Abstract：
:Multipotent mesenchymal stem/stromal cells (MSCs) have regenerative and immunomodulatory properties to restore and repair injured tissues, making them attractive candidates for cell-based therapies. Experimental and clinical evidence has demonstrated the effectiveness of MSC transplantation in managing diabetes mellitus (DM). Autologous MSCs are assumed to be favorable because patient-derived cells are readily available and do not entail sustained immunosuppressive therapy. DM is associated with hyperglycemia, oxidative stress and altered immune responses and inflammation. It may thus alter the biological characteristics and therapeutic qualities of human MSCs (hMSCs). Several studies have explored the effect of DM or the diabetic microenvironment on the engraftment and efficacy of transplanted MSCs, which are determined by proliferation, differentiation, senescence, angiogenesis supportive effect, migration, anti-oxidative capacity and immunomodulatory properties. This review aims to present the available data on how DM impacts MSC biology and functionality and identify future perspectives for autologous MSC-based therapy in diabetics.
journal_name
Stem Cell Rev Repjournal_title
Stem cell reviews and reportsauthors
Mahmoud M,Abu-Shahba N,Azmy O,El-Badri Ndoi
10.1007/s12015-018-9869-ysubject
Has Abstractpub_date
2019-04-01 00:00:00pages
194-217issue
2eissn
2629-3269issn
2629-3277pii
10.1007/s12015-018-9869-yjournal_volume
15pub_type
杂志文章,评审abstract：:Motor neuron loss or degeneration is the typical characteristic of amyotrophic lateral sclerosis (ALS), which often leads to weakness, paralysis, or even death. The underlying mechanisms of motor neuron degeneration and ALS progression remain elusive, and there is no effective treatment for ALS. The advances of stem c...
journal_title：Stem cell reviews and reports
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journal_title：Stem cell reviews and reports
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journal_title：Stem cell reviews and reports
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journal_title：Stem cell reviews and reports
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journal_title：Stem cell reviews and reports
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journal_title：Stem cell reviews and reports
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journal_title：Stem cell reviews and reports
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journal_title：Stem cell reviews and reports
pub_type： 杂志文章,评审
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journal_title：Stem cell reviews and reports
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journal_title：Stem cell reviews and reports
pub_type： 杂志文章,评审
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journal_title：Stem cell reviews and reports
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journal_title：Stem cell reviews and reports
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