Fragments of the Nonlytic Proline-Rich Antimicrobial Peptide Bac5 Kill Escherichia coli Cells by Inhibiting Protein Synthesis.

abstract：:The results of treatment of 10 patients with anaerobic infections with metronidazole are presented. Six patients were cured, three showed initial good response but circumstances required a change to another drug, and one patient did not respond. The unique spectrum of the drug, its pharmacology, and limitations are di...

journal_title：Antimicrobial agents and chemotherapy

authors： Tally FP,Sutter VL,Finegold SM

更新日期：1975-05-01 00:00:00

abstract：:NK-2, a membrane-acting antimicrobial peptide, was derived from the cationic core region of porcine NK-lysin and consists of 27 amino acid residues. It adopts an amphipathic, alpha-helical secondary structure and has been shown to interact specifically with membranes of negatively charged lipids. We therefore investig...

journal_title：Antimicrobial agents and chemotherapy

authors： Andrä J,Koch MH,Bartels R,Brandenburg K

更新日期：2004-05-01 00:00:00

abstract：:The current voriconazole dosing recommendation in adolescents is based on limited efficacy and pharmacokinetic data. To confirm the appropriateness of dosing adolescents like adults, a pharmacokinetic study was conducted in 26 immunocompromised adolescents aged 12 to <17 years following intravenous (IV) voriconazole t...

journal_title：Antimicrobial agents and chemotherapy

authors： Driscoll TA,Frangoul H,Nemecek ER,Murphey DK,Yu LC,Blumer J,Krance RA,Baruch A,Liu P

更新日期：2011-12-01 00:00:00

abstract：:Bacteriophage therapy of bacterial infections has received renewed attention owing to the increasing prevalence of antibiotic-resistant pathogens. A side effect of many antibiotics as well as of phage therapy with lytic phage is the release of cell wall components, e.g., endotoxins of gram-negative bacteria, which med...

journal_title：Antimicrobial agents and chemotherapy

authors： Hagens S,Habel A,von Ahsen U,von Gabain A,Bläsi U

更新日期：2004-10-01 00:00:00

abstract：:The efficacy of atovaquone alone or combined with pyrimethamine, sulfadiazine, clarithromycin, and minocycline was examined in vitro and in a murine model of acute toxoplasmosis. In vitro studies were performed with MRC5 fibroblast tissue cultures, with quantification of Toxoplasma growth by an enzyme-linked immunosor...

journal_title：Antimicrobial agents and chemotherapy

authors： Romand S,Pudney M,Derouin F

更新日期：1993-11-01 00:00:00

abstract：:We conducted time-kill studies to evaluate the inhibitory activities of either cefotaxime or minocycline alone and the two drugs in combination against a clinical strain of Vibrio vulnificus. The MICs of cefotaxime and minocycline were 0.03 and 0.06 microg/ml, respectively. When approximately 5 x 10(5) CFU of V. vulni...

journal_title：Antimicrobial agents and chemotherapy

authors： Chuang YC,Liu JW,Ko WC,Lin KY,Wu JJ,Huang KY

更新日期：1997-10-01 00:00:00

abstract：:As a relationship between nelfinavir antiretroviral efficacy and plasma concentrations has been previously established, nelfinavir pharmacokinetics was investigated in order to optimize the individual treatment schedule in a pediatric population. A population pharmacokinetic model was developed to describe the concent...

journal_title：Antimicrobial agents and chemotherapy

authors： Hirt D,Urien S,Jullien V,Firtion G,Rey E,Pons G,Blanche S,Treluyer JM

更新日期：2006-03-01 00:00:00

abstract：:Serial passage of Pseudomonas aeruginosa ATCC 27853 or Escherichia coli ATCC 25922 on agar with subinhibitory concentrations of norfloxacin rapidly produced isolates with minimal inhibitory concentrations (MICs) of norfloxacin up to 512-fold higher than that for the original strain. Although MICs of seven unrelated an...

