A review of studies with chlorhexidine applied directly to the umbilical cord.

Abstract:

:Infection-related neonatal mortality due to omphalitis in developing country home births is an important public health problem. Three cluster randomized trials of 4% chlorhexidine applied to the umbilical cord stump from once to multiple times in the days following a home birth have evaluated this intervention compared with other types of cord care on the development of omphalitis and neonatalmortality. Each of the three studies showed significant reductions in either omphalitis, neonatal mortality, or both with the 4% chlorhexidine. However, the optimal dosing schedule remains uncertain. Although further studies are needed to clarify this issue, from the three studies it is now clear that with a minimum of one application of 4% chlorhexidine to the umbilical cord stump following delivery, the incidence of omphalitis and neonatal mortality can be reduced, especially in preterm newborns. This intervention, which is safe and inexpensive and requires minimal training and skill, should strongly be considered for adoption wherever home births occur.

journal_name

Am J Perinatol

authors

Goldenberg RL,McClure EM,Saleem S

doi

10.1055/s-0032-1329695

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

699-701

issue

8

eissn

0735-1631

issn

1098-8785

journal_volume

30

pub_type

杂志文章,评审
  • Changes in the pathogenesis and prevention of chronic lung disease of prematurity.

    abstract::With the increasing survival of extremely premature infants there is a large number of them who are developing chronic lung disease (CLD), but the severity of the lung damage is considerably less than that observed in the classic form of bronchopulmonary dysplasia (BPD). Because many of these infants have only a mild ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章,评审

    doi:10.1055/s-2001-12940

    authors: Bancalari E

    更新日期:2001-01-01 00:00:00

  • Umbilical cord serum interleukin-6, C-reactive protein, and myeloperoxidase concentrations at birth and association with neonatal morbidities and long-term neurodevelopmental outcomes.

    abstract:OBJECTIVE:The aim of the study is to determine if umbilical cord serum concentrations of interleukin-6 (IL-6), C-reactive protein (CRP), and myeloperoxidase (MPO), in pregnancies at risk for preterm birth (PTB), are associated with neonatal morbidities and/or altered neurodevelopmental outcomes in the children. STUDY ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0033-1359723

    authors: Sorokin Y,Romero R,Mele L,Iams JD,Peaceman AM,Leveno KJ,Harper M,Caritis SN,Mercer BM,Thorp JM,O'Sullivan MJ,Ramin SM,Carpenter MW,Rouse DJ,Sibai B

    更新日期:2014-09-01 00:00:00

  • Survival and ventilatory course of a regional cohort of very low birthweight (501-1500 gm) infants.

    abstract::To minimize the selection bias inherent in reporting results gathered only in neonatal intensive care units, this study presents survival and respiratory course data on all 299 infants of birthweight 501 to 1500 gm liveborn to residents of the North Central Illinois Perinatal Region in 1985-1986. The survival rate was...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-999632

    authors: Powers WF,Hegwood PD

    更新日期:1989-10-01 00:00:00

  • Birth Tourism Is Associated with Fewer Neonatal Intensive Care Unit Admissions: A Healthy Migrant Effect?

    abstract:OBJECTIVE: This work aimed to study perinatal, maternal, and neonatal characteristics of birth tourism (BT) mother-baby dyads and the rate of neonatal intensive care unit (NICU) admissions of BT infants. STUDY DESIGN: Retrospective study at a regional perinatal center comparing BT mother-baby dyads to all dyads. BT in...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0040-1719117

    authors: Lim J,Sun WD,Zhang L,Mikhael M

    更新日期:2020-11-09 00:00:00

  • Conservative management of abdominal gunshot wound in a pregnant woman.

    abstract::An abdominal gunshot wound in pregnancy warrants prompt surgical exploration but does not mandate uterine evacuation. Despite an entry and exit bullet wound to the uterus an apparent desire for pregnancy termination, a conservative approach was adopted with primary repair of the uterus, in conjunction with surgical re...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-999691

    authors: Kirshon B,Young R,Gordon AN

    更新日期:1988-07-01 00:00:00

  • Pregnancy complicated by hemipelvectomy: case presentations and review of the literature.

    abstract::Nine patients with posthemipelvectomy with subsequent delivery of 13 living children are reported in the world's literature. This radical procedure is possible only in a modern age of intensive medical and surgical support. Additional cases can be expected in the future. We present two additional patients and three ch...

    journal_title:American journal of perinatology

    pub_type: 杂志文章,评审

    doi:10.1055/s-2007-999616

    authors: Snyder DJ,Thomas RL

    更新日期:1989-07-01 00:00:00

  • Equation for predicting weight gain in very low-birth-weight infants.

