Abstract：
BACKGROUND:There are limited reports on HIV-1 RNA load, CD4+ T-lymphocytes and antibody responses in relation to disease progression in HIV-1 infected untreated children in Africa. METHODS:To describe the relationships between these parameters, we conducted a longitudinal cohort study involving 51 perinatally HIV-1 infected children aged between 1 and 13 years. HIV status was determined by ELISA and confirmed by western blot and PCR. Antibodies were quantified by limiting dilution ELISA, plasma HIV-1 RNA load by RT-PCR and CD4+ T-lymphocytes by FACSCount. RESULTS:Asymptomatic and symptomatic disease had, respectively, a rise in median HIV-1 RNA load from 1,195 to 132,543 and from 42,962 to 1,109,281 copies/ml in children below 6 years. The increase in viral load was 10-fold higher for asymptomatic compared to other categories and 2-fold faster for children less than 6 years than those above. Similarly, symptomatic children below 6 years had initial median CD4+ T-lymphocyte counts of 647 (22%) cells/muL, declining to 378 (20%) while those above 6 years had initial values of below 335 (15%) but which increased to 428 (17%). Median viral load correlated significantly with median CD4+ T-lymphocyte percentage in children above 6 years (p=0.026) but not below. CONCLUSIONS:Viral load is lower in older than younger children and correlates significantly with percentage CD4+ T-lymphocytes. Survival by HIV-1 infected children requires a competent immune response early in infection to counter the rapidly replicating virus. Interventions aimed at boosting the naïve immune system may prolong survival in these children.
journal_name
Afr Health Scijournal_title
African health sciencesauthors
Ochieng W,Ogoyi D,Mulaa FJ,Ogola S,Musoke R,Otsyula MGdoi
10.5555/afhs.2006.6.1.3subject
Has Abstractpub_date
2006-03-01 00:00:00pages
3-13issue
1eissn
1680-6905issn
1729-0503journal_volume
6pub_type
杂志文章abstract：Objective:Acute organophosphorus(OP) pesticide poisoning is associated with dysfunctions in multiple organs, especially skeletal muscles, the nervous system and the heart. However, little is known about the specific microRNA (miRNA) changes that control the pathophysiological processes of acute OP poisoning damage. We ...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.4314/ahs.v18i2.18
更新日期：2018-06-01 00:00:00
abstract：BACKGROUND:Stigmatization and discrimination of people living with HIV/AIDS has a negative impact on the global efforts to control the HIV/AIDS pandemic. Due to fear of stigmatization and discrimination, many people are reluctant to undergo voluntary counseling and testing, infected individuals are often unwilling to d...
journal_title：African health sciences
pub_type： 杂志文章
doi：
更新日期：2007-12-01 00:00:00
abstract：Background:Overgrowth of candida results from factors that disrupt the intestinal microbial balance, such as the use of antibiotics. Unregulated antibiotic use and rampant practice of self-medication in Nigeria, is a cause for concern. Methods:A total of 314 stool specimens were collected from children <1 to 12 years ...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.4314/ahs.v17i4.27
更新日期：2017-12-01 00:00:00
abstract：Background:Acinetobacter baumannii (AB) is increasingly becoming a clinically relevant organism due to the rising number of associated nosocomial infections. The therapeutic options are extremely minimal because of its ability to develop resistance to all available antimicrobials, including colistin (CST). Data on the ...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.4314/ahs.v19i3.13
更新日期：2019-09-01 00:00:00
abstract：Background:The integrated approach to malaria prevention, which advocates for the use of several malaria prevention methods at households, is being explored to complement other existing strategies. We implemented a pilot project that promoted the integrated approach to malaria prevention in two rural communities in Wak...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.4314/ahs.v18i4.35
更新日期：2018-12-01 00:00:00
abstract：Backgrounds:People in Yemen and in East African countries chew khat more than five hours daily. Objectives:The aim of this study was to assess the relationship between khat and occlusal caries progression. Methods:A cohort study was carried out among 98 Yemeni khat chewers and 101 non-chewers aged 18-35 years old wit...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.4314/ahs.v18i4.25
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:Neurologic infections are an important cause of morbidity and mortality especially worldwide but much more in the African continent. The frequency of the different types of neurologic infections and their mortality in this part of Nigeria is not known. OBJECTIVES:To review cases admitted into the main terti...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.5555/afhs.2006.6.1.55
更新日期：2006-03-01 00:00:00
abstract：BACKGROUND:Seizures are a common presenting feature in children with cerebral malaria (CM) and neurologic deficits have been described in survivors of CM. However few prospective studies have described the frequency of seizure activity and neurologic deficits in survivors of CM over time. METHODS:Eighty-two children a...