journal_title：Antimicrobial agents and chemotherapy

authors： Tenney JH,Maack RW,Chippendale GR

更新日期：1983-01-01 00:00:00

abstract：:A mixed culture of an hypermutable hexA Streptococcus pneumoniae mutant strain and its hexA(+) isogenic ancestor was challenged with low cefotaxime concentrations. Despite identical original cefotaxime MICs, the hexA mutant population was significantly selected at very low concentrations, and all of the tested selecte...

journal_title：Antimicrobial agents and chemotherapy

authors： Negri MC,Morosini MI,Baquero MR,del Campo R,Blázquez J,Baquero F

更新日期：2002-02-01 00:00:00

abstract：:This study sought to characterize the impact of 3 types of variation on the Standardized Antimicrobial Administration Ratio (SAAR) utilizing local National Healthcare Safety Network (NHSN) data. SAAR and antimicrobial days per 1,000 days present (AD/1000DP) were compiled monthly for Northwestern Memorial Hospital from...

journal_title：Antimicrobial agents and chemotherapy

authors： Avedissian SN,Rhodes NJ,Liu J,Aljefri D,Postelnick MJ,Sutton SH,Zembower TR,Martin D,Pais G,Cruce CE,Scheetz MH

更新日期：2019-02-26 00:00:00

abstract：:A total of 201 critically ill patients were studied during 267 courses of gentamicin or tobramycin treatment (139 gentamicin courses and 128 tobramycin courses). Of these 267 courses, pharmacokinetic and clinical data were obtained for 240 (120 gentamicin and 120 tobramycin). The data collected for pharmacokinetic ana...

journal_title：Antimicrobial agents and chemotherapy

authors： Schentag JJ,Plaut ME,Cerra FB

更新日期：1981-05-01 00:00:00

abstract：:In published studies, cohorts of patients with bacteremia due to vancomycin-resistant Enterococcus (VRE) have predominantly been infected with Enterococcus faecium. Little is known about the epidemiology and outcomes associated with bacteremia due to VR Enterococcus faecalis. A retrospective study of isolates obtained...

journal_title：Antimicrobial agents and chemotherapy

authors： Hayakawa K,Marchaim D,Martin ET,Tiwari N,Yousuf A,Sunkara B,Pulluru H,Kotra H,Hasan A,Bheemreddy S,Sheth P,Lee DW,Kamatam S,Bathina P,Nanjireddy P,Chalana IK,Patel S,Kumar S,Vahia A,Ku K,Yee V,Swan J,Pogue JM

更新日期：2012-05-01 00:00:00

abstract：:Ceftolozane-tazobactam (C/T) is a novel cephalosporin with in vitro activity against Pseudomonas aeruginosa that is resistant to extended-spectrum penicillins and antipseudomonal cephalosporins. In order to assess the antimicrobial effect of C/T in treatment of Pseudomonas pneumonia, we investigated the pharmacokineti...

journal_title：Antimicrobial agents and chemotherapy

authors： Petraitis V,Petraitiene R,Naing E,Aung T,Thi WP,Kavaliauskas P,Win Maung BB,Michel AO,Ricart Arbona RJ,DeRyke AC,Culshaw DL,Nicolau DP,Satlin MJ,Walsh TJ

更新日期：2019-08-23 00:00:00

abstract：:Combination antiretroviral therapy has achieved dramatic reductions in the mortality and morbidity in people with HIV-1 infection. Darunavir (DRV) represents a most efficacious and well-tolerated protease inhibitor (PI) with a high genetic barrier to the emergence of drug-resistant HIV-1. However, highly DRV-resistant...

journal_title：Antimicrobial agents and chemotherapy

authors： Takamatsu Y,Aoki M,Bulut H,Das D,Amano M,Sheri VR,Kovari LC,Hayashi H,Delino NS,Ghosh AK,Mitsuya H

更新日期：2019-07-25 00:00:00

abstract：:Carbapenem resistance rates in Pseudomonas aeruginosa isolates in Colombia, as in many South American countries, are high for reasons that remain unclear. From our nationwide network, we describe the first detection of the metallo-beta-lactamase VIM-2 in clinical isolates of P. aeruginosa from multiple cities within C...

journal_title：Antimicrobial agents and chemotherapy

authors： Villegas MV,Lolans K,del Rosario Olivera M,Suarez CJ,Correa A,Queenan AM,Quinn JP,Colombian Nosocomial Resistance Study Group.

