Abstract:
:The lipid droplet (LD) is an organelle with vital functions found in nearly all organisms. LD proteomic research has provided fundamentally important insights into this organelle's functions. The review provides a summary of LD proteomic studies conducted across diverse organisms and cell and tissue types. The accumulated proteomic data are reviewed for evidence of a protein targeting mechanism for the organelle. The hypotheses for several specific localization mechanisms based on what is known about targeting mechanisms for other organelles and vesicles are provided. Although the nature of the mechanism is not known, the functional data demonstrate that the targeting mechanism and, indeed, the organelle itself, is conserved from prokaryotes to eukaryotes. It is hoped that the review will help inspire further research leading to novel discoveries in the field.
journal_name
Proteomicsjournal_title
Proteomicsauthors
Zhang C,Liu Pdoi
10.1002/pmic.201700223subject
Has Abstractpub_date
2019-05-01 00:00:00pages
e1700223issue
10eissn
1615-9853issn
1615-9861journal_volume
19pub_type
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