journal_title：African health sciences
pub_type： 杂志文章
doi：
更新日期：2009-06-01 00:00:00
abstract：BACKGROUND:Sonography is a valuable tool in the assessment of porto-systemic pathologies. This study aimed at determining the mean portal vein diameter based on age, gender and anthropometric variables. METHODS:A cross sectional study conducted among 201 apparently healthy adults in Bauchi Metropolis. Participants wer...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.4314/ahs.v16i4.35
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:Barriers to oral health utilization are many, but those that are significant for our environment are not yet clear. The current study was designed to identify and graduate the barriers to receipt of oral health care among a cross-section of patients attending our centre. We also investigated the influence of...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.4314/ahs.v12i4.17
更新日期：2012-12-01 00:00:00
abstract：Background:The risk of death from complications related to cancer of the cervix is a main health problem over the course of a woman's life in low income countries. It commonly affects women infected with HIV. Therefore, screening women infected with HIV should start in low income countries, including Ethiopia. Methods...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.4314/ahs.v19i1.46
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:Atrial fibrillation (AF) is the most common cardiac arrhythmia and increases the risk of stroke and death. Patients with hypertensive have an increased risk of developing atrial fibrillation. RDW (Red blood cell distribution width) levels are elevated in cardiovascular disorders including heart failure, stab...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.4314/ahs.v14i1.41
更新日期：2014-03-01 00:00:00
abstract：BACKGROUND:HIV/AIDS is a major public health problem in Cameroon which had a prevalence of 5.1% in 2010 with 141 new infections per day. The fear of voluntary counseling and testing (VCT) is an obstacle to HIV prevention. OBJECTIVES:To determine the prevalence of HIV-1, HIV-2 and HIV-1/HIV-2 co-infection among people ...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.4314/ahs.v12i3.5
更新日期：2012-09-01 00:00:00
abstract：Background:Impairment of peripheral skeletal muscle function is a common phenomenon in patients with cystic fibrosis (CF) in addition to great clinical connotations, such as lack of exercise tolerance and decrease of health-related quality of life. There is very limited data on the effects of maximal exercise on muscle...
journal_title：African health sciences
pub_type： 临床试验,杂志文章
doi：10.4314/ahs.v18i4.45
更新日期：2018-12-01 00:00:00
abstract：OBJECTIVES:This study was carried out to search for cases of undetected hypertension in young adult male and non-pregnant female patients (18 - 44years) attending a catholic mission hospital in Ibadan, Nigeria so as to provide evidence for routine blood pressure checks in this age group. It also sought to determine ris...
journal_title：African health sciences
pub_type： 杂志文章
doi：
更新日期：2009-09-01 00:00:00
abstract：BACKGROUND:Cancer can produce many different symptoms, some subtle and some not at all subtle. An increasingly important issue in oncology is to evaluate quality of life (QoL) in cancer patients. The cancer-specific QoL is related to all stages of this disease. OBJECTIVE:The aim of this study was to evaluate the QoL i...
journal_title：African health sciences
pub_type： 杂志文章
doi：
更新日期：2011-06-01 00:00:00
abstract：BACKGROUND:Day case surgery services are increasing all over the world. The prevalence of postoperative pain after day surgery is found to be high. Little is known about the prevalence of postoperative pain, in Kenya, after day case surgeries. OBJECTIVE:To investigate the prevalence of postoperative pain after day sur...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.4314/ahs.v13i3.36
更新日期：2013-09-01 00:00:00
abstract：Background:The use of illicit drugs has become a worldwide health problem. Substances with the potential to be abused may have direct or indirect effects on physiologic mechanisms that lead to organ system dysfunction and diseases. Objective:The present study aims to investigate the structural and reabsorption integri...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.4314/ahs.v18i3.35
更新日期：2018-09-01 00:00:00
abstract：Background:Acute myeloid leukemia (AML), an aggressive clonal disease, is genetically heterozygous. The prognostic role of expression of Breast Cancer Resistance Protein (BCRP) gene, which behaves as a multidrug transporter, in adult AML is ambiguous. Objective:The objective is to assess the level of mRNA expression o...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.4314/ahs.v18i4.15
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:We determined the genetic diversity of mycobacteria isolated from tuberculosis patients in Mbarara Uganda, using region of difference (RD) analysis and spacer oligonucleotide typing (spoligotyping). METHODS:Sputum samples were cultured on Lowenstein Jensen media. The isolates were characterized using RD ana...
