Abstract：
:Fetal exposure to infection and inflammation can result in accelerated lung maturation and simultaneously altered lung development. This alteration is characterized by reduced alveolar and vascular formation that is one of the hallmarks of the changes observed in animal models and in infants with bronchopulmonary dysplasia (BPD). These opposite effects on maturation and on lung development can explain the reduced severity of respiratory distress syndrome (RDS) but increased incidence of BPD observed in infants exposed to antenatal infections. This also explains why infants born to mothers with chorioamnionitis or colonized with ureaplasma urealitycum have an increased risk of lung injury and BPD. Despite the negative effects of infection on lung development, there is no clear evidence that antibiotic therapy improves the respiratory course in these infants. While the administration of azithromycin to ureaplasma colonized infants is effective in eradicating airway colonization, the effect on BPD is inconclusive. One of the few interventions that have been shown to improve respiratory outcome and reduce BPD in infants with severe RDS is the modulation of inflammation by the administration of systemic or intratracheal steroids early after birth. KEY POINTS: · Antenatal infection can reduce RDS.. · Fetal exposure to infection can alter lung development and increase BPD.. · The detrimental effect of infection is enhanced by mechanical ventilation..
journal_name
Am J Perinatoljournal_title
American journal of perinatologyauthors
Bancalari Edoi
10.1055/s-0040-1714347subject
Has Abstractpub_date
2020-09-01 00:00:00pages
S39-S41issue
S 02eissn
0735-1631issn
1098-8785journal_volume
37pub_type
杂志文章abstract：:The purpose of this study was to compare the delayed response to Bacillus Calmette-Guérin (BCG) immunization in preterm infants 31.4 to 34.6 weeks of age with full-terms infants by tuberculin test (tuberculin skin test with purified protein derivative [PPD]). One hundred newborns were studied from November 2000 to Apr...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-970080
更新日期：2007-03-01 00:00:00
abstract：:Preeclampsia is uncommon prior to 24 weeks gestation and has been associated with partial and complete hydatidiform moles. We present an unusual case in which a patient was diagnosed with preeclampsia at 17 weeks gestation. Ultrasound findings were consistent with a partial hydatidiform mole. Within 24 hours of the on...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2006-934093
更新日期：2006-04-01 00:00:00
abstract：:This investigation was undertaken to determine whether histologic examination of the placenta contributed to a better understanding of the cause of intrauterine fetal growth retardation. Placentas were examined of 151 liveborn infants whose birthweights were in the lower 10th percentile for gestational age. One or mor...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-999546
更新日期：1989-01-01 00:00:00
abstract：:Objective The objective of this study was to study the temporal profile of pulmonary hypertension (PH) in preterm infants. Study Design Infants < 28 weeks were screened for early PH at 10 to 14 days of life. Infants with early PH (n = 10) and gestationally matched controls (n = 18) underwent serial echocardiography ev...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0036-1581079
更新日期：2016-07-01 00:00:00
abstract：:Presented are three cases of fetal death, all of which occurred within 3 days of a normal biophysical profile. Despite the excellent record of this antepartum test in predicting fetal well-being, there is a low incidence of false-negative tests; increasing the frequency of testing will not prevent all false-negative t...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-999352
更新日期：1991-03-01 00:00:00
abstract：OBJECTIVE:To assess the association between altitudes of neonatal intensive care units (NICU) and the rate of bronchopulmonary dysplasia (BPD) and BPD/death in very preterm infants. STUDY DESIGN:Data from infants born at <33 weeks' gestation admitted to Canadian Neonatal Network during 2008 and 2009 were analyzed. The...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0032-1329690
更新日期：2013-08-01 00:00:00
abstract：:Amniocentesis to guide the management of preterm pregnancies complicated by premature rupture of the membranes (PROM) has been adopted at several centers. The purpose of this study was to evaluate this practice prospectively among comparable groups of patients, which has not previously been reported. Forty-seven patie...
journal_title：American journal of perinatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1055/s-2007-1000031
更新日期：1984-07-01 00:00:00
abstract：:Acute kidney injury (AKI) refers to the rapid loss of renal function. In clinical practice, AKI is common among hospitalized patients of all age groups including neonates and remains an important cause of morbidity and mortality due to its late diagnosis and therefore delayed therapeutic intervention. Although the pre...
