Abstract：
:Extent of resection and tumor grade are considered the most important predictors of progression-free survival (PFS) in meningiomas. However, adjuvant therapy for atypical meningiomas remains controversial, with variable PFS rates of up to 40%. The current mitotic index (MI) range for atypical meningiomas is broad, comprising all tumors with >4 and <20 mitotic count per 10 high-power fields, leading to substantial within-grade variation of recurrence risk, especially in borderline histologic cases, creating discordance between the clinical course and the application of the classification criteria. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a search of electronic databases from inception to July 2019 identified 121 articles for screening. After proper exclusion criteria, 7 articles were included for data extraction and analysis using meta-analysis of proportions. The MI was the variable of interest in the multivariate regressions and analyzed as a predictor of recurrence using hazard ratios (HRs) (95% confidence intervals). Separate random effect models were used for studies reporting the MI as a continuous or categorical variable. The pooled study results in this meta-analysis demonstrate a homogeneous statistically significant correlation between the MI and the rate of local recurrence after surgical resection regardless of the reporting method (continuous: HR = 1.20; categorical: HR = 2.65). However, significant limitations were noted, including the lack of a standardized method for MI calculation and heterogeneity of MI reports. We encourage the community to report their experience with the MI with greater precision and uniformity to further assess the influence of the MI on PFS within atypical meningiomas.
journal_name
World Neurosurgjournal_title
World neurosurgeryauthors
Domingo RA,Tripathi S,Vivas-Buitrago T,Lu VM,Chaichana KL,Quiñones-Hinojosa Adoi
10.1016/j.wneu.2020.06.189subject
Has Abstractpub_date
2020-10-01 00:00:00pages
191-196eissn
1878-8750issn
1878-8769pii
S1878-8750(20)31457-1journal_volume
142pub_type
杂志文章,评审abstract：OBJECTIVE:The purpose of this study was to determine whether combined diffusion-weighted imaging and dynamic susceptibility contrast-enhanced perfusion-weighted imaging magnetic resonance imaging can be used to differentiate between common malignant brain tumors, including lymphomas and high-grade gliomas. METHODS:We ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.10.141
更新日期：2018-04-01 00:00:00
abstract：OBJECTIVE:To elucidate the role of endoscopic third ventriculostomy (ETV) in patients with secondary and idiopathic communicating hydrocephalus (HCP). METHODS:A series of 36 patients with communicating HCP (21 men and 15 women) were treated by ETV between November 2007 and February 2010. The patients age ranged from 1...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2011.06.038
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pub_type： 杂志文章
doi：10.1016/j.wneu.2016.03.104
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pub_type： 杂志文章
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journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2020.08.161
更新日期：2021-01-01 00:00:00
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journal_title：World neurosurgery
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journal_title：World neurosurgery
pub_type： 杂志文章,评审
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更新日期：2016-11-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.07.083
更新日期：2020-10-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.wneu.2015.05.073
更新日期：2015-10-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.08.192
更新日期：2018-02-01 00:00:00
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journal_title：World neurosurgery
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.wneu.2017.10.063
更新日期：2018-01-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2016.03.024
更新日期：2016-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.wneu.2020.02.056
更新日期：2020-05-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.12.137
更新日期：2019-01-04 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.wneu.2014.05.015
更新日期：2014-11-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2020.06.022
更新日期：2020-09-01 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：2019-01-22 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
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更新日期：2020-09-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章,多中心研究
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更新日期：2018-04-01 00:00:00
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更新日期：2014-03-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章,meta分析,评审
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更新日期：2017-10-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.wneu.2020.03.226
更新日期：2020-07-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章,多中心研究
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更新日期：2020-11-01 00:00:00
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更新日期：2017-10-01 00:00:00