更新日期：2006-01-01 00:00:00

abstract：:Antibacterial compounds with novel modes of action are needed for management of bacterial infections. Here we describe a high-content screen of 9,800 compounds identifying acylated sulfonamides as novel growth inhibitors of the sexually transmitted pathogen Chlamydia trachomatis. The effect was bactericidal and distin...

journal_title：Antimicrobial agents and chemotherapy

authors： Marwaha S,Uvell H,Salin O,Lindgren AE,Silver J,Elofsson M,Gylfe A

更新日期：2014-05-01 00:00:00

abstract：:Dihydroorotate dehydrogenase (DHOD) is a pyrimidine biosynthetic enzyme which is usually directly linked to the mitochondrial respiratory chain. Antimalarial naphthoquinones such as atovaquone (566c80) inhibit malarial DHOD by inhibiting electron transport. Since atovaquone also has therapeutic activity against Pneumo...

journal_title：Antimicrobial agents and chemotherapy

authors： Ittarat I,Asawamahasakda W,Bartlett MS,Smith JW,Meshnick SR

更新日期：1995-02-01 00:00:00

abstract：:Enterococcus gallinarum N04-0414 (MIC for vancomycin, 256 microg/ml) harbored a vanD-type vancomycin resistance operon as well as the intrinsic vanC1 operon. The D-Ala:D-Ala ligase 2 gene (ddl2) was not present in the strain, though it is found downstream of the vanS gene from the vanC operon in E. gallinarum ATCC 495...

journal_title：Antimicrobial agents and chemotherapy

authors： Boyd DA,Miller MA,Mulvey MR

更新日期：2006-03-01 00:00:00

abstract：:Tildipirosin is a 16-membered-ring macrolide developed to treat bacterial pathogens, including Mannheimia haemolytica and Pasteurella multocida, that cause respiratory tract infections in cattle and swine. Here we evaluated the efficacy of tildipirosin at inhibiting protein synthesis on the ribosome (50% inhibitory co...

journal_title：Antimicrobial agents and chemotherapy

authors： Andersen NM,Poehlsgaard J,Warrass R,Douthwaite S

更新日期：2012-11-01 00:00:00

abstract：:Beta-l-2',3'-didehydro-2',3'-dideoxy-N(4)-hydroxycytidine (l-Hyd4C) was demonstrated to be an effective and highly selective inhibitor of hepatitis B virus (HBV) replication in HepG2.2.15 cells (50% effective dose [ED(50)] = 0.03 microM; 50% cytotoxic dose [CD(50)] = 2,500 microM). In the present study, we investigate...

journal_title：Antimicrobial agents and chemotherapy

authors： Matthes E,Bünger H

更新日期：2010-01-01 00:00:00

abstract：:Heteroresistant (methicillin-resistant) and nonheteroresistant strains of Staphylococcus aureus were tested for their susceptibility to penicillinase-resistant penicillins at incubation temperatures of 37, 35, and 30 C. Susceptibilities were determined by agar dilution and by the standard Kirby-Bauer agar diffusion te...

journal_title：Antimicrobial agents and chemotherapy

authors： Thornsberry C,Caruthers JQ,Baker CN

更新日期：1973-09-01 00:00:00

abstract：:C-8-methoxy fluoroquinolones were more lethal than C-8-bromine, C-8-ethoxy, and C-8-H derivatives for Staphylococcus aureus, especially when topoisomerase IV was resistant. The methoxy group also increased lethality against wild-type cells when protein synthesis was inhibited. These properties encourage refinement of ...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhao X,Wang JY,Xu C,Dong Y,Zhou J,Domagala J,Drlica K

