Neonatal effects of magnesium sulfate given to the mother.

Abstract:

OBJECTIVE:Magnesium historically has been used for treatment and/or prevention of eclampsia or preterm labor. More recently, antepartum magnesium sulfate has been suggested for prevention of cerebral palsy in preterm infants. Although adverse effects and toxicity of magnesium in pregnant women are well known, the fetal-neonatal effects of magnesium are less clear. The objective of this study was to evaluate the effects of magnesium on the newborn infant. STUDY DESIGN:This is a retrospective cohort analysis of women who received antepartum magnesium sulfate for prevention or treatment of eclampsia. Magnesium sulfate was given intravenously beginning with a 6-g dose, followed by 2- to 3-g/h infusion. Newborn hypotonia was diagnosed if an infant exhibited less than normal tone/activity upon admission to the nursery. RESULTS:Between January 2000 and February 2009, a total of 6654 women with preeclampsia were treated with intravenous magnesium sulfate as described; 88 (6%) of the infants were diagnosed with hypotonia. Lower 1-minute and 5-minute Apgar scores, intubation in the delivery room, admission to special care nursery, and hypotonia were all significantly increased as maternal serum magnesium concentrations increased before birth. CONCLUSION:Several neonatal complications are significantly related to increasing concentrations of magnesium in the maternal circulation.

journal_name

Am J Perinatol

authors

Abbassi-Ghanavati M,Alexander JM,McIntire DD,Savani RC,Leveno KJ

doi

10.1055/s-0032-1316440

subject

Has Abstract

pub_date

2012-11-01 00:00:00

pages

795-9

issue

10

eissn

0735-1631

issn

1098-8785

journal_volume

29

pub_type

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