Frequent blood donation and offspring scholastic attainment: an assessment of long-term consequences of prenatal iron deficiency.

Abstract:

BACKGROUND:Due to physiological demands, children and premenopausal women are at risk of developing iron deficiency. In premenopausal women, the risk may be further increased by repeated whole blood donations. Short-term consequences of iron deficiency in infancy include impaired cognitive development and lower IQ scores. This prompts concern that maternal iron deficiency before or during pregnancy may have long-term consequences for the offspring, for example, by affecting scholastic attainment. The aim of this study was to evaluate if prepregnancy donation intensity is associated with offspring scholastic attainment measured as grade averages in standardized national written examinations in Denmark. STUDY DESIGN AND METHODS:By using the Danish personal identification number as key, we obtained information on donation intensity before pregnancy, school grade, year of graduation, age of the students, students' sex, and parental length of education and income from various nationwide registers. Linear regression analyses were performed, with grade average as outcome and maternal donation status as explanatory variable (nondonor, n = 177,078; low-frequency donor, n = 4995 [one to five donations in the 3 years before pregnancy]; high-frequency donor, n = 414 [six or more donations in the 3 years before pregnancy), and further adjusted for the covariates listed above. RESULTS:Adjusted normalized (mean, 0; standard deviation [SD], 1) test scores were statistically significantly higher for children of active female donors compared with children of nondonors (SD, 0.104; 95% confidence interval, 0.079-0.129). We observed no differences in scholastic attainment between children of low-frequency donors and high-frequency donors. CONCLUSION:Prepregnancy donation intensity, as a proxy of iron stores, is not associated with subsequent offspring scholastic attainment.

journal_name

Transfusion

journal_title

Transfusion

authors

Rigas AS,Pedersen OB,Rostgaard K,Sørensen E,Erikstrup C,Hjalgrim H,Ullum H

doi

10.1111/trf.15193

subject

Has Abstract

pub_date

2019-05-01 00:00:00

pages

1717-1722

issue

5

eissn

0041-1132

issn

1537-2995

journal_volume

59

pub_type

杂志文章
  • Intraoperative cell salvage in obstetrics: is it a real therapeutic option?

    abstract::Obstetric hemorrhage is a leading cause of maternal and perinatal mortality worldwide. Intraoperative blood salvage is common practice in many surgical specialties but its safety in obstetrics is questioned for concerns on the risks of contamination of recovered blood with amniotic fluid (AF) and of maternal-fetal all...

    journal_title:Transfusion

    pub_type: 杂志文章,评审

    doi:10.1111/j.1537-2995.2011.03116.x

    authors: Liumbruno GM,Liumbruno C,Rafanelli D

    更新日期:2011-10-01 00:00:00

  • Mixed-type autoimmune hemolytic anemia: differential diagnosis and a critical review of reported cases.

    abstract:BACKGROUND:Autoimmune hemolytic anemia (AIHA) is usually classified as either warm or cold type. During the past few decades, mixed types (Mxs) have also been described in a number of cases (6%-8% of AIHA), often without serologic data to support the diagnosis. In this study, we demonstrate that the incidence of Mx AIH...

    journal_title:Transfusion

    pub_type: 杂志文章,评审

    doi:10.1111/j.1537-2995.2008.01805.x

    authors: Mayer B,Yürek S,Kiesewetter H,Salama A

    更新日期:2008-10-01 00:00:00

  • Risk behavior in Norwegian blood donors.

    abstract:BACKGROUND:Blood banks ensure the safety of blood components by testing them for a set of known infectious agents and by careful selection of donors based on a self-administered questionnaire and an interview. The purpose of this study is to describe the risk behavior for sexually transmitted diseases in Norwegian bloo...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2001.41121480.x

    authors: Stigum H,Bosnes V,Ørjasaeter H,Heier HE,Magnus P

    更新日期:2001-12-01 00:00:00

  • Autoagglutinins with apparent anti-P specificity reactive only by low-ionic-strength salt techniques.

