Abstract:
OBJECTIVE:The aim of the study is to determine if umbilical cord serum concentrations of interleukin-6 (IL-6), C-reactive protein (CRP), and myeloperoxidase (MPO), in pregnancies at risk for preterm birth (PTB), are associated with neonatal morbidities and/or altered neurodevelopmental outcomes in the children. STUDY DESIGN:Umbilical cord serum samples were collected at birth from 400 newborns delivered within a multicenter randomized controlled trial of repeated versus single course of antenatal corticosteroids (ACs), in women at increased risk for PTB. Newborns were followed through discharge and were evaluated between 36 and 42 months corrected age with neurological examination and Bayley Scales of Infant Development. Umbilical cord serum concentrations of IL-6, CRP, and MPO were determined using enzyme-linked immunoassays. Multivariate logistic regression analyses explored the relationship between umbilical cord serum IL-6, CRP, and MPO levels, adverse newborn outcomes, and PTB < 32 weeks of gestational age (GA). RESULTS:Univariate analysis revealed that umbilical cord IL-6 above the 75th percentile was associated with increased respiratory distress syndrome (RDS) and chronic lung disease (CLD), but not with necrotizing enterocolitis (NEC), intraventricular hemorrhage (IVH), or neonatal sepsis; however, this association was not significant after adjusting for GA at delivery and treatment group. No significant associations between CRP or MPO and RDS, CLD, NEC, sepsis, or IVH were evident. Regression analysis revealed that CRP above the 75th percentile was associated with a decreased risk of CLD (odds ratio, 0.10; 95% confidence interval, 0.02-0.41). No associations between umbilical cord IL-6, CRP, or MPO and MDI < 70 or PDI < 70 were evident. Umbilical cord serum concentrations of IL-6, CRP, and MPO, above the 75th percentile, were associated with more frequent PTB < 32 weeks of GA. CONCLUSION:Elevated umbilical cord serum concentration of CRP is associated with reduced risk for CLD even after adjusting for GA at delivery. Occurrence of levels > 75th percentile of IL-6, CRP, and MPO in umbilical cord serum was associated with PTB < 32 weeks of GA. Elevated umbilical cord serum concentrations of IL-6, CRP, and MPO at birth were not associated with poor neurodevelopmental outcomes.
journal_name
Am J Perinatoljournal_title
American journal of perinatologyauthors
Sorokin Y,Romero R,Mele L,Iams JD,Peaceman AM,Leveno KJ,Harper M,Caritis SN,Mercer BM,Thorp JM,O'Sullivan MJ,Ramin SM,Carpenter MW,Rouse DJ,Sibai Bdoi
10.1055/s-0033-1359723subject
Has Abstractpub_date
2014-09-01 00:00:00pages
717-26issue
8eissn
0735-1631issn
1098-8785journal_volume
31pub_type
杂志文章abstract:OBJECTIVE:The objective of this study was to evaluate the effectiveness of vaginal progesterone in reducing adverse neonatal outcome due to preterm birth (PTB) in low-risk pregnant women with a short cervical length (CL). STUDY DESIGN:Women with a singleton pregnancy without a history of PTB underwent CL measurement a...
journal_title:American journal of perinatology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1055/s-0035-1547327
更新日期:2015-08-01 00:00:00
abstract:OBJECTIVE:To determine the accuracy of clinically estimated fetal weight (CEFW) in patients with gestational diabetes (GDM), pregestational diabetes (DM), and obesity. STUDY DESIGN:This is a retrospective analysis of Consortium of Safe Labor data. Subjects were classified into six groups: DM, DM and obese, GDM, GDM an...
journal_title:American journal of perinatology
pub_type: 杂志文章
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journal_title:American journal of perinatology
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journal_title:American journal of perinatology
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更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:We have previously shown a decrease in the overall stillbirth rate at our institution in women receiving the seasonal influenza vaccine during pregnancy. The goal of this study was to ascertain factors associated with this decrease. STUDY DESIGN:This was a retrospective cohort study examining the stillbirth ...
journal_title:American journal of perinatology
pub_type: 杂志文章
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abstract:OBJECTIVE:To determine the risk of gestational diabetes mellitus (GDM) and insulin resistance (IR) in obesity defined by body mass index (BMI), waist-to-hip ratio (WHR), or both combined. METHODS:Secondary analysis of a randomized multicenter trial of antioxidant supplementation versus placebo in nulliparous low-risk ...
journal_title:American journal of perinatology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1055/s-0035-1562928
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journal_title:American journal of perinatology
pub_type: 临床试验,杂志文章
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abstract::This study assessed whether the amniotic fluid index (AFI) or the single deepest pocket (SDP) is the best technique to estimate amniotic fluid volume. The AFI and SDP were compared to a dye-determined or directly measured amniotic fluid volume. A PUBMED search from 1990 to 2006 was conducted using the search terms "si...
journal_title:American journal of perinatology
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journal_title:American journal of perinatology
pub_type: 杂志文章,评审
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journal_title:American journal of perinatology
pub_type: 临床试验,杂志文章
doi:10.1055/s-2007-999685
更新日期:1988-07-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2001-18697
更新日期:2001-11-01 00:00:00
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更新日期:2015-11-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
doi:10.1055/s-2000-13445
更新日期:2000-01-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994433
更新日期:1996-11-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1055/s-0034-1395482
更新日期:2015-07-01 00:00:00
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doi:10.1055/s-2007-999756
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更新日期:2014-08-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章,评审
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更新日期:2009-11-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2019-12-01 00:00:00
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doi:10.1055/s-0029-1236438
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journal_title:American journal of perinatology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2016-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2007-11-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994468
更新日期:1995-07-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0040-1721379
更新日期:2020-11-29 00:00:00
abstract::As new information about coronavirus disease 2019 (COVID-19) is rapidly discovered, clinicians are better equipped to make informed decisions for their patients. While current research suggests COVID-19 viral antigen is not found in vaginal secretions, its detectability in the female lower genital tract may have clini...
journal_title:American journal of perinatology
pub_type: 杂志文章
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更新日期:2020-09-01 00:00:00
abstract::Objective To assess the additive value of prenatal chromosomal microarray analysis (CMA) for all indications and the likelihood of detecting pathologic copy number variations (CNVs) based on specific indications. Methods A retrospective analysis was performed on amniocentesis and chorionic villi sampling results obtai...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0036-1586501
更新日期:2017-03-01 00:00:00