 to 22 months adjusted age. STUDY DESIGN:A total of 102 VLBW preterm infants (birthweight [BW] ≤ 1,500 g, gestational age [GA] ≤ 32 weeks) admitted to neonatal intensive care unit [NICU] were recruited. Neonatal risk factors examined were GA at birth, BW, bronchopulmonary dysplasia, necrotizing enterocolitis, retinopathy of prematurity, sepsis, and serum C-reactive protein (CRP), albumin, and total bilirubin over first 2 postnatal weeks. At 18 to 22 months, neurodevelopment was assessed with BSID-III and gait was assessed with an instrumented mat. RESULTS:Children with neonatal CRP ≥ 0.20 mg/dL (n = 52) versus < 0.20 mg/dL (n = 37) had significantly lower BSID-III composite cognitive (92.0 ± 13.1 vs. 100.1 ± 9.6, p = 0.002), language (83.9 ± 16.0 vs. 95.8 ± 14.2, p < 0.001), and motor scores (90.0 ± 13.2 vs. 98.8 ± 10.1, p = 0.002), and slower gait velocity (84.9 ± 19.0 vs. 98.0 ± 22.4 cm/s, p = 0.004). Higher neonatal CRP correlated with lower cognitive (rho = - 0.327, p = 0.002), language (rho = - 0.285, p = 0.007), and motor scores (rho = - 0.257, p = 0.015), and slower gait (rho = - 0.298, p = 0.008). Multivariate analysis demonstrated neonatal CRP ≥ 0.20 mg/dL significantly predicted BSID-III cognitive (adjusted R(2) = 0.104, p = 0.008), language (adjusted R(2) = 0.124, p = 0.001), and motor scores (adjusted R(2) = 0.122, p = 0.004). CONCLUSIONS:Associations between low-level neonatal inflammation and neurodevelopment suggest early biomarkers that may inform neuroprotective treatment for preterm children.
journal_name
Am J Perinatoljournal_title
American journal of perinatologyauthors
Rose J,Vassar R,Cahill-Rowley K,Hintz SR,Stevenson DKdoi
10.1055/s-0035-1557106subject
Has Abstractpub_date
2016-01-01 00:00:00pages
71-8issue
1eissn
0735-1631issn
1098-8785journal_volume
33pub_type
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journal_title:American journal of perinatology
pub_type: 杂志文章,评审
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更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE: The study objective was to assess the correlation between hypernatremia during the first week of life and neurodevelopmental outcomes at 18 months of corrected age in premature infants. STUDY DESIGN: A retrospective observational study of preterm infants born at less than 32 weeks of gestation who had a neu...
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journal_title:American journal of perinatology
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journal_title:American journal of perinatology
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journal_title:American journal of perinatology
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journal_title:American journal of perinatology
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journal_title:American journal of perinatology
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-02-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
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更新日期:1992-09-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章,评审
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更新日期:2013-04-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999444
更新日期:1990-01-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999514
更新日期:1990-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1055/s-2001-16990
更新日期:2001-08-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2005-870896
更新日期:2005-08-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0036-1579652
更新日期:2016-08-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 临床试验,杂志文章
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更新日期:2006-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-09-01 00:00:00
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journal_title:American journal of perinatology
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doi:10.1055/s-0038-1673651
更新日期:2019-05-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2006-951287
更新日期:2006-10-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
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更新日期:2017-07-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994402
更新日期:1995-01-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
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更新日期:2019-07-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:American journal of perinatology
pub_type: 杂志文章
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更新日期:1989-04-01 00:00:00
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pub_type: 杂志文章
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