Abstract：
BACKGROUND:The prognosis for patients with glioblastoma depends particularly on the degree of tumor resection. Patients with tumor remnants in postsurgical magnetic resonance imaging (<72 hours) may benefit from early reoperation. We present our results concerning the impact on overall survival (OS) and progression-free survival (PFS) of reoperation in patients who have already undergone surgery for glioblastoma. METHODS:This study included all patients who had undergone surgery for glioblastoma with control magnetic resonance imaging, who received adjuvant therapy as per the Stupp protocol, with a minimum follow-up of 24 months. We recorded the number of complete resections, partial resections, and early reoperations. We determined the impact on OS and PFS of the early reoperations and the functional status. We considered complete resection when the volume of the residual tumor was 0 cm3. RESULTS:A total of 112 patients were diagnosed with glioblastoma between March 2014 and March 2017. The study included 58 patients who fulfilled all the inclusion criteria. Complete resection was achieved in 24 patients (41.4%) and partial resection in 34 (58.6%). Of these 34 patients, 11 (32.35%) underwent early reoperation. The final result was complete resection in 58.62% of the patients. In the patients who underwent reoperation, OS and PFS were 30.3 months and 16.6 months compared with 12.7 months and 6.75 months in those without reoperation (P = 0.013 and P = 0.012). The functional prognosis was similar between the 2 groups. CONCLUSIONS:Early reoperation in patients with residual tumor improved OS and PFS without increasing the number of complications compared with the patients who did not undergo reoperation.
journal_name
World Neurosurgjournal_title
World neurosurgeryauthors
Troya-Castilla M,Kaen A,Márquez-Rivas FJ,Infante-Cossio P,Rius Díaz F,Narros Gimenez JL,Gonzalez-Pombo M,Cancela P,Segura Fernández-Nogueras M,Arráez Sánchez MÁdoi
10.1016/j.wneu.2020.04.072subject
Has Abstractpub_date
2020-07-01 00:00:00pages
e592-e600eissn
1878-8750issn
1878-8769pii
S1878-8750(20)30779-8journal_volume
139pub_type
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journal_title：World neurosurgery
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journal_title：World neurosurgery
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