    abstract::Two blood samples containing autoagglutinins reactive in room temperature tests using low-ionic strength salt (LISS) reagents, but not by conventional saline-albumin or enzyme tests, are reported. The anti-P specificity of both sera, when tested near or diluted in group AB serum, was evident by their failure to agglut...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1982.22382224937.x

    authors: Judd WJ,Steiner EA,Capps RD

    更新日期:1982-05-01 00:00:00

  • Prevention of bedside errors in transfusion medicine (PROBE-TM) study: a cluster-randomized, matched-paired clinical areas trial of a simple intervention to reduce errors in the pretransfusion bedside check.

    abstract:BACKGROUND:Transfusion of the incorrect blood component is a frequent serious incident associated with transfusion and often involves misidentification of the patient and/or the unit of blood. The objective of this study was to assess the effect of a simple intervention designed to improve performance of the bedside ch...

    journal_title:Transfusion

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1537-2995.2007.01189.x

    authors: Murphy MF,Casbard AC,Ballard S,Shulman IA,Heddle N,Aubuchon JP,Wendel S,Thomson A,Hervig T,Downes K,Carey PM,Dzik WH,BEST Research Collaborative.

    更新日期:2007-05-01 00:00:00

  • Bulk cryopreservation of lymphocytes in glycerol.

    abstract::The authors describe a method for freezing large amounts of peripheral blood lymphocytes (PBL) in a 20 percent glycerol solution. Between 0.6 and 4.3 X 10(9) cells in autologous plasma were frozen in polyethylene freezing bags in a final volume of 50 ml. The recovery after thawing averaged 89 +/- 14 percent with a mea...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1988.28288179020.x

    authors: Areman EM,Simonis TB,Carter CS,Read EJ,Klein HG

    更新日期:1988-03-01 00:00:00

  • Lack of correlation between the incidence of bloodborne AIDS and overall AIDS incidence in Western Europe.

    abstract:BACKGROUND:The incidence of bloodborne AIDS and the total incidence of AIDS in various areas of the United States are strongly correlated. STUDY DESIGN AND METHODS:To determine whether the same held true for Western Europe, data for 1985 through 1993 from the World Health Organization's European Non-Aggregate AIDS Dat...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1997.37297203528.x

    authors: Dal Maso L,Franceschi S,Lo Re A,De Angelis V,La Vecchia C

    更新日期:1997-02-01 00:00:00

  • Establishment of an unrelated umbilical cord blood bank qualification program: ensuring quality while meeting Food and Drug Administration vendor qualification requirements.

    abstract:BACKGROUND:Qualification of a cord blood bank (CBB) is a complex process that includes evaluation of multiple aspects of donor screening and testing, processing, accreditation and approval by professional cell therapy groups, and results of received cord blood units. The University of Minnesota Medical Center Cell Ther...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12085

    authors: Rabe F,Kadidlo D,Van Orsow L,McKenna D

    更新日期:2013-10-01 00:00:00

  • Longitudinal monitoring of WBC subsets in packed RBC units after filtration: implications for transfusion transmission of infections.

    abstract:BACKGROUND:Specific subsets of peripheral blood WBCs are reservoirs for infectious agents, such as CMV and EBV, and can serve as vectors for transfusion transmission of these agents. While filter WBC reduction has been used to prevent transfusion transmission of infections, its effectiveness has not been documented for...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2000.40050500.x

    authors: Roback JD,Bray RA,Hillyer CD

    更新日期:2000-05-01 00:00:00

  • Anti-K formation is not associated with the storage time of transfused red blood cells.

    abstract:BACKGROUND:The formation of red blood cell (RBC) antibodies could be enhanced by the presence of inflammation caused by prolonged RBC storage, as was shown in animal studies. The low occurrence (<10%) of K-antigen in most populations often enables identification of the K+ RBC unit that triggered anti-K formation and de...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12974

    authors: Hogervorst E,Middelburg R,Brand A,van de Watering L,Schonewille H

    更新日期:2015-06-01 00:00:00

  • Evaluation of a confidential method of excluding blood donors exposed to human immunodeficiency virus.