journal_title：African health sciences
pub_type： 杂志文章
doi：
更新日期：2010-12-01 00:00:00
abstract：BACKGROUND:Cholera, a severe acute watery diarrhea caused by Vibrio cholerae is endemic in Nigeria with most cases occurring in the rural areas. In South West Nigeria, some individuals resort to alternative treatments such as Ogi-tutu, Psidium guajava and Vernonia amygdalina during infections. The effectiveness of thes...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.4314/ahs.v16i2.33
更新日期：2016-06-01 00:00:00
abstract：BACKGROUND:Drug related problem (DRPs) is a key factor which will affect the outcome of therapy and safety. OBJECTIVE:To assess the DRPs in type 2 diabetes mellitus (T2DM) patients and psychological aspects of patients by community pharmacists to observe the rate of DRP. METHODS:Prospective randomized controlled inte...
journal_title：African health sciences
pub_type： 杂志文章,随机对照试验
doi：10.4314/ahs.v14i3.7
更新日期：2014-09-01 00:00:00
abstract：BACKGROUND:Recent publications show that smoking and alcohol use among adolescents with unplanned pregnancy is increasing and the causes need to be further studied. OBJECTIVE:To determine the association between living in a non-intact family household and the presence of smokers and consumers of alcoholic beverages in...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.4314/ahs.v16i1.4
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:Snake envenomation is a major public health problem of the Savannah regions of West Africa. Ocular manifestations of snakebites are rare with few reports documenting blindness as a complication. OBJECTIVE:To highlight an unusual manifestation of snake bites and its attendant problems. METHODS:A report of s...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.4314/ahs.v15i3.46
更新日期：2015-09-01 00:00:00
abstract：BACKGROUND:Frenkel's ambulatory activity has been routinely employed by physiotherapists for rehabilitation of gait coordination, however, its immediate influence on blood pressure and heart rate has not been investigated. OBJECTIVE:To investigate the acute effect of Frenkel's ambulatory activity on blood pressure and...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.4314/ahs.v14i4.19
更新日期：2014-12-01 00:00:00
abstract：Background:Oral contraceptives pills (OCPs) are common and a convenient form of contraception. The use of hormonal contraceptives by women has been considered to influence gingival and periodontal disease progression. Aim:This study was conducted to assess the effect of oral contraceptive pills on the periodontal heal...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.4314/ahs.v19i1.56
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:The morbid effects of urinary bilharziasis are becoming more evident with the advent of sophisticated diagnostics such as ultrasound. However, such diagnosis of Schistosoma haematobium morbidity is often hampered by lack of funds, proper equipment, or training. OBJECTIVE:We performed a cross-sectional inves...
journal_title：African health sciences
pub_type： 杂志文章
doi：
更新日期：2004-08-01 00:00:00
abstract：BACKGROUND:Honey is an ancient remedy for the treatment of infected wounds, which has recently been 'rediscovered' by the medical profession. The use to which honey is put in medical care is increasing daily with many authors pointing out its importance and role in wound care. There have been reports that honey contain...
journal_title：African health sciences
pub_type： 杂志文章,评审
doi：10.5555/afhs.2007.7.3.159
更新日期：2007-09-01 00:00:00
abstract：BACKGROUND:Despite the slight progress made on Antenatal Care (ANC) utilization, skilled delivery care service utilization in Ethiopia is still far-below any acceptable standards. Only 10% of women receive assistance from skilled birth attendants either at home or at health institutions, and as a result the country is ...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.4314/ahs.v14i4.29
更新日期：2014-12-01 00:00:00
abstract：BACKGROUND:Lassa fever is a rodent-borne zoonosis that clinically manifests as an acute hemorrhagic fever. It is treated using ribavarin. Surviving Lassa fever without receiving the antiviral drug ribavarin is rare. Only few cases have been documented to date. CASE PRESENTATION:We report a case of a 59-year old female...
journal_title：African health sciences
pub_type： 杂志文章
doi：10.4314/ahs.v14i4.40
更新日期：2014-12-01 00:00:00
