Abstract：
BACKGROUND:Measurements of quantitative blood flow are crucial during brain vascular surgery. Indocyanine green video angiography (ICG-VAG) is an accepted method of blood flow visualization; however, quantitative techniques have not yet been established. Thus, the aim of this study was to further develop ICG analysis for visualizing intraoperative flow changes. METHODS:We conducted basic experiments and clinical investigations to establish a relationship between ICG-VAG and measured blood flow. We evaluated several parameters and identified optimal indicators that precisely reflect blood (or fluid) flow. Both in vitro and in vivo studies were performed to calculate the interval between baseline and the intensity peak (Grad) and to measure actual flow rate. RESULTS:Grad and actual flow rate showed good exponential correlation, with R2 values of 0.90 in vitro and 0.82 in vivo. In a representative patient (case 3), we performed intraoperative flow analysis using FlowInsight, which identified a marked elevation in Grad on the brain surface. Because this observation is predictive of brain hyperperfusion, we used these data to carefully manage blood pressure postoperatively. CONCLUSIONS:Grad is the optimum parameter for estimating flow conditions. Although ICG-VAG provides only visual profiles of blood circulation in the brain, this procedure has the potential to be widely used in clinical situations. ICG-based flow measurement can be used to identify normal and abnormal blood flow conditions, such as graft flow and vascular pathology. The novelty of this technique is that the fluorescence intensity of Grad enables surgeons to quantitatively measure real blood flow.
journal_name
World Neurosurgjournal_title
World neurosurgeryauthors
Saito M,Saga T,Hayashi H,Noro S,Wada H,Kamada Kdoi
10.1016/j.wneu.2018.04.148subject
Has Abstractpub_date
2018-08-01 00:00:00pages
e187-e193eissn
1878-8750issn
1878-8769pii
S1878-8750(18)30868-4journal_volume
116pub_type
杂志文章abstract：:The innominate artery, also known as the brachiocephalic artery, is the first vessel off the aortic arch and provides blood to the right arm, neck, and head. Occlusion of the innominate artery can be treated with endarterectomy, angioplasty, stenting, and bypass grafting. Bypass grafting describes a surgical procedure...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.05.134
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abstract：BACKGROUND:Patients with brain tumors, particularly gliomas, commonly present with seizures. Higher incidence of seizure has been reported in low-grade gliomas and tumors located within the temporal and insular area. The association between IDH1 and IDH2 mutations with preoperative seizures in glioma and the magnitude ...
journal_title：World neurosurgery
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.wneu.2017.12.112
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abstract：BACKGROUND:Electrocardiogram (ECG)-triggered angiography non-contrast-enhanced (TRANCE) imaging is useful for investigating peripheral vessel diseases; however, its efficacy for access route assessment in cerebral angiography has yet to be reported. Therefore we aimed to evaluate the efficacy of TRANCE imaging in the a...
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doi：10.1016/j.wneu.2018.07.283
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doi：10.1016/j.wneu.2019.10.038
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journal_title：World neurosurgery
pub_type： 杂志文章,评审
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pub_type： 杂志文章
doi：10.1016/j.wneu.2019.03.289
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journal_title：World neurosurgery
pub_type： 杂志文章
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2016.12.029
更新日期：2017-03-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2018.04.053
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.03.023
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journal_title：World neurosurgery
pub_type： 历史文章,杂志文章
doi：10.1016/j.wneu.2017.02.021
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:Direct extracranial-intracranial (EC-IC) bypass is one of the fundamental techniques to prevent recurrent stroke in patients with adult-onset ischemic moyamoya disease. When the standard superficial temporal artery (STA) cannot be used for a graft, the posterior auricular artery (PAA) can be a potential surr...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2017.09.005
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pub_type： 杂志文章,评审
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更新日期：2017-02-01 00:00:00
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pub_type： 杂志文章,多中心研究
doi：10.1016/j.wneu.2016.12.005
更新日期：2017-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.wneu.2019.02.008
更新日期：2019-05-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章,评审
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更新日期：2020-05-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2017.11.078
更新日期：2018-02-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2016.04.086
更新日期：2016-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.wneu.2011.12.003
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pub_type： 杂志文章,评审
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更新日期：2011-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.wneu.2018.11.212
更新日期：2019-03-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章,评审
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更新日期：2019-11-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2020-10-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.wneu.2017.06.105
更新日期：2017-09-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.03.130
更新日期：2018-07-01 00:00:00
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journal_title：World neurosurgery
pub_type： 传,历史文章,杂志文章,评审
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更新日期：2015-11-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.04.175
更新日期：2019-08-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.wneu.2015.05.073
更新日期：2015-10-01 00:00:00