    abstract::A confidential self-administered questionnaire was given to all donors prior to blood donation (n = 95,917). The questionnaire describes acquired immunodeficiency syndrome (AIDS) high-risk groups and requires the donor to designate his blood for either laboratory purposes or for transfusion. Six-hundred and twenty-sev...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1986.26687043622.x

    authors: Nusbacher J,Chiavetta J,Naiman R,Buchner B,Scalia V,Herst R

    更新日期:1986-11-01 00:00:00

  • Hematology patterns after hemoglobin-based oxygen carrier resuscitation from severe controlled hemorrhage with prolonged delayed definitive care.

    abstract:BACKGROUND:The hemoglobin-based oxygen carrier (HBOC-201) resuscitation fluid improves outcome in hemorrhagic shock swine models with minimal coagulopathy. Herein, coagulation parameters were evaluated after resuscitation with HBOC-201 after severe bleeding and prolonged delay to definitive care. STUDY DESIGN AND METH...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2007.01435.x

    authors: Arnaud F,Fasipe D,Philbin N,Rice J,Flournoy WS,Ahlers S,McCarron R,Freilich D

    更新日期:2007-11-01 00:00:00

  • Center error reduction by recheck of blood type.

    abstract::Our computer system currently stores donor blood types for seven years and checks typing of all repeat donors against these files. In a recent three-month period (42,500 units), five discrepancies were found--two representing current error. Retrospective analysis of 18 errors made over the last three years showed that...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1981.21281178157.x

    authors: Grindon AJ,Liles BA

    更新日期:1981-03-01 00:00:00

  • Further evaluation of a new standard of efficacy for stored platelets.

    abstract:BACKGROUND:The proposal to assess the viability capabilities of platelets (PLTs) collected, treated, or stored in a developmental system against "fresh" PLTs from the same subject poses several important methodologic issues pertaining to the timing and manner of the collecting and separating the fresh PLTs. This study ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2005.00177.x

    authors: AuBuchon JP,Herschel L,Roger J

    更新日期:2005-07-01 00:00:00

  • M and N specific hemagglutinins of human erythrocytes stored in glucose solutions.

    abstract::Alloagglutinins of M and N specificites with unique characteristics found in normal sera are described. Specific M or N agglutination by these sera occurred only when erythrocytes had been exposed to glucose-containing solutions. Conversion to the form of MN recognized by these sera required incubation of the cells in...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1981.21682085751.x

    authors: Morel PA,Bergren MO,Hill V,Garratty G,Perkins HA

    更新日期:1981-11-01 00:00:00

  • Immune-mediated agglutination of cytoskeleton-free RBC microvesicles.

    abstract:BACKGROUND:The factors contributing to RBC agglutination are complex. The RBC cytoskeleton's participation in and contribution to this phenomenon are difficult to separate from those of the plasma membrane. Immunoreactive, cytoskeleton-free, band 3-enriched microvesicles can be generated from normal RBCs. Band 3 has be...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2000.40050566.x

    authors: Jaime JC

    更新日期:2000-05-01 00:00:00

  • Safety of blood donation by individuals over age 70 and their contribution to the blood supply in five developed countries: a BEST Collaborative group study.

    abstract:BACKGROUND:Some countries impose an upper age limit on whole blood and double RBC donation while others do not. We evaluated the safety of blood donation in older individuals (≥71 years), and their contribution to the blood supply of five countries. STUDY DESIGN AND METHODS:Twelve blood center members of the Biomedica...

    journal_title:Transfusion

    pub_type: 杂志文章,多中心研究

    doi:10.1111/trf.15132

    authors: Goldman M,Germain M,Grégoire Y,Vassallo RR,Kamel H,Bravo M,Irving DO,Di Angelantonio E,Steele WR,O'Brien SF,Biomedical Excellence for Safer Transfusion Collaborative (BEST) Investigators.

