Abstract:
:Infant respiratory distress syndrome (IRDS) can lead to impaired alveolarization and dysmorphic vascularization of bronchopulmonary dysplasia. Clara cell secretory protein (CC10) has anti-inflammatory properties but is deficient in the premature infant. Because surfactant and vascular endothelial growth factor (VEGF) profiles are impaired by inflammation and CC10 inhibits lung inflammation, we hypothesized that CC10 may up-regulate surfactant protein (SP) and VEGF expression. Preterm lambs ( N = 24; 126 +/- 3 days [standard error] gestation) with IRDS were randomized to receive 100 mg/kg surfactant, 100 mg/kg surfactant followed by intratracheal 0.5, 1.5, or 5 mg/kg rhCC10 and studied for 4 hours. Gas exchange and lung mechanics were monitored; surfactant protein and VEGF mRNA profiles in lung were assessed. There was a significant rhCC10 dose-dependent increase in respiratory compliance and ventilation efficiency index; both parameters were significantly greater in animals treated with 5 mg/kg rhCC10 than those treated with surfactant alone. Similarly, there was a significant rhCC10 dose and protein-dependent increase in surfactant protein (SP-B > SP-C > SP-A) and dose- and isoform-dependent increase in VEGF (VEGF189 > VEGF165 > VEGF121). These data demonstrate that early intervention with rhCC10 up-regulates surfactant protein and VEGF expression, supporting the role of CC10 to protect against hyperoxia and mechanical ventilation in the immature lung.
journal_name
Am J Perinatoljournal_title
American journal of perinatologyauthors
Wolfson MR,Funanage VL,Kirwin SM,Pilon AL,Shashikant BN,Miller TL,Shaffer THdoi
10.1055/s-0028-1090587subject
Has Abstractpub_date
2008-11-01 00:00:00pages
637-45issue
10eissn
0735-1631issn
1098-8785journal_volume
25pub_type
杂志文章abstract::Caffeine is commonly used in the treatment of apnea of prematurity. The skin of preterm infants varies considerably in its level of maturity. To understand skin absorption in low birthweight infants (less than 1500 gm) with gestational age between 26 and 34 weeks, a group of 56 preterm babies was studied after percuta...
journal_title:American journal of perinatology
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doi:10.1055/s-2007-999282
更新日期:1992-09-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章,评审
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abstract:OBJECTIVE:We have previously shown a decrease in the overall stillbirth rate at our institution in women receiving the seasonal influenza vaccine during pregnancy. The goal of this study was to ascertain factors associated with this decrease. STUDY DESIGN:This was a retrospective cohort study examining the stillbirth ...
journal_title:American journal of perinatology
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journal_title:American journal of perinatology
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journal_title:American journal of perinatology
pub_type: 杂志文章
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journal_title:American journal of perinatology
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doi:10.1055/s-0032-1304819
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journal_title:American journal of perinatology
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journal_title:American journal of perinatology
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journal_title:American journal of perinatology
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journal_title:American journal of perinatology
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journal_title:American journal of perinatology
pub_type: 杂志文章,评审
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更新日期:2015-05-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章,评审
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更新日期:1996-05-01 00:00:00
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journal_title:American journal of perinatology
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doi:10.1055/s-0040-1714347
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journal_title:American journal of perinatology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1984-07-01 00:00:00
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journal_title:American journal of perinatology
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更新日期:2008-04-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 临床试验,杂志文章
doi:10.1055/s-0032-1323580
更新日期:2013-03-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-04-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0030-1253097
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journal_title:American journal of perinatology
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journal_title:American journal of perinatology
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journal_title:American journal of perinatology
pub_type: 杂志文章
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更新日期:2018-08-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994524
更新日期:1994-01-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2015-04-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
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更新日期:2020-07-23 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
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journal_title:American journal of perinatology
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更新日期:2014-11-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
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更新日期:2020-09-21 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
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更新日期:1996-01-01 00:00:00
abstract::While treatment of respiratory distress syndrome (RDS) with surfactant in premature neonates is well established, evidence for its use in non-RDS conditions, especially in the term neonate, has been less abundant. The last published review on a PubMed search was in 2001. In this review, we comprehensively and critical...
journal_title:American journal of perinatology
pub_type: 杂志文章,评审
doi:10.1055/s-0035-1556883
更新日期:2016-01-01 00:00:00