Abstract:
Background:Acute myeloid leukemia (AML), an aggressive clonal disease, is genetically heterozygous. The prognostic role of expression of Breast Cancer Resistance Protein (BCRP) gene, which behaves as a multidrug transporter, in adult AML is ambiguous. Objective:The objective is to assess the level of mRNA expression of BCRP gene in newly diagnosed cytogenetically normal adult Egyptian AML patients; and to clarify its potential influence and association between therapeutic responsiveness and disease free survival. Methods:The BCRP gene expression was evaluated by quantifying its mRNA using real time RT-PCR in fifty newly diagnosed cytogenetically normal adult AML patients and 20 healthy normal controls. The expression was evaluated in relation to clinical and prognostic factors, response to treatment and the survival rate. Results:BCRP mRNA was over expressed in adult AML patients compared to controls. This study showed a positive statistical correlation between BCRP gene expression and the percent of CD34 expression. Statistical analysis did not reveal any association between BCRP expression level and chemotherapeutic responsiveness or disease free survival rate. Conclusion:The significance of BCRP gene expression and its function in AML is very complicated, therefore more standardized clinical studies are needed.
journal_name
Afr Health Scijournal_title
African health sciencesauthors
El-Masry MW,Gouda HM,Shaheen IA,Edesa W,Hassan NM,Ramzy Rdoi
10.4314/ahs.v18i4.15subject
Has Abstractpub_date
2018-12-01 00:00:00pages
958-964issue
4eissn
1680-6905issn
1729-0503pii
jAFHS.v18.i4.pg958journal_volume
18pub_type
杂志文章abstract:BACKGROUND:South Africa has endorsed a World Health Assembly (WHA) resolution calling for control of soil-transmitted helminths (STHs). In Cape Town, services and housing that exist in old-established suburbs should minimise the prevalence of intestinal parasitic infections, even when residents are poor. Where families...
journal_title:African health sciences
pub_type: 杂志文章
doi:
更新日期:2005-06-01 00:00:00
abstract:Background:Hospital-acquired infections (HAIs), one of the leading causes of, morbidity and mortality, are common in developing countries. Methicillin-resistant staphylococcus aureus (MRSA), commonest cause of HAIs, has been isolated from the hands of more than half of health care workers. Practice of hand hygiene may ...
journal_title:African health sciences
pub_type: 杂志文章
doi:10.4314/ahs.v18i1.11
更新日期:2018-03-01 00:00:00
abstract:Background:Crimean-Congo hemorrhagic fever (CCHF) is an endemic zoonosis in Kastamonu, Turkey. Clinical and laboratory findings may not be specific in the early phase of the disease, hence bringing a challenge to the clinician. Objective:We aimed to distinguish CCHF cases among all suspected cases by comparing them wi...
journal_title:African health sciences
pub_type: 杂志文章
doi:10.4314/ahs.v19i1.16
更新日期:2019-03-01 00:00:00
abstract:Background:Type 2 diabetes mellitus is usually related to vascular problems and is associated with impairment in endothelial function characterized by impaired endothelial-dependent vasodilation and increased platelet adhesion. There is limitation in clinical studies that have addressed the beneficial effects of weight...
journal_title:African health sciences
pub_type: 杂志文章,随机对照试验
doi:10.4314/ahs.v18i4.5
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Lassa fever is a rodent-borne zoonosis that clinically manifests as an acute hemorrhagic fever. It is treated using ribavarin. Surviving Lassa fever without receiving the antiviral drug ribavarin is rare. Only few cases have been documented to date. CASE PRESENTATION:We report a case of a 59-year old female...
journal_title:African health sciences
pub_type: 杂志文章
doi:10.4314/ahs.v14i4.40
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:Zoonoses pose a risk to public health. OBJECTIVE:To carry out the investigation of the prevalence of gastrointestinal parasites of baboons, Papio anubis, frequenting the Wikki base Camp in Yankari National Park, Nigeria. METHOD:Formol-ether concentration technique was used to isolate parasite eggs and cyst...
journal_title:African health sciences
pub_type: 杂志文章
doi:10.4314/ahs.v13i2.7
更新日期:2013-06-01 00:00:00
abstract::Health professionals in developing countries want access to information to help them make changes in health care and contribute to medical research. However, they face challenges of technology limitations, lack of training, and, on the village level, culture and language. This report focuses on the U.S. National Libra...