    更新日期:2019-04-01 00:00:00

  • Disseminated histoplasmosis presenting as thrombotic microangiopathy.

    abstract:BACKGROUND:Thrombotic microangiopathies (TMA) are systemic vasoocclusive disorders associated with significant morbidity and mortality. Rapid and reliable diagnosis of TMA is critical. The diagnosis is complicated by a lack of objective and sensitive laboratory testing as well as multiple concurrent diseases, including...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2006.00873.x

    authors: Dwyre DM,Bell AM,Siechen K,Sethi S,Raife TJ

    更新日期:2006-07-01 00:00:00

  • The National Marrow Donor Program.

    abstract::As the number of successful marrow transplants has increased, the lack of HLA-identical sibling donors for 60 to 70 percent of transplant candidates has become a serious problem. Pilot studies established that marrow transplantation between phenotypically HLA-identical, unrelated individuals can be accomplished succes...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1993.33793325052.x

    authors: Stroncek D,Bartsch G,Perkins HA,Randall BL,Hansen JA,McCullough J

    更新日期:1993-07-01 00:00:00

  • Red blood cells stored for increasing periods produce progressive impairments in nitric oxide-mediated vasodilation.

    abstract:BACKGROUND:Clinical outcomes in transfused patients may be affected by the duration of blood storage, possibly due to red blood cell (RBC)-mediated disruption of nitric oxide (NO) signaling, a key regulator of vascular tone and blood flow. STUDY DESIGN AND METHODS:AS-1 RBC units stored up to 42 days were sampled at se...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12111

    authors: Alexander JT,El-Ali AM,Newman JL,Karatela S,Predmore BL,Lefer DJ,Sutliff RL,Roback JD

    更新日期:2013-11-01 00:00:00

  • A possible role for the production of multiple HLA antibodies in fatal platelet transfusion refractoriness after peripheral blood progenitor cell transplantation from the mother in a patient with relapsed leukemia.

    abstract:BACKGROUND:There has been controversy over whether HLA alloimmunization is a risk factor for platelet (PLT) transfusion refractoriness (PTR) in hematopoietic peripheral blood progenitor cell transplantation (HPBPCT). STUDY DESIGN AND METHODS:Reported here is a boy with relapsed leukemia who developed fatal PTR after a...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2007.01109.x

    authors: Nakazawa Y,Saito S,Hasegawa Y,Yanagisawa R,Sakashita K,Kamijo T,Miyazaki T,Sato S,Ikeda H,Ikebuchi K,Koike K

    更新日期:2007-02-01 00:00:00

  • Preventing murine transfusion-related acute lung injury by expansion of CD4+ CD25+ FoxP3+ Tregs using IL-2/anti-IL-2 complexes.

    abstract:BACKGROUND:Transfusion-related acute lung injury (TRALI) is one of the most serious adverse events following transfusion, and there is no specific treatment in clinical practice. However, regulatory T cells (Tregs) have been suggested to play a potential role in the treatment of TRALI. This study investigated whether i...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15064

    authors: He R,Li L,Kong Y,Tian L,Tian X,Fang P,Bian M,Liu Z

    更新日期:2019-02-01 00:00:00

  • The impact of temporary deferral due to low hemoglobin: future return, time to return, and frequency of subsequent donation.

    abstract:BACKGROUND:This study investigated the effects of a 6-month deferral due to low hemoglobin (Hb) on the subsequent donation patterns of Australian whole blood donors. STUDY DESIGN AND METHODS:The study was a retrospective cohort study of the donation patterns of all whole blood donors deferred for low Hb during a 2-mon...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2010.02881.x

    authors: Hillgrove T,Moore V,Doherty K,Ryan P

    更新日期:2011-03-01 00:00:00

  • Liquid storage of marrow stromal cells.

