Abstract:
OBJECTIVE:Magnesium historically has been used for treatment and/or prevention of eclampsia or preterm labor. More recently, antepartum magnesium sulfate has been suggested for prevention of cerebral palsy in preterm infants. Although adverse effects and toxicity of magnesium in pregnant women are well known, the fetal-neonatal effects of magnesium are less clear. The objective of this study was to evaluate the effects of magnesium on the newborn infant. STUDY DESIGN:This is a retrospective cohort analysis of women who received antepartum magnesium sulfate for prevention or treatment of eclampsia. Magnesium sulfate was given intravenously beginning with a 6-g dose, followed by 2- to 3-g/h infusion. Newborn hypotonia was diagnosed if an infant exhibited less than normal tone/activity upon admission to the nursery. RESULTS:Between January 2000 and February 2009, a total of 6654 women with preeclampsia were treated with intravenous magnesium sulfate as described; 88 (6%) of the infants were diagnosed with hypotonia. Lower 1-minute and 5-minute Apgar scores, intubation in the delivery room, admission to special care nursery, and hypotonia were all significantly increased as maternal serum magnesium concentrations increased before birth. CONCLUSION:Several neonatal complications are significantly related to increasing concentrations of magnesium in the maternal circulation.
journal_name
Am J Perinatoljournal_title
American journal of perinatologyauthors
Abbassi-Ghanavati M,Alexander JM,McIntire DD,Savani RC,Leveno KJdoi
10.1055/s-0032-1316440subject
Has Abstractpub_date
2012-11-01 00:00:00pages
795-9issue
10eissn
0735-1631issn
1098-8785journal_volume
29pub_type
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journal_title:American journal of perinatology
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pub_type: 杂志文章,评审
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journal_title:American journal of perinatology
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更新日期:1993-11-01 00:00:00
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