    abstract::I developed a single equation that simulated previously published growth charts for very low-birth-weight infants, using birth weight as the only variable. The intent of this study was to validate the equation using infants admitted to our neonatal intensive care unit (NICU) and to determine if this equation could be ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-993914

    authors: Meetze WH

    更新日期:1998-02-01 00:00:00

  • Antenatal Infections and Respiratory Outcome in Preterm Infants.

    abstract::Fetal exposure to infection and inflammation can result in accelerated lung maturation and simultaneously altered lung development. This alteration is characterized by reduced alveolar and vascular formation that is one of the hallmarks of the changes observed in animal models and in infants with bronchopulmonary dysp...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0040-1714347

    authors: Bancalari E

    更新日期:2020-09-01 00:00:00

  • Randomized, controlled pilot trial of bupropion for pregnant smokers: challenges and future directions.

    abstract:OBJECTIVE:The aim of the study is to conduct an initial pilot trial evaluating the feasibility, safety, and efficacy of bupropion for smoking cessation in pregnancy. STUDY DESIGN:A randomized, double-blind, parallel-group pilot study of bupropion versus placebo with 50 pregnant smokers was planned. Eligibility criteri...

    journal_title:American journal of perinatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1055/s-0034-1386635

    authors: Stotts AL,Northrup TF,Cinciripini PM,Minnix JA,Blalock JA,Mullen PD,Pedroza C,Blackwell S

    更新日期:2015-03-01 00:00:00

  • Ultrastructure of human colostral cells.

    abstract::The ultrastructural architecture of colostral cells of mothers of pre- and full-term infants is described. The polymorphonuclears were engaged in vivid phagocytosis of fat droplets. Similar findings were observed on the macrophages. The lymphocytes appeared normal in size and ultrastructure. A small number of eosinoph...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-994162

    authors: Straussberg R,Hart J,Alexandrova S,Sirota L,Djaldetti M,Bessler H

    更新日期:1997-07-01 00:00:00

  • The risk for preterm labor in women receiving 17 alpha-hydroxyprogesterone caproate prophylaxis for preterm birth prevention.

    abstract::We sought to identify maternal or clinical characteristics of women likely to develop preterm labor (PTL) at <34 weeks' gestation while receiving 17 alpha-hydroxyprogesterone caproate (17P) prophylaxis. Current singleton gestations with prior preterm delivery enrolled for outpatient 17P administration at <27 weeks' ge...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0029-1243306

    authors: Joy S,Rhea DJ,Istwan NB,Desch CN,Stanziano G

    更新日期:2010-04-01 00:00:00

  • Comparison of the Miller Laryngoscope and Videolaryngoscope for Tracheal Intubation by Novice Doctors during Neonatal Cardiopulmonary Resuscitation: A Randomized Crossover Simulation Trial.

    abstract:OBJECTIVE:Recent guidelines for neonatal cardiopulmonary resuscitation emphasize the importance of adequate ventilation. In cases of failed resuscitation with positive pressure ventilation, tracheal intubation and chest compressions are recommended. The present study compared the utility of the Miller laryngoscope (Mil...

    journal_title:American journal of perinatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1055/s-0034-1395482

    authors: Komasawa N,Ueki R,Kaminoh Y,Nishi S

    更新日期:2015-07-01 00:00:00

  • The History and Contributions of the Diabetes in Pregnancy Study Group of North America (1997-2015).

    abstract::The Diabetes in Pregnancy Study Group of North America (DPSG-NA) was founded in 1997 in San Antonio, Texas, out of the recognition that the field of maternal-fetal medicine should support and conduct research to address the specialized needs of pregnant women with type 1, type 2, or gestational diabetes mellitus. Sinc...

    journal_title:American journal of perinatology

    pub_type: 历史文章,杂志文章

    doi:10.1055/s-0036-1585082

    authors: Rosen JA,Langer O,Reece EA,Miodovnik M

    更新日期:2016-11-01 00:00:00

  • Nonimmune hydrops fetalis due to congenital syphilis associated with negative intrapartum maternal serology screening.

    abstract::We present an unusual case, in which a woman presenting with markedly decreased fetal movements at 29 weeks gestation following a recent increase in fundal height was noted sonographically to have fetal hydrops consisting of scalp edema, marked hepatomegaly, ascites, and polyhydramnios. No lethal structural congenital...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-993933

    authors: Levine Z,Sherer DM,Jacobs A,Rotenberg O

    更新日期:1998-04-01 00:00:00

  • Liposomal amphotericin B in neonates with invasive candidiasis.