journal_title：American journal of perinatology
pub_type： 杂志文章,评审
doi：10.1055/s-0032-1326985
更新日期：2013-05-01 00:00:00
abstract：:Objective To determine if mandatory online training in electronic fetal monitoring (EFM) improved agreement in documentation between obstetric care providers and nurses on labor and delivery. Methods Health care professionals working in obstetrics at our institution were required to complete a course on EFM interpreta...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0036-1572540
更新日期：2016-07-01 00:00:00
abstract：:Serial ultrasound measurements of the fetus under investigation is an important indicator of fetal growth, and thus fetal health. To assess how reliable those measurements are, a videotape was made, and, utilizing an ultrasound machine that allowed the placement of callipers on the videotape, the dispersion of the mea...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-999271
更新日期：1992-09-01 00:00:00
abstract：:Our purpose was to evaluate the impact of intravenous and oral tocolysis on prolongation of gestation for women with preterm uterine contractions and/or labor. Candidates for evaluation and treatment including women with contractions between 24 and 35 weeks. Two hundred women (group I) without cervical changes met the...
journal_title：American journal of perinatology
pub_type： 临床试验,杂志文章
doi：10.1055/s-2007-994169
更新日期：1997-08-01 00:00:00
abstract：:We evaluated if maternal demographic and ultrasound parameters predict perinatal mortality in preterm intrauterine growth restriction (IUGR). Retrospective cohort study of preterm IUGR (delivery gestational age <35 weeks and birth weight <10th percentile for gestation). We excluded twins and fetuses with aneuploidy, i...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0029-1223284
更新日期：2009-11-01 00:00:00
abstract：OBJECTIVE:To evaluate the association between adequacy of prenatal care utilization and risk of fetal and neonatal mortality and adverse outcomes. METHODS:We conducted a population-based cohort study using the Center for Disease Control and Prevention's Linked Birth-Infant Death and Fetal Death data on all deliveries ...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0032-1316439
更新日期：2012-11-01 00:00:00
abstract：:The objective of this paper is to evaluate the efficacy of various magnetic resonance imaging (MRI) sequences and the general usefulness of prenatal MRI in determining the position of the fetal liver and visualizing lung tissue in fetuses who have congenital diaphragmatic hernia (CDH). This was a retrospective review ...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-1999-6821
更新日期：1999-01-01 00:00:00
abstract：OBJECTIVE:To determine the risk of gestational diabetes mellitus (GDM) and insulin resistance (IR) in obesity defined by body mass index (BMI), waist-to-hip ratio (WHR), or both combined. METHODS:Secondary analysis of a randomized multicenter trial of antioxidant supplementation versus placebo in nulliparous low-risk ...
journal_title：American journal of perinatology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1055/s-0035-1562928
更新日期：2016-01-01 00:00:00
abstract：:We present an unusual complication of midtrimester genetic amniocentesis of a monochorionic twin gestation in which prolonged fetal bradycardia of 60 to 80 beats per minute sustained over two hours was associated with multiple subsequent fetal anomalies. These included: microcephaly, bilateral closed-lip schizencephal...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-994354
更新日期：1996-08-01 00:00:00
abstract：:The objective of this study was to identify the most efficient and cost-effective nebulizer device for delivery of albuterol aerosol as a bronchodilator in ventilated preterm infants. Bronchodilators are frequently used as part of the therapeutic regimen of ventilated preterm infants. This can be delivered by differen...