journal_title:African health sciences
pub_type: 杂志文章
doi:
更新日期:2011-09-01 00:00:00
abstract:Background:Viral hemorrhagic fevers (VHF) refers to a group of febrile illnesses caused by different viruses that result in high mortality in animals and humans. Many risk factors like increased human-animal interactions, climate change, increased mobility of people and limited diagnostic facility have contributed to t...
journal_title:African health sciences
pub_type: 杂志文章
doi:10.4314/ahs.v20i3.17
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Despite the slight progress made on Antenatal Care (ANC) utilization, skilled delivery care service utilization in Ethiopia is still far-below any acceptable standards. Only 10% of women receive assistance from skilled birth attendants either at home or at health institutions, and as a result the country is ...
journal_title:African health sciences
pub_type: 杂志文章
doi:10.4314/ahs.v14i4.29
更新日期:2014-12-01 00:00:00
abstract:Background:Drug-therapy problems(DTPs) among hypertensive patients can result in patient's morbidity and mortality. The main aim of this study was to assess drug therapy problem and associated factors among hypertensive patients. Methods:A hospital based cross sectional study was conducted. The data was collected from...
journal_title:African health sciences
pub_type: 杂志文章
doi:10.4314/ahs.v19i3.33
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:Noise induced hearing loss (NIHL) is within the top five occupational illnesses in Zimbabwe. Workers at a mining company complained about loss of hearing at the mine clinic. OBJECTIVE:To determine the prevalence of NIHL among employees at the Mine. METHODS:We conducted a descriptive cross sectional study a...
journal_title:African health sciences
pub_type: 杂志文章
doi:10.4314/ahs.v13i4.6
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Little information is available on the rapid diagnostic testing for syphilis in Burkina Faso. The objectives of the study were (i) to assess the sensitivity and specificity of four on site rapid tests in comparison with Treponema pallidum haemagglutination assay (TPHA) as a gold standard and (i...
journal_title:African health sciences
pub_type: 杂志文章
doi:10.4314/ahs.v15i2.8
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Malaria is the primary cause of hospitalization in Côte d'Ivoire. Early treatment is one of the strategies to control this illness. However, the spread of resistance of Plasmodium falciparum to antimalarial drugs can seriously compromise this strategy. OBJECTIVES:The aim of this study was to assess the in v...
journal_title:African health sciences
pub_type: 杂志文章
doi:
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Resistance to most antimalarial drugs has encouraged the use of herbal preparations along with prescribed orthodox drugs. OBJECTIVE:To investigate effect of co-administration of aqueous extract of T. occidentalis leaves; commonly used as antimalarial and haematinic agent in Nigeria and artesunate using P. b...
journal_title:African health sciences
pub_type: 杂志文章
doi:10.4314/ahs.v13i4.16
更新日期:2013-12-01 00:00:00
abstract:Background:The integrated approach to malaria prevention, which advocates for the use of several malaria prevention methods at households, is being explored to complement other existing strategies. We implemented a pilot project that promoted the integrated approach to malaria prevention in two rural communities in Wak...
journal_title:African health sciences
pub_type: 杂志文章
doi:10.4314/ahs.v18i4.35
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:In tackling the ongoing malnutrition problem in many parts of Kenya, the government has initialized preventive actions such as mother support groups in order to improve health and nutrition among children. Few studies have evaluated the effectiveness of such intervention. OBJECTIVE:This study aimed at deter...
journal_title:African health sciences
pub_type: 杂志文章
doi:10.4314/ahs.v16i4.4
更新日期:2016-12-01 00:00:00
abstract:Background:The staphylococci have increasingly been associated with infections worldwide and anti-microbial resistance has made these versatile pathogens more recalcitrant in the hospital setting. Objectives:This study sought to investigate the occurrence and distribution of Staphylococcus species as well as determine...
journal_title:African health sciences
pub_type: 杂志文章
doi:10.4314/ahs.v17i4.7
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Mistakes in the identification and administration of drugs may be fatal. This is especially so in the practice of anaesthesia. This is a report of 2 cases of near fatality due to mistakes in drug administration from look-alike medications. OBJECTIVE:To highlight the significance of medication errors in our ...
journal_title:African health sciences
pub_type: 杂志文章,评审
doi:10.4314/ahs.v13i3.46
更新日期:2013-09-01 00:00:00
abstract:Background:The risk of death from complications related to cancer of the cervix is a main health problem over the course of a woman's life in low income countries. It commonly affects women infected with HIV. Therefore, screening women infected with HIV should start in low income countries, including Ethiopia. Methods...