    abstract::Liposomal amphotericin B L-Amp B, a novel formulation of Amp B, is effective for the treatment of invasive fungal infections in children and adults and is associated with less toxicity than the conventional preparation. Data on the use of L-Amp B in neonates is scarce. We describe the clinical course of two premature ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-994337

    authors: al Arishi H,Frayha HH,Kalloghlian A,al Alaiyan S

    更新日期:1997-10-01 00:00:00

  • First trimester disulfiram exposure: report of two cases.

    abstract::Disulfiram has been used effectively to deter alcohol consumption in patients with a history of alcohol abuse. Its use in reproductive age women has become increasingly common in recent years, intensifying the risk of fetal exposure. Nonspecific but significant abnormalities have been described in the infants of women...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-994688

    authors: Helmbrecht GD,Hoskins IA

    更新日期:1993-01-01 00:00:00

  • Feto-neonatal ultrasonography to detect renal abnormalities: evaluation of 1-year screening program.

    abstract::To determine the accuracy of antenatal renal pelvis measurement as a screening tool for renal anomalies we reviewed the antenatal ultrasounds performed at our institution over 1 year. Renal pelvis dilation was found in 3.8% of pregnancies followed by our obstetrics department. In nine (17.6%) infants renal anomalies w...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-993918

    authors: Fasolato V,Poloniato A,Bianchi C,Spagnolo D,Valsecchi L,Ferrari A,Paesano P,Del Maschio A

    更新日期:1998-03-01 00:00:00

  • A Genome-Wide Analysis of Clinical Chorioamnionitis among Preterm Infants.

    abstract:OBJECTIVE:To identify single nucleotide polymorphisms (SNPs) associated with clinical chorioamnionitis among preterm infants. STUDY DESIGN:We reanalyzed a genome-wide association study (GWAS) from preterm newborns at less than 30 weeks' gestation. Cases and control definitions were determined using administrative reco...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0038-1677503

    authors: Spiegel AM,Li J,Oehlert JW,Mayo JA,Quaintance CC,Girsen AI,Druzin ML,El-Sayed YY,Shaw GM,Stevenson DK,Gibbs RS

    更新日期:2019-12-01 00:00:00

  • Temporal Profile of Early Pulmonary Hypertension in Preterm Infants.

    abstract::Objective The objective of this study was to study the temporal profile of pulmonary hypertension (PH) in preterm infants. Study Design Infants < 28 weeks were screened for early PH at 10 to 14 days of life. Infants with early PH (n = 10) and gestationally matched controls (n = 18) underwent serial echocardiography ev...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0036-1581079

    authors: Mirza H,Ziegler J,Ford S,Padbury J,Tucker R,Laptook A

    更新日期:2016-07-01 00:00:00

  • Are maternal serum troponin I levels affected by vaginal or cesarean delivery?

    abstract::Our objective was to describe the change in the level of troponin I in patients who undergo a vaginal or cesarean delivery. We obtained troponin I levels on admission and 1 hour after delivery in women undergoing vaginal and cesarean deliveries. Exclusion criteria included <37 weeks' gestation, a history of cardiac di...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2004-820507

    authors: Koscica KL,Bebbington M,Bernstein PS

    更新日期:2004-01-01 00:00:00

  • Implementation of a universal cervical length screening program for the prevention of preterm birth.

    abstract:OBJECTIVE:The objective of this article is to evaluate the implementation and acceptability of a universal cervical length (CL) screening program for prediction and prevention of preterm birth (PTB). STUDY DESIGN:We performed a prospective observational study to evaluate the implementation and acceptability of a unive...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0034-1371710

    authors: Orzechowski KM,Nicholas SS,Baxter JK,Weiner S,Berghella V

    更新日期:2014-12-01 00:00:00

  • Gentamicin levels in pregnant women with pyelonephritis.

    abstract::This study was performed at University Medical Center, Lubbock, Texas, from July 1989 to June 1990. We obtained serum gentamicin peak and trough levels in 23 pregnant women with pyelonephritis. The patients were given a loading dose of 2 mg/kg gentamicin, followed by 1.5 mg/kg gentamicin adjusted for obesity every 8 h...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-994533

    authors: Graham JM,Blanco JD,Oshiro BT,Magee KP

    更新日期:1994-01-01 00:00:00

  • Obestatin Reduces Intestinal Damage in Experimental Necrotizing Enterocolitis in Newborn Rats.