journal_title：American journal of perinatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1055/s-2001-14526
更新日期：2001-05-01 00:00:00
abstract：:Chorioamnionitis contributes to neonatal and maternal morbidity and mortality. We aimed to evaluate of the impact of clinical and histological chorioamnionitis on mortality and morbidity of preterm infants. Maternal and neonatal data were collected in a retrospective cohort of preterm infants less than 30 weeks' gesta...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0032-1321501
更新日期：2013-01-01 00:00:00
abstract：:Twenty-five patients undergoing nipple stimulation contraction stress tests were enrolled in this study. Plasma 13,14-dihydro, 15-keto prostaglandin F2 alpha and plasma prolactin concentrations were analyzed before and during the contraction stress tests. Prolactin concentrations were significantly higher (p less than...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-999444
更新日期：1990-01-01 00:00:00
abstract：:Intra-amniotic infection is often the cause of a second-trimester abortion. The bacterial species involved include bacteria with low pathogenicity like Ureaplasma urealyticum and various Mycoplasma species. In this case we describe an intra-amniotic infection caused by Capnocytophaga sputigena, often found in the norm...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-993854
更新日期：1999-01-01 00:00:00
abstract：:The aim of this study was to determine the risk of respiratory distress syndrome (RDS) and neonatal death (NND) in relation to birth weight in preterm neonates. A group of 255 singleton preterm neonates born at 22-36 weeks were examined. The mean birth weight for each gestational week was estimated from a fitted curve...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-994327
更新日期：1997-10-01 00:00:00
abstract：OBJECTIVE:To investigate the effect of pretreatment with obestatin (OB), an endogenous hormone also found in mother's milk, in experimental necrotizing enterocolitis (NEC). STUDY DESIGN:Pups were randomized into four groups: control, OB-control, NEC, and OB-NEC. NEC was induced by asphyxia and hypothermia in the NEC a...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0038-1676491
更新日期：2019-09-01 00:00:00
abstract：OBJECTIVE: The objective of this study was to determine predictors of health care utilization and its association with neurodevelopmental outcome in a recent cohort of preterm infants. STUDY DESIGN: A total of 405 infants (born 2008-2011) seen in neonatal intensive care unit (NICU) follow-up were compared for use of h...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0037-1608678
更新日期：2018-04-01 00:00:00
abstract：:Four hundred sixty-four fetuses underwent real time ultrasound examination within 72 hours before birth to evaluate other factors than the weight formula itself that might influence the accuracy of ultrasound weight estimation. The results indicated that fetal sex had no effect on weight estimation accuracy, but that ...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-999866
更新日期：1986-07-01 00:00:00
abstract：OBJECTIVE:To determine epidemiology and clinical characteristics of infants with methicillin-susceptible (MSSA) and -resistant Staphylococcus aureus (MRSA) in a level III neonatal intensive care unit (NICU). STUDY DESIGN:All NICU admissions (2001 to 2008) with any positive S. aureus culture were included as cases. Cas...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0032-1304819
更新日期：2012-06-01 00:00:00
abstract：:An abdominal gunshot wound in pregnancy warrants prompt surgical exploration but does not mandate uterine evacuation. Despite an entry and exit bullet wound to the uterus an apparent desire for pregnancy termination, a conservative approach was adopted with primary repair of the uterus, in conjunction with surgical re...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-999691
更新日期：1988-07-01 00:00:00
abstract：OBJECTIVE:We assessed the utility of plasma B-type natriuretic peptide (BNP) in infants with persistent pulmonary hypertension of the newborn (PPHN) in the prediction of inhaled nitric oxide (iNO) requirement. METHODS:This prospective study involved neonates (gestational age ≥ 34 weeks) with PPHN and confirmatory echo...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0035-1548540
更新日期：2015-09-01 00:00:00
abstract：OBJECTIVE: Delayed maturation of auditory brainstem pathway in neonates admitted to the neonatal intensive care unit (NICU) may lead to misdiagnosis of children with normal peripheral hearing and inappropriate use of amplification devices. The aim of this study is to determine the pattern of auditory brain stem respons...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0040-1709467
更新日期：2020-04-10 00:00:00
abstract：OBJECTIVE:Magnesium historically has been used for treatment and/or prevention of eclampsia or preterm labor. More recently, antepartum magnesium sulfate has been suggested for prevention of cerebral palsy in preterm infants. Although adverse effects and toxicity of magnesium in pregnant women are well known, the fetal...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0032-1316440
更新日期：2012-11-01 00:00:00
abstract：PURPOSE:We hypothesized that surgical energy could be used to create hysterotomies in open fetal surgery. STUDY DESIGN:Initial studies compared the LigaSure Impact and Harmonic ACE + 7 Shears in the efficiency of hysterotomy and thermal damage. Pregnant ewes at an estimated gestational age (EGA) of 116 to 120 days (te...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0038-1673664
更新日期：2019-06-01 00:00:00