journal_title:African health sciences
pub_type: 杂志文章
doi:10.4314/ahs.v19i1.46
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:Due to increasing stress, individual personality traits are becoming a significant contributor to CRT (Crash Related Trauma). In the present study, we hypothesized that there will be no difference in personality characteristics of CRT patients and control subjects and there will be no association between tra...
journal_title:African health sciences
pub_type: 杂志文章
doi:10.4314/ahs.v16i3.27
更新日期:2016-09-01 00:00:00
abstract:Background:Colorectal cancer (CRC) is one of the most prevalent cancers in Saudi Arabia that is highly characterized with poor survival rate and advanced metastasis. Many studies contribute this poor outcome to the expression of ABC transporters on the surface of cancer cells. Objectives:In this study, two ABCB1 varia...
journal_title:African health sciences
pub_type: 杂志文章
doi:10.4314/ahs.v19i3.23
更新日期:2019-09-01 00:00:00
abstract:Background:Surgical site infections (SSI) are a potential cause of morbidity and increased cost of care after operations such as open prostatectomy. Objective:To audit the occurrence of SSI after open prostatectomy at the Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC), Ile-Ife, Nigeria. Methods:A revi...
journal_title:African health sciences
pub_type: 杂志文章
doi:10.4314/ahs.v19i2.30
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Reduction in renal length was found to be an insufficient independent indicator of chronic renal disease. OBJECTIVE:To determine the ultrasound normative values of renal parenchymal thickness (RPT) among adults and correlate them with age and somatometric parameters. METHODS:This was a prospective clinic b...
journal_title:African health sciences
pub_type: 杂志文章
doi:10.4314/ahs.v14i3.27
更新日期:2014-09-01 00:00:00
abstract:Background:Mulago Hospital is a high volume referral hospital under the Makerere University School of Medicine and Health Sciences. Basic obstetric ultrasound is a useful skill that can aid patient care. Objectives:The purpose of the study was to assess the effectiveness of an intervention implemented to teach basic u...
journal_title:African health sciences
pub_type: 杂志文章
doi:10.4314/ahs.v18i1.21
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Carbohydrate antigen (CA)19-9 that is the most widely used biomarker for pancreatic cancer has certain limitations in diagnosis, which results in a tough job to distinguish pancreatic cancer from benign tumors with normal CA19-9. The aim of this study was to investigate the diagnostic utility of clinical par...
journal_title:African health sciences
pub_type: 杂志文章
doi:10.4314/ahs.v15i1.17
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:There are limited reports on HIV-1 RNA load, CD4+ T-lymphocytes and antibody responses in relation to disease progression in HIV-1 infected untreated children in Africa. METHODS:To describe the relationships between these parameters, we conducted a longitudinal cohort study involving 51 perinatally HIV-1 in...
journal_title:African health sciences
pub_type: 杂志文章
doi:10.5555/afhs.2006.6.1.3
更新日期:2006-03-01 00:00:00
abstract:Background:HIV causes a decrease in CD4+ lymphocyte cells count, exposing the individual to infections (urinary tract infections). This study was carried out to determine the prevalence of bacteriuria and antimicrobial susceptibility pattern of bacteria isolates among HIV patients. Methods:Clean catch mid-stream urine...
journal_title:African health sciences
pub_type: 杂志文章
doi:10.4314/ahs.v20i3.7
更新日期:2020-09-01 00:00:00
abstract::Hearing impairment is a significant disability. According to the World Health Organization (WHO), more than 80% of the world's approximately 120 million people with hearing impairment live in developing countries. Cochlear implant is the only therapeutic intervention for those with severe-profound sensorineural hearin...
journal_title:African health sciences
pub_type: 杂志文章
doi:10.4314/ahs.v15i4.38
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Frenkel's ambulatory activity has been routinely employed by physiotherapists for rehabilitation of gait coordination, however, its immediate influence on blood pressure and heart rate has not been investigated. OBJECTIVE:To investigate the acute effect of Frenkel's ambulatory activity on blood pressure and...
journal_title:African health sciences
pub_type: 杂志文章
doi:10.4314/ahs.v14i4.19
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the antimicrobial activity of Momordica charantia extracts on reference strains and microorganisms isolated from clinical specimens. METHOD:Petroleum ether and methanolic crude extracts of fruits and leaves of the plant were evaluated for antimicrobial activity using the disk diffusion method on ...
journal_title:African health sciences
pub_type: 杂志文章
doi:
更新日期:2009-03-01 00:00:00