Abstract：
OBJECTIVE:Obesity has become a worldwide epidemic, with very few long-term successful treatment options for refractory disease. Deep brain stimulation (DBS) of the bilateral lateral hypothalamus (LH) in refractory obesity has been performed safely. However, questions remain regarding the optimal settings and its effects on metabolic rate. The goals of our experiment were to determine the optimal DBS settings and the actual effect of optimal stimulation on energy expenditure. METHODS:After bilateral LH DBS implantation, 2 subjects with treatment refractory obesity underwent 4 days of metabolic testing. The subjects slept overnight in a respiratory chamber to measure their baseline sleep energy expenditure, followed by 4 consecutive days of resting metabolic rate (RMR) testing at different stimulation settings. On day 4, the optimized DBS settings were used, and sleep energy expenditure was measured again overnight in the room calorimeter. RESULTS:During daily testing, the RMR fluctuated acutely with changes in stimulation settings and returned to baseline immediately after turning off the stimulation. Optimal stimulation settings selected for participants showed a 20% and 16% increase in RMR for the 2 participants. Overnight sleep energy expenditure measurements at these optimized settings on day 4 yielded a 10.4% and 4.8% increase over the baseline measurements for the 2 participants. CONCLUSIONS:These findings have demonstrated the efficacy of optimized DBS of the LH on increasing the RMR acutely and maintaining this increase during overnight sleep. These promising preliminary findings have laid the groundwork for the possible treatment of refractory obesity with DBS.
journal_name
World Neurosurgjournal_title
World neurosurgeryauthors
Whiting AC,Sutton EF,Walker CT,Godzik J,Catapano JS,Oh MY,Tomycz ND,Ravussin E,Whiting DMdoi
10.1016/j.wneu.2018.10.002subject
Has Abstractpub_date
2019-01-01 00:00:00pages
e867-e874eissn
1878-8750issn
1878-8769pii
S1878-8750(18)32294-0journal_volume
121pub_type
杂志文章abstract：OBJECTIVE:This study aimed to compare the ultrasound (US)-guided erector spinae plane block (ESPB) and modified-thoracolumbar interfascial plane (mTLIP) block for postoperative pain management in lumbar discectomy surgery patients. METHODS:A total of 90 patients scheduled for lumbar discectomy were randomly assigned i...
journal_title：World neurosurgery
pub_type： 杂志文章
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abstract：BACKGROUND:Unfavorable anatomy can preclude traditional anterograde endovascular interventions. Transcirculation approaches, which consist of primary catheterization of a target artery from the contralateral side or opposite cerebral circulation, can provide alternative pathways for successful treatment of these patien...
journal_title：World neurosurgery
pub_type： 杂志文章,多中心研究
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abstract：BACKGROUND:Comparative outcomes of extracranial-to-intracranial (EC-IC) and intracranial-to-intracranial (IC-IC) bypass for complex aneurysm treatment based on rupture status are not well described in the literature. In this study, we compare outcomes of EC-IC and IC-IC bypass for complex intracranial aneurysm treatmen...
journal_title：World neurosurgery
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2015.10.060
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journal_title：World neurosurgery
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journal_title：World neurosurgery
pub_type： 杂志文章,评审
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journal_title：World neurosurgery
pub_type： 传,历史文章,杂志文章
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更新日期：2015-12-01 00:00:00
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journal_title：World neurosurgery
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pub_type： 杂志文章
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更新日期：2018-04-01 00:00:00
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journal_title：World neurosurgery
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.03.053
更新日期：2018-06-01 00:00:00
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journal_title：World neurosurgery
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doi：10.1016/j.wneu.2017.07.104
更新日期：2017-10-01 00:00:00
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doi：10.1016/j.wneu.2012.03.032
更新日期：2013-01-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.12.196
更新日期：2019-01-17 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.01.257
更新日期：2019-05-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章,多中心研究
doi：10.1016/j.wneu.2016.06.065
更新日期：2016-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.wneu.2017.03.133
更新日期：2017-06-01 00:00:00
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journal_title：World neurosurgery
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journal_title：World neurosurgery
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更新日期：2016-08-01 00:00:00
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更新日期：2017-07-01 00:00:00
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更新日期：2020-06-01 00:00:00
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更新日期：2021-01-01 00:00:00
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更新日期：2019-06-01 00:00:00
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journal_title：World neurosurgery
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更新日期：2018-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2018-01-01 00:00:00
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journal_title：World neurosurgery
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更新日期：2020-05-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2010.04.006
更新日期：2010-07-01 00:00:00
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journal_title：World neurosurgery
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更新日期：2020-06-01 00:00:00