更新日期：1998-04-01 00:00:00

abstract：:IncK plasmids encoding CTX-M-14 extended-spectrum β-lactamase (ESBL) and highly related to plasmid pCT were detected in 13 of 67 (19%) human clinical isolates of Escherichia coli with a group 9 CTX-M-type ESBL from the United Kingdom and in 2 quality assurance isolates. None of these E. coli strains was related to the...

journal_title：Antimicrobial agents and chemotherapy

authors： Dhanji H,Khan P,Cottell JL,Piddock LJ,Zhang J,Livermore DM,Woodford N

更新日期：2012-06-01 00:00:00

abstract：:The in vitro activities of HMR 3647 (telithromycin) and HMR 3004, two novel semisynthetic ketolides, were investigated and compared with that of the reference macrolide drug, clarithromycin, against 34 strains of slowly growing mycobacteria at pHs 6.8 and 7.4, as determined radiometrically. The MICs at pH 7.4 were abo...

journal_title：Antimicrobial agents and chemotherapy

authors： Rastogi N,Goh KS,Berchel M,Bryskier A

更新日期：2000-10-01 00:00:00

abstract：:Polysorbate 80 (PS80) is a nonionic surfactant and detergent that inhibits biofilm formation by Pseudomonas aeruginosa at concentrations as low as 0.001% and is well tolerated in human tissues. However, certain clinical and laboratory strains (PAO1) of P. aeruginosa are able to form biofilms in the presence of PS80. T...

journal_title：Antimicrobial agents and chemotherapy

authors： Zegans ME,Wozniak D,Griffin E,Toutain-Kidd CM,Hammond JH,Garfoot A,Lam JS

更新日期：2012-08-01 00:00:00

abstract：:Pseudomonas aeruginosa 579 biofilms formed on dialysis membranes retarded piperacillin diffusion. Treatment of biofilms with 5.0 mM CaCl2.2H2O prevented diffusion. Biofilms permitted equilibration of [14C]glucose. Thin-layer chromatography of fluids distal to untreated (viable and nonviable) and viable Ca(2+)-treated ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hoyle BD,Alcantara J,Costerton JW

更新日期：1992-09-01 00:00:00

abstract：:Groups of mice infected intravenously with Candida albicans were treated intraperitoneally with amphotericin B, caspofungin, or fluconazole, starting at intervals before and after challenge. Survival was longest and tissue burdens were most reduced with early treatment, and survival times fell proportionately as treat...

journal_title：Antimicrobial agents and chemotherapy

authors： MacCallum DM,Odds FC

更新日期：2004-12-01 00:00:00

abstract：:The mortality rate associated with Vibrio vulnificus sepsis remains high. An in vitro time-kill assay revealed synergism between tigecycline and ciprofloxacin. The survival rate was significantly higher in mice treated with tigecycline plus ciprofloxacin than in mice treated with cefotaxime plus minocycline. Thus, com...

journal_title：Antimicrobial agents and chemotherapy

authors： Kim SE,Kim HK,Choi SM,Yu Y,Kim UJ,Darboe KS,Kang SJ,Park KH,Kang G,Kim YR,Rhee JH,Jung SI,Jang HC

更新日期：2019-09-23 00:00:00

abstract：:Bactericidal activity in serum produced after administration of 1-g intravenous doses of cefoperazone, cefotaxime, ceftizoxime, and moxalactam was ascertained in six healthy subjects. The assay organisms were a strain of Staphylococcus aureus which was moderately susceptible to the drugs (MBC, 2 to 8 micrograms/ml) an...

journal_title：Antimicrobial agents and chemotherapy

authors： Barriere SL,Ozasa DC,Mordenti J

更新日期：1985-07-01 00:00:00

abstract：:Therapeutic treatment for systemic mycoses is severely hampered by the extremely limited number of antifungals. The difficulty of treatment of fungal infections in the central nervous system is further compounded by the poor central nervous system (CNS) penetration of most antifungals due to the blood-brain barrier. O...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhai B,Wu C,Wang L,Sachs MS,Lin X

更新日期：2012-07-01 00:00:00