    abstract:OBJECTIVE:To investigate the effect of pretreatment with obestatin (OB), an endogenous hormone also found in mother's milk, in experimental necrotizing enterocolitis (NEC). STUDY DESIGN:Pups were randomized into four groups: control, OB-control, NEC, and OB-NEC. NEC was induced by asphyxia and hypothermia in the NEC a...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0038-1676491

    authors: Korkut S,Özdemir A,Yay AH,Yalçın B,Ceylan M,Korkmaz L,Yazıcı C,Güntürk İ,Kurtoğlu S

    更新日期:2019-09-01 00:00:00

  • Fetal and neonatal mortality among twin gestations in a Canadian population: the effect of intrapair birthweight discordance.

    abstract::The purpose of this study was to examine the association between intrapair birthweight discordance and fetal and neonatal mortality. This was a historical cohort study, using the Statistics Canada linked birth-infant death file. Twin births in Canada (excluding Ontario) for the period 1986-1997 were studied. Outcome m...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2005-870899

    authors: Wen SW,Fung KF,Huang L,Demissie K,Joseph KS,Allen AC,Kramer MS,Fetal and Infant Health Group of the Canadian Perinatal Surveillance System.

    更新日期:2005-07-01 00:00:00

  • Histologic examination of the placenta in the growth-retarded fetus.

    abstract::This investigation was undertaken to determine whether histologic examination of the placenta contributed to a better understanding of the cause of intrauterine fetal growth retardation. Placentas were examined of 151 liveborn infants whose birthweights were in the lower 10th percentile for gestational age. One or mor...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-999546

    authors: Rayburn W,Sander C,Compton A

    更新日期:1989-01-01 00:00:00

  • Obstetrical determinants of neonatal neurological morbidity in < or = 1000-gram infants.

    abstract::The purpose of this study is to identify obstetrical factors associated with adverse neurological outcome in < or =1000-g infants. In a 1-year (1992-1993) observational study, the NICHD MFMU Network collected obstetrical risk factors for 486 infants who weighed < or =1000 g at birth and who survived > 2 days. Infants'...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-993833

    authors: Goepfert AR,Goldenberg RL,Hauth JC,Bottoms SF,Iams JD,Mercer B,MacPherson CA,Moawad AH,VanDorsten JP,Thurnau GR

    更新日期:1999-01-01 00:00:00

  • Association of midgestational paraoxonase 1 activity with pregnancies complicated by preeclampsia.

    abstract::The antioxidant enzyme paraoxonase 1 is a marker of oxidative stress and has been implicated in the pathogenesis of preeclampsia. Our objective was to determine if an association exists between low paraoxonase 1 activity at midgestation and the development of preeclampsia. We conducted a case-control study of 50 women...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0029-1236438

    authors: Baker AM,Klein RL,Haeri S,Moss KL,Boggess KA

    更新日期:2010-03-01 00:00:00

  • Prenatal Diagnosis of Vasa Previa: Outpatient versus Inpatient Management.

    abstract:OBJECTIVE:The aim of this study was to compare the pregnancy outcome of two different management strategies: outpatient versus inpatient in women with prenatal diagnosis of vasa previa. MATERIALS AND METHODS:This is a retrospective cohort study conducted at a single tertiary center. Women with a prenatally diagnosed v...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0038-1669396

    authors: Fishel Bartal M,Sibai BM,Ilan H,Katz S,Schushan Eisen I,Kassif E,Yoeli R,Yinon Y,Mazaki-Tovi S

    更新日期:2019-03-01 00:00:00

  • Recombinant human Clara cell secretory protein treatment increases lung mRNA expression of surfactant proteins and vascular endothelial growth factor in a premature lamb model of respiratory distress syndrome.

    abstract::Infant respiratory distress syndrome (IRDS) can lead to impaired alveolarization and dysmorphic vascularization of bronchopulmonary dysplasia. Clara cell secretory protein (CC10) has anti-inflammatory properties but is deficient in the premature infant. Because surfactant and vascular endothelial growth factor (VEGF) ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0028-1090587

    authors: Wolfson MR,Funanage VL,Kirwin SM,Pilon AL,Shashikant BN,Miller TL,Shaffer TH

    更新日期:2008-11-01 00:00:00

  • A simplified risk-scoring system for prematurity.

    abstract::Prematurity, the major cause of perinatal morbidity and mortality, results from a multifactorial interaction of medical, historic, and psychosocial conditions. Although the literature contains several reports of prematurity risk-scoring systems, the relative importance of specific risk factors may depend on the popula...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-999893

    authors: Ross MG,Hobel CJ,Bragonier JR,Bear MB,Bemis RL

    更新日期:1986-10-01 00:00:00