    abstract:BACKGROUND:Marrow stromal cells (MSCs) for clinical trials are inevitably stored before administration, but little is known about the effects of storage on MSCs. The effects of short-term liquid storage on the in vitro function of MSCs intended for a clinical trial were studied. STUDY DESIGN AND METHODS:Early-passage ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2009.02138.x

    authors: Lane TA,Garls D,Mackintosh E,Kohli S,Cramer SC

    更新日期:2009-07-01 00:00:00

  • Protein composition of clots detected in pooled cryoprecipitate units.

    abstract:BACKGROUND:On rare occasions, upon thawing of stored cryoprecipitate components, clots are observed on visual inspection. Although it has been assumed that the clot reflects fibrinogen to fibrin conversion, there are few published studies that document that this assumption is correct. Our studies were conducted to furt...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2012.03778.x

    authors: MacPhee M,Wilmer B,Beall D,Moroff G

    更新日期:2013-03-01 00:00:00

  • Buffering and dilution in red blood cell storage.

    abstract:BACKGROUND:Red blood cell (RBC) storage solutions work in a narrow pH range between 7.2 and 6.4. While keeping RBC within that pH range, ATP production can be increased by buffering or dilution. STUDY DESIGN AND METHODS:In the first study, 12 units of packed CP2D RBCs were pooled in groups of four, re-aliquoted, and a...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2005.00672.x

    authors: Hess JR,Rugg N,Joines AD,Gormas JF,Pratt PG,Silberstein EB,Greenwalt TJ

    更新日期:2006-01-01 00:00:00

  • The use of polymerase chain reaction in plasma pools for the concomitant detection of hepatitis C virus and HIV type 1 RNA.

    abstract:BACKGROUND:Detection of viral nucleic acids might increase blood transfusion safety through the detection of recently infected blood donors during the preseroconversion window period. Individual screening is difficult to apply, because of technical and financial constraints. STUDY DESIGN AND METHODS:A polymerase chain...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1998.381098440854.x

    authors: Yerly S,Pedrocchi M,Perrin L

    更新日期:1998-10-01 00:00:00

  • A comparative study of the postoperative allogeneic blood-sparing effects of tranexamic acid and of desmopressin after total knee replacement.

    abstract:BACKGROUND:Tissue hypoxia and reperfusion induce abnormal hemostatic function. Therefore, bleeding after total knee replacement (TKR) may be a result of a tourniquet-induced imbalance of the procoagulant and fibrinolytic systems. Because laboratory confirmation of tourniquet-induced abnormal hemostasis is difficult to ...

    journal_title:Transfusion

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1537-2995.2001.41101285.x

    authors: Zohar E,Fredman B,Ellis MH,Ifrach N,Stern A,Jedeikin R

    更新日期:2001-10-01 00:00:00

  • Hemostatic effects of fibrinogen gamma-chain dodecapeptide-conjugated polymerized albumin particles in vitro and in vivo.

    abstract:BACKGROUND:Prototypes of platelet (PLT) substitutes have been studied and the focus was on a dodecapeptide, HHLGGAKQAGDV (H12), which is a fibrinogen gamma-chain carboxy-terminal sequence (gamma 400-411) and exists only in the fibrinogen domain. STUDY DESIGN AND METHODS:H12 was conjugated to the surface of polymerized...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2005.00173.x

    authors: Okamura Y,Takeoka S,Teramura Y,Maruyama H,Tsuchida E,Handa M,Ikeda Y

    更新日期:2005-07-01 00:00:00

  • Leukocyte depletion of red cell units at the bedside by transfusion through a new filter.

    abstract::Standard packed red cell (PRC) units can be depleted of leukocytes and platelets if they are transfused through a blood administration set in which the usual 170-mu filter has been replaced by a leukocyte removal filter (Sepacell R-500). During a 6-month period, 1550 PRC units were transfused through this filter in 61...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1987.27587320533.x

    authors: Sirchia G,Rebulla P,Parravicini A,Carnelli V,Gianotti GA,Bertolini F

    更新日期:1987-09-01 00:00:00